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Nanoarchitectonics for Smart Delivery and Drug Targeting
1st Edition - July 12, 2016
Authors: Alina Maria Holban, Alexandru Mihai Grumezescu
Hardback ISBN:9780323473477
9 7 8 - 0 - 3 2 3 - 4 7 3 4 7 - 7
eBook ISBN:9780323477222
9 7 8 - 0 - 3 2 3 - 4 7 7 2 2 - 2
Nanoarchitectonics for Smart Delivery and Drug Targeting is one of the first books on the market to exclusively focus on the topic of nanoarchitectonics, a rapidly developing area… Read more
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Nanoarchitectonics for Smart Delivery and Drug Targeting
is one of the first books on the market to exclusively focus on the topic of nanoarchitectonics, a rapidly developing area of nanotechnology which allows scientists to arrange nanoscale structural units, typically a group of atoms or molecules, in an intended configuration.
This book assesses novel applications of nanomaterials in the areas of smart delivery and drug targeting using nanoarchitectonics and discusses the advantages and disadvantages of each application.
Provides a scholarly introduction to the uses of nanoarchitectonics in drug delivery and targeting
Explores novel opportunities and ideas for developing and improving nanoscale drug delivery systems through the use of nanoarchitectonics, allowing scientists to see how this exciting new technology is used in practice
Assesses the pros and cons of each application, allowing readers to assess when it is most appropriate to use nanoarchitectonics in drug delivery
Nanomaterials scientists and biomedical scientists seeking to learn more about how nanoarchitectonics can help them to create more effective drug delivery systems.
List of Contributors
Preface
Part 1: Smart Delivery
1: Therapeutic Nanostructures: Application of Mechanical Engineering in Drug Delivery
Abstract
1. Introduction
2. Application of Electromagnetism in Drug Delivery
3. Application of Ultrasonic Waves in Drug Delivery
4. Simulation Methods for Dispersion of Nanoparticles in Drug Delivery Systems
5. Conclusions
2: Nanoarchitectured Biomaterials: Present Status and Future Prospects in Drug Delivery
Abstract
1. Introduction
2. Liposomes
3. Dendrimers
4. Aquasomes
5. Nanoparticles
6. Nanogels
7. Nanoemulsions
8. Carbon Nanotubes
9. Quantum Dots
10. Conclusions
3: Smart Nanopolysaccharides for the Delivery of Bioactives
Abstract
1. Introduction
2. Structural Basis for Smartness of Nanopolysaccharides
3. Fabrication of Polysaccharide Nanostructures
4. Polysaccharide Nanostructures in the Delivery of Therapeutics
5. Conclusions
4: Drug-Delivery Applications of Cellulose Nanofibrils
Abstract
1. Background
2. Preparation and Methods
3. Drug Delivery and Other Pharmaceutical Applications of CNFs
4. Toxicology of CNFs
5. Conclusions
5: Nanoarchitectured Polysaccharide-Based Drug Carrier for Ocular Therapeutics
Abstract
1. Introduction
2. Barriers in Ophthalmic Therapeutics
3. Nanotechnology in Ocular Drug Delivery
4. Polysaccharide Nanocarrier in Ocular Drug Delivery
5. Physicochemical Properties of Polysaccharide Nanocarrier
6. Preparation of Polysaccharide Nanocarrier
7. Polysaccharide Nanoparticles and the Anterior Section of the Eye
8. Polysaccharide Nanoparticles and the Posterior Segment of the Eye
9. Polysaccharide Nanoparticles for Gene Therapies
10. Future Prospects
11. Conclusions
6: Current Polyesteric Systems for Advanced Drug Delivery
Abstract
1. Introduction
2. Chemistry of Biodegradable Polyesters
3. Biocompatibility and Regulatory Status
4. Applications
5. Limitations of Polyesters in Pharmaceutical Drug Delivery
6. Future Prospects
7: Nanobiomaterials Architectured for Improved Delivery of Antimalaria Drugs
Abstract
1. Introduction
2. Nanobiomaterials in Drug Delivery
3. Conclusions
Acknowledgment
8: Formulation of Innovative Hybrid Chitosan/TiO2- and Chitosan/SiO2-Based Drug-Delivery Systems
4. Multifunctionality of Mesoporous Silica Particles
5. Conclusions and Outlook
Acknowledgments
14: Recent Advances in Self-Emulsifying Drug-Delivery Systems for Oral Delivery of Cancer Chemotherapeutics
Abstract
1. Introduction
2. Self-Emulsifying Drug-Delivery Systems: Compositions and Ingredient Selection
3. Mechanisms for Enhancing Oral Bioavailability Using SEDDS Formulations
4. Advances in SEDDS Formulations
5. SEDDS for Oral Delivery of Chemotherapeutic Agents
6. Combinatorial Chemotherapy Using Self-Emulsifying Drug-Delivery Systems
7. Conclusions
15: Scientometric Overview in Nanobiodrugs
Abstract
1. Overview
2. Anticancer Nanobiodrugs
3. Other Nanobiodrugs
4. Conclusions
Part 2: Drug Targeting
16: Polymer: Lipid Hybrid Nanostructures in Cancer Drug Delivery: Successes and Limitations
Abstract
1. Introduction
2. Polymer–Lipid Hybrid Nanostructures
3. Preparation Methods of PLH
4. Factors Affecting Formation of PLH Nanoparticles
5. Applications of PLH in Cancer Therapy
6. Conclusions and Future Scope
Abbreviations
17: Carbon Nanotubes: A Promising Carrier for Drug Delivery and Targeting
Abstract
1. Introduction
2. Types of CNTs
3. Synthesis of CNTs
4. Purification
5. Properties
6. Functionalization
7. Drug-Loading Mechanisms and Cellular Uptake of CNTs
8. Breakdown Mechanism of CNTs in the Body
9. Targeted Drug Delivery by CNTs
10. Conclusions
18: Polymeric Nanoparticles as siRNA Drug Delivery System for Cancer Therapy: The Long Road to Therapeutic Efficiency
Abstract
1. Introduction
2. Structure and Characteristics of Polymers
3. Formulation of Polyplexes
4. Physicochemical Characterization
5. Stability of Polyplexes
6. Blood Stability After Systemic Injection
7. Targeting
8. Endocytosis
9. Endosomal Escape
10. Release of the siRNA From the Polyplexes
11. mRNA Degradation and Protein Shutdown
12. Nanotoxicity
13. Conclusions
Acknowledgment
Abbreviations
19: Polymeric Nanobiomaterials for Tumor Targeting
Abstract
1. Introduction
2. Natural Polymeric Nanobiomaterials Used for Tumor Targeting
3. Synthetic Polymeric Nanobiomaterials Used for Tumor Targeting
4. Patents of Polymeric Nanobiomaterials for Tumor Targeting
5. Current Status and Commercial Aspects
6. Conclusions
20: Alginate Containing Nanoarchitectonics for Improved Cancer Therapy
Abstract
1. Introduction
2. Advantages of the Use of Alginate Nanocarriers for the Treatment of Cancer
3. Disadvantages of the Use of Alginate Nanocarriers for the Treatment of Cancer
4. Physical and Chemical Properties of Alginate
5. Nanotechnology for Cancer Treatment
6. Alginate Nanocarriers
7. Preparation of Alginate Nanoparticles
8. Alginate Nanocarriers for Controlled Drug Delivery
9. Alginate Nanocarriers for the Treatment of Various Cancers
10. Future Prospects
11. Conclusions
21: Multifunctional Magnetic Nanostructures for Cancer Hyperthermia Therapy
Abstract
1. Introduction
2. An Overview of Cancer Treatments
3. Hyperthermia Treatment for Cancer
4. Theory of Magnetic Fluid Hyperthermia
5. Literature Survey on MNPs Used for Hyperthermia
6. Surface Coating on Magnetic Nanoparticles for Hyperthermia
7. Biocompatibility Issue of Magnetic Nanoparticles for Hyperthermia
8. In Vitro and In Vivo Hyperthermia
9. In Vivo Hyperthermia by Using Magnetic Nanoparticles: Challenges, Possibilities, and Outcomes
10. Conclusions and Future Perspectives
Acknowledgment
22: Advances in Lasers and Nanoparticles in Treatment and Targeting of Epithelial Originated Cancers
Abstract
1. Introduction
2. Cancer
3. Principles of Nanotechnology
4. Principles of Lasers
5. Combination of Lasers and Nanoparticles for Treatment of Cancers With Epithelial Origin
6. Discussion
7. Conclusions
23: Gold Nanoparticles: Their Properties and Role as Therapeutic Anticancer Agents
Abstract
1. Introduction
2. Cancer and Its Types
3. Properties of AuNPs
4. Synthesis of AuNPs
5. Bioapplications
6. Drawbacks of AuNPs
7. Future Aspects
8. Conclusions
24: Iron Oxide Nanoparticles for Cancer Diagnosis and Therapy
Abstract
1. Introduction
2. Basic Requirements for Biomedical Applications
3. Synthesis of Iron Oxide Nanoparticles
4. MNP Surface Modification
5. Application of Therapeutic Iron Oxide Nanoparticles in Cancer Diagnosis and Treatment
6. Future Prospects for Nanotechnology in Cancer Medicine
25: Nanoparticle and Targeted Systems for Colon Cancer Therapy
Abstract
1. Overview
2. Cancer Nanotechnology
3. Classes of Nanomaterials
4. Nanoparticle-Based Colon-Specific Drug Delivery
5. Nanotherapies for Colon Cancer
Abbreviations
26: Nanohybrid Stimuli-Responsive Microgels: A New Approach in Cancer Therapy
Abstract
1. Introduction
2. Microgels and Nanogels
3. Stimuli-Responsive Polymers
4. Synthesis of Microgels and Nanogels
5. Applications in Cancer Therapy
6. Conclusions
27: Multifunctional Magnetic Liposomes for Cancer Imaging and Therapeutic Applications
Abstract
1. Introduction
2. Chronological Developmental Stages of Cancer Therapeutics
3. Cancer Imaging—A Crucial Diagnosis Method
4. Overview of the Different Magnetic Nanostructures Used in Cancer Theragnostic Applications
5. Cancer Targeting
6. Magnetic Liposomes and Their Applications in Nanomedicines
7. Stimuli-Responsive Release of Anticancer Agents From Magnetic Liposomes
8. Magnetic Liposomes for Overcoming Multidrug Resistance in Tumors
9. Biocompatibility and Toxicity Issues
10. Current Status and Future Prospects
11. Challenges Encountered
12. Conclusions
Acknowledgments
28: The Chemotherapeutic Potential of Gold Nanoparticles Against Human Carcinomas: A Review
Abstract
1. Introduction
2. Nanoparticles
3. Green Synthesis
4. M. oleifera Leaves and Flowers
5. Gold Nanoparticles
6. Gold Nanoparticles in Chemotherapy
7. Potential Targets for Chemotherapy
8. Conclusions and Future Prospects
Acknowledgments
29: Nanotherapeutic Platforms for Cancer Treatment: From Preclinical Development to Clinical Application
Abstract
1. Cancer
2. Nanocarriers
3. Mechanisms of Targeted Delivery of Nanocarriers
4. Nanocarriers for Cancer Therapy in Clinical Development
5. Ligand-Based Active Targeting in Preclinical Development
6. Concluding Remarks and Future Perspectives
30: The Scientometric Overview in Cancer Targeting
Abstract
1. Overview
2. The Nanoparticle Anticancer Nanobiomaterials
3. The Other Anticancer Nanobiomaterials
4. Conclusions
Index
No. of pages: 970
Language: English
Published: July 12, 2016
Imprint: William Andrew
Hardback ISBN: 9780323473477
eBook ISBN: 9780323477222
AH
Alina Maria Holban
Alina-Maria Holban is a lecturer in Microbiology and Immunology, at the Faculty of Biology, University of Bucharest; and associate researcher at the University Politehnica of Bucharest, Romania. Her primary area of research is the development of bionanomaterials with antimicrobial applications. Dr. Holban has published 75 papers in peer-reviewed journals, 42 conference/symposia proceedings, and has edited more than 21 edited books.
Affiliations and expertise
Botany and Microbiology Department, Faculty of Biology, University of Bucharest, Romania
AG
Alexandru Mihai Grumezescu
Dr. Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biomaterials, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, and Biomaterials and Tissue Engineering Bulletin. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 6 co-authored books and 11 edited books.
Affiliations and expertise
Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science and Faculty of Medical Engineering, Politehnica University of Bucharest, Romania