Mitochondrial Physiology and Vegetal Molecules

Therapeutic Potential of Natural Compounds on Mitochondrial Health

1st Edition - July 14, 2021
Imprint: Academic Press
Editor: Marcos Roberto de Oliveira
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 5 6 2 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 5 8 3 - 8

Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiolog… Read more

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Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area.

This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others.

Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editor
Preface
Acknowledgments
Part I: Overview of mitochondrial physiology
Chapter 1: Mitochondria: Ultrastructure, dynamics, biogenesis, and main functions
Abstract
Acknowledgments
1: Introduction
2: Mitochondrial ultrastructure
3: Mitochondrial morphology, distribution, and dynamics
4: Biogenesis, maintenance, and quality control
5: Mitochondrial functions
6: Concluding remarks
Chapter 2: Mitochondrial biogenesis and mitophagy
Abstract
1: Introduction
2: Mitochondrial biogenesis
3: Molecular pathways for mitophagy
4: Interventions targeting mitochondrial biogenesis and mitophagy to enhance mitochondrial health and longevity
5: Concluding remarks
Chapter 3: DNA transcription and translation in mitochondria
Abstract
Acknowledgment
1: DNA transcription and translation in mitochondria
2: Concluding remarks
Chapter 4: Mitochondrial redox biology: Reactive species production and antioxidant defenses
Abstract
1: Introduction
2: Mitochondria, oxidative phosphorylation, and its regulation
3: Mitochondrial ROS production and its modulation
4: Mitochondrial systems of antioxidant defense and its modulation
5: Mitochondria as sink of ROS
6: Mitochondrial ROS removal and ROS signaling
7: Conclusion
Chapter 5: Mitochondria and apoptosis
Abstract
1: Introduction
2: Mitochondria and apoptosis
3: Post-MOMP inner mitochondrial membrane remodeling
4: Post-MOMP regulation of apoptotic assembly
5: Post-MOMP cellular fate
6: Survival after MOMP
7: Mitochondria and nonapoptotic cell death
8: Conclusion
Chapter 6: Mitochondria-associated membranes in the maintenance of cell homeostasis
Abstract
1: Introduction
2: MAM and phospholipid synthesis and transfer
3: The yeast ERMES complex
4: MAM and Ca2 + signaling
5: MAM and apoptotic cell death
6: MAM and autophagy/mitophagy
7: Concluding remarks
Part II: The effects of plant molecules on the mitochondria in health and disease
Chapter 7: Biopharmaceutical properties of natural products
Abstract
Acknowledgment
1: Introduction
2: Solubility and dissolution
3: Permeability
4: Presystemic metabolism
5: Biopharmaceutical classification systems
6: Novel natural product formulations
7: Standardization
8: Mitochondrial biopharmaceutics
9: Conclusion
Chapter 8: Carnosic acid and brain mitochondria
Abstract
Acknowledgments
1: Introduction
2: The mitochondria-related effects induced by CA in in vitro experimental model
3: The mitochondria-related effects induced by CA in ex vivo/in vivo experimental models
4: Conclusion
5: Future directions
Chapter 9: Rosmarinic acid and mitochondria
Abstract
1: Background
2: Factors involved in mitochondrial dysfunction
3: Pathological basis of mitochondrial dysfunction in diseases
4: Rosmarinic acid and mitochondrial regulation
5: Rosmarinic acid in metabolic disease
6: Rosmarinic acid in central nervous system diseases
7: Pharmacokinetic profile and clinical aspects of Rosmarinic acid
8: Conclusions
Chapter 10: Sulforaphane and mitochondria
Abstract
Acknowledgments
1: Sulforaphane overview
2: Nrf2-dependent impacts of SFN on mitochondrial structure and function
3: Nrf2-independent impacts of SFN on mitochondrial structure and function
4: Future challenges
Chapter 11: Cannabinoids and mitochondria
Abstract
Acknowledgments
1: Introduction
2: The endocannabinoid system
3: Mitochondria are affected by cannabinoids
4: Cannabinoids alter mitochondrial membranes and functions
5: Cannabinoid receptors in cannabinoid-dependent alterations of mitochondria
6: CBD and mitochondria
7: The mitochondrial CB1
8: Protective roles of cannabinoids
9: Conclusion
Chapter 12: Anthocyanins, effects in mitochondria and metabolism
Abstract
Acknowledgments
1: Introduction
2: Anthocyanin molecules, food sources, and bioavailability
3: Effects of anthocyanins on mitochondria and metabolism in health and disease
4: Conclusions and future directions
Chapter 13: Preclinical evidence of the therapeutic role of pterostilbene: Focus on the mitochondria
Abstract
1: Introduction
2: Chemistry
3: Sources
4: Bioavailability
5: Pterostilbene and mitochondria
6: Pterostilbene and mitochondrial biogenesis
7: Pterostilbene and mitochondrial oxidative stress
8: Pterostilbene and mitochondrial apoptosis
9: Nanotechnology-related strategies of pterostilbene
10: Conclusion and future directions
Chapter 14: Polyphenols attenuate mitochondrial dysfunction induced by amyloid peptides
Abstract
1: Amyloid β peptides and Alzheimer’s disease
2: Alterations of mitochondrial metabolism and Ca2 + signaling by Aβ peptide
3: Polyphenols and their role protecting mitochondria processes
4: Therapeutic potential of polyphenols in AD
5: Concluding remarks
Chapter 15: Plant molecules to treat eye mitochondria
Abstract
Acknowledgments
1: Introduction
2: Mitochondrial disorders
3: Mitochondrial eye complications
4: Plant antioxidants to treat mitochondrial dysfunction of the eye
5: Conclusion
Author contributions
Conflicts of interest
Chapter 16: Mitochondria as a target for monoterpenes
Abstract
1: Monoterpenes
2: Biological effects related to mitochondria
3: Cytotoxicity of monoterpenes on cancer cells
4: Protective effects of monoterpenes
5: Final considerations
Chapter 17: Baccharis trimera phytochemicals and the mitochondria
Abstract
Graphical abstract
1: Introduction
2: B. trimera phytochemicals
3: Role of B. trimera in mitochondria
4: Conclusion and future directions
Chapter 18: Citrus flavonoids and the mitochondria
Abstract
Acknowledgment
1: Introduction
2: Citrus flavonoids in health and disease
3: Citrus flavonoids and mitochondria
4: Future direction
Chapter 19: Caffeine and mitochondria with a focus on the central nervous system
Abstract
1: Introduction
2: Caffeine and mitochondria: General effects
3: The effects of caffeine on the peripheral mitochondria
4: Caffeine and the brain mitochondria
5: Conclusion
Authors’ contribution
Chapter 20: Curcumin and mitochondria
Abstract
1: Introduction
2: Role of mitochondria in the etiology and onset of human diseases
3: Dietary phytochemicals acting on mitochondria
4: Mitochondrial respiration, energy generation, and curcumin
5: Mitochondria, reactive oxygen species, and curcumin
6: Mitochondrial biogenesis, mitophagy, and curcumin
7: Mitochondria, apoptosis, and curcumin
8: Need for derivatives of curcumin
9: Conclusion
Chapter 21: Catechins, neuroprotection, and brain mitochondria
Abstract
1: Chemical properties of catechins
2: Antiinflammatory and immunomodulatory effects of catechins
3: The role of catechins in neuroprotection
4: Effects of catechins on brain mitochondria
5: Conclusion
Chapter 22: The effects of catechins on the cardiac mitochondria
Abstract
1: Bioavailability of catechins
2: Catechins in oxidative stress
3: Catechins in cardiovascular diseases
4: Cardiac mitochondria as direct targets of catechins
Chapter 23: Possible roles of garlic and its bioactive components on mitochondrial function in physiological and pathological conditions
Abstract
1: Introduction
2: Effects of garlic and its active components on the mitochondrial and cellular functions in physiological conditions
3: Effects of garlic preparations on the mitochondrial and cellular functions in noncancer-related conditions
4: Effects of allicin on the mitochondrial and cellular functions in noncancer-related conditions
5: Effects of OSCs on the mitochondrial and cellular functions in noncancer-related conditions
6: Effects of garlic preparations on the mitochondrial and cellular functions under cancer-related conditions
7: Effects of allicin on the mitochondrial and cellular functions in cancer-related conditions
8: Effects of OSCs on the mitochondrial and cellular functions in noncancer-related conditions
9: Conclusion
Chapter 24: Resveratrol effects on skeletal muscle mitochondria and contractile function
Abstract
Acknowledgments
1: Introduction
2: Resveratrol effects on muscle mitochondria
3: Molecular mechanisms of resveratrol’s effects on mitochondria
4: Resveratrol effects on muscle function and anatomy
5: Conclusions and future perspectives
Chapter 25: Antiaging effects of natural agents in the skin: Focus on mitochondria
Abstract
1: The skin
2: Skin aging
3: Mitochondrial role in skin aging
4: Prevention of skin aging
5: Antiaging effects of natural agents in the skin
6: Polyphenols and their benefits on human skin, acting as a scavenger of free radicals
7: Nonflavonoids
8: Flavonoids
9: Carotenoids and vitamins for improved skin health
10: Focus on some natural sources of bioactive compounds
11: Conclusion
Chapter 26: Role of quercetin in the glial mitochondria: Implications for health and disease
Abstract
1: Introduction
2: Glial cells: Metabolism and physiology
3: Existing targeted molecules/drugs for mitochondrial dysfunction
4: Flavonoids: Potential candidate
5: Quercetin: Potential candidate for solving mitochondrial dysfunction
6: Quercetin: Glial cell mitochondria function/dysfunctions
7: Conclusions and future perspectives
Conflict of interest statement
Chapter 27: The therapeutic effects of lycopene on mitochondrial function in human diseases
Abstract
1: Introduction
2: Oxidative stress and lycopene
3: Mitochondrial oxidative stress and dysfunction
4: Mitochondrial oxidative damage, disease, and lycopene
5: Conclusion
Chapter 28: Ascorbic acid and the mitochondria
Abstract
Acknowledgments
1: Introduction
2: Ascorbic acid characteristics
3: Mitochondrial accumulation of ascorbic acid
4: Effects of ascorbic acid on mitochondria
5: Mitochondrial ROS and ascorbic acid
6: Ascorbic acid modulates mitochondria function, dynamics, and biogenesis
7: Conclusion and future directions
Chapter 29: Soy isoflavones, mitochondria and cell fate
Abstract
Acknowledgment
1: Introduction
2: Flavonoids—Bliss of mankind
3: Soy isoflavones—Structure and functions
4: Soy isoflavones in health and disease
5: Mitochondria signaling pathways
6: Soy isoflavones as modulators of cell death pathways
7: Oxidative stress and mitochondrial dysfunction—A perilous liaison
8: Mitochondrial dynamics and quality check—The powerful nexus
9: Soy isoflavones and mitochondria in health and disease
10: Future prospective
11: Conclusion
Chapter 30: Resveratrol and brain mitochondria
Abstract
1: Introduction
2: Resveratrol: Overview
3: Resveratrol promotes mitochondrial function in brain cells
4: Resveratrol effects on inflammation and mitochondrial-related apoptosis and autophagy
5: Resveratrol influence on neurodegenerative disorders
6: Clinical trials
7: Conclusions
Chapter 31: Plant-derived molecules for the prevention and treatment of mitochondria-related diseases
Abstract
1: Introduction
2: Mitochondrial diseases
3: Chemical exposure
4: Herbals
5: Conclusion
Chapter 32: Mitochondrial toxicity induced by plant molecules
Abstract
1: Introduction
2: Mitochondria and the vulnerability to toxic compounds
3: Plant toxic compounds and mechanism of action on mitochondria
4: Conclusions
Chapter 33: Mitohormesis
Abstract
1: Introduction
2: Mitohormesis
3: Mitohormesis and phytochemicals
4: Concluding remarks
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Mitochondrial Physiology and Vegetal Molecules

Therapeutic Potential of Natural Compounds on Mitochondrial Health

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