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Movement Disorders in Childhood
- 2nd Edition - October 27, 2015
- Authors: Harvey S. Singer, Jonathan W. Mink, Donald L. Gilbert, Joseph Jankovic
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 1 1 5 7 3 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 1 1 5 8 0 - 4
Movement Disorders in Childhood, Second Edition, provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specializ… Read more
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provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology.Over the past several decades, advances in genetics, neuroimaging, neurophysiology, and other areas of neuroscience have provided new understanding of the underlying etiologies and mechanisms of these conditions as well as new opportunities for more accurate diagnosis and effective treatment.
This new edition builds upon the success of the first edition, with comprehensive scientific and clinical updates of all chapters. In addition, there are new chapters on hereditary spastic paraplegia, quantitative motor assessments, autoimmune disorders, and movement disorders in the developmental neuropsychiatric disorders ADHD, OCD, and autism.
Additional materials are provided on the latest in drug treatments, computer based strategies for genetic diagnosis, and helpful videos for phenomenology.
- Provides the only current reference specifically focused on childhood movement disorders
- Investigates the underlying etiologies and mechanisms of these disorders
- Completely revised and updated with new materials and a more disease-oriented approach
- New coverage of genetics and movement disorders, immunology and movement disorders, and an introduction to the latest quantitative analysis
- New videos of instructive and unusual childhood movement disorders
- 2016 BMA Medical Book Awards Highly Commended in Neurology
Neurologists, pediatricians, developmental pediatricians, and clinical researchers interested in pediatric neurology
- Preface
- Acknowledgment
- Section I: Overview
- Chapter 1. Basal Ganglia Anatomy, Biochemistry, and Physiology
- Abstract
- Introduction
- Circuits and Neurotransmitters in the Basal Ganglia
- Subthalamic Nucleus (STN)
- Output Nuclei: Globus Pallidus Interna (GPi) and Substantia Nigra pars reticulata (SNpr)
- Globus Pallidus externa (GPe)
- Inhibiting and Disinhibiting Motor Patterns
- Implications for Disease: Focal Lesions and Abnormal Movements
- References
- Chapter 2. Cerebellar Anatomy, Biochemistry, Physiology, and Plasticity
- Abstract
- Introduction
- Overview of Cerebellar Structure, Function, and Symptoms
- Macroscopic to Microscopic Cerebellar Structure
- Neurotransmitters in the Cerebellum
- Neuroplasticity in the Cerebellum
- Cerebellar Stimulation
- Conclusion
- References
- Chapter 3. Classification of Movement Disorders
- Abstract
- Introduction
- Ataxia (Chapter 14)
- Athetosis (Chapter 10)
- Ballismus (Chapter 10)
- Chorea (Chapter 10)
- Dystonia (Chapter 11)
- Myoclonus (Chapter 12)
- Parkinsonism (Chapter 15)
- Stereotypies (Chapter 8)
- Tics (Chapter 7)
- Tremor (Chapter 13)
- References
- Chapter 4. Diagnostic Evaluation of Children with Movement Disorders
- Abstract
- Introduction
- Preclinic
- In Clinic
- The Diagnosis
- Summary
- References
- Chapter 5. Motor Assessments
- Abstract
- Introduction
- Quantitative Measurement in Movement Disorders
- Rating Scales for Pediatric Movement Disorders
- References
- Chapter 1. Basal Ganglia Anatomy, Biochemistry, and Physiology
- Section II: Developmental Movement Disorders
- Chapter 6. Transient and Developmental Movement Disorders in Children
- Abstract
- Benign Neonatal Sleep Myoclonus
- Benign Myoclonus of Early Infancy (Benign Infantile Spasms)
- Jitteriness
- Shuddering
- Paroxysmal Tonic Upgaze of Infancy
- Spasmus Nutans
- Head Nodding
- Benign Paroxysmal Torticollis
- Benign Idiopathic Dystonia of Infancy
- Sandifer Syndrome
- Posturing During Masturbation
- References
- Chapter 6. Transient and Developmental Movement Disorders in Children
- Section III: Paroxysmal Movement Disorders
- Chapter 7. Tics and Tourette Syndrome
- Abstract
- Introduction
- Tic Phenomenology
- Tic Disorders
- Epidemiology
- Scales
- Outcome
- Associated Behaviors and Psychopathologies in Tic Disorders
- Etiology
- Pathophysiology of Tic Disorders
- Treatment
- References
- Chapter 8. Motor Stereotypies
- Abstract
- Introduction
- Definition
- Differentiating Stereotypies from Other Disorders
- Pathophysiology
- Classification of Motor Stereotypies
- Therapy
- Patient and Family Resources
- References
- Chapter 9. Paroxysmal Dyskinesias
- Abstract
- Introduction
- Clinical Characteristics
- Specific Disorders
- References
- Chapter 7. Tics and Tourette Syndrome
- Section IV: Hyperkinetic and Hypokinetic Movement Disorders
- Chapter 10. Chorea, Athetosis, and Ballism
- Abstract
- Introduction and Overview
- Definitions of Chorea, Athetosis, and Ballism
- Clinical Characteristics—Phenomenology of Chorea, Athetosis, and Ballism in Children
- Localization and Pathophysiology
- Diseases and Disorders
- Summary of Diagnostic and Therapeutic Approach
- References
- Chapter 11. Dystonia
- Abstract
- Introduction
- Classification of Dystonias
- Localization and Pathophysiology
- Etiologies
- Diagnostic Approach to Dystonia
- Management and Treatment
- Patient and Family Resources
- References
- Chapter 12. Myoclonus
- Abstract
- Introduction and Overview
- Definition of Myoclonus
- Clinical Characteristics—Phenomenology of Myoclonus in Children
- Localization and Pathophysiology
- Diseases and Disorders
- Autosomal Dominant, Cortical Myoclonus without Epilepsy
- Hemifacial Spasm
- Summary of Diagnostic and Therapeutic Approach
- References
- Chapter 13. Tremor
- Abstract
- Introduction and Overview
- Definition of Tremor
- Clinical Characteristics—Phenomenology of Tremor in Children
- Localization and Pathophysiology
- Diseases and Disorders
- Approach to Diagnosis and Management
- References
- Chapter 14. Ataxia
- Abstract
- Introduction and Overview
- Definition of Ataxia
- Clinical Characteristics—Phenomenology of Ataxia in Children
- Localization and Pathophysiology
- Diseases and Disorders
- Approach to Diagnosis and Management
- Summary
- References
- Chapter 15. Parkinsonism
- Abstract
- Introduction
- Clinical Features of Parkinsonism
- Pathophysiology of Parkinsonism
- Etiologies of Parkinsonism in Children
- Secondary Parkinsonism
- Treatment of Parkinsonism
- References
- Chapter 16. Hereditary Spastic Paraplegia
- Abstract
- Introduction and Overview
- Definitions of Spasticity and Hypertonia
- Clinical Characteristics—Phenomenology of Spastic Paraplegia in Children
- Localization and Pathophysiology
- Diseases and Disorders
- Treatment
- Diagnostic and Management Approach
- Summary
- References
- Chapter 10. Chorea, Athetosis, and Ballism
- Section V: Selected Secondary Movement Disorders
- Chapter 17. Inherited Metabolic Disorders with Associated Movement Abnormalities
- Abstract
- Pediatric Neurotransmitter Disorders
- Metabolic Disorders
- References
- Chapter 18. Movement Disorders in Autoimmune Diseases
- Abstract
- Complication of a Systemic Autoimmune Disorder
- Post-Streptococcal Infections
- Autoimmune Basal Ganglia Encephalitis
- Autoimmune Encephalopathies
- Other Paraneoplastic Syndromes
- References
- Chapter 19. Movements that Occur in Sleep
- Abstract
- Overview of Sleep Physiology
- Classification of Movements in Sleep
- Sleep-Related Movement Disorders
- Hyperkinetic Movement Disorders that are Present during the Daytime and Persist during Sleep
- Seizures in and Around the Time of Sleep
- References
- Chapter 20. Cerebral Palsy
- Abstract
- Introduction
- Epidemiology
- Etiology
- Differentiating Hypertonia in Children
- Cerebral Palsy Syndromes
- Diagnostic Tests
- Management of Cerebral Palsy
- References
- Chapter 21. Movement Disorders and Neuropsychiatric Conditions
- Abstract
- Attention Deficit Hyperactivity Disorder
- Obsessive Compulsive Disorder
- Autism Spectrum Disorder
- Conclusion
- References
- Chapter 22. Drug-Induced Movement Disorders in Children
- Abstract
- Introduction and Overview
- Definition of DIMDs
- Clinical Characteristics—Phenomenology of DIMDs in Children
- Drug-Induced Movement Disorders
- Conclusion
- References
- Chapter 23. Functional (Psychogenic) Movement Disorders
- Abstract
- Introduction
- Conclusion
- References
- Chapter 17. Inherited Metabolic Disorders with Associated Movement Abnormalities
- Appendices
- Appendix A. Drug Appendix
- Acetazolamide
- Amantidine
- Amphetamine
- Aripiprazole
- Atomoxetine
- Baclofen
- Baclofen; Intrathecal Pump
- Benztropine
- Botulinum Toxin
- Carbamazepine
- Carbidopa/Levodopa
- Clonazepam
- Clonidine
- Clozapine
- Coenzyme Q10
- Creatine
- Cyclophosphamide
- Dantroline
- Fluphenazine
- Gabapentin
- Guanfacine
- Haloperidol
- IVIG
- Levetiracetam
- Methylphenidate
- Modafinil/Armodafinil
- Olanzapine
- Penicillamine
- Pimozide
- Piracetam
- Pramipexole
- Prednisone and Methylprednisolone
- Pregabalin
- Primidone
- Propranolol
- Quetiapine
- Reserpine
- Risperidone
- Rituximab
- Ropinirole
- Sodium Oxybate
- Tetrabenazine
- Tetrathiomolybdate (TM)
- Tizanidine
- Topiramate
- Trientine
- Trihexyphenidyl
- Valproic Acid
- Zinc
- Ziprasidone
- Zonisamide
- Appendix B. Search Strategy for Genetic Movement Disorders
- Using OMIM to Aid in Diagnosis
- Example 1 Advanced Search: OMIM
- Example 2 Advanced Search: Clinical Synopsis
- Example 3 Advanced Search: Gene Map Advanced Search
- Next Steps after the OMIM search
- Using Simulconsult to Aid in Diagnosis
- Example 1 Simulconsult Search
- Summary
- Appendix C. Video Atlas
- Chapter 6 Transient and Developmental Movement Disorders in Children
- Chapter 7 Tics and Tourette Syndrome
- Chapter 8 Motor Stereotypies
- Chapter 9 Paroxysmal Dyskinesias
- Chapter 10 Chorea, Athetosis, and Ballism
- Chapter 11 Dystonia
- Chapter 12 Myoclonus
- Chapter 13 Tremor
- Chapter 14 Ataxia
- Chapter 15 Parkinsonism
- Chapter 17 Inherited Metabolic Disorders with Associated Movement Abnormalities
- Chapter 18 Movement Disorders in Autoimmune Diseases
- Chapter 20 Cerebral Palsy
- Chapter 22 Drug-Induced Movement Disorders
- Chapter 23 Functional Movement Disorders
- Index
- Appendix A. Drug Appendix
- No. of pages: 594
- Language: English
- Edition: 2
- Published: October 27, 2015
- Imprint: Academic Press
- Hardback ISBN: 9780124115736
- eBook ISBN: 9780124115804
HS
Harvey S. Singer
JM
Jonathan W. Mink
DG
Donald L. Gilbert
At Cincinnati Children's, Dr. Gilbert directs the Movement Disorders and Tourette Syndrome Clinics, which specializes in evaluation and pharmacologic treatment of tics, tremor, chorea, ataxia, dystonia, stereotypies, drug-induced movement disorders, paroxysmal movement disorders, and functional movement disorders https://www.cincinnatichildrens.org/service/m/movement. Dr. Gilbert directs or participates in a number of single and multi-center studies into causes and treatments of Tourette syndrome and pediatric movement disorders. Dr. Gilbert also studies physiological mechanisms of motor control in Tourette Syndrome and Attention Deficit Hyperactivity Disorder in childhood at the Transcranial Magnetic Stimulation Laboratory https://www.cincinnatichildrens.org/research/divisions/n/neurology/labs/gilbert-wu at Cincinnati Children's.
JJ