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Multifunctional Nanocarriers
- 1st Edition - August 20, 2022
- Editors: Neelesh Kumar Mehra, Saurabh Srivastava, Jitender Madan, Pankaj Kumar Singh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 0 4 1 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 2 9 4 - 4
Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with produc… Read more
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Request a sales quoteMultifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications.
- Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications
- Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications
- Assesses major challenges in applying multifunctional nanocarriers on an industrial scale
Materials scientists and engineers
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Editors
- Preface
- Chapter 1. Nanotechnology: advanced drug-targeting concepts, fundamentals, and strategies
- 1. Introduction
- 2. Approaches for drug targeting
- 3. Fundamental strategies for drug delivery systems
- 4. Conclusion and future perspectives
- Section I. Multifunctional nanocarriers
- Chapter 2. Recent advances in dendrimer-based nanocarriers
- 1. Introduction
- 2. Advantages of dendrimers
- 3. Types of dendrimers
- 4. Applications of dendrimers
- 5. Challenges
- 6. Conclusion
- Chapter 3. Carbon nanomaterials in controlled and targeted drug delivery
- 1. Introduction
- 2. Synthesis of carbon nanomaterials
- 3. Top-down techniques
- 4. Bottom-up techniques
- 5. Carbon nanomaterials for drug delivery
- 6. GN for drug delivery
- 7. CNTs for drug delivery
- 8. Graphene for cancer targeting
- 9. Toxic effects of carbon-based nanomaterials
- 10. Applications
- 11. Conclusion
- Abbreviations
- Chapter 4. Liposomal formulation: opportunities, challenges, and industrial applicability
- 1. Introduction
- 2. Types of liposomes
- 3. Methods of preparation
- 4. Targeted delivery
- 5. Challenges facing liposomal drug-delivery systems
- 6. Marketed and clinical liposomes
- 7. Conclusion and future perspectives
- Chapter 5. Polymers-drug-conjugates strategies in drug delivery
- 1. Introduction
- 2. Polymer
- 3. Types of polymer
- 4. Different strategies to conjugate polymers
- 5. Conclusions
- Chapter 6. Metallic nanoparticles in drug delivery: concepts, challenges, and current advancement
- 1. Introduction
- 2. Metallic nanoparticles and their general method of synthesis
- 3. Fundamentals of metallic nanoparticles
- 4. Biomedical applications of metallic nanoparticles
- 5. Challenges and perspectives
- 6. Conclusion
- Chapter 7. Needle-free technology for biomedical applications
- 1. Introduction
- 2. Components of a needle-free injection devices
- 3. Fluid dynamics behind the formation of jet and penetration into the skin
- 4. Type of material to be delivered
- 5. Risks and challenges
- 6. Emerging parameters
- 7. Growth hormones
- 8. Gene therapy
- 9. Local anesthesia
- 10. Intralesional 5-ALA
- 11. Dermal applications
- 12. Conclusion
- Chapter 8. Nanoparticles: opportunities, biopharmaceuticals aspects, and applications
- 1. Introduction
- 2. Biopharmaceutical aspects
- 3. Nanoparticle opportunities
- 4. Nanoparticle applications
- Chapter 9. Polymer conjugates: implications and roles in biomedical applications
- 1. Introduction
- 2. Polymer-drug conjugates
- 3. PPCs
- 4. Linkers in conjugation
- 5. Modified drug delivery system formulated through conjugation
- 6. Biomedical applications of PCs
- 7. Conclusion
- Abbreviations
- Chapter 10. Magnetic nanoparticles: challenges and practical considerations
- 1. Introduction
- 2. Types of MNPs
- 3. Synthesis of MNPs
- 4. Nanoparticle superlattices or supracrystals [5,25,48]
- 5. Effect of surface attributes on MNPs pharmacokinetics
- 6. Superparamagnetism, superspin glass, surface spin glass, and super ferromagnetism: magnetic properties of interacting MNPs
- 7. Revolutionary applications and evolving considerations of the magnetic nanocarriers
- 8. Future outlook
- Section II. Nanocarriers-mediated delivery of drugs in different diseases/organs
- Chapter 11. Approaches for drug delivery to the mitochondria: current status and future trends
- 1. Introduction
- 2. What is mitochondria?
- 3. Structure of mitochondria
- 4. Why target mitochondria?
- 5. Characteristics of mitochondria relevant to drug delivery
- 6. Membrane potential of mitochondria
- 7. Protein import machinery of mitochondria
- 8. Strategies for drug delivery to mitochondria
- 9. Delocalized lipophilic cations (DLC)
- 10. Mitochondria penetrating peptides (MPPs)
- 11. Mitochondrial targeting sequences (MTS)
- 12. Nanodrug delivery carriers
- 13. Nanoparticles
- 14. Liposomes
- 15. DQAsomes and MITO-porter
- 16. Gene delivery
- 17. Organ-specific mitochondrial targeting
- 18. Challenges
- 19. Conclusion
- Chapter 12. Brain targeting drug delivery systems for the management of brain disorders: molecular targets and nanotechnological strategies
- 1. Introduction
- 2. Anatomy and Physiology of Brain
- 3. Overview of brain disorders and molecular targets
- 4. Overview of drug delivery approaches used for targeting brain
- 5. Preclinical and clinical status of brain targeting drug delivery systems used in the management of brain disorders
- 6. Conclusion
- Chapter 13. Decoding the signaling cascaded in immunotherapy of cancer: role played by nanoimmunoadjuvants
- 1. Introduction
- 2. Types of immunoadjuvants serving the vaccine
- 3. Pathway for immunoadjuvant to stimulate humoral and cellular immune response
- 4. Conventional immunoadjuvants and their limitations
- 5. Biomaterials based nanoimmunoadjuvants for cancer vaccine delivery
- 6. Innate immune stimulators
- 7. Combination adjuvants
- 8. Adjuvant systems
- 9. Challenges associated with development of cancer vaccine
- 10. Opportunities
- 11. Conclusion
- Chapter 14. Nanomaterials in nose-to-brain delivery: a synergistic breakthrough in meeting the unmet
- 1. Introduction
- 2. Nose-to-brain drug delivery
- 3. Challenges associated with nose-to-brain delivery
- 4. Nanocarrier-based nose-to-brain drug delivery
- 5. Regulatory aspect of nose-to-brain formulations
- 6. Conclusions and future perspective
- Chapter 15. Role of novel drug delivery systems in overcoming the challenges associated with intraocular delivery of drugs: an overview
- 1. Introduction
- 2. Conventional therapies for ocular diseases
- 3. Challenges associated with conventional therapy related to delivery of drugs at posterior segment of eye
- 4. Novel drug delivery systems for ocular diseases
- 5. Conclusion
- Chapter 16. Nanoformulations for neurodegenerative disorders
- 1. Introduction
- 2. Nanotherapeutics for neurodegenerative disorders
- 3. Future prospects
- 4. Conclusion
- Section III. Biopharmaceutical, pharmacokinetics, and regulatory issues
- Chapter 17. Pharmacokinetics and pharmacodynamics of nanopharmaceuticals
- 1. Introduction
- 2. Pharmacokinetics of nanopharmaceuticals
- 3. Factors affecting PK of nanopharmaceuticals
- 4. Mathematical modeling of PK and PD of nanopharmaceuticals
- 5. Conclusion and future directions
- Chapter 18. Nanotoxicology: toxicity and safety issues of nanoparticles
- 1. Introduction
- 2. Blessings of NPs in pharmaceutical field
- 3. Toxicity of NPs
- 4. Factors responsible for NP toxicity
- 5. Mechanisms underlying nanotoxicity
- 6. Need of nanotoxicology
- 7. Studies involved in nanotoxicological assessment
- 8. Challenges faced in the nanotoxicological study
- 9. Regulatory relevance
- 10. Conclusion
- Chapter 19. Stability testing parameters of nanoscaled product development
- 1. Introduction
- 2. Tools and techniques for the characterization of NSP
- 3. Stability consideration for characterization of NSPs
- 4. Considerations for selection of suitable method
- 5. Regulatory perspective for development and evaluation of NSP
- 6. Case studies: regulatory expectation on development and evaluation of NSP
- 7. Future perspectives of novel characterization strategies
- 8. Conclusion
- Chapter 20. Current status of FDA-approved marketed nano drug products: regulatory considerations
- 1. Introduction
- 2. Current regulatory challenges for nanotherapeutics
- 3. Nanotherapeutic platforms approved by the FDA
- 4. Industry guidance for the FDA regulated products containing nanomaterials
- 5. Conclusions and future directions
- Chapter 21. Nanomaterial-mediated biosensors: concept and biological applications
- 1. Introduction
- 2. Biosensor principle
- 3. Characteristics of biosensors
- 4. Types of biosensor
- 5. Nanomaterials-mediated biosensor
- 6. Challenges, future perspectives, and conclusion
- Index
- No. of pages: 600
- Language: English
- Edition: 1
- Published: August 20, 2022
- Imprint: Elsevier
- Paperback ISBN: 9780323850414
- eBook ISBN: 9780323852944
NM
Neelesh Kumar Mehra
Neelesh Kumar Mehra is Senior Research Scientist at the Sentiss Research Center, Haryana, India. His area of research is in the design, development, evaluation of ophthalmic nanoemulsion, lipospheres, liposomes, fullerenes, and nanoparticles for topical/parenteral delivery of drugs/biomolecules.
Affiliations and expertise
Senior Research Scientist, Sentiss Research Center, Haryana, IndiaSS
Saurabh Srivastava
Saurabh Srivastava is an Associate Professor of Pharmaceutics, at the National Institute of Pharmaceutical Education and Research, Hyderabad, India. His research interests include the development and optimization of industrially viable, feasible and scalable differentiated formulations, for the purpose of bioavailability enhancement, food effect minimization, repurposing/new indication, synergism for FDCs, and dose/dosing frequency reduction.
Affiliations and expertise
Associate Professor of Pharmeceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, IndiaJM
Jitender Madan
Dr. Madan’s major areas of research include Self-assembled Supramolecular systems viz. liposomes, niosomes, cyclodextrin, nano- & micro-particles and solid-lipid nanoparticles. The focus is centered onto the exploitation of US FDA approved biomaterials in combination with other potential lipids and polymers to develop the innovative dosage forms and drug delivery systems in order to improve the bioavailability, stability, safety (tolerance) and patient-compliance.
Whilst a wide range of applications are being taken up, the special emphasis is given to augment the aqueous solubility and bioavailability of lipophilic drugs.
Affiliations and expertise
Associate Professor, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, IndiaPS
Pankaj Kumar Singh
Pankaj Kumar Singh, PhD, is senior research fellow at Punjabi University, India. He received his PhD degree on bioinformatics at the same institution. His research interests are computer-based modelling of molecules, with focus on developing models to study how synthetic molecules interact with cancer cells.
Affiliations and expertise
Senior Research Fellow, Punjabi University, Patiala, Punjab, IndiaRead Multifunctional Nanocarriers on ScienceDirect