Part I: Overview: Genetic, Epigenetic and Cell Signaling Alterations
- Chapter One: Molecular and Cellular Changes During Cancer Progression Resulting From Genetic and Epigenetic Alterations
- Abstract
- 1 Introduction
- 2 DNA Methylation
- 3 Lysine Acetylation
- 4 Lysine and Arginine Methylation
- 5 Noncoding RNA
- 6 Epigenetic Readers
- 7 Concluding Remarks
- Chapter Two: Wnt/β Catenin-Mediated Signaling Commonly Altered in Colorectal Cancer
- Abstract
- 1 Wnt Signaling in Colorectal Cancer
- 2 Mutations in the Wnt Signaling Pathway
- 3 Cancer Stem Cells
- 4 Treatments
- 5 Markers for Early Detection and Prognosis
- 6 Summary
- Chapter Three: Interplay Between Inflammation and Epigenetic Changes in Cancer
- Abstract
- 1 Introduction
- 2 Complex Relationship Between the Immune System and Cancer
- 3 Chronic Inflammatory Diseases Predispose Individuals to Cancer
- 4 Overview of Epigenetics and Its Role in Normal Physiological Processes and Cancer
- 5 The Role of Inflammation in Initiating Epigenetic Alterations
- 6 Cancer Prevention and Treatment
- 7 Concluding Remarks
Part II: Viral Influences in Cancer Initiation and Progression
- Chapter Four: Viral Carcinogenesis
- Abstract
- 1 RNA Retroviruses
- 2 DNA Viruses
- 3 RNA Viruses
- 4 Conclusion
- Chapter Five: The Interaction Between Human Papillomaviruses and the Stromal Microenvironment
- Abstract
- 1 Introduction
- 2 The Stromal Microenvironment
- 3 The HPV Life Cycle
- 4 Growth Factors
- 5 Fibroblasts
- 6 Immune Interactions
- 7 Angiogenesis and the Hypoxic Response
- 8 ECM and MMPs
- 9 Unresolved Questions
Part III: Pancreatic Cancer: Altered Signaling Networks and Emerging Treatment Strategies
- Chapter Six: Molecular Pathogenesis of Pancreatic Cancer
- Abstract
- 1 Introduction
- 2 Genetic Alterations in Pancreatic Cancer
- 3 Deregulated EMT in Pancreatic Cancer
- 4 Molecular Subtype Classifications of Pancreatic Cancer
- 5 Deregulated Signaling Networks in Pancreatic Cancer
- 6 Current and Future Therapeutic Strategies for Pancreatic Cancer
- 7 Conclusions
- Chapter Seven: Current and Emerging Targeting Strategies for Treatment of Pancreatic Cancer
- Abstract
- 1 Introduction
- 2 Current Therapeutic Strategies
- 3 Novel and Emerging Therapeutic Options
- 4 Concluding Remarks
Part IV: Soft Tissue Sarcomas: Genomic and Epigenomic Alterations
- Chapter Eight: Molecular Changes Associated With Tumor Initiation and Progression of Soft Tissue Sarcomas: Targeting the Genome and Epigenome
- Abstract
- 1 Introduction
- 2 Clinical Parameters of EWSR1-Translocation-Associated Soft Tissue Sarcoma Subtypes
- 3 Developing Novel Molecular Therapeutic Strategies for the Treatment of EWSR1 Translocation Soft Tissue Sarcoma Subtypes
- 4 Discussion
Part V: Leukemias: Molecular Changes and Treatment Strategies
- Chapter Nine: Molecular Changes During Acute Myeloid Leukemia (AML) Evolution and Identification of Novel Treatment Strategies Through Molecular Stratification
- Abstract
- 1 Acute Myeloid Leukemia
- 2 Challenges in AML Treatment Stem From Disease Heterogeneity
- 3 Targeted Chemotherapy and Mechanism Based, Targeted Drug Discovery in AML
- 4 Combinatorial Control and Discovery of Relevant Drug Combinations
- 5 Combination Chemotherapy as a Way to Overcome Challenges in AML Treatment
- 6 Summary
- Acknowledgments
- Chapter Ten: Myeloproliferative Neoplasms: Molecular Drivers and Therapeutics
- Abstract
- 1 Myeloproliferative Neoplasms
- 2 Etiologic Driver and Nondriver Mutations in MPNs
- 3 Molecular Biology of MPN Driver Mutations
- 4 MPN Therapeutics
- 5 Concluding Remarks
Part VI: Breast Cancer: Endocrine Signaling, Resistance to Endocrine Therapy and Novel Contributors to Pathology
- Chapter Eleven: Dysregulation of Aromatase in Breast, Endometrial, and Ovarian Cancers: An Overview of Therapeutic Strategies
- Abstract
- 1 Introduction
- 2 Aromatase and Estrogen Biosynthesis
- 3 Expression of Aromatase in Normal and Pathological Human Tissues
- 4 Estrogen and Its Receptors in Hormone Responsive Cancers
- 5 Aberrant Expression of Aromatase in Three Common Women's Cancers
- 7 Understanding of the Role HDAC Inhibitors in Common Women's Cancers
- 8 Summary and Conclusions
- Chapter Twelve: Molecular Changes During Breast Cancer and Mechanisms of Endocrine Therapy Resistance
- Abstract
- 1 Introduction
- 2 Estrogen Receptors
- 3 Mechanisms of Endocrine Therapy Resistance
- Chapter Thirteen: Molecular and Cellular Changes in Breast Cancer and New Roles of lncRNAs in Breast Cancer Initiation and Progression
- Abstract
- 1 Introduction
- 2 Identifying lncRNA Signals in the Cancer Transcriptome
- 3 Functions of lncRNAs in Breast Cancer
- 4 Approaches for RNA-Targeted Therapeutic Intervention
- 5 Concluding Remarks
- Acknowledgments