Molecularly Imprinted Polymers (MIPs)

Commercialization Prospects

1st Edition - May 12, 2023
Imprint: Elsevier
Editor: Meenakshi Singh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 9 2 5 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 4 1 7 - 8

Molecularly Imprinted Polymers (MIPs): Commercialization Prospects guides the reader through the various steps in the conceptualization, design, preparation and innovativ… Read more

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Molecularly Imprinted Polymers (MIPs): Commercialization Prospects guides the reader through the various steps in the conceptualization, design, preparation and innovative applications of molecularly imprinted polymers while also demystifying the challenges relating to commercialization. Sections cover molecularly imprinted polymers, design, modeling, compositions and material selection. Other sections describe novel methods and discuss the challenges relating to the use of molecularly imprinted polymers in specific application areas. The final chapters of the book explore the current situation in terms of patents and commercialized materials based on MIPs, as well as prospects and possible opportunities.

This is a valuable resource for all those with an interest in the development, application, and commercialization of molecularly imprinted polymers, including researchers and advanced students in polymer science, polymer chemistry, nanotechnology, materials science, chemical engineering, and biomedicine, as well as engineers, scientists and R&D professionals with an interest in MIPs for advanced applications.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1. An introduction to molecularly imprinted polymers
1. Introduction
2. Concept
3. Components required for synthesis of MIP
4. Polymerization methods
5. Polymeric format for molecular imprinting
6. Thermodynamic and kinetic aspects
7. Conclusion
Chapter 2. Computer-aided modeling for rational design of molecularly imprinted polymers
1. Introduction
2. Computational techniques
3. Drawbacks and improvements
4. Conclusion
Chapter 3. Inefficient removal of templates as a limitation for molecular imprinting of polymers
Abbreviations
1. Introduction
2. Factors leading to efficient removal of templates as limitations to molecular imprinting
3. Conclusion
Chapter 4. Role of monomer compositions for molecularly imprinted polymers (MIPs)
1. Introduction
2. Factors and challenges in molecular imprinting
3. Role of monomers
4. Binding interactions
5. Multiple monomer composition: Importance and advances
6. Future aspects and conclusions
Chapter 5. Material selection for the fabrication of MIP-based devices: An overview
1. Introduction
2. Materials selection for MIPs
3. Commercialization of MIP
4. Conclusion and future prospects
Chapter 6. Signal generation in MIP sensors
1. Introduction
2. Signal generation in MIP sensors
3. Conclusions
Chapter 7. Adaptability of MIPs for cutting-edge technology to devise cheap sensing tools
1. Introduction
2. Synthesis of novel monomers for MIP
3. MIPs based on carbonaceous material
4. MIP nanoparticles
5. MIP sensors
6. Conclusion
Chapter 8. Molecularly imprinted polymers in electrochemical sensing—A step closer to achieving technology readiness
1. Introduction
2. Approaches to imprinting
3. Interface with biosensors
4. Application in electrochemical sensing
5. Technology readiness level of MIPs
6. Conclusions
Chapter 9. Molecularly imprinted polymers in optical sensing—an outlook for future
1. Introduction
2. Role of MIP in optical sensing
3. MIP-based optical sensors
4. Applications of MIP optical sensor
5. Current research in MIP – optical sensing
6. Conclusions and outlook
Chapter 10. Biopolymers and their nanoparticles as imprinting matrix—introspection and commercialization prospects
1. Introduction
2. Different methods for synthesizing the biopolymeric NP-MIP
3. Applications of biopolymer NP
4. Shortcomings
5. Future prospects
6. Conclusion
Chapter 11. Protein imprinting via epitope approach: An overview
1. Introduction
2. Common approaches of protein sensing
3. Molecularly imprinted polymers sensing
4. Conclusion
Chapter 12. Challenges facing protein imprinting via epitope approach
1. Introduction
2. Key requirements to choose specific epitope for biosensor
3. Various methods used to form epitope-based MIP sensor
4. Application
5. Conclusion
Chapter 13. Molecularly imprinted polymers: Applications and challenges in biological and environmental sample analysis
1. Introduction
2. Application of MIPs
3. Conclusions
Chapter 14. Challenges to molecularly imprinted polymers in competition with biosensors at commercial scale
1. Introduction
2. What is a biosensor?
3. Label-free biosensors
4. Challenges with label-free biosensors
5. Labeled biosensors
6. Aptamers in biosensing and therapeutics
7. Limitations and advantages with Si RNA and aptamers
8. Integration of molecularly imprinted polymers in (bio)sensors
9. Strategies required in commercialization
10. Conclusions
Chapter 15. Patents based on molecularly imprinted polymers: Exploring their commercial potential
1. Introduction
2. History
3. Types of MIPS
4. Microcontact stamping MIPS
5. Applications of MIPs
6. Patents
7. Commercial MIP synthesis
8. Conclusion and future challenges
Chapter 16. MIP-based commercial materials: Molecularly-imprinted polymers for commercial application: potentials and barriers
1. Introduction
2. Polymer-coated materials
3. Application of MIP
4. Commercial materials
5. Barriers in industrialization
6. Molecular imprinting and coronavirus
7. Future prospects and conclusions
Chapter 17. Commercialization prospects for MIPs: A summary
1. Introduction
2. Designing of imprinting matrices through “in silico” approaches
3. Limitations of extraction channels
4. Monomer compositions
5. Significance of material
6. Electronics behind signal enhancement
7. Adaptations of current technological innovations
8. Electrochemical sensors
9. Optoelectronic MIP sensors
10. Biopolymeric formats for imprinting
11. Protein imprinting through epitope imprinting
12. Analysis of environmental and biological sensing
13. MIP sensors vis-a-vis biosensors
14. Current status of patenting
15. Commercial MIP devices status
Index

Meenakshi Singh

Prof. Meenakshi Singh is a Professor in the Dept. of Chemistry, at Banaras Hindu University, in India. Prof. Singh’s research is currently focused on designing novel polymeric formats for crafting molecular recognition elements to device sensors for biomolecules/drugs/proteins/virus using molecular imprinting technology. These functionalized polymeric frameworks are incorporated in analytical technology based on molecularly imprinted polymers for detection of target molecules. The molecular imprinting technique using zwitterionic polymeric format functionalized over surface for scrutinizing their bicompatibilty. Additionally, theoretical predictions of geometry and other vital parameters of newly synthesized monomers using ab-initio methods are also carried out. Polymeric hydrogels/organogels are also designed and examined for their characteristics to explore their application as functional materials for application in drug-delivery, waste-water treatment and/or other industrial applications. The group has shown water-compatible imprinting with novel polymer format in which the entire imprinting protocol is followed in water only for selective and sensitive detection of many drug molecules amino acids, peptides, proteins by molecular imprinting. Recently this laboratory is working on development of diagnostic tool for common diseases through ‘epitope imprinting’ approach for detection of proteins from virus/bacteria causing infection. This approach was successfully tested on patients and has already been reported in journals through publication of papers. Prof. Singh’s interests also include environmental chemistry, solid phase extraction, solid phase microextraction, electroanalysis and detection principles for chemical analysis. Currently, her group are engaged in developing MIP-QCM-sensor for biomolecules. A pioneer in the field of molecular imprinting in India. Prof. Singh has published 61 articles in international peer reviewed journals. 3 book chapters, and 1 book, with more than 400 citations.

Affiliations and expertise

Professor, Department of Chemistry, Banaras Hindu University, India

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