Nanostructures for Cancer Therapy

1st Edition - April 11, 2017
Imprint: Elsevier
Editors: Alexandru Mihai Grumezescu, Anton Ficai
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 4 6 1 4 4 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 4 6 1 5 0 - 4

Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends an… Read more

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Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics.

In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents.

The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer.

Chapter 1: Nanotechnology for personalized medicine: cancer research, diagnosis, and therapy

Abstract
1. Introduction
2. Main Types of Cancer
3. Personalized Treatment of Cancer
4. Nanotreatment of Cancer
5. Nanodrugs and Nanocarriers
6. Conclusions
Acknowledgments

Chapter 2: Bioengineered nanomaterials for chemotherapy

Abstract
1. Introduction
2. Polymeric Nanoparticles
3. Carbon Nanotubes
4. Gold Nanoparticles
5. Supermagnetic Iron Oxide Nanoparticles
6. Fullerenes
7. Dendrimers
8. Quantum Dots
9. Conclusions
Acknowledgments

Chapter 3: Biofunctionalized nanomaterials for targeting cancer cells

Abstract
1. Introduction
2. Targeting Strategies for Cancer Cells
3. Combination of Nanostructures With Chemotherapeutic Agents
4. Conclusions
Acknowledgment

Chapter 4: Improving chemotherapy drug delivery by nanoprecision tools

Abstract
1. Introduction
2. Conventional Cancer Treatment
3. Nanoparticles for Chemotherapy Delivery System
4. Challenges Facing Nanomedicine in Oncology
5. Conclusions

Chapter 5: RIPL peptide as a novel cell-penetrating and homing peptide: design, characterization, and application to liposomal nanocarriers for hepsin-specific intracellular drug delivery

Abstract
1. Introduction
2. Cell-Penetrating and Homing Peptide
3. RIPL Peptide for Hpn-Specificity
4. RIPL-Conjugated Liposomes
5. Cytotoxicities of RIPL and RIPL-Lipo
6. Summary
Acknowledgments

Chapter 6: Progress of nanoparticles research in cancer therapy and diagnosis

Abstract
1. Introduction
2. Nanoparticles as Efficient Drug-Delivery Systems
3. Nanoparticles for Cancer Therapy
4. Conclusions
Acknowledgement

Chapter 7: Interfacial engineering of nanoparticles for cancer therapeutics

Abstract
1. Introduction
2. Characteristics of Drug Delivery Carriers
3. Different Types of Nanoparticle-Based Delivery Systems
4. Site-Specific Targeting of Nanoparticles
5. Pharmacokinetics and Biodistribution of Nanoparticles
6. Future Perspectives

Chapter 8: Nanotechnological approaches toward cancer chemotherapy

Abstract
1. Nanotherapeutics
2. The Development of Nanotherapeutics
3. Nanostructures for Cancer Therapy
4. Methods for Fabrication of Nanoparticles
5. Mode of Entry of Nanoparticles in Cells
6. Controlled Drug Delivery Systems
7. Nanoparticles for Cancer Drug Delivery: Active versus Passive Targeting
8. Targeted Drug Delivery Systems
9. Pharmacokinetics of Nanotherapeutics
10. Toxicology of Nanoformulations
11. The Gap Between Laboratory Synthesis and Commercial Viability of Production of Nanoformulations
12. Conclusions

Chapter 9: Cancer therapies: applications, nanomedicines and nanotoxicology

Abstract
1. Introduction
2. Applications of Chemotherapy
3. Nanomedicines for Cancer Therapy
4. Nanotoxicology
5. Conclusions
Acknowledgments

Chapter 10: Multifunctional polymeric micelles as therapeutic nanostructures: targeting, imaging, and triggered release

Abstract
1. Introduction
2. Encapsulation of Drug
3. Drug Delivery
4. Triggered Release
5. Appropriate Targeting
6. Imaging
7. Multifunctional Micelles
8. Conclusions

Chapter 11: Recent advances in diagnosis and therapy of skin cancers through nanotechnological approaches

Abstract
1. Introduction
2. Epidemiology of Skin Cancers
3. Modern Diagnosis of Skin Cancers
4. Modern Treatment of Skin Cancers
5. Nanosystems in the Diagnosis of Skin Cancers
6. Nanosystems in the Therapy of Skin Cancers
7. Conclusions and Perspectives

Chapter 12: Design of nanoparticle structures for cancer immunotherapy

Abstract
1. Introduction
2. Dendritic Cells
3. Targeting Dendritic Cells in Vaccine Development by Nanoparticles
4. Nanoparticle-Based Immunotherapy for Cancer
5. Immunological Properties of Engineered Nanoparticles
6. Conclusions

Chapter 13: Recent advances of folate-targeted anticancer therapies and diagnostics: current status and future prospectives

Abstract
1. Introduction
2. Principles of Folate-Targeting Strategy
3. Folate-Targeted Anticancer Therapy
4. Folate-Targeted Systems as Diagnostic Tools in Cancer
5. Conclusions and Future Prospectives
Acknowledgments

Chapter 14: Anticancer efficiency of curcumin-loaded invertible polymer micellar nanoassemblies

Abstract
1. Introduction
2. Synthesis of Amphiphilic Invertible Polymers
3. Micellization, Self-Assembly, and Invertible Properties of AIPs
4. Self-Assembly of AIPs in Water: Potential for Stimuli-Responsive Drug Delivery
5. Invertible Polymer Micellar Nanoassemblies as a Unique Delivery System Targeted to Osteosarcoma Cells
6. Conclusions

Chapter 15: Dose enhancement effect in radiotherapy: adding gold nanoparticles to tumor in cancer treatment

Abstract
1. Introduction
2. Application of Gold Nanoparticles in Radiotherapy
3. Dose Enhancement due to Gold Nanoparticle Addition
4. Gold Nanoparticle-Enhanced Radiotherapy
5. Conclusions
Acknowledgment

Chapter 16: Silver-based nanostructures for cancer therapy

Abstract
1. Introduction
2. Silver-Based Nanostructures for Tumor Diagnosis
3. Silver-Based Nanostructures for Tumor Targeted and Controlled Delivery Systems
4. Silver-Based Nanostructures for Tumor External-Activated Treatment
5. Conclusions
Acknowledgments

Chapter 17: Ligand-decorated polysaccharide nanocarriers for targeting therapeutics to hepatocytes

Abstract
1. Introduction
2. Different Ligand-Polysaccharide Nanocarriers
3. Conclusions

Chapter 18: Targeted delivery of anticancer drugs: new trends in lipid nanocarriers

Abstract
1. Introduction
2. Drug Delivery Systems: Concepts and Characteristics of Lipid Nanocarriers
3. Strategies for Targeted Drug Delivery in Cancer
4. Conclusions
Acknowledgments

Chapter 19: Nanoparticles for magnetic hyperthermia

Abstract
1. Magnetic Hyperthermia in Cancer Therapy
2. Clinical Constraints
3. Magnetic Fluid Hyperthermia
4. Mechanisms of Heat Dissipation
5. Nanoparticles Synthesis and Coating
Acknowledgments

Chapter 20: Nanotechnology: a challenge in hard tissue engineering with emphasis on bone cancer therapy

Abstract
1. Introduction
2. Representative Materials for Hard Tissue Engineering
3. Drug Delivery Systems Designed for Hard Tissue Engineering
4. Conclusions
Acknowledgments

Chapter 21: Combination therapy of macromolecules and small molecules: approaches, advantages, and limitations

Abstract
1. Introduction
2. Peptides and Proteins as Therapeutic Agents in Cancer
3. Proteins as Targeting Agents in Cancer
4. Nucleic Acid-Based Macromolecule Therapeutics
5. Conclusions

Chapter 22: Nanosized drug delivery systems as radiopharmaceuticals

Abstract
1. Introduction
2. Future Perspectives

Chapter 23: Mesoporous silica nanoparticles: a promising multifunctional drug delivery system

Abstract
1. Introduction
2. Types and Synthesis of Mesoporous Silica Nanoparticles
3. Surface Functionalization of Mesoporous Silica Nanoparticles
4. Therapeutic Applications of MSNPs
5. Biological Performance of MSNPs
6. Characterization of MSNPs
7. Conclusion

Chapter 24: Cancer therapies based on enzymatic amino acid depletion

Abstract
1. Introduction
2. Amino Acid Deprivation Enzymes
3. Conclusions
Acknowledgments

Chapter 25: Self-emulsifying delivery systems: one step ahead in improving solubility of poorly soluble drugs

Abstract
1. Introduction
2. Various Formulation Strategies to Enhance Solubility and Permeability
3. Self-Emulsifying Drug Delivery System
4. Lipid Formulations (Charman et al., 1992; Colin, 2000; Collin, 1997; Pouton, 2000; Pouton and Porter, 2008)
5. Type of Spontaneously Emulsifying System (SEDDS)
6. Structure of SEDDS
7. Theories and Thermodynamics of Microemulsion Formulation
8. Difference Between SMEDDs and SNEDDs
9. Factors to be Consider for the Development of SEDDS
10. Suitable Drug Candidate Identification for SEDDS (Gursoy and Benita, 2004)
11. Composition of SEDDS
12. Formation of SEDDS
13. Construction of Phase Diagram (Aungst et al., 1993; Colin, 2000; Collin, 1997; Patel et al., 2008; Sahji, 2010; Singh et al., 2009b)
14. Mechanism of Self-Emulsification
15. Factors Affecting Formation of Microemulsion (Adhvait, 2010; Bhupinder et al., 2013; Khan et al., 2012; Patil and Paradkar, 2004; Tatyana, 2000)
16. Absorption Mechanism for Self-Microemulsification (Colin, 2008; Gupta et al., 2013; Pouton and Porter, 2008; Tatyana, 2000)
17. Biopharmaceutical Issues in the Selection of SEDDS
18. Advantages
19. Disadvantages (Chavda et al., 2012; Chavda, 2013; Colin, 2008; Muzaffar et al., 2013)
20. Evaluation
21. Applications
22. Advancement in Self-Emulsifying Systems
23. Marketed Formulation of SMEDDS
24. Recent Patents on Advanced Self-Emulsifying Systems
25. Conclusions

Chapter 26: Near-infrared light-responsive nanotherapeutic agents: application in medical oncology

Abstract
1. Introduction
2. Near-Infrared Light-Responsive Nanomolecule and Its Application in Medicine
3. Using Near-Infrared Light-Responsive Nanomolecule in Medical Oncology
4. Safety Consideration in Using Near-Infrared Light-Responsive Nanomolecule in Medical Oncology
5. Conclusions

Chapter 27: Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach

Abstract
1. Introduction
2. Nanosystems Containing Anticancer Agents Used for Metastatic Breast Cancer: Current Clinical Practice and Trial Studies
3. Use of Selective Biomarkers for Breast Cancer Detection, Analysis, Diagnosis, and Therapeutic Intervention
4. Overcoming Breast Cancer Drug Resistance
5. Conclusions
Acknowledgment

Chapter 28: Natural plant-derived anticancer drugs nanotherapeutics: a review on preclinical to clinical success

Abstract
1. Introduction
2. Plants as Source of Anticancer Agents
3. Physicochemical and Biopharmaceutical Limitations of Plant-Derived Anticancer Drugs
4. Nanomedicines in Cancer
5. Preclinical or Clinical Status of Plant-Derived Natural Anticancer Nanomedicines
6. Conclusions

Chapter 29: Nanotherapy: a next generation hallmark for combating cancer

Abstract
1. Introduction
2. Nanotechnology in Cancer and Treatment
3. Conclusions and Final Remarks
Acknowledgments

Chapter 30: Nanostructures for cancer therapy: from targeting to selective toxicology

Abstract
1. Introduction
2. Targeted Cancer Therapies
3. Nanoparticles Used in Cancer Therapy
4. Toxicological Aspects of Nanoscale Drug Delivery Systems
5. Conclusions
Acknowledgments

Alexandru Mihai Grumezescu

Dr. Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biomaterials, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, and Biomaterials and Tissue Engineering Bulletin. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 6 co-authored books and 11 edited books.

Affiliations and expertise

Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science and Faculty of Medical Engineering, Politehnica University of Bucharest, Romania

Anton Ficai

Anton Ficai is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Romania. His research activity is mainly focused on biomaterials for bone healing and treatment. He has been involved in various projects dealing with bone cancer treatment and pain management (especially associated with bone cancer). His patent application related to bone cancer treatment was recently awarded with the Gold Medal by “BRUSSELS INNOVA - The World Exhibition on Inventions, Research and New Technologies”. Anton Ficai is also active in the field of synthesis and characterization of drug delivery systems, synthesis and characterization of nanomaterials, biomaterials or antimicrobial materials, etc. Dr Ficai serves on he Editorial Board of three journals, and has also been the guest editor of Current Pharmaceutical Design.

He has been awarded over 20 prizes for his academic and research activity, and was invited as Visiting Professor of University of Beira Interior. He has given oral presentations at more than 10 international conferences and published over 100 papers and 12 books and book chapters.

Affiliations and expertise

Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Romania

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