Molecular Pharmacology V3

List of Contributors

Preface

Foreword

Some Introductory Remarks on the Conception of Receptors

Contents of Volume II

Part I A Molecular Approach to General Pharmacology

General Introduction

Section I.A Drug Transference: Distribution of Drugs in the Organism

Introduction

I.A.1. Passive Processes

I.A.2. Active Transport

Concluding Remarks

References

Section I.B Drug Transference: Drug Metabolism

Introduction

I.B.1. Dissimilation of Drug

I.B.2. Factors Influencing Drug Metabolism

I.B.3. General Aspects of Drug Metabolism

I.B.4. Inhibitors of Drug Metabolism

I.B.5. Assimilation of Drugs

I.B.6. Drugs Acting Indirectly

Concluding Remarks

References

Section II.A Drug-Receptor Interaction: Interaction of One or More Drugs with One Receptor System

Introduction

II.A.1. Structure and Action

II.A.2. Dose-Response Curves

II.A.3. Competitive Interaction

II.A.4. Affinity and Intrinsic Activity

II.A.5. Affinity and Intrinsic Activity in Relation to Chemical Structure

II.A.6. Stereoisomers

II.A.7. The Receptors

Concluding Remarks

References

Section II.B Drug-Receptor Interaction: Interaction of One or More Drugs with Different Receptor Systems

Introduction

II.B.l. Noncompetitive Interaction

II.B.2. Uncompetitive Interaction

II.B.3. Chemical Antagonism

II.B.4. Functional Interaction

II.B.5. Compounds with Multiple Actions

II.B.6. Specific and Nonspecific Drug Action

II.B.7. Chemical and Physical Properties of Drugs with Local Anesthetic Action

II.B.8. The pH and Drug Action

Concluding Remarks

References

Section III The Relation between Stimulus and Effect

Introduction

III.1. The All-or-None Response

III.2. Threshold Phenomena

III.3. Receptor Reserve

III.4. Mechanical Factors and Reserve in Receptors

III.5. The Sequence of Events after Interaction of a Drug with Its Specific Receptors

III.6. Integral Dose-Response Relations

Concluding Remarks

References

Author Index

Subject Index