Multifunctional Nanocarriers

1st Edition - August 20, 2022
Editors: Neelesh Kumar Mehra, Saurabh Srivastava, Jitender Madan, Pankaj Kumar Singh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 0 4 1 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 2 9 4 - 4

Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with produc… Read more

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Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications.

Cover image
Title page
Table of Contents
Copyright
Contributors
Editors
Preface
Chapter 1. Nanotechnology: advanced drug-targeting concepts, fundamentals, and strategies
1. Introduction
2. Approaches for drug targeting
3. Fundamental strategies for drug delivery systems
4. Conclusion and future perspectives
Section I. Multifunctional nanocarriers
Chapter 2. Recent advances in dendrimer-based nanocarriers
1. Introduction
2. Advantages of dendrimers
3. Types of dendrimers
4. Applications of dendrimers
5. Challenges
6. Conclusion
Chapter 3. Carbon nanomaterials in controlled and targeted drug delivery
1. Introduction
2. Synthesis of carbon nanomaterials
3. Top-down techniques
4. Bottom-up techniques
5. Carbon nanomaterials for drug delivery
6. GN for drug delivery
7. CNTs for drug delivery
8. Graphene for cancer targeting
9. Toxic effects of carbon-based nanomaterials
10. Applications
11. Conclusion
Abbreviations
Chapter 4. Liposomal formulation: opportunities, challenges, and industrial applicability
1. Introduction
2. Types of liposomes
3. Methods of preparation
4. Targeted delivery
5. Challenges facing liposomal drug-delivery systems
6. Marketed and clinical liposomes
7. Conclusion and future perspectives
Chapter 5. Polymers-drug-conjugates strategies in drug delivery
1. Introduction
2. Polymer
3. Types of polymer
4. Different strategies to conjugate polymers
5. Conclusions
Chapter 6. Metallic nanoparticles in drug delivery: concepts, challenges, and current advancement
1. Introduction
2. Metallic nanoparticles and their general method of synthesis
3. Fundamentals of metallic nanoparticles
4. Biomedical applications of metallic nanoparticles
5. Challenges and perspectives
6. Conclusion
Chapter 7. Needle-free technology for biomedical applications
1. Introduction
2. Components of a needle-free injection devices
3. Fluid dynamics behind the formation of jet and penetration into the skin
4. Type of material to be delivered
5. Risks and challenges
6. Emerging parameters
7. Growth hormones
8. Gene therapy
9. Local anesthesia
10. Intralesional 5-ALA
11. Dermal applications
12. Conclusion
Chapter 8. Nanoparticles: opportunities, biopharmaceuticals aspects, and applications
1. Introduction
2. Biopharmaceutical aspects
3. Nanoparticle opportunities
4. Nanoparticle applications
Chapter 9. Polymer conjugates: implications and roles in biomedical applications
1. Introduction
2. Polymer-drug conjugates
3. PPCs
4. Linkers in conjugation
5. Modified drug delivery system formulated through conjugation
6. Biomedical applications of PCs
7. Conclusion
Abbreviations
Chapter 10. Magnetic nanoparticles: challenges and practical considerations
1. Introduction
2. Types of MNPs
3. Synthesis of MNPs
4. Nanoparticle superlattices or supracrystals [5,25,48]
5. Effect of surface attributes on MNPs pharmacokinetics
6. Superparamagnetism, superspin glass, surface spin glass, and super ferromagnetism: magnetic properties of interacting MNPs
7. Revolutionary applications and evolving considerations of the magnetic nanocarriers
8. Future outlook
Section II. Nanocarriers-mediated delivery of drugs in different diseases/organs
Chapter 11. Approaches for drug delivery to the mitochondria: current status and future trends
1. Introduction
2. What is mitochondria?
3. Structure of mitochondria
4. Why target mitochondria?
5. Characteristics of mitochondria relevant to drug delivery
6. Membrane potential of mitochondria
7. Protein import machinery of mitochondria
8. Strategies for drug delivery to mitochondria
9. Delocalized lipophilic cations (DLC)
10. Mitochondria penetrating peptides (MPPs)
11. Mitochondrial targeting sequences (MTS)
12. Nanodrug delivery carriers
13. Nanoparticles
14. Liposomes
15. DQAsomes and MITO-porter
16. Gene delivery
17. Organ-specific mitochondrial targeting
18. Challenges
19. Conclusion
Chapter 12. Brain targeting drug delivery systems for the management of brain disorders: molecular targets and nanotechnological strategies
1. Introduction
2. Anatomy and Physiology of Brain
3. Overview of brain disorders and molecular targets
4. Overview of drug delivery approaches used for targeting brain
5. Preclinical and clinical status of brain targeting drug delivery systems used in the management of brain disorders
6. Conclusion
Chapter 13. Decoding the signaling cascaded in immunotherapy of cancer: role played by nanoimmunoadjuvants
1. Introduction
2. Types of immunoadjuvants serving the vaccine
3. Pathway for immunoadjuvant to stimulate humoral and cellular immune response
4. Conventional immunoadjuvants and their limitations
5. Biomaterials based nanoimmunoadjuvants for cancer vaccine delivery
6. Innate immune stimulators
7. Combination adjuvants
8. Adjuvant systems
9. Challenges associated with development of cancer vaccine
10. Opportunities
11. Conclusion
Chapter 14. Nanomaterials in nose-to-brain delivery: a synergistic breakthrough in meeting the unmet
1. Introduction
2. Nose-to-brain drug delivery
3. Challenges associated with nose-to-brain delivery
4. Nanocarrier-based nose-to-brain drug delivery
5. Regulatory aspect of nose-to-brain formulations
6. Conclusions and future perspective
Chapter 15. Role of novel drug delivery systems in overcoming the challenges associated with intraocular delivery of drugs: an overview
1. Introduction
2. Conventional therapies for ocular diseases
3. Challenges associated with conventional therapy related to delivery of drugs at posterior segment of eye
4. Novel drug delivery systems for ocular diseases
5. Conclusion
Chapter 16. Nanoformulations for neurodegenerative disorders
1. Introduction
2. Nanotherapeutics for neurodegenerative disorders
3. Future prospects
4. Conclusion
Section III. Biopharmaceutical, pharmacokinetics, and regulatory issues
Chapter 17. Pharmacokinetics and pharmacodynamics of nanopharmaceuticals
1. Introduction
2. Pharmacokinetics of nanopharmaceuticals
3. Factors affecting PK of nanopharmaceuticals
4. Mathematical modeling of PK and PD of nanopharmaceuticals
5. Conclusion and future directions
Chapter 18. Nanotoxicology: toxicity and safety issues of nanoparticles
1. Introduction
2. Blessings of NPs in pharmaceutical field
3. Toxicity of NPs
4. Factors responsible for NP toxicity
5. Mechanisms underlying nanotoxicity
6. Need of nanotoxicology
7. Studies involved in nanotoxicological assessment
8. Challenges faced in the nanotoxicological study
9. Regulatory relevance
10. Conclusion
Chapter 19. Stability testing parameters of nanoscaled product development
1. Introduction
2. Tools and techniques for the characterization of NSP
3. Stability consideration for characterization of NSPs
4. Considerations for selection of suitable method
5. Regulatory perspective for development and evaluation of NSP
6. Case studies: regulatory expectation on development and evaluation of NSP
7. Future perspectives of novel characterization strategies
8. Conclusion
Chapter 20. Current status of FDA-approved marketed nano drug products: regulatory considerations
1. Introduction
2. Current regulatory challenges for nanotherapeutics
3. Nanotherapeutic platforms approved by the FDA
4. Industry guidance for the FDA regulated products containing nanomaterials
5. Conclusions and future directions
Chapter 21. Nanomaterial-mediated biosensors: concept and biological applications
1. Introduction
2. Biosensor principle
3. Characteristics of biosensors
4. Types of biosensor
5. Nanomaterials-mediated biosensor
6. Challenges, future perspectives, and conclusion
Index

Neelesh Kumar Mehra

Neelesh Kumar Mehra is Senior Research Scientist at the Sentiss Research Center, Haryana, India. His area of research is in the design, development, evaluation of ophthalmic nanoemulsion, lipospheres, liposomes, fullerenes, and nanoparticles for topical/parenteral delivery of drugs/biomolecules.

Affiliations and expertise

Senior Research Scientist, Sentiss Research Center, Haryana, India

Saurabh Srivastava

Saurabh Srivastava is an Associate Professor of Pharmaceutics, at the National Institute of Pharmaceutical Education and Research, Hyderabad, India. His research interests include the development and optimization of industrially viable, feasible and scalable differentiated formulations, for the purpose of bioavailability enhancement, food effect minimization, repurposing/new indication, synergism for FDCs, and dose/dosing frequency reduction.

Affiliations and expertise

Associate Professor of Pharmeceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, India

Jitender Madan

Dr. Madan’s major areas of research include Self-assembled Supramolecular systems viz. liposomes, niosomes, cyclodextrin, nano- & micro-particles and solid-lipid nanoparticles. The focus is centered onto the exploitation of US FDA approved biomaterials in combination with other potential lipids and polymers to develop the innovative dosage forms and drug delivery systems in order to improve the bioavailability, stability, safety (tolerance) and patient-compliance. Whilst a wide range of applications are being taken up, the special emphasis is given to augment the aqueous solubility and bioavailability of lipophilic drugs.

Affiliations and expertise

Associate Professor, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India

Pankaj Kumar Singh

Dr. Pankaj Kumar Singh, Ph.D., is currently working as an Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research-Hyderabad (NIPER-Hyderabad) India. He has received his Doctorate in Pharmaceutics from CSIR-Central Drug Research Institute, Lucknow, India. He has been closely associated with several scientific and socially impactful projects funded by various prestigious bodies like TSCOST-DBT, CCRUM, DST, ICMR and Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India.

He has gained experience of over a decade in the field of teaching and research related to pharmaceuticals. He has more than 10 years of experience in working on targeted drug delivery systems for various hydrophobic and hydrophilic drug candidates. He has gained experience in the development of peptide-based liposomal delivery and ligand anchored delivery systems for the treatment of various life-threatening diseases, especially cancer and visceral leishmaniasis. He has published more than 85 quality papers along with reviews in journals of high repute and has a cumulative impact factor of more than 500, h-index 24, i10 index 44 and 1675 citations. He has edited 5 books, co-authored 40 book chapters and filed 7 patents with 2 patents granted. He is also involved in technology transfer of one product.

He has also bagged several accolades like the “CSIR-Research Associate” award, “CSIR-Senior Research Fellowship” award, two times travel grant award and financial Assistance and Incentive award for research paper publication. He has been keenly involved and associated with allied works say posters, abstracts, symposiums, invited talks, training and workshop and other research activities. He holds the membership of several nationally and internationally recognized bodies of repute like the Indian Pharma Education Society, Indian Science Congress Association and Bioencapsulation Research Group. He is a peer reviewer of various international Journals and publishers. He has guided 26 M.S. students for their dissertations/research projects and 11 Ph.D. students continuing their research work under his guidance. He has rich research and teaching experience in the formulation and development of various novel and targeted drug delivery systems.

Affiliations and expertise

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana 500037, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Multifunctional Nanocarriers

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Neelesh Kumar Mehra

Saurabh Srivastava

Jitender Madan

Pankaj Kumar Singh