Nanophototherapy

Preparations and Applications

1st Edition - August 23, 2024
Imprint: Elsevier
Editors: Panchanathan Manivasagan, Jayachandran Venkatesan, Eue-Soon Jang
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 9 3 7 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 9 3 8 - 3

Nanophototherapy: Preparations and Applications provides a comprehensive overview of the various multifunctional nanoparticles used for phototherapy, with an emphasis on fundament… Read more

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Nanophototherapy: Preparations and Applications provides a comprehensive overview of the various multifunctional nanoparticles used for phototherapy, with an emphasis on fundamental nanotechnology and the latest research of photothermal therapy (PTT) and photodynamic therapy (PDT). The different types of phototherapeutic nanomaterials are thoroughly described, along with their structural features and synthesis. This is the first book to cover nanomaterial-based phototherapy for both cancer and bacterial infections. It is an essential resource for researchers, academics, and professionals interested in the potential of multifunctional nanomaterials for therapeutic applications.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editors
Preface
Part I: Introduction of nanophototherapy
Chapter 1. Introduction to nanophototherapy
Abstract
1.1 Introduction
1.2 Nanomaterials used for phototherapy
1.3 Phototherapy
1.4 Combination therapy
1.5 Conclusions and future perspectives
Acknowledgment
References
Chapter 2. Milestones in nanotechnology-aided cancer phototherapy
Abstract
Abbreviations
2.1 Introduction
2.2 Noble metal nanoparticles
2.3 Liposomes, micelles, and polymer nanoparticles
2.4 Carbon-based nanomaterials
2.5 Metal oxide and sulfide-based nanomaterials
2.6 Nanomaterials with natural ligands
2.7 Concluding remarks
References
Chapter 3. Light responsive plasmonic nanomaterials applied to cancer phototherapy
Abstract
3.1 Introduction
3.2 Upmost light-responsive plasmonic nanomaterial
3.3 Gold-based nanomaterials light-responsive to therapies
3.4 Nanomaterials light-responsive to image diagnosis
3.5 Conclusion and perspectives
References
Chapter 4. Nanohydrogels for application in phototherapy
Abstract
4.1 Introduction
4.2 Nanohydrogels derived from natural polymers for phototherapy
4.3 Nanohydrogels derived from synthetic polymers for phototherapy
4.4 Composite nanohydrogels for phototherapy
4.5 Perspectives and conclusions
References
Chapter 5. Nanomaterial based phototherapy for cancer and infectious disease treatment
Abstract
5.1 Introduction
5.2 Nano phototherapy for the treatment of cancer
5.3 Photosensitizer mechanism of action
5.4 Reported concepts
5.5 Applications of nanobased delivery in cancer treatment
5.6 Research advancements
5.7 Nanomaterial based phototherapy for treatment of infectious disease
5.8 Photothermal therapy for infectious disease
5.9 Photodynamic therapy for infectious disorders
5.10 Applications of photothermal therapy in the management of infections
5.11 Present obstacles and factors to deliberate in phototherapy
5.12 Applications of photodynamic therapy in infectious diseases
5.13 Hurdles in photodynamic therapy material development
5.14 Conclusions and future perspective
References
Part II: Photothermal therapy of cancer
Chapter 6. Noble metal nanoparticles for photothermal therapy
Abstract
Abbreviations
6.1 Introduction
6.2 Noble metal nanoparticles
6.3 Fabrication methods—noble metal nanoparticles
6.4 Surface modifications of noble metal nanoparticles
6.5 Photothermal therapy of noble metal nanoparticles
6.6 Conclusions
References
Chapter 7. Conjugated polymer nanoparticles for photothermal therapy of cancer
Abstract
7.1 Introduction
7.2 Natural polymers
7.3 Synthetic polymers
7.4 Conducting polymers
Acknowledgments
References
Chapter 8. Carbon dot–based photonic nanomaterials for photothermal tumor therapy
Abstract
8.1 Introduction
8.2 Synthesis strategy of carbon dots for photothermal therapy
8.3 Carbon dot–based nanomaterials for photothermal therapy
8.4 Application of carbon dot–based nanomaterials for image-guided photothermal therapy
8.5 Application of carbon dot–based nanomaterials in synergistic therapy
8.6 Future prospect and outlook
References
Chapter 9. MXenes in photothermal cancer therapy: applications and advances
Abstract
Abbreviations
9.1 Introduction
9.2 MXenes in photothermal therapy applications
9.3 Cytotoxicity and biosafety concerns
9.4 Challenges and future directions
9.5 Conclusions
References
Part III: Photodynamic therapy of cancer
Chapter 10. Metallic nanoparticles for photodynamic cancer therapy
Abstract
10.1 Introduction
10.2 Metal nanoparticles and photosensitizer
10.3 Combination of metal nanoparticles–induced photodynamic therapy with other therapy
10.4 Biological fate of metallic nanoparticles for photodynamic cancer therapy
10.5 Potential toxicity
10.6 Recent advancements
10.7 Conclusion
References
Chapter 11. Metal nanoparticles effect on the efficiency of organic sensitizers
Abstract
11.1 Photodynamic therapy
11.2 Effect of nanomaterials on the photophysics of organic sensitizers
11.3 Silver nanomaterials
11.4 Gold nanomaterials
11.5 Platinum nanomaterials
11.6 Conclusion and perspectives
Acknowledgment
References
Chapter 12. Recent progress in multifunctional conjugated nanocarriers for photodynamic therapy of tumors
Abstract
12.1 Introduction
12.2 Nanocarriers for targeted delivery of photosensitizers
12.3 Nanocarriers for alleviating tumor hypoxia
12.4 Nanocarriers combined with other cancer treatment approaches to enhance the efficacy of photodynamic therapy
12.5 Conclusions and future perspectives
References
Chapter 13. Lipids and natural polymer–based carrier systems for photodynamic therapy
Abstract
Abbreviations
13.1 Introduction
13.2 Brief history
13.3 Detail mechanisms of photocytotoxicity
13.4 Nanoparticulate systems in photodynamic therapy
13.5 Conclusion
References
Chapter 14. Metal organic framework based photodynamic therapy for cancer treatment
Abstract
14.1 Introduction
14.2 Metal-organic framework
14.3 Summary and future aspect
References
Chapter 15. Supramolecular photosensitizer-dendrimer complexes for photodynamic therapy in cancer treatment
Abstract
15.1 Introduction
15.2 Dendrimers in cancer drug delivery
15.3 Dendrimers in cancer phototherapy
15.4 Conclusion
Acknowledgment
References
Part IV: Combination therapy of cancer
Chapter 16. Photothermal-chemotherapy: the emerging supramolecular photothermal molecules and the recent advances
Abstract
16.1 Introduction
16.2 Common photothermal converting platforms
16.3 Supramolecular photothermal assemblies
16.4 Photothermal-chemotherapy materials enable synergized antitumor outcome
16.5 Engineering hydrogel for localized photothermal-chemotherapy
16.6 Tumor accumulating or penetrating materials
16.7 Cell mimicking materials and engineered cell as therapeutics carrier
16.8 Regulation of cancer cell stemness as antitumor strategy
16.9 Conclusion and future perspective
Acknowledgment
References
Further reading
Chapter 17. Green inorganic metal nanomaterials for combination nanotherapy: synthesis, advantages, and future perspectives
Abstract
17.1 Green inorganic nanomaterials
17.2 Therapy
17.3 Conclusions
References
Chapter 18. Phototherapy meets chemodynamic therapy: a win–win strategy rejuvenating cancer treatment
Abstract
18.1 Introduction
18.2 Basis of phototherapy
18.3 Basis of chemodynamic therapy
18.4 Strategies for photo/chemodynamic combination therapy of cancers
18.5 Conclusions and perspectives
References
Chapter 19. Nanophotosensitizer-based photothermal therapy for cancer immunotherapy
Abstract
19.1 Introduction
19.2 Nanophotosensitizers for photothermal therapy and cancer immunotherapy
19.3 Conclusions
References
Chapter 20. Nanotechnology at the forefront of liver cancer diagnosis
Abstract
20.1 Introduction
20.2 Conventional diagnostic techniques for liver cancer
20.3 Nanotechnology-based cancer diagnostic tools
20.4 Applications of nanotechnology in liver cancer diagnosis
20.5 Nanotheranostics and photothermal therapy
20.6 Molecular perspective on nanotheranostics and photothermal therapy
20.7 Future scope
20.8 Conclusion
References
Chapter 21. Unveiling the potential of combining photodynamic with anti-vascular therapy for cancer treatment
Abstract
21.1 Introduction
21.2 Mechanism of photodynamic therapy in cancer treatment
21.3 Mechanism of action (drug)
21.4 Limitations of photodynamic therapy as monotherapy
21.5 Mechanism of anti-vascular therapy for cancer treatment
21.6 Limitations of anti-vascular therapy as monotherapy
21.7 Tumor vascular changes due to photodynamic therapy
21.8 The rationale for combining anti-vascular therapy with photodynamic therapy
References
Part V: Phototherapy of microbial infections
Chapter 22. Ultradeformable nanoparticles for active targeting of microbial infections: a photothermal approach
Abstract
Graphical abstract
22.1 Introduction
22.2 Ultradeformable nanoformulations or vesicular drug delivery systems
22.3 Future outcomes and applications
22.4 Conclusion
Acknowledgments
References
Chapter 23. Nanoenabled photodynamic therapy of microbial infections
Abstract
23.1 Introduction
23.2 Photodynamic therapy and its mechanism of action
23.3 Challenges associated with photodynamic therapy
23.4 Nano-based photodynamic therapy
23.5 Conclusion
References
Index

Panchanathan Manivasagan

Dr. Panchanathan Manivasagan is a Research Professor in the Department of Chemistry & Bio-Science at Kumoh National Institute of Technology (KIT) in Gumi, South Korea. A primary focus of his current research is the development of multifunctional nanomaterials for multimodal imaging (in vivo fluorescence imaging, photoacoustic imaging, CT imaging, and MR imaging) and therapy (chemotherapy, phototherapy, chemodynamic therapy, electrodynamic therapy, sonodynamic therapy, immunotherapy, starvation therapy, and electrolytic ablation therapy) for cancer and microbial infections.

Affiliations and expertise

Research Professor, Kumoh National Institute of Technology, South Korea

Jayachandran Venkatesan

Dr. Jayachandran Venkatesan M.Sc., M.Phil., Ph.D. is an assistant professor in Yenepoya Research Centre (YRC), Yenepoya (Deemed to be University), India. He worked as a postdoctoral researcher in the Division of Bioengineering, Incheon National University, and Hanyang University, South Korea. Previously, he worked as a Research Professor at the Department of Chemistry and Marine Bioprocess Research Center (MBPRC) at Pukyong National University, South Korea. He received his Master of Science in chemistry from Thiruvalluvar University in 2005. Further, He received his Ph.D. from Pukyong National University in 2011. His primary research interests are the investigation and development of naturally derived polymers, ceramics, and protein-based materials for biomedical applications. Furthermore, he works on natural biomaterials for tissue engineering and drug delivery applications.

Affiliations and expertise

Assistant Professor, Yenepoya Research Centre, Mangaluru, Karnataka, India

Eue-Soon Jang

Prof. Eue-Soon Jang is a Professor at the Department of Chemistry & Bio-Science at Kumoh National Institute of Technology (KIT) in Gumi, South Korea. He has held positions as a Post-Doctoral Fellow at Stanford University School of Medicine in Stanford, USA, and at the Department of Materials Science and Engineering at POSTECH in South Korea. Additionally, he worked as a Senior Researcher in the Department of Future Technology Research at Korea Telecom in South Korea. Prof. Jang obtained his B.Sc. degree from the Department of Chemistry at Chungnam National University in South Korea and his Master's and Ph.D. degrees from the Department of Chemistry at Seoul National University in Seoul, South Korea. His research program primarily revolves around the synthesis of various metal nanoparticles and the crystal engineering of solid nanoparticles.

Affiliations and expertise

Professor, Kumoh National Institute of Technology, South Korea

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Nanophototherapy

Preparations and Applications

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Eue-Soon Jang

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