Multiparametric Ultrasound for the Assessment of Diffuse Liver Disease

A Practical Approach

1st Edition - October 21, 2022
Editors: Richard G. Barr, Giovanna Ferraioli
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 7 4 7 9 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 7 4 8 3 - 0

For those who treat and diagnose liver disease, whether radiologists, emergency medical physicians, hepatologists, or sonographers, a clear understanding of the strict protocol… Read more

Multiparametric Ultrasound for the Assessment of Diffuse Liver Disease

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For those who treat and diagnose liver disease, whether radiologists, emergency medical physicians, hepatologists, or sonographers, a clear understanding of the strict protocol needed to obtain accurate measurements is essential. Multiparametric Ultrasound for the Assessment of Diffuse Liver Disease offers a practical approach to liver shear wave elastography acquisition from globally recognized leaders in the field. It answers critical questions such as how to use each of the current techniques to best characterize your patients’ liver disease, how to deal with the limitations of each of these techniques, and what to ask—and not to ask—of your devices and software.

Cover image
Title page
Table of Contents
Copyright
Foreword
Preface
Contributors
List of Tables
List of Illustrations
1. Introduction
The burden of chronic liver disease
Staging of liver fibrosis
Stages of cirrhosis
Clinically significant portal hypertension
References
2. Conventional ultrasound findings in chronic liver disease
Introduction
B-mode imaging
Doppler features
Acute hepatitis and Budd-Chiari syndrome
References
3. Liver stiffness measurement techniques: Basics
Introduction to stiffness
Techniques
References
4. Protocols for liver stiffness acquisition
General protocol
Quality assessment
Reproducibility, failures, and unreliable results
Intersystem variability
References
5. Tips and tricks for liver stiffness evaluation
Before scanning the patient
During the acquisition
After data acquisition, before the patient is discharged
Reporting results
References
6. Artifacts in liver stiffness evaluation
Overview of artifacts in liver shear wave elastography
References
7. Staging liver fibrosis with shear wave elastography
Introduction
Chronic viral hepatitis and nonalcoholic fatty liver disease
Alcohol-related liver disease
Cholestatic and autoimmune liver disease
Screening for liver fibrosis in the general population
Pediatrics
References
8. The role of ultrasound in portal hypertension
Introduction
Which equipment do we need and how do we perform ultrasound to assess the presence of portal hypertension?
Ultrasound features of portal hypertension in advanced chronic liver disease: Intrahepatic portal hypertension
Prehepatic portal hypertension: Portal vein thrombosis
Posthepatic portal hypertension
Other causes of noncirrhotic portal hypertension
The role of elastography in portal hypertension
References
9. Liver stiffness beyond the staging of liver fibrosis
Introduction
Heart diseases
Liver diseases beyond the staging of fibrosis
References
10. Liver shear wave elastography: Guidelines
Introduction
European federation of societies for ultrasound in medicine and biology guidelines
World federation for ultrasound in medicine and biology guidelines
Society of radiologists in ultrasound consensus
Asian-pacific association for the study of the liver guidelines
American gastroenterological association guidelines
European association for the study of the liver guidelines
References
11. Noninvasive assessment of liver steatosis with ultrasound techniques
Introduction
Reference standard for liver fat quantification
Noninvasive assessment: Ultrasound
Does steatosis affect liver stiffness values?
References
12. Shear wave dispersion
Introduction
Physics
Review of systems with dispersion imaging
Reproducibility studies
Association between dispersion measurement and liver inflammation
Clinical significance of dispersion quantification in the liver
References
13. Focal liver lesions in the setting of chronic liver disease
Introduction
Bubble specific imaging
Contrast-enhanced ultrasound arterial phase and portal venous phase
Contrast-enhanced ultrasound algorithm
The importance of liver imaging reporting and data system in at-risk livers
Integration to liver imaging
Elastography of liver masses
Conclusions
References
14. Conclusions (multiparametric ultrasound for the work-up of chronic liver disease)
Overview
Ultrasound multiparametric approach
Future advancements
Conclusions
References
Index

Richard G. Barr

Dr. Barr is a Professor of Radiology at Northeast Ohio Medical University. He practices at Southwoods Imaging in Youngstown, Ohio. He received his BS in Chemistry at Ohio State University, a PhD in Inorganic Chemistry at Michigan State University, and his MD from Case Western Reserve University. He completed a year internship in internal medicine at University Hospitals of Cleveland and a Diagnostic Radiology residency at the Cleveland Clinic Foundation where he was chief resident. Dr. Barr completed a cross sectional imaging fellowship at University of California at San Francisco. Dr. Barr has published over 150 peer reviewed papers, several book chapters, and a book “Breast Elastography” and a book “Elastography, a Practical Approach”. His book has been translated into Italian, Chinese, and Russian. He has presented over 500 scientific and educational presentations and invited lectures world-wide. He has been involved in elastography and ultrasound contrast for over 15 years presenting multiple presentations worldwide on these subjects. He was the Principal Investigator on several ultrasound contrast agents phase 2, 3 and 4 studies. He has relationships with multiple ultrasound vendors for the improvement of elastography and CEUS on their systems. He is the Editor-in-Chief of Journal of Ultrasound in Medicine. Aunt Minnie named him a semi-finalist for the most influential radiology researcher in the world in 2018. Dr. Barr is a chairman of the Quantitative Image Biomarker Association for ultrasound contrast committee. He has been the lead author on several national and international guidelines on elastography and ultrasound contrast.

Affiliations and expertise

Professor of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio; Editor-in Chief Journal of Ultrasound in Medicine

Giovanna Ferraioli

Dr. Ferraioli is the coordinator of the Ultrasound School at Fondazione IRCCS San Matteo Hospital Foundation, Medical School University of Pavia, Italy, and co-director of the EFSUMB Ultrasound Learning Centre at the same Institution. Her research interests include elastography in diffuse liver diseases, non-invasive assessment of liver steatosis, ultrasound contrast agents, and Doppler in portal hypertension. Dr. Ferraioli has published over 90 peer reviewed papers and several book chapters. She has presented over 300 scientific and educational presentations and invited lectures worldwide. She has been involved in liver elastography for over 11 years presenting multiple presentations worldwide on this subject. She has relationships with multiple ultrasound vendors for the improvement of elastography on their systems. She is member of the scientific editorial board of European Radiology, World Journal of Gastroenterology, Journal of Ultrasound, and she’s the subspecialty Editor on Elastography for the Journal of Ultrasound in Medicine. She has been the lead author of WFUMB guidelines on liver elastography and has been involved on several international guidelines on elastography.

Affiliations and expertise

Researcher, Medical School University of Pavia, Italy

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