Mitochondrial Genomics: Insights into Dysfunction and Disease
- 1st Edition - January 1, 2026
- Imprint: Elsevier
- Authors: Aruna Pal, Keshav K. Singh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 6 6 5 5 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 6 6 5 6 - 0
Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitoch… Read more
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Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.
- Introduces mitochondrial genetics and function using animal models
- Discusses the role of mitogenomics in various disease states
- Considers the implication of whole mitochondrial genome sequencing in animals
- Explores mitochondrial replacement theory and gene editing
Academic researchers and industry scientists in the fields of animal disease resistance, immunology, and mitogenomics
1. Overview of mitochondria
2. Structural organization of mitochondria and mitochondrial genetics in different animal models
3. Mitophagy
4. Introduction to MAVS in different livestock species
5. Mitogenomics and metabolic disease
6. Mitogenomics and viral disease
7. Mitogenomics and bacterial disease
8. Mitogenomics and parasitic disease
9. Mitogenomics and fungal infestations
10. Mitogenomics and neurodegenerative disorder
11. Mitogenomics and cancer
12. Numtogenesis and its association to disease
13. Whole mitochondrial genome sequencing and its implication in diseases in animal models
14. Mitochondrial replacement therapy: Its prospects
15. Implication of gene editing in mitochondrial repair
2. Structural organization of mitochondria and mitochondrial genetics in different animal models
3. Mitophagy
4. Introduction to MAVS in different livestock species
5. Mitogenomics and metabolic disease
6. Mitogenomics and viral disease
7. Mitogenomics and bacterial disease
8. Mitogenomics and parasitic disease
9. Mitogenomics and fungal infestations
10. Mitogenomics and neurodegenerative disorder
11. Mitogenomics and cancer
12. Numtogenesis and its association to disease
13. Whole mitochondrial genome sequencing and its implication in diseases in animal models
14. Mitochondrial replacement therapy: Its prospects
15. Implication of gene editing in mitochondrial repair
- Edition: 1
- Published: January 1, 2026
- Imprint: Elsevier
- Language: English
AP
Aruna Pal
Dr. Aruna Pal is Assistant Professor at West Bengal University of Animal and Fishery Sciences (WBUASFSCI). She obtained her MVSc at the National Dairy Research Institute, India, and her PhD in Animal Genetics and Breeding at the Indian Veterinary Research Institute. She has acted as Convenor for the Human Genetics and Genomics Task Force for India’s Ministry of Science and Technology and currently heads the Animal Genomics lab for WBUASFSCI’s Department of Animal Genetics and Breeding. Her research focuses on mitochondrial genetics and diseases using animal models. She has authored multiple books, including Elsevier’s Genetics and Breeding for Disease Resistance of Livestock.
Affiliations and expertise
West Bengal University of Animal and Fishery Sciences, IndiaKS
Keshav K. Singh
Dr. Keshav Singh is Professor of Genetics and Endowed Chair within the University of Alabama at Birmingham’s Genetics Research Division. He obtained his MSc in India, PhD in Australia, and postdoctoral studies at Harvard University. He is a leader in the field of mitochondrial determinants of health, disease, diversity, and health disparities. He is the founding Editor-in-Chief of Elsevier’s Mitochondrion journal, founder of the Mitochondria Research and Medicine Society (USA), and founder of the Society for Mitochondrial Research and Medicine (India).
Affiliations and expertise
University of Alabama at Birmingham, USA