Mims' Pathogenesis of Infectious Disease

Preface to the Fifth EditionPreface to the Fourth EditionPreface to the Third EditionPreface to the Second EditionPreface to the First Edition1 General Principles References2 Attachment to and Entry of Microorganisms into the Body Introduction Adhesion/Entry: Some General Considerations The Skin Respiratory Tract Gastro-Intestinal Tract Oropharynx Urinogenital Tract Conjunctiva The Normal Microbial Flora Exit of Microorganisms From the Body References3 Events Occurring Immediately After the Entry of the Microorganism Growth in Epithelial Cells Intracellular Microorganisms and Spread through the Body Subepithelial Invasion Nutritional Requirements of Invading Microbes References4 The Encounter with the Phagocytic Cell and the Microbe's Answers Cell Biology of Phagocytosis Phagocytosis in Polymorphonuclear Leucocytes Phagocytosis in Macrophages Microbial Strategy in Relation to Phagocytes Growth in the Phagocytic Cell Killing the Phagocyte Entry into the Host Cell Other than by Phagocytosis Consequences of Defects in the Phagocytic Cell Summary References5 The Spread of Microbes through the Body Direct Spread Microbial Factors Promoting Spread Spread via Lymphatics Spread via the Blood Spread via Other Pathways References6 The Immune Response to Infection Antibody Response T-Cell-Mediated Immune Response Natural Killer Cells Macrophages, Polymorphs and Mast Cells Complement and Related Defense Molecules Conclusions Concerning the Immune Response to Microorganisms References7 Microbial Strategies in Relation to the Immune Response Infection Completed before the Adaptive Immune Response Intervenes Induction of Immunological Tolerance Immunosuppression Absence of a Suitable Target for the Immune Response Microbial Presence in Bodily Sites Inaccessible to the Immune Response Induction of Inappropriate Antibody and T-Cell Responses Antibodies Mopped Up by Soluble Microbial Antigens Local Interference with Immune Forces Reduced Interferon Induction or Responsiveness Antigenic Variation Microorganisms that Avoid Induction of an Immune Response References8 Mechanisms of Cell and Tissue Damage Infection with no Cell or Tissue Damage Direct Damage by Microorganisms Microbial Toxins Indirect Damage via Inflammation Indirect Damage via the Immune Response (Immunopathology) Other Indirect Mechanisms of Damage Diarrhoea References9 Recovery from Infection Immunological Factors in Recovery Inflammation Complement Interferons Multimechanistic Recovery: An Example Temperature Tissue Repair Resistance to Re-Infection References10 Failure to Eliminate Microbe Latency Persistent Infection with Shedding Epidemiological Significance of Persistent Infection with Shedding Persistent Infection without Shedding Significance for the Individual of Persistent Infections Conclusions References11 Host and Microbial Factors Influencing Susceptibility Genetic Factors in the Microorganism Genetic Factors in the Host Hormonal Factors and Stress Other Factors References12 Vaccines and How they Work Introduction General Principles Complications and Side Effects of Vaccines The Development of New Vaccines ReferencesAppendixConclusions ReferencesGlossaryIndex