Mitophagy in Health and Disease
Mechanisms, Health Implications, and Therapeutic Opportunities
- 1st Edition - November 28, 2024
- Imprint: Academic Press
- Editor: John J. Lemasters
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 6 0 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 6 1 - 0
Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostas… Read more
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Request a sales quoteMitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention.
This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.
- Covers biologic machinery and mechanisms involved with mitophagy
- Explores changes in mitophagy across the human lifespan
- Points out directions in targeting mitophagy with therapeutic interventions
Graduate students and researchers in cell and molecular biology at the PhD level, Established researchers in other areas, seeking a deeper understanding of mitophagy will also find this book helpful in becoming proficient in the area, Research physicians in medical fields involved with mitochondrial issues, including pneumologists, cardiologists, neurologists and others
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Preface
- 1 The invitation
- 2 Why edit this book?
- 3 The contents
- Chapter 1. PINK1-Parkin quality control mitophagy pathway in Parkinson’s disease
- Abstract
- Introduction
- Parkin, PINK1, and Parkinson’s disease
- Discovery of a PINK1-Parkin stress-responsive quality control pathway
- Mechanism of PINK1-Parkin stress response pathway
- Mitophagy in physiologic contexts
- Mitophagy in mammalian neurons
- Mito QC in the mitochondrial fission–fusion cycle
- PINK1-Parkin mitophagy in Drosophila
- PINK1-Parkin pathway in mice
- Therapeutic development
- Enhancing PINK1 activity
- Enhancing Parkin activity
- Other enhancers of PINK1-Parkin mitophagy
- Perspective on the therapeutic potential PINK1-Parkin pathway modulation
- Conclusion
- Acknowledgments
- References
- Chapter 2. Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions
- Abstract
- Introduction
- Ubiquitin-dependent and -independent pathways of mitophagy
- BCL2 family protein-mediated mitophagy
- FUNDC1-mediated mitophagy
- FKBP8-mediated mitophagy
- PHB2-mediated mitophagy
- NIPSNAP1- and NIPSNAP2-mediated mitophagy
- Lipids in mitophagy
- Connection of ubiquitin-dependent and -independent mitophagy
- Conclusion and perspectives
- References
- Chapter 3. Role of AMPK/ULK1 signaling in mitophagy
- Abstract
- Abbreviations
- Introduction
- Concluding remarks
- Acknowledgments
- References
- Chapter 4. Mitochondrial proteases
- Abstract
- Abbreviations
- Mitochondrial protease network
- Mitochondrial proteases as emerging pharmacological targets
- Concluding remarks
- References
- Further reading
- Chapter 5. The mitochondrial unfolded protein response in health and disease
- Abstract
- Abbreviations
- Introduction
- Noncanonical pathways that mediate a mitochondrial stress response in mammals
- Effects of UPRmt activation in health and disease
- Mitochondrial stress response and mitophagy in recovery of the mitochondrial network
- References
- Chapter 6. Mitochondria-derived vesicles: from quality control to inflammation and extracellular vesicles
- Abstract
- Abbreviations
- Introduction
- Mitochondrial quality control
- Mitochondria-derived vesicles
- Mechanisms of MDV formation
- The roles of MDVs in inflammation
- Release of mitochondrial content within extracellular vesicles
- Nature of the mitochondrial content within EVs
- Roles of mitoEVs
- Conclusion
- References
- Chapter 7. Molecular regulation of mitochondrial turnover by exercise: tissue adaptation through mitochondrial biogenesis and mitophagy
- Abstract
- Introduction
- Skeletal muscle form and function: important considerations
- Effect of exercise on skeletal muscle mitochondria turnover
- Mechanisms of exercise-mediated mitochondrial biogenesis and mitophagy
- Energy sensor AMPK regulates exercise-induced mitochondrial biogenesis and mitophagy
- Contraction-induced calcium release activates mitochondrial biogenesis and mitophagy
- Exercise-induced ROS signaling promotes mitochondrial turnover in skeletal muscle
- Effect of exercise on mitochondrial biogenesis and mitophagy in other tissues
- Conclusion
- References
- Chapter 8. Role of mitophagy and mitochondria in aging and cellular senescence
- Abstract
- List of abbreviations
- Introduction
- Conclusions
- Acknowledgments
- References
- Chapter 9. Mitophagy in erythropoiesis
- Abstract
- Abbreviations
- Introduction
- Mitochondria clearance and normal red blood cell maturation
- Concluding remarks
- Acknowledgments
- References
- Chapter 10. The dual role of mitophagy in cancer and its targeting for effective anticancer therapy
- Abstract
- Abbreviations
- Introduction
- Brief insights into mitophagy mechanisms
- Role of mitophagy in cancer
- Mitophagy in tumor suppression
- Mitophagy in tumor growth and progression
- Therapeutic targeting of mitophagy for effective anticancer strategy
- Conclusion
- References
- Chapter 11. Mitophagy and neurodegenerative disease
- Abstract
- Abbreviations
- Introduction
- Mitophagy in AD
- Mitophagy in PD
- Mitophagy in HD
- Mitophagy in ALS
- Mitophagy in stroke
- Cerebellar atrophy
- Mitophagy as a potential therapeutic target for neurodegenerative disease
- Future perspectives
- Acknowledgments
- Conflict of interests
- Data availability
- References
- Chapter 12. The antiaging role of mitophagy
- Abstract
- Abbreviations
- Introduction
- Conclusions
- Acknowledgments
- Author contributions
- Funding
- References
- Chapter 13. Compromised mitophagy in aging and neurodegenerative diseases
- Abstract
- Abbreviations
- Introduction
- Mitophagy
- Compromised mitophagy in aging
- Compromised mitophagy in Alzheimer’s disease
- Compromised mitophagy in Parkinson’s disease
- Compromised mitophagy in amyotrophic lateral sclerosis diseaset?
- Mitophagy in Huntington’s disease
- Concluding remarks
- Acknowledgments
- Declaration of competing interest
- References
- Chapter 14. Mitophagy inducers as potential therapeutic agents
- Abstract
- Why inducing mitophagy is a promising medical strategy
- A detailed discussion of the mechanisms of action of five well-characterized inducers of mitophagy
- Concluding remarks
- References
- Chapter 15. Mitochondrial quality control and the microphthalmia/transcription factor E (MiTF/TFE) family
- Abstract
- Introduction
- The lay of the land: mitophagy players
- Concluding remarks
- References
- Chapter 16. Cardioprotection through mitophagy
- Abstract
- Abbreviations
- Introduction
- Overview of mechanisms of mitophagy
- Mitophagy in basal homeostasis of the heart
- Cardiac aging
- Myocardial infarction (MI)
- Ischemia/reperfusion
- Hypertension
- Diabetic cardiomyopathy
- Concluding remarks
- Acknowledgments
- References
- Chapter 17. Fasting, mitophagy, and aging
- Abstract
- List of abbreviations
- Introduction
- Fasting: benefits and risks on health
- The impact of caloric restriction on mitochondria
- The role of mitophagy in longevity and aging
- Caloric restriction and mitophagy during aging
- Caloric restriction and mitophagy in age-related diseases
- Conclusions
- References
- Chapter 18. Aldehydes, mitophagy, and the pathogenesis of alcohol-associated and metabolic dysfunction-associated steatohepatitis
- Abstract
- Abbreviations
- Introduction
- Aldehyde metabolism
- Hepatic adaptations for EtOH metabolism
- Closure of voltage-dependent anion channels after EtOH
- Mitochondrial depolarization and uncoupling after ethanol
- Mitophagy in the pathogenesis of alcohol-associated and metabolic dysfunction-associated steatohepatitis
- Role of mitochondrial damage-associated molecular pattern molecules as drivers of inflammation and fibrosis
- Aldehyde mutagenic genotoxicity and hepatocellular carcinoma
- Conclusions and future directions
- Acknowledgments
- References
- Chapter 19. Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis
- Abstract
- Abbreviations
- Introduction
- Mitochondrial quality control mechanism
- Molecular machinery of mitochondrial dynamics
- Alcohol metabolism and mitochondrial adaptation
- Mitochondrial dynamics in ALD
- Mitochondrial dynamics in liver tumorigenesis
- Conclusion and future perspectives
- Author contributions
- Acknowledgments
- Conflict of interest
- References
- Chapter 20. The Sodom and Gomorrah conundrum of yeast mitophagy
- Abstract
- Abbreviations
- The relationship of mitophagy to general autophagy and macroautophagy
- Assays for detecting and measuring mitophagy in yeast
- Conditions and genetic requirements for inducing mitophagy in S. cerevisiae
- Protein factors required for mitophagy
- Mitophagic selectivity at the molecular level: a second dimension to the problem
- Mitophagy and mitochondrial quality control in yeast
- Mitophagy versus mitochondrial fission and fusion
- Mitophagy and mitochondrial heterogeneity
- Regulation of the Atg32 mitophagy receptor
- Differences and similarities between mitophagy in yeast and in mammalian cells
- Physiological role of mitophagy in S. cerevisiae
- Future directions
- Acknowledgments
- References
- Chapter 21. Sphingolipid metabolism in the regulation of mitophagy: implications in cancer therapy, immune cell function, and neurodegeneration
- Abstract
- Introduction
- Mitophagy process and types
- Key regulators of mitophagy
- Mitophagy in the regulation of different biological processes
- Neurodegenerative diseases
- Cancer cell death versus survival
- T lymphocytes and immune cell functions
- Regulation of mitophagy by cellular metabolism
- Ceramide structure and metabolism
- Ceramide synthases: chain length and tissue specificity
- Ceramides in the mitochondria
- Ceramides and mitophagy
- Ceramide-dependent mitophagy
- Aging-induced mitophagy in T cells: role of ceramides
- Conclusions and future directions
- Acknowledgments
- References
- Chapter 22. Formation of mitophagosomes
- Abstract
- Abbreviations
- Introduction
- The basic machinery of autophagy
- Eat-me signals specify cargo selection during mitophagy
- Adapters recognize eat-me signals
- Is there a source membrane for mitophagosome formation?
- The dynamics of mitophagy in comparison to autophagy
- Regulation of mitophagosome formation
- Future directions
- References
- Chapter 23. Mitophagy in hepatic ischemia/reperfusion
- Abstract
- Abbreviations
- Introduction
- Mitochondria and autophagy in ischemic hepatocytes
- Mitochondria and autophagy in reperfused hepatocytes
- Mitophagy during I/R in marginal livers
- Drug repositioning strategy to enhance mitophagy in ischemic livers
- Conclusion
- Acknowledgments
- References
- Index
- Edition: 1
- Published: November 28, 2024
- No. of pages (Paperback): 524
- No. of pages (eBook): 350
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443152603
- eBook ISBN: 9780443152610
JL
John J. Lemasters
Dr. Lemasters' research is focused on developing and applying new techniques of laser scanning confocal and multiphoton microscopy to characterize the physiology of single living cells, including the assessment of ion homeostasis, mitochondrial function, electrical potentials, oxygen and nitrogen free radical formation, membrane permeability and other biochemical parameters during the pathogenesis of lethal cell injury.
Affiliations and expertise
Professor and GlaxoSmithKline Distinguished Endowed Chair, Director, Cell & Molecular Imaging Core, Departments of Drug Discovery and Biomedical Sciences and Biochemistry and Molecular Biology, Medical University of South Carolina, USARead Mitophagy in Health and Disease on ScienceDirect