Nano- and Microscale Drug Delivery Systems

Chapter 1: Microscale Drug Delivery Systems: Current Perspectives and Novel ApproachesValentina Grumezescu

• Abstract
• 1. Introduction
• 2. Microscale Drug Delivery Systems
• 3. Conclusions
• Acknowledgment

Chapter 2: Sustainable Delivery Systems Through Green NanotechnologyKiruba Krishnaswamy

• Abstract
• 1. History and Development of Nanotechnology
• 2. Different Forms of Nanostructures
• 3. Synthesis of Gold Nanoparticles (AuNP)
• 4. Transition Toward Green Nanotechnology
• 5. Green Synthesis of Gold Nanoparticles From Plant Extracts
• 6. Sustainable Gold Nanoparticles
• 7. Summary

Chapter 3: Polymer Therapeutics: Design, Application, and PharmacokineticsB. A. Atim Aderibigbe

• Abstract
• 1. Introduction
• 2. Polymeric Therapeutics for Treatment of Cancer
• 3. Polymeric Therapeutics for Treatment of Viral Infections
• 4. Polymeric Therapeutics for Treatment of Diabetes
• 5. Polymeric Therapeutics for Treatment of Osteoporosis
• 6. Polymer Therapeutics for Treatment of Digestive Tract Diseases
• 7. Polymeric Therapeutics for Wound Dressing and Tissue Regeneration
• 8. Polymeric Therapeutics for Treatment of Sepsis
• 9. Polymer Therapeutics for Treatment of Bacterial Infections
• 10. Polymer Therapeutics for Treatment of Fungal Infections
• 11. Polymer Therapeutics for Treatment of Malaria
• 12. Polymer Therapeutics for Treatment of Inflammation
• 13. Polymer Therapeutics for Treatment of Ocular Diseases
• 14. Polymer Therapeutics for Treatment of Leishmaniasis
• 15. Polymer Therapeutics for Treatment of Hypertension
• 16. Conclusions
• 17. Websites

Chapter 4: Fibonacci Nanostructures for Novel Nanotherapeutical ApproachLidija Matija

• Abstract
• 1. Introduction
• 2. Motivation
• 3. Biomolecular Signaling and Fibonacci Nanostructures
• 4. Fibonacci Nanostructures/C60
• 5. Conclusions
• Acknowledgments

Chapter 5: Dendrimers and Dendrimers-Grafted Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization, Functionalization, and Biological Applications in Drug Delivery SystemsHamidreza Shirzadfar

• Abstract
• 1. Introduction
• 2. Dendrimers as Nanoscale Containers
• 3. Dendrimers in Gene Transfection
• 4. Dendrimers in Drug Delivery
• 5. Dendrimers Modified Magnetic Nanoparticles in Drug Delivery
• 6. Conclusions

Chapter 6: Nanotechnology and the New Frontiers of Drug Delivery in Cerebral GliomasGerardo Caruso

• Abstract
• 1. Introduction
• 2. Glioma
• 3. Nanoparticles: New Therapeutic Potentials
• 4. Nanotoxicology
• 5. Applications in Brain Tumors
• 6. Conclusion

Chapter 7: Nanoparticles: A Novel Approach to Target TumorsGaurav Verma

• Abstract
• 1. Introduction
• 2. Types of Nanoformulations for Therapeutic Delivery
• 3. Modern Trends in Therapeutic Nanoformulations
• 4. Polymers and Methods Concerned in Nanodrug Delivery Systems
• 5. Challenges in the Fabrication of Nanoparticles as Targeted Delivery
• 6. Toxicity Control Process During Fabrication of Nanoparticles
• 7. Future Prospects
• 8. Conclusions

Chapter 8: Therapeutic Nanostructures for Dermal and Transdermal Drug DeliveryYousef Javadzadeh

• Abstract
• 1. Introduction
• 2. Nanocarriers in Skin Delivery
• 3. Nanoparticles in Skin Delivery
• 4. Conclusions

Chapter 9: Electrospun Nanofibrous Scaffold as a Potential Carrier of Antimicrobial Therapeutics for Diabetic Wound Healing and Tissue RegenerationCharu Dwivedi Sr.

• Abstract
• 1. Introduction
• 2. Materials for the Fabrication of Antimicrobial Nanofibrous Scaffolds
• 3. Methods of Fabrication of Nanofibrous Scaffolds
• 4. Antimicrobial Applications of Nanofibrous Scaffolds
• 5. Physicochemical Characterization of Antimicrobial Nanofibrous Scaffolds
• 6. Detecting Resistance to Antimicrobial Agents
• 7. Evaluation of Antimicrobial Efficacy of Antimicrobial Nanofibrous Scaffolds
• 8. Strategies for the Incorporation of Antimicrobial Compounds on Nanofibrous Scaffolds
• 9. Conclusions
• Acknowledgment

Chapter 10: Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic TechniquesSibel A. Ozkan

• Abstract
• 1. Introduction
• 2. Nanocarrier-Based Approaches for Oral Delivery of Anticancer Compounds
• 3. The Place of Chromatographic Techniques in Cancer Drugs
• 4. Conclusions

Chapter 11: Promising Novel Nanopharmaceuticals for Improving Topical Antifungal Drug DeliveryNagendra Singh Chauhan and Madhu Gupta

• Abstract
• 1. Introduction
• 2. Skin Structure and Penetration Route
• 3. Topical Drug Delivery System and Skin
• 4. Topical Antifungal Drugs and Available Dosage Forms
• 5. Need for Novel Nanopharmaceuticals for Topical Delivery
• 6. Conclusions

Chapter 12: Nanoconstructs Based on Cyclodextrins for Antimicrobial ApplicationsAntonino Mazzaglia

• Abstract
• 1. Cyclodextrins and Their Nanoconstructs
• 2. CD-Ns and Antibacterial/Antibiotic Drugs
• 3. CD-Ns and Antiviral Agents
• 4. CD-Ns and Antifungal Agents
• 5. CD-Ns, Disinfectants, and Antiseptics
• 6. Photodynamic Antimicrobial Chemotherapy by Using CD-Ns
• 7. CD-Capped AgNPs for Antimicrobial Applications
• 8. Conclusions and Perspectives
• Acknowledgments

Chapter 13: Nanoemulsions: A Novel Antimicrobial Delivery SystemMojdeh -. Hakemi –Vala

• Abstract
• 1. Introduction
• 2. Definitions
• 3. Preparation Techniques
• 4. Fundamental Concepts on the Formation of Nanoemulsions
• 5. Thermo Dynamical Concept
• 6. Applications of Nanoemulsions in Pharmaceuticals
• 7. Pharmaceutical Applications
• 8. Mechanism of Antimicrobial Action of Nanoemulsions
• 9. Anticancer Nanoemulsions
• 10. Food Applications of Nanoemulsions
• 11. Microbial Food Spoilage
• 12. Microbial Products as Preservative
• 13. Food-Borne Diseases
• 14. Microbial Fermented Foods
• 15. Nanoemulsions as Food Preservative
• 16. Nanoemulsions as a Food Antimicrobial Delivery System
• 17. Food Marketing
• 18. Cosmetics
• 19. Conclusions

Chapter 14: Nanodrug Delivery Systems for Dermal and Transdermal Photosensitizer DrugsAntonio Claudio Tedesco Sr.

• Abstract
• 1. Dermal and Transdermal Drug Delivery Systems: Concepts and Classification
• 2. Photosensitizer Drugs and Drug Delivery Systems
• 3. Biological Studies of Dermal and Transdermal Photosensitized Nanomaterials
• 4. Tissue Engineering and Dermal/Transdermal Photosensitized Nanomaterials
• 5. Conclusion and Future Directions

Chapter 15: Recent Advances in the Delivery of Chemotherapeutic AgentsSwarnali Das Paul

• Abstract
• 1. Background
• 2. Overview of New Generation Cancer Chemotherapeutics
• 3. Targeted Therapies
• 4. Cancer Vaccine
• 5. Chemoprevention
• 6. Patent Information
• 7. Conclusions

Chapter 16: Polyurethane Nanostructures for Drug Delivery ApplicationsMurthy Chavali

• Abstract
• 1. Introduction
• 2. Biocompatibility
• 3. Processing of Polyurethanes
• 4. Drug Delivery Applications of Polyurethanes
• 5. Conclusions

Chapter 17: Nanoemulsion as a Valuable Nanostructure Platform for Pharmaceutical Drug DeliveryRashmin Bharatbhai Patel

• Abstract
• 1. Introduction
• 2. Nanoemulsion for Pharmaceutical Drug Delivery
• 3. Research in Nanoemulsion in the 21st Century
• 4. Conclusions
• Conflicts of Interest
• List of Abbreviations
• Acknowledgment

Chapter 18: The Supramolecular Complex of Sertraline With Cyclodextrins: Physicochemical and Pharmacological PropertiesVyacheslav Buko

• Abstract
• 1. Introduction
• 2. Sertraline and β-Cyclodextrin Supramolecular Complex: Thermodynamic Parameters
• 3. Cyclodextrins as Drug Carriers
• 4. Cyclodextrins as Hypodlycemic Agents
• 5. Sertraline as a Hypoglycemic Agent
• 6. The Efficacy of the HPβCD: Sertraline Complex in Prevention of Alloxan-Induced Diabetic Lesions in Rats
• 7. Conclusions

Chapter 19: Pharmacokinetic and Pharmacodynamic Modulations of Therapeutically Active Constituents From Orally Administered Nanocarriers Along With a Glimpse of Their Advantages and LimitationsBiswajit Mukherjee

• Abstract
• 1. Introduction
• 2. Nanocarriers in Oral Drug Delivery
• 3. Various Types of Oral Nanocarrier Systems
• 4. Major Obstacles in Successful Oral Delivery of Nanocarriers
• 5. Transport Across the Intestinal Epithelium
• 6. PK/PD Modulation of Orally Administered Drugs Loaded in Nanocarriers Based on Recent Research Findings
• 7. Critical Factors Affecting the PK/PD and Fate of Orally Administered Nanocarriers
• 8. Some Strategies to Enhance Bioavailability of Oral Nanocarriers
• 9. Challenges in Clinical Feasibility of Oral Nanocarriers
• 10. Conclusions and Future Prospects

Chapter 20: Nanostructured Propolis as Therapeutic Systems With Antimicrobial ActivityMarcos Luciano Bruschi

• Abstract
• 1. Introduction
• 2. Terminology and Identification
• 3. Historical and Current Uses of Propolis
• 4. Botanical Origin and Composition
• 5. Therapeutic Activity and Biological Properties
• 6. Micro/Nanotherapeutic Systems Containing Propolis
• 7. Strategies to Release Propolis
• 8. Conclusions and Remarks

Chapter 21: Nanostructures for Curcumin Delivery: Possibilities and ChallengesVenkata Ramireddy Narala

• Abstract
• 1. Introduction and Background of Curcumin
• 2. Photophysical and Photochemical Properties of Curcumin
• 3. Antimicrobial Properties of Curcumin
• 4. Bioavailability of Curcumin
• 5. Nanostructures for the Delivery of Curcumin
• 6. Conclusions
• Acknowledgments

Chapter 22: Nanostructures for Improved Antimonial Therapy of LeishmaniasisFrederic Frezard

• Abstract
• 1. Introduction
• 2. Chemistry and Pharmacology of Pentavalent Antimonials
• 3. Injectable Liposomal Formulations of Antimonial Drugs
• 4. Injectable Nonlipid-Based Nanocarriers for Antimonial Drugs
• 5. Oral Formulations for Antimonial Drugs
• 6. Topical Formulations of Antimonial Drugs for Cutaneous Leishmaniasis
• 7. Conclusions
• Acknowledgments

Chapter 23: Nanoarchitectures for Neglected Tropical Protozoal Diseases: Challenges and State of the ArtSwati Pund

• Abstract
• 1. Neglected Protozoal Diseases: A Treatment Challenge
• 2. Nanoarchitectures and Classification
• 3. Chagas Disease (American Trypanosomiasis)
• 4. Leishmaniasis
• 5. African Trypanosomiasis and Nanodelivery of Trypanocidal Agents
• 6. Concluding Remarks