Mitochondria as a Key Intracellular Target of Thallium Toxicity
- 1st Edition - June 1, 2022
- Imprint: Academic Press
- Author: Sergey Korotkov
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 5 3 1 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 5 3 2 - 4
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- Highlights the differences between the toxic effect of thallium and the action of other heavy metals on cells and mitochondria
- Explains why the toxicity of thallium in experiments in vivo is higher than that of bivalent heavy metals
- Discusses the applied in vitro model when searching for new inhibitors of the mitochondrial permeability transition pore
Researchers in cell biology, biochemistry, biochemical toxicology, ecology, neurobiology and environmental science. Clinicians; Graduate students
- Cover image
- Title page
- Table of Contents
- Copyright
- Introduction
- Abstract
- List of abbreviations:
- Chapter 1. Toxicity of thallium and its compounds
- 1.1. Thallium and its compounds: chemical and toxic properties, distribution, and release into the environment
- 1.2. Thallium toxicity to biological organisms (humans, animals, and plants)
- 1.3. Classification, symptomatology, diagnosis, and treatment of thallium poisoning
- 1.4. Methods of thallium analysis in biological samples
- Chapter 2. Toxicology of thallium
- 2.1. The toxic effect of thallium on the human body and animals
- 2.2. The toxic effect of thallium compounds on body systems
- 2.3. Toxic effects of thallium on aquatic protozoa and unicellular organisms
- Chapter 3. Toxic thallium effects on cells
- 3.1. Molecular mechanisms of thallium transport across cell membranes: use of isotopes and ion channel inhibitors
- 3.2. Thallium toxicity mechanisms on mammalian cells
- 3.3. Interaction of Tl+ and Tl3+ with molecular thiol groups
- Chapter 4. Effect of thallium on mitochondria
- 4.1. Heavy metal effects on isolated mitochondria
- 4.2. Effect of thallium on the inner membrane potential and ion permeability and the mitochondrial respiration
- 4.3. Thallium effects on the concentration of free thiol groups in mitochondrial proteins
- 4.4. Tl+induces the opening of the mitochondrial permeability transition pore in the inner membrane of calcium-loaded mitochondria: The effects of the pore inhibitors
- 4.5. The role of calcium sites and potassium channels of the inner membrane in the Tl+-induced MPTP opening
- 4.6. The dependence of the Tl+-induced MPTP opening in the inner membrane of rat liver mitochondria on the adenine nucleotide translocase conformation and the phosphate symporter state
- 4.7. Conclusing remarks
- Index
- Edition: 1
- Published: June 1, 2022
- No. of pages (Paperback): 278
- No. of pages (eBook): 278
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323955317
- eBook ISBN: 9780323955324
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Sergey Korotkov
Sergey Korotkov is a Leading Researcher in the Laboratory of Inorganic Ions’ Biochemistry at the Sechenov Institute of Evolutionary Physiology and Biochemistry. He graduated from the Chemical Department of St. Petersburg State University in 1979 and defended his PhD thesis at Russian Academy of Sciences in 1987.
Affiliations and expertise
Leading Researcher, Russian Academy of Sciences, Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, RussiaRead Mitochondria as a Key Intracellular Target of Thallium Toxicity on ScienceDirect