Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip
Principles and Applications
- 1st Edition - September 19, 2021
- Imprint: Elsevier
- Editors: Xiujun (James) Li, Chaoyong Yang, Paul C. H. Li
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 5 9 4 3 2 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 5 9 4 6 1 - 7
Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharm… Read more
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Request a sales quoteMultidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery.
Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.
- Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles
- Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems
- Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology
Researchers in analytical chemistry, biology and engineering, researchers enrolled in a lab-on-chip, microfluidics, or biomedical devices course or engaged in research related fields. Researchers in medical instrumentation, health sciences, biotechnology, pharmaceuticals, and engineering professionals and industries wishing an overview of the microfluidics and life sciences microsystems fields
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editors
- Preface
- Part I: Microfluidic Techniques
- Chapter 1. Fabrication of microfluidic chips
- Abstract
- 1.1 Introduction
- 1.2 Microelectromechanical systems
- 1.3 Soft photolithography
- 1.4 Thermoplastic polymer-based microfluidics
- 1.5 Hydrogels for the fabrication of microfluidic chips
- 1.6 Three-dimensional printing
- 1.7 Microfluidic paper-based analytical devices
- 1.8 Modular microfluidics
- 1.9 Nanofluidics
- 1.10 Conclusion and outlook
- 1.11 Study questions
- References
- Chapter 2. Fluid–substrate interactions
- Abstract
- 2.1 Static wetting
- 2.2 Dynamic wetting
- 2.3 Conclusions and perspectives
- 2.4 Study questions
- References
- Chapter 3. Magnetism in microfluidics: computational fluid dynamics simulations, mixing, transport, and control of fluids and particles at micro scale
- Abstract
- 3.1 Introduction
- 3.2 Review of modeling and CFD simulation in microfluidics
- 3.3 CFD techniques suitable for microfluidics: 2D, 3D, steady-state, and transient models
- 3.4 Numerical simulations of the redox MHD–based microfluidics cases
- 3.5 Results and discussion
- 3.6 Two-phase flow with magnetic particles
- 3.7 Conclusions
- 3.8 Study questions
- Acknowledgments
- References
- Chapter 4. Microfluidic capillary electrophoresis chip techniques: theory and different separation modes
- Abstract
- 4.1 Theoretical aspects
- 4.2 Injection of chip electrophoresis
- 4.3 Detector of chip electrophoresis
- 4.4 Separation modes of µCE
- 4.5 Integration of µCE with multifunctional units
- 4.6 Conclusion and perspectives
- 4.7 Study questions
- References
- Part II: Applications
- Chapter 5. Cell manipulation and cellular analysis
- Abstract
- 5.1 Introduction
- 5.2 Cell manipulation
- 5.3 Cell analysis
- 5.4 Conclusion and perspective
- 5.5 Study questions
- References
- Chapter 6. Organ-on-a-chip
- Abstract
- 6.1 Introduction of organ-on-a-chip
- 6.2 Key features of organ-on-a-chip
- 6.3 Emerging organ-on-a-chip devices
- 6.4 Conclusions and perspectives
- 6.5 Study questions
- References
- Chapter 7. Recent advances in nucleic acid analysis and detection with microfluidic and nanofluidics
- Abstract
- 7.1 Introduction of polymerase chain reaction
- 7.2 Isothermal amplification
- 7.3 Amplification-free genetic analysis
- 7.4 Conclusions and perspectives
- 7.5 Study questions
- References
- Chapter 8. Conventional and unconventional methodologies for multiplex nucleic acid tests
- Abstract
- 8.1 What are multiplex nucleic acid tests?
- 8.2 Probe immobilization
- 8.3 Hybridization of target DNAs
- 8.4 Detection of successful hybridization
- 8.5 Unconventional hybridization methodologies
- 8.6 Conclusions and perspectives
- 8.7 Study questions
- References
- Chapter 9. Microfluidic protein analysis and applications
- Abstract
- 9.1 Traditional protein analysis methods
- 9.2 Principles of protein analysis on chips
- 9.3 Applications of chip-based protein analysis
- 9.4 Conclusions and perspectives
- 9.5 Study questions
- References
- Chapter 10. Microfluidics in three key aspects of the drug-development process: biomarker discovery, preclinical studies, and drug delivery systems
- Abstract
- 10.1 Introduction
- 10.2 Microfluidics and biomarker discovery
- 10.3 Microfluidics and preclinical studies
- 10.4 Microfluidics and drug delivery systems
- 10.5 Conclusions and perspectives
- 10.6 Study questions
- References
- Chapter 11. Fundamentals and applications of acoustics in microfluidics
- Abstract
- 11.1 Introduction
- 11.2 Physics of acoustics in microfluidics
- 11.3 Principles of microfluidic acoustic technologies
- 11.4 Applications of microfluidic acoustics
- 11.5 Conclusion and perspectives
- 11.6 Study questions
- References
- Part III: New Emerging Techniques & Applications
- Chapter 12. Rapid disease diagnosis using low-cost paper and paper-hybrid microfluidic devices
- Abstract
- 12.1 Introduction
- 12.2 Fabrication techniques for paper and paper-hybrid microfluidic devices
- 12.3 Disease diagnostic applications using paper and paper-hybrid microfluidic devices
- 12.4 Conclusion and perspectives
- 12.5 Study questions
- Acknowledgments
- References
- Chapter 13. Energy harvesting and self-powered devices in droplet microfluidics
- Abstract
- 13.1 Energy harvesting in droplet microfluidics
- 13.2 Self-powered devices in droplet microfluidics
- 13.3 Conclusion and perspective
- 13.4 Study questions
- References
- Chapter 14. Integration of three-dimensional printing and microfluidics
- Abstract
- 14.1 Introduction
- 14.2 Technology and configuration
- 14.3 Applications of 3D-printed microfluidics
- 14.4 Merits, limitations, and trends for the integration of 3D printing and microfluidics
- 14.5 Conclusion and perspectives
- 14.6 Study questions
- References
- Chapter 15. Principles and applications of the nano-in-nano integration for multidisciplinary nanofluidics
- Abstract
- 15.1 Introduction
- 15.2 Principle and fabrication of nano-in-nano integration
- 15.3 Applications of nano-in-nano integration
- 15.4 Assistive technologies for nano-in-nano integration
- 15.5 Conclusions and perspective
- 15.6 Study questions
- Acknowledgments
- References
- Chapter 16. Microfluidics for nanomaterial synthesis
- Abstract
- 16.1 Introduction
- 16.2 Continuous flow microfluidics for synthesis of nanomaterials
- 16.3 Segmented flow microfluidics for synthesis of nanomaterials
- 16.4 Integrated microfluidic devices for multistep fabrication of nanomaterials
- 16.5 Conclusions and future perspectives
- 16.6 Study questions
- Acknowledgments
- References
- Index
- Edition: 1
- Published: September 19, 2021
- Imprint: Elsevier
- No. of pages: 484
- Language: English
- Hardback ISBN: 9780444594327
- eBook ISBN: 9780444594617
XL
Xiujun (James) Li
XiuJun (James) Li, Ph.D., is an Associate Professor with early tenure in the Department of Chemistry and Biochemistry, Biomedical Engineering, and Border Biomedical Research Center at the University of Texas at El Paso (UTEP), USA. After he obtained his Ph.D. degree in microfluidic lab-on-a-chip bioanalysis from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University, while holding a Postdoctoral Fellowship from Natural Sciences and Engineering Research Council (NSERC) of Canada. He has gained extensive experience in bioanalysis using microfluidic systems, such as single-cell analysis, genetic analysis, low-cost diagnosis, pathogen detection, 3D cell culture, and so on. Dr. Li’s current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, biomaterial, biomedical engineering, and environmental applications, including but not limited to low-cost diagnosis, nano-biosensing, tissue engineering, and single-cell analysis. He has coauthored about 100 publications in high-impact journals (such as Adv. Drug Deliv. Rev, Appl. Catal. B-Environ, Anal. Chem., Lab Chip, Biosens. Bioelectron.) and 22 patents, including two books from Elsevier on microfluidic devices for biomedical applications. He is an Advisory Board member of Lab on a Chip and Analyst, the Founder of microBioChip Diagnostics LLC, and an editor of 6 journals including Scientific Reports from the Nature publishing group, Micromachines, etc. He is the recipient of the “Bioanalysis New Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award in 2009, and so on. For more information, please visit http://li.utep.edu.
Affiliations and expertise
Department of Chemistry and Biochemistry, Biomedical Engineering, Environmental Science and Engineering, Border Biomedical Research Center, University of Texas at El PasoCY
Chaoyong Yang
Dr. Chaoyong Yang received his PhD from University of Florida in 2006 under the guidance of Professor Weihong Tan. He joined Professor Richard Mathies’ group at the University of California, Berkeley as a postdoc. In 2008, he joined Xiamen University where he is now a Distinguished Professor in the Department of Chemical Biology. Professor Yang has published over 200 articles in international journals which have received over 11 000 citations, and is named inventor on over 40 patents. He serves as associate editor for ACS Applied Bio Materials. He is a Fellow of the Royal Society of Chemistry. He is the recipient of CAPA Distinguished Faculty Award in 2012, National Outstanding Young Investigator Award in 2013, Chinese Young Analyst Award in 2015, Chinese Chemical Society-Royal Society of Chemistry Young Chemist Award in 2016, and 2021 ACS Advances in Measurement Science Lectureship Award. His current research is particularly focused on bio-sensing, high throughput evolution, single cell analysis and microfluidics.
Affiliations and expertise
Professor, Department of Chemical Biology, Xiamen University, ChinaPL
Paul C. H. Li
Dr. Paul Li obtained his Ph.D. in analytical chemistry at the University of Toronto, and conducted postdoctoral work at the University of Alberta. Then, he developed the microfluidic lab-on-a-chip at Simon Fraser University, where he was promoted to full professor. Dr. Li is interested in integrating chip microfluidics for chemical sensing, single-cell analysis, and nucleic acid bioassay. He has been visiting professors at Johannes Gutenberg Universitat-Mainz (Germany), Griffith University (Australia) and City University of Hong Kong. Dr. Li has published several books, e.g. Fundamentals of lab on a chip for biological analysis and discovery, and Microarray Technology: Methods and Applications. He is associate editor of Canadian Journal of Pure and Applied Sciences, and sits on the editorial board of Hong Kong Pharmaceutical Journal. Dr. Li is the inventor of six patented technologies and 5 pending patents, and he is the founder of ZellChip Technologies Inc. specializing in microfluidics-based instruments and solutions.
Affiliations and expertise
Professor of Bioanalytical Chemistry, Department of Chemistry, Simon Fraser University, CanadaRead Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip on ScienceDirect