Nanocarriers Based Colon Targeting
Design, Development, Mechanism and Case Studies
- 1st Edition - April 1, 2025
- Imprint: Academic Press
- Editors: Lalit Kumar, Yashwant Pathak
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 8 0 6 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 4 8 0 7 - 8
Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing dru… Read more
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Request a sales quoteNanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.
- Introduces different colonic diseases and their pathophysiology
- Explains the mechanism of action of different nanocarriers in colon targeting
- Presents case studies of different nanocarriers in colon targeting
Pharma researchers involved in targeted drug delivery to the colon
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1. An overview on colonic diseases
- Introduction
- Inflammatory bowel disease: Ulcerative colitis and Crohn's disease
- Epidemiology and risk factors
- Pathophysiology
- Common presentations
- Historically performed treatments
- Irritable bowel syndrome
- Risk factors
- Epidemiology
- Pathophysiology
- Common presentations
- Treatment
- Diverticulitis
- Introduction
- Epidemiology
- Pathophysiology
- Presentation
- Diagnostic methodology
- Treatment
- Proctitis
- Introduction
- Epidemiology
- Pathophysiology
- Presentation and diagnostic criteria
- Treatment
- Colorectal cancer and colonic polyps
- Risk factors for colorectal cancer
- Pathophysiology of colorectal cancer
- Diagnosis of colorectal cancer
- Treatment of colorectal cancer
- Conclusion
- Chapter 2. Colonic disease—Targeting strategies
- Introduction
- Anatomy of the colon
- Approaches in colon targeting
- pH-dependent systems
- Time-dependent systems
- Microbiota-triggered mechanism-based systems
- Combination of pH, time, and microbiota approaches
- pH- and time-triggered systems
- pH- and microbiota enzyme-triggered systems
- Time- and microbiota-triggered systems
- pH-, microbiota-, and time-triggered systems
- Redox potential systems
- Receptor-based systems
- Folate receptors
- Transferrin receptor
- CD44 receptor
- Macrophage galactose lectin
- CD98
- Peptide transporter 1
- Nanocarrier-based systems
- Liposomes
- Polymeric micelles
- Dendrimers
- Carbon nanotubes
- Solid lipid nanoparticles
- Magnetic nanoparticles
- Self-nanoemulsifying delivery systems
- Nanocarrier-based rectal systems
- Liquid suppositories and rectal enemas
- Gels
- Rectal foam
- Future prospects
- Chapter 3. Nanocarriers for the colonic diseases
- Introduction
- Nanomaterials
- Differentiating based on structural characteristics and composition
- Differentiating based on number of dimensions
- Differentiating based on pore dimensions
- Differentiating based on origin
- Nanocarriers
- Lipid-based nanocarriers
- Inorganic nanocarriers
- Polymeric nanocarriers
- The sciences and nanotechnology
- Physics and nanotechnology
- Chemistry and nanotechnology
- Nanotechnology
- Conclusion
- Chapter 4. Applications of nanocarriers in colon targeting
- Introduction
- Nanomedicine and colon diseases
- Nanoparticles in colon-targeted diagnosis
- Nanoparticles in colon-targeted therapy
- Gold nanoparticles
- Platinum nanoparticles
- Silver nanoparticles
- Quantum dots
- Dendrimers
- Carbon-based nanoparticles
- Fullerenes
- Mesoporous silica nanoparticles
- Lipid nanoparticles
- Superparamagnetic iron oxide nanoparticles (SPIONs)
- Other biomedical applications of nanoparticles
- Conclusion
- Chapter 5. Polymeric nanoparticles in colon targeting
- Introduction
- Anatomy and functions of colon
- Natural and synthetic polymers for colon targeting
- Chitosan
- Guar gum
- Pectin
- Dextrans
- Alginates
- Cyclodextrins
- Inulin
- Starch
- Chondroitin sulfate
- Locust bean gum
- Abelmoschus gum
- Carrageenan
- Katira gum
- Xanthan gum
- Gellan gum
- Eudragit
- Shellac
- Ethyl cellulose
- Cellulose acetate phthalate
- Poly (lactic-co-glycolic acid)
- Poly (methacrylic acid)
- Poly (acrylic acid)
- PNPs and colon drug delivery
- Classification of PNPs
- Nanospheres
- Nanocapsules
- Advantages of PNPs
- Methods of preparation of PNPs
- Emulsification-solvent evaporation
- Emulsification-solvent diffusion
- Emulsification-reverse salting-out
- Nanoprecipitation method
- Dialysis
- Supercritical fluid technology
- Mechanism of PNPs to achieve colon targeting
- Size-dependent polymeric systems
- Surface-functionalized polymeric systems
- pH-sensitive drug delivery system
- Delayed release/time-controlled release polymeric systems
- Microbially triggered polymeric systems
- Colonic drug delivery system (CODES)
- Enzyme sensitive polymeric systems
- Redox-sensitive polymeric systems
- Pressure controlled polymeric delivery systems
- Osmotically controlled polymeric systems
- PNPs and colon targeting
- Future perspectives and conclusion
- Chapter 6. Polymersomes in colon targeting
- Introduction (principles)
- Materials, design, and development of polymersomes
- Categories of polymersomes
- Methods of preparation
- Circulation kinetics and biodistribution of polymersomes
- Applications
- Protein delivery
- Anticancer moiety delivery
- Vaccine delivery
- Colorectal cancer therapy
- Regulatory issues
- Conclusion and future perspectives
- Chapter 7. Polymeric micelles in colon targeting
- Introduction
- Challenges and opportunities in therapy for colon diseases
- Polymeric micelles and their types
- Types of polymeric micelles
- Mechanism of formation of polymeric micelles
- Micelles formed by hydrophobic interactions
- Micelles formed by electrostatic interactions
- Methods to prepare polymeric micelles and drug entrapment
- Applications of polymeric micelles in colon diseases
- Polymeric micelles for ulcerative colitis and inflammatory bowel disease
- pH-responsive polymeric micelles
- Reactive oxygen species–responsive polymeric micelles
- Enzyme-responsive system polymeric micelles
- Dual-targeted polymeric micelles for colon targeting
- Polymeric micelles for colon cancer
- Block polymeric micelles for colon cancer
- Conclusion and future perspectives
- Chapter 8. Solid lipid nanoparticles in colon targeting
- Introduction
- Solid lipid nanoparticles for colon targeting
- Lipid selection and functionality
- Surface modification strategies for colon targeting
- Solid lipid nanoparticles preparation methods
- Production of solid lipid nanoparticles
- Drug incorporation techniques
- Applications of colon-targeted solid lipid nanoparticles
- Colon-targeted delivery of solid lipid nanoparticles for local action
- Colon-targeted delivery of solid lipid nanoparticles for systemic action
- Challenges and future perspectives of colon-targeted SLNs
- Regulatory considerations
- Scaling up production for clinical use
- Conclusion
- Chapter 9. Nanostructured lipid carriers in colon targeting
- Introduction
- Methods for preparing NLCs
- High-pressure homogenization method
- Solvent evaporation method
- Microemulsion method
- Ultrasonication method
- Solvent injection method
- Evaluation for NLCs
- Particle size and particle size distribution
- Surface morphology
- Drug loading capacity and entrapment efficiency
- Determination of lipid polymorphism and crystallinity
- Release of the active ingredient in vitro
- Stability of NLCs
- In vitro studies of NLCs
- In vivo studies of NLCs
- Application of NLCs for colon targeting
- Targeting colon diseases like IBD, UC, and Crohn's disease
- Targeting colon cancers
- Conclusion
- Chapter 10. Liposomes in colon targeting
- Colon-targeted drug delivery
- Liposomes
- Composition of liposomes
- Preparation of liposomes
- Lipid film hydration method
- Ethanol or ether injection method
- Emulsification method
- Polymers used to enhance liposomal formulations
- Clinical applications and formulation approaches for Colon-targeted drug delivery
- Recent trends
- Other clinical applications
- Cancer therapy
- Colorectal pain
- Bacterial infections in the gastrointestinal tract
- Challenges in the biological landscape confronting liposomal drug delivery systems
- Gastrointestinal pH variability
- Enzymatic degradation
- Mucus layer
- Colonic microflora
- Reticuloendothelial system clearance
- Colon transit time variability
- Patient-specific variability
- Inflammatory conditions
- Future directions
- Conclusion
- Chapter 11. Carbon-based nanomaterials in colon cancer targeting
- Introduction
- Epidemiology and etiology of colorectal cancer
- Pathophysiology of colorectal cancer
- Different carbon-based nanomaterials for targeted therapy of colorectal cancer
- Carbon dots/carbon quantum dots
- Nanodiamonds
- Carbon nanotubes
- Development techniques of colorectal cancer–targeting carbon-based nanomaterials
- Carbon dots/carbon quantum dots
- Nanodiamonds
- Carbon nanotubes
- Colorectal cancer–targeting strategies of developed carbon-based nanomaterials
- Carbon dots/carbon quantum dots
- Nanodiamonds
- Carbon nanotubes
- Expert opinion
- Conclusion
- Chapter 12. Gold nanoparticles in colon targeting
- Introduction
- Characteristics and applications of gold nanoparticles
- Synthesis of gold nanoparticles
- Chemical method for synthesis of gold nanoparticles
- Biosynthesis of gold nanoparticles
- Gold nanoparticles in colon disease therapy
- Gold nanoparticles in inflammatory bowel disease research
- Gold nanoparticles in colon cancer research
- Gold nanoparticles as photothermal agents
- Gold nanoparticles as radiosensitizers
- Gold nanoparticles as drug carriers
- Therapeutic activity of gold nanoparticles
- Theranostic properties of gold nanoparticles
- Toxicity aspects of gold nanoparticles
- Expert opinion
- Conclusion and prospects
- Chapter 13. Supramagnetic iron oxide nanoparticles for colon targeting
- Introduction
- Synthesis of supramagnetic iron oxide nanoparticles
- Chemical synthesis
- Biological method
- Characteristics of SPIONs
- Structural properties of supramagnetic iron oxide nanoparticles
- Magnetic property
- Size and shape of supramagnetic iron oxide nanoparticles
- Surface charge
- Application of supramagnetic iron oxide nanoparticles in drug delivery
- Combination of supramagnetic iron oxide nanoparticles with chemotherapy for colorectal treatment
- Combination of supramagnetic iron oxide nanoparticles with immunotherapy in colorectal treatment
- Application of supramagnetic iron oxide nanoparticles in diagnostic and imaging
- Application of supramagnetic iron oxide nanoparticles in Magnetic Hyperthermia for colorectal cancer
- Application of supramagnetic iron oxide nanoparticles in environmental remediation
- Shortcoming of supramagnetic iron oxide nanoparticles
- Conclusion and future perspectives
- Chapter 14. Magnetic triblock copolymer nanoparticles in colon targeting
- Introduction
- Magnetic triblock copolymer nanoparticles: Synthesis and characterization
- Explanation of the structure and composition
- Detailed synthesis methods
- Emulsion techniques
- Self-assembly
- Characterization techniques
- Transmission electron microscopy
- Scanning electron microscopy
- X-ray diffraction
- Magnetic properties and functionalization
- Understanding the magnetic properties
- Functionalization with targeting ligands and therapeutic agents
- Achieving colloidal stability and biocompatibility
- Colon-specific drug delivery
- Anatomy and physiology of the colon
- Functions
- Physiological conditions
- Challenges in achieving colon-specific drug delivery
- How magnetic triblock nanoparticles address these challenges?
- Precise targeting
- Controlled release
- Reduced systemic exposure
- Versatile drug loading
- Improved drug stability
- Magnetic guidance and targeting mechanisms
- Principles of magnetic guidance and targeting
- Navigation through the gastrointestinal tract
- Role of external magnetic fields in targeting
- Drug release and therapeutic efficacy
- Controlled drug release from magnetic triblock nanoparticles
- In vitro and in Vivo Studies demonstrating colon-specific drug delivery
- Case studies highlighting therapeutic efficacy in colon-related diseases
- Case study 1: Inflammatory bowel disease
- Case study 2: Colon cancer
- Case study 3: Irritable bowel syndrome
- Safety and toxicity considerations
- Assessing the biocompatibility and safety of magnetic nanoparticles
- Discussion of potential toxicity issues and Mitigation strategies
- Regulatory aspects and approval pathways for clinical use
- Applications and case studies
- Future directions and challenges
- Emerging trends in magnetic nanoparticle research for colon targeting
- Challenges and Limitations that need to be addressed
- Prospects for clinical translation and commercialization
- Conclusion
- Summary of key findings and takeaways
- The potential impact of magnetic triblock nanoparticles on colon-targeted therapy
- Call to action for further research in this field
- Chapter 15. Dendrimer nanoparticles for colon targeting
- Introduction
- Dendrimer nanoparticles: Properties and characteristics
- Colon targeting in drug delivery systems
- pH-responsive systems for colon targeting
- Enzyme-responsive systems for colon targeting
- Challenges in dendrimer-based colon targeting
- Current applications
- Problem and limitations in dendrimer-based colon targeting
- Biocompatibility and toxicity
- Manufacturing and scalability issues
- Stability and drug loading capacity
- Limited drug compatibility
- Controlled release kinetics
- Targeting efficiency
- Clearance and elimination
- Regulatory difficulties
- Clinical translation
- Future prospects and applications
- Conclusion
- Chapter 16. Emerging trends of mesoporous silica nanoparticles in colon targeting
- Introduction to mesoporous silica nanostructures
- Synthesis of mesoporous silica nanoparticles
- Mesoporous silica nanoparticles as targeted drug delivery systems for colon disease
- Functionalization of MSNs for active colon targeting
- MSNs-based stimuli-responsive controlled delivery approaches for colon
- Internal stimuli-responsive approaches
- pH-responsive MSNs
- Redox-responsive MSNs
- Enzyme-triggered systems
- External stimuli-responsive drug delivery MSNs
- Light-activated systems
- Magnetically triggered systems
- Temperature-responsive systems
- Ultrasound-triggered systems
- Multistimuli responsive
- Biosafety of mesoporous silica nanoparticles
- Conclusion and future outlook
- Chapter 17. Redox nanoparticles in colon drug targeting
- Introduction
- Reactive oxidant species and inflammatory bowel disease
- Drug delivery to the gastrointestinal tract and reactive oxygen species-responsive nanoscaffolds for colon drug delivery
- Principles and design strategies for redox-responsive nanoparticles for inflammatory bowel disease
- Materials for redox-sensitive nanoplatforms
- Substances with a reactive oxygen species-induced solubility transition
- Polypropylene sulfide
- Block copolymers with selenium
- Polythioether ketal
- Materials with reactive oxygen species-induced backbone cleavage
- Materials with boronic esters
- Silicon
- Materials containing proline residues
- Polythioketal
- Fabrication techniques and characterization of redox-sensitive nanocarriers
- Redox nanotherapeutic approaches to colon drug targeting
- Nanocarrier transport of protein-based pharmacologic agents to regulate oxidative stress
- Nanocarrier transport of nucleic acid-based pharmacologic agents to modulate antioxidative pathways
- Nanocarrier transport of small-molecule antioxidative agents to scavenge reactive oxygen species
- Nanosized enzymes to generate protection against oxidation
- Reactive oxygen species-responsive nanoplatforms
- pH and reactive oxygen species dual-sensitive platforms
- External triggers for multiresponsive drug transport mechanisms
- Conclusions and future perspectives
- Chapter 18. State of the art application for protein and peptides in colon targeting
- Introduction
- Rationale for administration of protein/peptides by colonic delivery
- Colon as a therapeutic site of action
- Proteins and peptides as a therapeutic payload
- Key Challenges and critical considerations in the design of protein/peptide based colon-specific drug delivery systems
- Challenges related to site of action
- Challenges related to protein and peptide drugs
- Stratagems for ameliorating bioavailability of proteins/peptides through oral route
- Mechanistic pathways for drug absorption through colon
- Conventional drug delivery systems for colon targeting
- pH-dependent drug delivery system
- Enzyme-dependent (polysaccharide-mediated microbiota-dependent) systems
- Time-dependent systems
- Time- and pH-dependent systems
- Pressure-dependent systems
- Miscellaneous technological approaches
- Hydrogel-based approaches
- The dawn of nanotechnology in colon drug delivery
- Polymer-based nanoparticles
- Mucoadhesive polymeric nanoparticles
- Polysaccharide-based nanoparticles
- Ceramic-based inorganic nanoparticles
- Calcium phosphate-based nanoparticles
- Mesoporous silica nanoparticle-based hybrid nanoparticles
- Lipid-based nanoparticles
- Lipid vesicular systems/liposomes
- Solid lipid nanoparticles
- Plant-derived lipid nanoparticles
- Ligand/receptor-mediated drug delivery system
- Magnetically driven drug delivery system
- Technological advancements and strategic considerations for the state-of-the-art design of peptide-based colon drug therapeutics
- Summary and perspectives
- Chapter 19. Hybrid nanoparticles in colon targeting
- Introduction
- Colon targeting
- Challenges associated with colon targeting
- Lipid-polymeric hybrid nanoparticles
- Advantages of lipid-polymer hybrid nanoparticles
- Preparation of hybrid lipid-polymeric nanoparticles
- Two-step technique:
- Conventional
- Nonconventional
- One-step technique
- Modified nanoprecipitation
- Modified solvent evaporation
- Applications
- Future perspectives
- Conclusions
- Chapter 20. Polysaccharide-based nanocarriers in colon targeting drug delivery system
- Introduction
- Principle
- Design and development of polysaccharide based-nanoparticle
- Characterization of polysaccharide-based nanoparticles
- Particle size and distribution
- Zeta potential
- Polydispersity index
- Drug loading and release
- Chemical composition
- Stability and dispersibility
- Release kinetics
- Biocompatibility and cytotoxicity
- Materials
- Polysaccharides used for colon targeting nanocarriers
- Chitosan
- Alginate
- Dextran
- Pectin
- Hyaluronic acid (HA)
- Pullulan
- Gellan gum
- Guar originated gum
- Xanthan gum
- Inulin
- Mechanism
- Colonic targeted drug delivery systems (TDDSs)
- Advantages
- Disadvantages
- Criteria for selection of drug
- Colon anatomy
- Colonic pH
- Transit time
- Colonic microflora
- Case study
- Application
- Biocompatibility and biodegradability
- Controlled drug release
- pH sensitivity
- Mucoadhesive properties
- Encapsulation of the bioactive molecules
- Imaging and diagnostic applications
- Expert opinion
- Chapter 21. Nanocrystal based approach in colon targeting
- Introduction
- Mechanism underlying the superiority of drug nanocrystal
- Increased saturation solubility
- Increased dissolution rate
- Increased adhesiveness to surface/cell membranes
- Formulation approaches for drug nanocrystal
- Manufacturing methods of drug nanocrystals
- Bottom up technology
- Top down technology
- Wet milling
- High pressure homogenization
- Combination technologies
- Factors affecting mucopenetration of nanocrystal
- Case studies and applications
- Expert opinion
- Conclusion
- Chapter 22. Nano based enemas for colon targeting
- Introduction
- Anatomy and physiology of the colon
- Significance and suitability of colon-specific drug delivery
- Conventional enema and its limitations
- Nano-based enema as colon-specific drug delivery system
- Pharmacokinetics of nano-based enemas
- Preclinical/clinical applications of nano-based enemas
- Challenges and limitations
- Future prospects and emerging trends
- Conclusion
- Chapter 23. Exosomes in colon targeting
- Introduction: Overview of colon targeting in drug delivery
- Significance of exosomes in targeted delivery
- Principles of exosome-based delivery
- Biological composition of exosomes
- Role of exosomal membrane proteins and lipids
- Exosomal cargo: miRNA, mRNA, proteins, etc.
- Sources of exosomes
- Endogenous exosome sources
- Exogenous sources: Engineered exosomes
- Endogenous exosome sources
- Exogenous sources: Engineered exosomes
- Principles of exosome-based delivery
- Biological composition of exosomes
- Role of exosomal membrane proteins and lipids
- Exosomal cargo: miRNA, mRNA, proteins, etc.
- Isolation and purification of exosomes
- Isolation methods
- Purification techniques
- Drug loading in exosomes
- Passive loading methods
- Active loading methods
- Strategies to improve loading efficiency
- Mechanism of exosome-mediated colon targeting
- Intercellular communication via exosomes
- Gastrointestinal tract as target
- Exosome uptake by colonic cells
- Intracellular fate of exosomes
- Release of drug payload in the colon
- Case studies and applications of exosome-mediated colon targeting
- Case study 1: Exosome-based treatment of inflammatory bowel disease
- Case study 2: Targeted chemotherapy for colorectal cancer
- Case study 3: Exosome-mediated vaccination for colonic infections
- Case study 4: Drug delivery to colonic tumors via exosome-mimetic nanovesicles
- Expert opinions on current achievements
- Challenges and limitations
- Emerging trends and innovations
- Personalized medicine and patient-centric approaches
- Clinical translation and commercialization
- Ethical considerations and patient education
- Conclusion and future directions in exosome-mediated colon targeting
- Beyond treatment: Exosomes as tools for health
- The enduring promise of exosomes
- Chapter 24. Nanocarriers in inflammatory bowel disease and colorectal cancer
- Introduction
- Pathophysiology of IBD and CRC
- Crohn's disease
- Ulcerative colitis
- Pathogenesis of CRC
- Genetic factors
- Environmental factors
- Current treatment challenges
- The limitations and challenges in the treatment of IBD and CRC
- Inflammatory bowel disease
- Colorectal cancer
- Need for targeted and personalized therapies
- Nanocarrier-based drug delivery systems
- Nanocarriers in IBD management
- Recent studies and advancements in using nanocarriers for the treatment of IBD
- Specific drugs and therapeutic agents delivered via nanocarriers
- Anti-inflammatory agents
- Biologics
- Nanocarriers in CRC therapy
- Targeted drug delivery
- Chemotherapy
- Targeted immunotherapy
- RNA-based therapies
- Gene therapy
- Imaging and diagnosis
- Overcoming drug resistance
- Challenges of targeting colorectal tumors and strategies to overcome them using nanocarriers
- Future directions and challenges
- IBD
- Future directions
- Challenges
- CRC
- Future directions
- Challenges
- Conclusion
- Chapter 25. Self nanoemulsifying drug delivery systems in colon targeting
- Principal
- Materials
- Oils
- Surfactants
- Cosolvents
- Design and development
- Selection of drugs for SNEDDS
- Solubility of oils, surfactants, and cosurfactants
- Screening of surfactant
- Screening of cosurfactant
- Excipient compatibility assessment
- Ternary phase diagrams
- Mechanism
- Mechanism of self nanoemulsifying formation
- Mechanism of self nanoemulsifying formation
- Case studies for colon cancer
- Case 1
- Case 2
- Case 3
- Case 4
- Applications
- Inflammatory disease
- Cancer disease
- Diabetes disease
- Ocular disease
- Infectious disease
- Expert opinion
- Conclusion
- Chapter 26. Preclinical and clinical status of nanocarriers for colon targeting
- Introduction
- Inflammatory bowel disease: Crohn's disease
- Current clinical studies
- Certolizumab/pegol (Cimzia)—2008
- Mesenchymal stem cells—phase 3
- Antibody (Ab) coating for imaging
- Indocyanine green fluorescence—2012
- l-carnitine—Withdrawn
- Preclinical studies
- PEGylated anti-MAdCAM 1-Ab
- Rifaximin-loaded gum polysaccharide
- Adalimumab
- Pectin
- Omega 3 fatty Acid
- Glycocalyx-mimicking nanoparticles
- Reactive oxygen species nanoparticle scavenger
- PASylated certolizumab
- Vitamin D lipid carrier
- Budesonide-hyaluronic Acid
- Plant based nanoformulations
- Challenges
- Conclusion
- Inflammatory bowel disease: Ulcerative colitis
- Introduction
- Preclinical studies
- 5-Aminosalicylic Acid
- Corticosteroids
- Immunosuppressants
- Biologics
- Alternative treatments: Ginger and turmeric
- Clinical studies
- Fluorescent labeled targeting
- Treatment uses of nanoparticles
- Conclusion
- Colorectal cancer
- Introduction
- Colorectal cancer clinical trials
- Nanoparticle based therapies
- Ethylcellulose nanoparticles loaded with cetuximab and targeted with somatostatin (2020)
- Carbon nanoparticle-loaded iron—2022
- Nanopharmaceutical formulation of camptothecin combined dosed with capecitabine 2013
- Nanoparticles as immune modulators for cancer
- Trained immunity in thyroid carcinoma and colon carcinoma
- MT-302, an LNP mRNA particle as a TROP2-targeted in vivo CAR. 2023
- Nanoparticles as a tracer
- Lymph node mapping in CRC using novel magnetic tracers/indocyanine green
- Carbon nanoparticles versus indocyanine green for lymph node tracing 2021
- Using magnetomotoric ultrasound and nanoparticles to assess lymph nodes in rectal cancer 2022
- Preclinical studies
- Synthetic high density lipoprotein nanoparticles delivering docetaxel and CpG
- Nanoparticles for codelivery of camptothecin and survivin short hairpin RNA
- 7-Ethyl-10-hydroxy camptothecin prodrug forming stable liposomes
- MicroRNA-204-5p and oxaliplatin-loaded silica nanoparticles
- Cisplatin-loaded nanoplatform
- 5-Fluorouracil and (−)-epigallocatechin-3-gallate loaded into nanoparticles
- miRNA-145-delivering nanocarriers
- Carrier-free nanoparticles
- Conclusion
- Other colonic pathologies
- Diverticulitis
- Proctitis
- Non-Crohn's perianal fistula
- Conclusion and future direction
- Comprehensiveness
- Chapter 27. Regulatory issues and toxicological concerns related to nanocarriers
- Introduction
- Nanocarriers in drug delivery, types, and applications in medicine
- Organic nanocarriers
- Solid lipid nanocarriers
- Liposome
- Dendrimers
- Polymeric nanocarriers
- Inorganic nanocarriers
- Carbon nanotubes
- Gold nanocarriers
- Magnetic nanocarriers
- Quantum dot
- Mesoporous silica
- Hybrid nanocarriers
- Regulatory framework
- Regulatory bodies
- United States Food and Drug Administration (FDA)
- European Union—European Medicines Agency (EMA)
- Pharmaceuticals and Medical Devices Agency (PMDA), Japan
- Health Canada, Canada
- Therapeutic Goods Administration (TGA), Australia
- Central Drugs Standard Control Organization (CDSCO), India
- National Medical Products Administration (NMPA), China
- Ministry of Food and Drug Safety (MFDS), South Korea
- National Health Surveillance Agency (ANVISA), Brazil
- Federal Service for Surveillance in Healthcare (Roszdravnadzor), Russia
- Gulf Cooperation Council (GCC), GCC Health Council
- Saudi Food and Drug Authority (SFDA), Saudi Arabia
- Ministry of Health and Prevention (MOHAP), United Arab Emirates
- Characterization of nanocarriers
- Physicochemical characterization
- Size
- Surface morphology
- Surface charge
- Differential scanning calorimetry
- X-ray diffraction
- Drug encapsulation and loading capacity
- Drug localization and drug release
- In situ/vivo characterization of nanoparticles
- In vivo assessment: In vivo evaluation of nanocarriers
- Toxicological concerns
- Carbon-based nanoparticles
- Metal-based nanoparticles
- Lipid-based nanoparticles
- Protein-based nanoparticles
- Polymeric nanoparticles
- Silica nanoparticles
- Regulatory compliance and safety data requirements
- Preclinical testing, clinical trials, and phases
- Postmarket surveillance
- Conclusion and future directions
- Index
- Edition: 1
- Published: April 1, 2025
- Imprint: Academic Press
- No. of pages: 840
- Language: English
- Paperback ISBN: 9780443248061
- eBook ISBN: 9780443248078
LK
Lalit Kumar
Lalit Kumar is an Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research, Hajipur, Vaishali, Bihar, India. His area of research includes the development of nanocarriers for drug-targeting tumor cells in the colon, brain, breast, and lungs.
Affiliations and expertise
Assistant Professor, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, IndiaYP
Yashwant Pathak
Yashwant Pathak is a Professor and Associate Dean for faculty affairs at the Taneja College of Pharmacy at the University of South Florida, Tampa, USA. Prof. Pathak is also an Adjunct Professor at the Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia. His area of research is in health care education, nanotechnology, drug delivery systems, and nutraceuticals.
Affiliations and expertise
Professor and Associate Dean, Faculty Affairs, College of Pharmacy, University of South Florida, Tampa, USARead Nanocarriers Based Colon Targeting on ScienceDirect