Mims' Pathogenesis of Infectious Disease
- 5th Edition - September 19, 2000
- Imprint: Academic Press
- Authors: Anthony A. Nash, Cedric A. Mims, John Stephen
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 3 9 0 9 3 8 - 1
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 9 8 2 6 5 - 9
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 7 4 1 5 - 8
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 3 8 5 0 - 1
Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date de… Read more
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Request a sales quoteMims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.
- Microbial gene sequencing
- Up-to-date picture of the global burden of infectious diseases
- Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence
- Latest data on combination vaccines, the promise of edible vaccines
- The spread of antibiotic resistance genes among bacteria
- HIV1 and HIV2; molecular biology, pathogenesis and origin
- Latest data on tuberculosis - the number one infectious disease worldwide
- Recent work on papillomaviruses, herpesviruses, BSE and variant CJD
- Latest data on microbial evasion of immune defences
- Origin and molecular biology of pandemic influenza
- Significance of toxins
- An update on vaccines, prions, immune evasion, microbial ligands and receptors
Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases.
Preface to the Fifth EditionPreface to the Fourth EditionPreface to the Third EditionPreface to the Second EditionPreface to the First Edition1 General Principles References2 Attachment to and Entry of Microorganisms into the Body Introduction Adhesion/Entry: Some General Considerations The Skin Respiratory Tract Gastro-Intestinal Tract Oropharynx Urinogenital Tract Conjunctiva The Normal Microbial Flora Exit of Microorganisms From the Body References3 Events Occurring Immediately After the Entry of the Microorganism Growth in Epithelial Cells Intracellular Microorganisms and Spread through the Body Subepithelial Invasion Nutritional Requirements of Invading Microbes References4 The Encounter with the Phagocytic Cell and the Microbe's Answers Cell Biology of Phagocytosis Phagocytosis in Polymorphonuclear Leucocytes Phagocytosis in Macrophages Microbial Strategy in Relation to Phagocytes Growth in the Phagocytic Cell Killing the Phagocyte Entry into the Host Cell Other than by Phagocytosis Consequences of Defects in the Phagocytic Cell Summary References5 The Spread of Microbes through the Body Direct Spread Microbial Factors Promoting Spread Spread via Lymphatics Spread via the Blood Spread via Other Pathways References6 The Immune Response to Infection Antibody Response T-Cell-Mediated Immune Response Natural Killer Cells Macrophages, Polymorphs and Mast Cells Complement and Related Defense Molecules Conclusions Concerning the Immune Response to Microorganisms References7 Microbial Strategies in Relation to the Immune Response Infection Completed before the Adaptive Immune Response Intervenes Induction of Immunological Tolerance Immunosuppression Absence of a Suitable Target for the Immune Response Microbial Presence in Bodily Sites Inaccessible to the Immune Response Induction of Inappropriate Antibody and T-Cell Responses Antibodies Mopped Up by Soluble Microbial Antigens Local Interference with Immune Forces Reduced Interferon Induction or Responsiveness Antigenic Variation Microorganisms that Avoid Induction of an Immune Response References8 Mechanisms of Cell and Tissue Damage Infection with no Cell or Tissue Damage Direct Damage by Microorganisms Microbial Toxins Indirect Damage via Inflammation Indirect Damage via the Immune Response (Immunopathology) Other Indirect Mechanisms of Damage Diarrhoea References9 Recovery from Infection Immunological Factors in Recovery Inflammation Complement Interferons Multimechanistic Recovery: An Example Temperature Tissue Repair Resistance to Re-Infection References10 Failure to Eliminate Microbe Latency Persistent Infection with Shedding Epidemiological Significance of Persistent Infection with Shedding Persistent Infection without Shedding Significance for the Individual of Persistent Infections Conclusions References11 Host and Microbial Factors Influencing Susceptibility Genetic Factors in the Microorganism Genetic Factors in the Host Hormonal Factors and Stress Other Factors References12 Vaccines and How they Work Introduction General Principles Complications and Side Effects of Vaccines The Development of New Vaccines ReferencesAppendixConclusions ReferencesGlossaryIndex
- Edition: 5
- Published: September 19, 2000
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780123909381
- Paperback ISBN: 9780124982659
- eBook ISBN: 9780080574158
- eBook ISBN: 9780080538501
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Anthony A. Nash
Tony Nash is Emeritus Professor of Infectious Diseases at the University of Edinburgh. He has had a distinguished career i the field of viral pathogenesis in which he has over a 150 publications. He is a Fellow of the Royal Society of Edinburgh and of the Academy of medical sciences of the UK.
Affiliations and expertise
University of Edinburgh, UKCM
Cedric A. Mims
Cedric Mims began as a zoologist, studying under GP Wells and JBS Haldane at University College, London. He then went to the Middlesex Hospital Medical School, London, graduating in 1952. After hospital appointments he spent three years in Uganda studying tropical fevers, and then 16 years in Canberra, Australia, interspersed with two years in the USA. This was followed by a 20-year period in London as Professor of Microbiology at Guy's Hospital Medical School, where his enthusiasm for teaching found its outlet. His entire career has focused on infectious diseases and immunology, and he has produced five books and more than a hundred scientific papers on these subjects. He has four children and nine grandchildren and lives in the Sussex countryside.
Affiliations and expertise
Guy's Hospital Medical School, UMDS, London, U.K.JS
John Stephen
Affiliations and expertise
University of Birmingham, Edgbaston, U.K.Read Mims' Pathogenesis of Infectious Disease on ScienceDirect