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Molecular Neurology
- 1st Edition - July 17, 2007
- Author: Stephen Waxman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 6 9 5 0 9 - 3
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 4 6 1 8 - 6
Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology… Read more
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Request a sales quoteWhy a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.
- Describes the newest molecular aspects of neurological disorders
- Provides an introduction to neurological disorders for basic scientists
- Updates clinicians and clinical researchers on the most recent developments
Neuroscientists, molecular biologists, pharmacologists, neurologists, neurology residents, and clinical researchers.
Molecular Neurology
Edited by Stephen G. Waxman
Table of Contents
PREFACE – Stephen G. Waxman
Chapter 1
Genetics as a Tool in Neurology
Dennis R. Johnson, Fuki M. Hisama
Chapter 2
Neurology and Genomic Medicine
Jeffery Vance
Chapter 3
Mitochondrial Function and Dysfunction in the Nervous System
Neggy Rismanchi and Craig Blackstone
Chapter 4
Neuronal Channels and Receptors
Alan L. Goldin
Chapter 5
Protein Misfolding, Chaperone Networks, and the Heat Shock Response
in the Nervous System
Cindy Voisine, Kai Orton, and Richard I. Morimoto
Chapter 6
Metabolic Biopsy of the Brain
Ognen A. C. Petroff
Chapter 7
Gene therapy approaches in neurology
Edward A. Burton, Joseph C. Glorioso, David J. Fink
Chapter 8
Programmed Cell Death and its Role in Neurological Disease
D. E. Bredesen, R. V. Rao and P. Mehlen1
Chapter 9
Developmental Neurology: A Molecular Perspective
Juan M. Pascual
Chapter 10
Metabolic Diseases of the Nervous System
Juan M. Pascual
Chapter 11
Genetic Disorders of Neuromuscular Development
Juan M. Pascual
Chapter 12
Molecular Mechanisms of Ischemic Brain Disease
Thomas M. Hemmen, Justin A. Zivin
Chapter 13
Hemorrhagic Brain Disease
Michael L. DiLuna, Kaya Bilguvar, Gamze Tanriover, Murat Gunel
Chapter 14
The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury
Noam Y. Harel, Yvonne S. Yang, Stephen M. Strittmatter, Jeffery D. Kocsis, and Stephen G. Waxman
Chapter 15
Parkinson’s Disease: Molecular Insights
Ted M. Dawson, Josesph M. Savitt, Valina L. Dawson
Chapter 16
The molecular basis of Alzheimer’s disease
Martin Ingelsson, Bradley T. Hyman
Chapter 17
Polyglutamine Disorders including Huntington’s Disease
Sokol V. Todi, Aislinn J. Williams, Henry L. Paulson
Chapter 18
Friedreich’s Ataxia and Related RNA Loss-Of-Function Disorders
Masimo Pandolfo
Chapter 19
DYT1, a Primary Torsion Dystonia
Susan B. Bressman, Laurie Ozelius
Chapter 20
Motor Neuron Disease: Amyotrophic Lateral Sclerosis
Nicholas J. Maragakis and Jeffrey D. Rothstein
Chapter 21
Genetic Disorders of the Autonomic Nervous System
Stephen J. Peroutka
Chapter 22
Multiple sclerosis as a neurodegenerative disease
Stephen G. Waxman
Chapter 23
Acquired Epilepsy: Cellular and Molecular Mechanisms
Christopher B. Ransom and Hal Blumenfeld
Chapter 24
Disorders of Excitation and Transmission: Genetic Epilepsies
Ingo Helbig, Ingrid E. Scheffer and Samuel F. Berkovic
Chapter 25
Hyperekplexia (startle disease / stiff baby syndrome): Molecular pathology of the glycine receptor complex
Cord-Michael Becker
Chapter 26
Tourette’s Syndrome
James F. Leckman, Michael H. Bloch
Chapter 27
Disorders of Sleep and Circadian Rhythms
Sebastiaan Overeem, Gert Jan Lammers, Mehdi Tafti
Chapter 28
Chronic pain as a molecular disorder
John N Wood and Stephen G Waxman
Chapter 29
Migraine as a cerebral ionopathy with impaired central sensory processing
Michel D Ferrari, Arn M.J.M. van den Maagdenberg, Rune R. Frants, and Peter J. Goadsby
Chapter 30
Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies
John A. Kamholz
Chapter 31
Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis
Alexander Flugel, Hartmut Wekerle
Chapter 32
Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal
Angela Vincent
Chapter 33
Paraneoplastic Neurologic Syndromes
Josep Dalmau
Chapter 34
Mitochondrial Disorders
Salvator DiMauro, Eric A. Schon
Chapter 35
Molecular Neurology of HIV-1 Infection and AIDs
Markus Kaul, Stuart A. Lipton
Edited by Stephen G. Waxman
Table of Contents
PREFACE – Stephen G. Waxman
Chapter 1
Genetics as a Tool in Neurology
Dennis R. Johnson, Fuki M. Hisama
Chapter 2
Neurology and Genomic Medicine
Jeffery Vance
Chapter 3
Mitochondrial Function and Dysfunction in the Nervous System
Neggy Rismanchi and Craig Blackstone
Chapter 4
Neuronal Channels and Receptors
Alan L. Goldin
Chapter 5
Protein Misfolding, Chaperone Networks, and the Heat Shock Response
in the Nervous System
Cindy Voisine, Kai Orton, and Richard I. Morimoto
Chapter 6
Metabolic Biopsy of the Brain
Ognen A. C. Petroff
Chapter 7
Gene therapy approaches in neurology
Edward A. Burton, Joseph C. Glorioso, David J. Fink
Chapter 8
Programmed Cell Death and its Role in Neurological Disease
D. E. Bredesen, R. V. Rao and P. Mehlen1
Chapter 9
Developmental Neurology: A Molecular Perspective
Juan M. Pascual
Chapter 10
Metabolic Diseases of the Nervous System
Juan M. Pascual
Chapter 11
Genetic Disorders of Neuromuscular Development
Juan M. Pascual
Chapter 12
Molecular Mechanisms of Ischemic Brain Disease
Thomas M. Hemmen, Justin A. Zivin
Chapter 13
Hemorrhagic Brain Disease
Michael L. DiLuna, Kaya Bilguvar, Gamze Tanriover, Murat Gunel
Chapter 14
The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury
Noam Y. Harel, Yvonne S. Yang, Stephen M. Strittmatter, Jeffery D. Kocsis, and Stephen G. Waxman
Chapter 15
Parkinson’s Disease: Molecular Insights
Ted M. Dawson, Josesph M. Savitt, Valina L. Dawson
Chapter 16
The molecular basis of Alzheimer’s disease
Martin Ingelsson, Bradley T. Hyman
Chapter 17
Polyglutamine Disorders including Huntington’s Disease
Sokol V. Todi, Aislinn J. Williams, Henry L. Paulson
Chapter 18
Friedreich’s Ataxia and Related RNA Loss-Of-Function Disorders
Masimo Pandolfo
Chapter 19
DYT1, a Primary Torsion Dystonia
Susan B. Bressman, Laurie Ozelius
Chapter 20
Motor Neuron Disease: Amyotrophic Lateral Sclerosis
Nicholas J. Maragakis and Jeffrey D. Rothstein
Chapter 21
Genetic Disorders of the Autonomic Nervous System
Stephen J. Peroutka
Chapter 22
Multiple sclerosis as a neurodegenerative disease
Stephen G. Waxman
Chapter 23
Acquired Epilepsy: Cellular and Molecular Mechanisms
Christopher B. Ransom and Hal Blumenfeld
Chapter 24
Disorders of Excitation and Transmission: Genetic Epilepsies
Ingo Helbig, Ingrid E. Scheffer and Samuel F. Berkovic
Chapter 25
Hyperekplexia (startle disease / stiff baby syndrome): Molecular pathology of the glycine receptor complex
Cord-Michael Becker
Chapter 26
Tourette’s Syndrome
James F. Leckman, Michael H. Bloch
Chapter 27
Disorders of Sleep and Circadian Rhythms
Sebastiaan Overeem, Gert Jan Lammers, Mehdi Tafti
Chapter 28
Chronic pain as a molecular disorder
John N Wood and Stephen G Waxman
Chapter 29
Migraine as a cerebral ionopathy with impaired central sensory processing
Michel D Ferrari, Arn M.J.M. van den Maagdenberg, Rune R. Frants, and Peter J. Goadsby
Chapter 30
Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies
John A. Kamholz
Chapter 31
Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis
Alexander Flugel, Hartmut Wekerle
Chapter 32
Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal
Angela Vincent
Chapter 33
Paraneoplastic Neurologic Syndromes
Josep Dalmau
Chapter 34
Mitochondrial Disorders
Salvator DiMauro, Eric A. Schon
Chapter 35
Molecular Neurology of HIV-1 Infection and AIDs
Markus Kaul, Stuart A. Lipton
- No. of pages: 600
- Language: English
- Edition: 1
- Published: July 17, 2007
- Imprint: Academic Press
- Hardback ISBN: 9780123695093
- eBook ISBN: 9780080546186
SW
Stephen Waxman
Affiliations and expertise
Yale University School of Medicine, CT, USA