Mitochondrial Dysfunction and Nanotherapeutics
Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine
- 1st Edition - July 15, 2021
- Imprint: Academic Press
- Editor: Marcos Roberto de Oliveira
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 6 6 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 8 6 1 8 - 5
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochond… Read more
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Request a sales quoteMitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.
This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described.
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.
- Contains detailed information on mitochondrial dysfunction
- Reviews our current understanding of the role of mitochondria in aging
- Includes coverage of specific conditions, including sports and affective disorders, among others
- Discusses mitochondria targeted delivery of therapeutic compounds
Researchers in Bioscience (from PhD level and up). Clinician Researchers (Human disease) - MD (Pharmacology, Nutrition) and DVM - Graduate students (nutrition, medicine, pharmacology)
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Acknowledgments
- Part I: Mitochondrial dysfunction
- Chapter 1: Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging
- Abstract
- Brain, energy, and mitochondrial physiology
- Genomic and proteomic studies
- Oxidative stress and decreased energy production
- Mitochondria, apoptosis, and depression
- Diet
- Exercise
- Age
- The effects of medications on mitochondrial function
- Conclusion
- Chapter 2: Mitochondrial dysfunction in inborn errors of metabolism
- Abstract
- Introduction
- IEM with secondary mitochondrial involvement
- Conclusion
- Chapter 3: Impaired mitochondrial dynamics in disease
- Abstract
- Introduction
- Mitochondrial fusion
- Mitofusins: Structure, membrane topology, localization, and functions
- MFN2 in Charcot-Marie-Tooth type 2A
- Opa1: Structure, localization, and functions
- OPA1 in autosomal dominant optic atrophy
- Mitochondrial fission
- Therapeutic targeting of mitochondrial fission in disease
- Dynamics of physically constrained mitochondria
- Intercellular transfer of mitochondria
- Quantitative assessment of mitochondrial dynamics
- Conclusions
- Chapter 4: Mitochondrial dysfunction in metabolic disorders
- Abstract
- Introduction
- Mitochondrial machinery and electron transport chain (ETC)
- Mitochondrial dysfunction and insulin signaling
- Pharmacological applications of mitochondrial dysfunction-mediated metabolic disease
- Emerging therapeutic approaches to treat mitochondrial dysfunction: Implications in NDDs and metabolic disease
- Conclusion and future perspective
- Chapter 5: Mitochondrial dysfunction and autophagy in neurodegeneration
- Abstract
- Conflicts of Interests and Author’s Contribution
- Acknowledgment
- Introduction
- Insights into the regulation of autophagy, lysosomal, and endosomal pathways
- Linking mitochondrial dysfunction and autophagy pathway: Role of Ca2 + influx
- Regulation of autophagic pathway mediated through oxidized mitochondrial stress
- Potential mechanism of mitochondrial dysfunction in the autophagy pathway
- The implication of endosomal and lysosomal degradation pathways in mitochondrial dysfunction-mediated NDDs
- Therapeutic approach to eliminate mitochondrial dysfunction and defective autophagy pathway in NDDs
- Conclusion and future perspectives
- Chapter 6: Mitochondrial dysfunction in sepsis
- Abstract
- Normal mitochondrial function
- Mitochondrial pathophysiology
- Sepsis and mitochondrial-free radical generation
- Sepsis and mitochondrial electron transport chain alterations
- Sepsis and mitochondrial ATP transport alterations
- Sepsis and skeletal muscle weakness
- Sepsis-induced cardiac dysfunction
- Sepsis-mediated tissue dysoxia and mitochondria
- Mitochondrially modulated alterations in immune function
- Mitochondrial DAMPS
- Antioxidants as treatments to enhance mitochondrial performance
- Other therapeutic agents that improve mitochondrial performance
- Summary
- Chapter 7: Drug- or toxin-induced mitochondrial toxicity
- Abstract
- Introduction
- Drugs
- Pesticides
- Environmental toxins
- Plant molecules that mitigate mitochondrial intoxication
- Chapter 8: Aging, mitochondria, and autophagy
- Abstract
- Introduction
- Mitochondrial dysfunction in aging
- Molecular mechanisms of mitophagy
- Mitophagy in cardiovascular aging
- Mitophagy in neurodegeneration
- Mitophagy in cancer
- Mitophagy in metabolic disorders
- Concluding remarks
- Chapter 9: Skin aging and mitochondria
- Abstract
- Acknowledgments
- Skin
- Mitochondria
- Intrinsic and extrinsic skin aging
- The effect of ethnicity on skin aging
- Part II: Strategies utilized to deliver natural molecules to the mitochondria
- Chapter 10: Organelle targeting: Focus on the mitochondria
- Abstract
- Acknowledgments
- Introduction
- Mitochondria: Structure and functions
- Treatment and formulation strategies to target mitochondria
- Conclusion
- Chapter 11: Nanotechnology, mitochondria, and cancer: Mitochondria-targeting particles for biomedical applications
- Abstract
- Introduction
- Liposomes and lipid-based particles
- Polymeric particles/micelles
- Inorganic particles
- Conclusion and future perspectives
- Chapter 12: Nanomaterials aimed toward the cardiac mitochondria: from therapeutics to nanosafety
- Abstract
- Introduction to nanomaterials
- Nanomaterials for drug delivery
- Tunable properties of nanoparticles
- Functionalization of nanoparticles
- Mitochondrial nanotherapeutics and cardiovascular effect of natural compound-loaded nanoparticles
- Nanosafety considerations
- Conclusions and future perspectives
- Chapter 13: Increasing resveratrol bioavailability: A therapeutic challenge focusing on the mitochondria
- Abstract
- Introduction
- Resveratrol bioavailability
- Biological activities of resveratrol
- Mitochondria as target of resveratrol
- Methodological approaches to enhance resveratrol bioavailability
- Conclusions
- Chapter 14: Advances in nanotechnology-related strategies against melanoma
- Abstract
- Melanoma—General overview
- Natural compounds with therapeutic potential
- Nanotechnology applied to natural compounds research
- Conclusions and future perspectives
- Chapter 15: Challenges in the delivery of polyphenols to cancer cells
- Abstract
- Introduction
- Overview of drug delivery nanocarriers for delivery of polyphenols
- Enhanced efficacy of nanoformulated natural polyphenols for cancer treatment
- Challenges in the action of polyphenols in cancerous cells
- Conclusion and future perspective
- Chapter 16: Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets
- Abstract
- Introduction
- Nanopreparations with natural products targeting mitochondria
- Could nanoformulation of plant extracts mimic the efficacy of advanced purification?
- Regulatory framework of nanosized plant-derived molecules—A challenge to overcome
- Toxicity assessment
- More in vivo evaluations and clinical studies needed
- Conclusions
- Future directions
- Chapter 17: Therapeutic implications of targeting antioxidants to mitochondria
- Abstract
- Acknowledgments
- Mitochondria
- Strategies for mitochondria-targeted antioxidants
- Conclusions
- Chapter 18: Nanomedicines and phytochemicals targeting Alzheimer’s disease
- Abstract
- Introduction
- Alzheimer’s disease
- Targeting AD through nanomedicine
- Alternative therapy using medicinal plants
- Conclusion
- Chapter 19: Mitochondria-targeted drugs and immune function
- Abstract
- Acknowledgments
- Introduction
- Overview of immune responses
- Mitochondria and immunity
- Mitochondria-targeted drugs
- Concluding remarks
- Chapter 20: Polymeric drug delivery systems for mitigating oxidative stress
- Abstract
- Introduction
- Deleterious effects of oxidants and onset of pathogenesis
- Combining nanotechnology and plant-based drugs
- Conclusion
- Chapter 21: Polyphenols and the microbiota: A challenge in mitochondrial therapy
- Abstract
- Acknowledgments
- Introduction
- Gut microbiota composition
- Polyphenol
- Beneficial effects of polyphenols as mitochondrial uncouplers
- The crosstalk between gut microbiota and mitochondria
- Conclusion
- Index
- Edition: 1
- Published: July 15, 2021
- No. of pages (Paperback): 600
- No. of pages (eBook): 600
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323856669
- eBook ISBN: 9780323886185
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Marcos Roberto de Oliveira
Marcos Roberto de Oliveira, PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a master’s and a Ph.D. in Biochemistry from the same institution. He is currently a professor and coordinates research at UFRGS. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models.
Affiliations and expertise
Professor, Department of Biochemistry, Federal University of Rio Grande do Sul, Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saude (ICBS), Departamento de Bioquímica, Rua Ramiro Barcelos, BrazilRead Mitochondrial Dysfunction and Nanotherapeutics on ScienceDirect