
Mitochondrial Physiology and Vegetal Molecules
Therapeutic Potential of Natural Compounds on Mitochondrial Health
- 1st Edition - July 14, 2021
- Imprint: Academic Press
- Editor: Marcos Roberto de Oliveira
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 6 2 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 8 3 - 8
Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiolog… Read more

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Request a sales quoteMitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area.
This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others.
Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle.
- Contains detailed information on plant products and their effect on mitochondria
- Proposes therapies and reviews mechanisms of absorption at the cellular level
- Discusses the limited bioavailability of plant molecules/compounds in the human organism
- Includes coverage of specific conditions such as Sports and affective disorders, among others
- Presents the protective effects of plant products in mitochondrial health through all stages of life
Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Acknowledgments
- Part I: Overview of mitochondrial physiology
- Chapter 1: Mitochondria: Ultrastructure, dynamics, biogenesis, and main functions
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Mitochondrial ultrastructure
- 3: Mitochondrial morphology, distribution, and dynamics
- 4: Biogenesis, maintenance, and quality control
- 5: Mitochondrial functions
- 6: Concluding remarks
- Chapter 2: Mitochondrial biogenesis and mitophagy
- Abstract
- 1: Introduction
- 2: Mitochondrial biogenesis
- 3: Molecular pathways for mitophagy
- 4: Interventions targeting mitochondrial biogenesis and mitophagy to enhance mitochondrial health and longevity
- 5: Concluding remarks
- Chapter 3: DNA transcription and translation in mitochondria
- Abstract
- Acknowledgment
- 1: DNA transcription and translation in mitochondria
- 2: Concluding remarks
- Chapter 4: Mitochondrial redox biology: Reactive species production and antioxidant defenses
- Abstract
- 1: Introduction
- 2: Mitochondria, oxidative phosphorylation, and its regulation
- 3: Mitochondrial ROS production and its modulation
- 4: Mitochondrial systems of antioxidant defense and its modulation
- 5: Mitochondria as sink of ROS
- 6: Mitochondrial ROS removal and ROS signaling
- 7: Conclusion
- Chapter 5: Mitochondria and apoptosis
- Abstract
- 1: Introduction
- 2: Mitochondria and apoptosis
- 3: Post-MOMP inner mitochondrial membrane remodeling
- 4: Post-MOMP regulation of apoptotic assembly
- 5: Post-MOMP cellular fate
- 6: Survival after MOMP
- 7: Mitochondria and nonapoptotic cell death
- 8: Conclusion
- Chapter 6: Mitochondria-associated membranes in the maintenance of cell homeostasis
- Abstract
- 1: Introduction
- 2: MAM and phospholipid synthesis and transfer
- 3: The yeast ERMES complex
- 4: MAM and Ca2 + signaling
- 5: MAM and apoptotic cell death
- 6: MAM and autophagy/mitophagy
- 7: Concluding remarks
- Part II: The effects of plant molecules on the mitochondria in health and disease
- Chapter 7: Biopharmaceutical properties of natural products
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Solubility and dissolution
- 3: Permeability
- 4: Presystemic metabolism
- 5: Biopharmaceutical classification systems
- 6: Novel natural product formulations
- 7: Standardization
- 8: Mitochondrial biopharmaceutics
- 9: Conclusion
- Chapter 8: Carnosic acid and brain mitochondria
- Abstract
- Acknowledgments
- 1: Introduction
- 2: The mitochondria-related effects induced by CA in in vitro experimental model
- 3: The mitochondria-related effects induced by CA in ex vivo/in vivo experimental models
- 4: Conclusion
- 5: Future directions
- Chapter 9: Rosmarinic acid and mitochondria
- Abstract
- 1: Background
- 2: Factors involved in mitochondrial dysfunction
- 3: Pathological basis of mitochondrial dysfunction in diseases
- 4: Rosmarinic acid and mitochondrial regulation
- 5: Rosmarinic acid in metabolic disease
- 6: Rosmarinic acid in central nervous system diseases
- 7: Pharmacokinetic profile and clinical aspects of Rosmarinic acid
- 8: Conclusions
- Chapter 10: Sulforaphane and mitochondria
- Abstract
- Acknowledgments
- 1: Sulforaphane overview
- 2: Nrf2-dependent impacts of SFN on mitochondrial structure and function
- 3: Nrf2-independent impacts of SFN on mitochondrial structure and function
- 4: Future challenges
- Chapter 11: Cannabinoids and mitochondria
- Abstract
- Acknowledgments
- 1: Introduction
- 2: The endocannabinoid system
- 3: Mitochondria are affected by cannabinoids
- 4: Cannabinoids alter mitochondrial membranes and functions
- 5: Cannabinoid receptors in cannabinoid-dependent alterations of mitochondria
- 6: CBD and mitochondria
- 7: The mitochondrial CB1
- 8: Protective roles of cannabinoids
- 9: Conclusion
- Chapter 12: Anthocyanins, effects in mitochondria and metabolism
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Anthocyanin molecules, food sources, and bioavailability
- 3: Effects of anthocyanins on mitochondria and metabolism in health and disease
- 4: Conclusions and future directions
- Chapter 13: Preclinical evidence of the therapeutic role of pterostilbene: Focus on the mitochondria
- Abstract
- 1: Introduction
- 2: Chemistry
- 3: Sources
- 4: Bioavailability
- 5: Pterostilbene and mitochondria
- 6: Pterostilbene and mitochondrial biogenesis
- 7: Pterostilbene and mitochondrial oxidative stress
- 8: Pterostilbene and mitochondrial apoptosis
- 9: Nanotechnology-related strategies of pterostilbene
- 10: Conclusion and future directions
- Chapter 14: Polyphenols attenuate mitochondrial dysfunction induced by amyloid peptides
- Abstract
- 1: Amyloid β peptides and Alzheimer’s disease
- 2: Alterations of mitochondrial metabolism and Ca2 + signaling by Aβ peptide
- 3: Polyphenols and their role protecting mitochondria processes
- 4: Therapeutic potential of polyphenols in AD
- 5: Concluding remarks
- Chapter 15: Plant molecules to treat eye mitochondria
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Mitochondrial disorders
- 3: Mitochondrial eye complications
- 4: Plant antioxidants to treat mitochondrial dysfunction of the eye
- 5: Conclusion
- Author contributions
- Conflicts of interest
- Chapter 16: Mitochondria as a target for monoterpenes
- Abstract
- 1: Monoterpenes
- 2: Biological effects related to mitochondria
- 3: Cytotoxicity of monoterpenes on cancer cells
- 4: Protective effects of monoterpenes
- 5: Final considerations
- Chapter 17: Baccharis trimera phytochemicals and the mitochondria
- Abstract
- Graphical abstract
- 1: Introduction
- 2: B. trimera phytochemicals
- 3: Role of B. trimera in mitochondria
- 4: Conclusion and future directions
- Chapter 18: Citrus flavonoids and the mitochondria
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Citrus flavonoids in health and disease
- 3: Citrus flavonoids and mitochondria
- 4: Future direction
- Chapter 19: Caffeine and mitochondria with a focus on the central nervous system
- Abstract
- 1: Introduction
- 2: Caffeine and mitochondria: General effects
- 3: The effects of caffeine on the peripheral mitochondria
- 4: Caffeine and the brain mitochondria
- 5: Conclusion
- Authors’ contribution
- Chapter 20: Curcumin and mitochondria
- Abstract
- 1: Introduction
- 2: Role of mitochondria in the etiology and onset of human diseases
- 3: Dietary phytochemicals acting on mitochondria
- 4: Mitochondrial respiration, energy generation, and curcumin
- 5: Mitochondria, reactive oxygen species, and curcumin
- 6: Mitochondrial biogenesis, mitophagy, and curcumin
- 7: Mitochondria, apoptosis, and curcumin
- 8: Need for derivatives of curcumin
- 9: Conclusion
- Chapter 21: Catechins, neuroprotection, and brain mitochondria
- Abstract
- 1: Chemical properties of catechins
- 2: Antiinflammatory and immunomodulatory effects of catechins
- 3: The role of catechins in neuroprotection
- 4: Effects of catechins on brain mitochondria
- 5: Conclusion
- Chapter 22: The effects of catechins on the cardiac mitochondria
- Abstract
- 1: Bioavailability of catechins
- 2: Catechins in oxidative stress
- 3: Catechins in cardiovascular diseases
- 4: Cardiac mitochondria as direct targets of catechins
- Chapter 23: Possible roles of garlic and its bioactive components on mitochondrial function in physiological and pathological conditions
- Abstract
- 1: Introduction
- 2: Effects of garlic and its active components on the mitochondrial and cellular functions in physiological conditions
- 3: Effects of garlic preparations on the mitochondrial and cellular functions in noncancer-related conditions
- 4: Effects of allicin on the mitochondrial and cellular functions in noncancer-related conditions
- 5: Effects of OSCs on the mitochondrial and cellular functions in noncancer-related conditions
- 6: Effects of garlic preparations on the mitochondrial and cellular functions under cancer-related conditions
- 7: Effects of allicin on the mitochondrial and cellular functions in cancer-related conditions
- 8: Effects of OSCs on the mitochondrial and cellular functions in noncancer-related conditions
- 9: Conclusion
- Chapter 24: Resveratrol effects on skeletal muscle mitochondria and contractile function
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Resveratrol effects on muscle mitochondria
- 3: Molecular mechanisms of resveratrol’s effects on mitochondria
- 4: Resveratrol effects on muscle function and anatomy
- 5: Conclusions and future perspectives
- Chapter 25: Antiaging effects of natural agents in the skin: Focus on mitochondria
- Abstract
- 1: The skin
- 2: Skin aging
- 3: Mitochondrial role in skin aging
- 4: Prevention of skin aging
- 5: Antiaging effects of natural agents in the skin
- 6: Polyphenols and their benefits on human skin, acting as a scavenger of free radicals
- 7: Nonflavonoids
- 8: Flavonoids
- 9: Carotenoids and vitamins for improved skin health
- 10: Focus on some natural sources of bioactive compounds
- 11: Conclusion
- Chapter 26: Role of quercetin in the glial mitochondria: Implications for health and disease
- Abstract
- 1: Introduction
- 2: Glial cells: Metabolism and physiology
- 3: Existing targeted molecules/drugs for mitochondrial dysfunction
- 4: Flavonoids: Potential candidate
- 5: Quercetin: Potential candidate for solving mitochondrial dysfunction
- 6: Quercetin: Glial cell mitochondria function/dysfunctions
- 7: Conclusions and future perspectives
- Conflict of interest statement
- Chapter 27: The therapeutic effects of lycopene on mitochondrial function in human diseases
- Abstract
- 1: Introduction
- 2: Oxidative stress and lycopene
- 3: Mitochondrial oxidative stress and dysfunction
- 4: Mitochondrial oxidative damage, disease, and lycopene
- 5: Conclusion
- Chapter 28: Ascorbic acid and the mitochondria
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Ascorbic acid characteristics
- 3: Mitochondrial accumulation of ascorbic acid
- 4: Effects of ascorbic acid on mitochondria
- 5: Mitochondrial ROS and ascorbic acid
- 6: Ascorbic acid modulates mitochondria function, dynamics, and biogenesis
- 7: Conclusion and future directions
- Chapter 29: Soy isoflavones, mitochondria and cell fate
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Flavonoids—Bliss of mankind
- 3: Soy isoflavones—Structure and functions
- 4: Soy isoflavones in health and disease
- 5: Mitochondria signaling pathways
- 6: Soy isoflavones as modulators of cell death pathways
- 7: Oxidative stress and mitochondrial dysfunction—A perilous liaison
- 8: Mitochondrial dynamics and quality check—The powerful nexus
- 9: Soy isoflavones and mitochondria in health and disease
- 10: Future prospective
- 11: Conclusion
- Chapter 30: Resveratrol and brain mitochondria
- Abstract
- 1: Introduction
- 2: Resveratrol: Overview
- 3: Resveratrol promotes mitochondrial function in brain cells
- 4: Resveratrol effects on inflammation and mitochondrial-related apoptosis and autophagy
- 5: Resveratrol influence on neurodegenerative disorders
- 6: Clinical trials
- 7: Conclusions
- Chapter 31: Plant-derived molecules for the prevention and treatment of mitochondria-related diseases
- Abstract
- 1: Introduction
- 2: Mitochondrial diseases
- 3: Chemical exposure
- 4: Herbals
- 5: Conclusion
- Chapter 32: Mitochondrial toxicity induced by plant molecules
- Abstract
- 1: Introduction
- 2: Mitochondria and the vulnerability to toxic compounds
- 3: Plant toxic compounds and mechanism of action on mitochondria
- 4: Conclusions
- Chapter 33: Mitohormesis
- Abstract
- 1: Introduction
- 2: Mitohormesis
- 3: Mitohormesis and phytochemicals
- 4: Concluding remarks
- Index
- Edition: 1
- Published: July 14, 2021
- Imprint: Academic Press
- No. of pages: 806
- Language: English
- Paperback ISBN: 9780128215623
- eBook ISBN: 9780128215838
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Marcos Roberto de Oliveira
Marcos Roberto de Oliveira, PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a master’s and a Ph.D. in Biochemistry from the same institution. He is currently a professor and coordinates research at UFRGS. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models.