
Miller's Anesthesia, 2-Volume Set
- 9th Edition - May 2, 2019
- Imprint: Elsevier
- Editors: Michael A. Gropper, Lars I. Eriksson, Lee A. Fleisher, Jeanine P. Wiener-Kronish, Neal H. Cohen, Kate Leslie
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 6 1 2 6 3 - 0
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 5 9 6 0 4 - 6
**Selected for Doody’s Core Titles® 2024 with "Essential Purchase" designation in Anesthesiology & Pain Medicine**Covering everything from historical and international perspect… Read more

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Request a sales quote**Selected for Doody’s Core Titles® 2024 with "Essential Purchase" designation in Anesthesiology & Pain Medicine**
Covering everything from historical and international perspectives to basic science and current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in the field. Dr. Michael Gropper leads a team of global experts who bring you the most up-to-date information available on the technical, scientific, and clinical issues you face each day – whether you’re preparing for the boards, studying for recertification, or managing a challenging patient care situation in your practice.
- Contains fully revised and updated content throughout, including numerous new videos online.
- Includes four new chapters: Clinical Care in Extreme Environments: High Pressure, Immersion, and Hypo- and Hyperthermia; Immediate and Long-Term Complications; Clinical Research; and Interpreting the Medical Literature.
- Addresses timely topics such as neurotoxicity, palliation, and sleep/wake disorders.
- Streamlines several topics into single chapters with fresh perspectives from new authors, making the material more readable and actionable.
- Features the knowledge and expertise of former lead editor Dr. Ronald Miller, as well as new editor Dr. Kate Leslie of the University of Melbourne and Royal Melbourne Hospital.
- Provides state-of-the-art coverage of anesthetic drugs, guidelines for anesthetic practice and patient safety, new techniques, step-by-step instructions for patient management, the unique needs of pediatric patients, and much more – all highlighted by more than 1,500 full-color illustrations for enhanced visual clarity.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices, in addition to accessing regular updates, related websites, and an expanded collection of procedural videos.
The initial printing of Miller’s Anesthesia, 9e contained a dosage error in chapter 26, "Intravenous Drug Delivery Systems," on page 771, Table 26.5 (Manual Infusion Schemes). A maintenance infusion of Dexmedetomidine was mistakenly reported as 0.3 – 0.7 mcg/kg/min instead of 0.3 – 0.7 mcg/kg/hr (or 0.005-0.015 mcg/kg/min). As of October 2, 2020 all stock has been corrected. If you find that you have a book with this error please contact publisher for correction sticker.
- Instructions for online access
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Associate Editors
- Contributors
- Preface
- Video Contents
- VOLUME 1
- Section I. Introduction
- 1. The Scope of Modern Anesthetic Practice
- Introduction
- Forces That Will Change Practice (Fig. 1.1)
- Conclusions
- 2. Anesthesia and Analgesia in the Global Context
- Introduction
- Section 1: Anesthesia and “Global Health”
- Section 2: Evolution of Anesthesia Care Models and Challenges Around the World
- Section 3: Essentials for Practice in Resource-Constrained Settings
- Appendix 1 Links and Useful Resources
- Conclusions
- 3. Perioperative Medicine
- Introduction
- Perioperative Management
- Models of Perioperative Care
- Conclusion
- 4. Informatics in Perioperative Medicine
- Introduction
- Computer Systems
- Computer Networks
- The Internet
- Information Security
- Standards for Healthcare Data Exchange
- Regulation of Electronic Data Exchange
- The Nature of Healthcare Information in the Anesthesia Encounter
- Development and Deployment of Anesthesia Information Management Systems
- Integration of Anesthesia Care Information with Operating Room Information Systems
- Development of Decision Support Tools
- Integration with the Enterprise Electronic Health Record
- Billing System Interactions
- Challenges in Anesthesia Information Management System Implementation
- Additional Uses for Collected Data
- Interactions of Electronic Devices with the Delivery of Anesthesia Care
- Conclusion
- 5. Quality Improvement in Anesthesia Practice and Patient Safety
- What Is Quality?
- Approaches to Quality Assessment
- Quality Improvement Measures and Tools
- Sources of Quality Improvement Information
- Examples of Quality Improvement Programs
- The Future: Research, Education, and Ethics
- Summary
- 6. Avoiding Patient Harm in Anesthesia: Human Performance and Patient Safety
- What this Chapter is About: An Overview
- Human Performance and Patient Safety in Anesthesia: Why is this Important?
- Nature of the Anesthesia Professional’s Operational Domain: A Dynamic and Complex Environment
- Nature of the Anesthesia Professional’s Work: Task Variation and Workload Management
- Patient Safety on the Individual and Team Level
- Patient Safety on the Organizational Level
- The Bigger Picture: Patient Safety Efforts on the U.S. National and International Level
- Conclusion and Outlook
- Appendix 6.1. Online Links and Valuable Public Sources
- 7. Patient Simulation
- What This Chapter Is About: An Overview
- Simulation in Anesthesia: Why Is It Important?
- Application of Simulation in Anesthesia and Health Care
- History, Development, and Types of Simulators and Simulation
- Simulation Fidelity and Classification of Simulators
- Sites of Simulation
- Simulation Team Training Participants: Who Should Be Trained and in What Composition?
- Patient Simulation Timing: Announced in Advance Versus Unannounced in Advance
- Scopes of Simulation in Health Care: The 12 Dimensions of Simulation
- Crisis Resource Management (ACRM; CRM): Part of Modern Patient Simulation Team Training
- Anatomy of a Patient Simulation Team Training Exercise
- Scenario Design and Execution: Knowing the Learning Objectives and Making It Real
- Debriefing: Heart and Soul of Patient Simulation
- Qualification and Certification of Simulation Instructors
- Accreditation of Simulation Programs, Sites, and Centers
- Benefits, Effectiveness, and Ecological Validity of Simulation Training
- Cost of Patient Simulation and Simulation Centers
- Using Simulation for Assessment of Clinical Performance
- Simulation Societies and Simulation Journals
- The Future of Patient Simulation in Anesthesia
- Appendix 7.1 Online Links and Useful Resources
- 8. Ethical Aspects of Anesthesia Care
- Ethical Theory
- Clinical Ethics
- Special Issues in Informed Consent and Informed Refusal
- Ethics of Anesthesia Involving Pregnant Women
- The Uncooperative Patient—Coercion and Restraint
- Truth Telling—Disclosure of Errors and Apology
- Research Ethics
- Section II. Anesthetic Physiology
- 9. Consciousness, Memory, and Anesthesia
- Introduction
- Consciousness
- Memory
- Organization and Function of Normal Memory
- Effects of Anesthetic Drugs on Declarative Memory Function in Humans
- Nonhuman Studies of Anesthetic Effects on Memory Processes and Behavior in the Medial Temporal Lobe
- Human and Nonhuman Studies of Anesthetic Effects on Fear Memory Systems
- Anesthetic Effects on Implicit Memory Function
- 10. Sleep Medicine
- Definition of Sleep
- Physiology
- How to Assess Sleep
- Sleep and Breathing
- Sleep and Anesthesia: Two Unequal Twins Influencing Perioperative Medicine
- Sleep and Sedation in the Intensive Care Unit
- Acknowledgment
- 11. Cerebral Physiology and the Effects of Anesthetic Drugs
- The Anatomy of the Cerebral Circulation
- Effects of Anesthetics on Cerebral Blood Flow and Cerebral Metabolic Rate
- Other Effects of Anesthetics on Cerebral Physiology
- Cerebral Physiology in Pathologic States
- 12. Neuromuscular Physiology and Pharmacology
- Neuromuscular Transmission
- Neuromuscular Junction
- Drug Effects on Postjunctional Receptors
- Biology of Prejunctional and Postjunctional Nicotinic Acetylcholine Receptors
- Neuromuscular Junction at Extremes of Age
- 13. Respiratory Physiology and Pathophysiology
- Respiratory Physiology Is Central to the Practice of Anesthesia
- Pulmonary Physiology in Health
- Ventilation
- Static Lung Volumes—Functional Residual Capacity
- Respiratory Mechanics
- Distribution of Inspired Gas
- Perfusion
- Clinical Assessment of Lung Function
- Intraoperative Respiratory Events
- Ventilation-Perfusion Matching During Anesthesia
- Factors that Influence Respiratory Function During Anesthesia
- Lung Function After Cardiac Surgery
- Protective Ventilation
- Postoperative Physiotherapy
- Intraoperative Hyperoxia
- Effect of Sleep on Respiration
- 14. Cardiac Physiology
- Physiology of the Intact Heart
- Cellular Cardiac Physiology
- Control of Cardiac Function
- 15. Gastrointestinal Physiology and Pathophysiology
- Introduction
- Gastrointestinal Anatomy and Function
- Transit Time in Health and Disease
- Methods of Evaluating Colonic Motility
- The Effects of General Anesthesia on Bowel Function
- Effect of Opioids on Bowel Function
- Effect of Open Abdominal Surgery, Ischemia, Stomas, and Bowel Anastomosis on Gastrointestinal Physiology and Function
- Gastrointestinal System Nociception
- 16. Hepatic Physiology, Pathophysiology, and Anesthetic Considerations
- Anatomy of the Liver
- Hepatic Physiology
- Evaluation of the Liver
- Hepatic Pathophysiology
- Strategies for Minimizing Blood Loss
- 17. Renal Anatomy, Physiology, Pharmacology, and Evaluation of Function
- Introduction
- Organization of the Kidney
- Induced Hypotension
- 18. Basic Principles of Pharmacology
- Introduction
- Pharmacokinetic Models
- Special Interests in Anesthetic Pharmacokinetics
- Pharmacodynamic Principles
- Special Populations
- Summary
- 19. Inhaled Anesthetics: Mechanisms of Action
- History
- Integrated Effects on Central Nervous System Function
- Identification of Molecular Sites of Anesthetic Action
- Cellular Mechanisms
- Simple Circuits and Complex Networks
- Research Strategies for the Future
- Summary
- 20. Inhaled Anesthetic Uptake, Distribution, Metabolism, and Toxicity
- Introduction
- Uptake and Distribution of Inhaled Anesthetics
- Synthesis of the Model and Inhaled Anesthetic Induction: PK/PD
- Metabolism and Toxicity of Inhaled Anesthetics
- 21. Pulmonary Pharmacology and Inhaled Anesthetics
- Introduction
- Inhaled Anesthetics
- Mucociliary Function and Surfactant
- Nonvolatile Inhaled Agents
- Summary
- 22. Inhaled Anesthetics: Delivery Systems
- Standards and Guidelines for Anesthesia Workstations
- Functional Anatomy of the Anesthesia Workstation
- Checking Your Anesthesia Workstation
- 23. Intravenous Anesthetics
- Propofol
- Pharmacodynamics
- Uses
- Barbiturates
- Physicochemical Characteristics
- Pharmacokinetics
- Pharmacology
- Uses
- Benzodiazepines
- Pharmacodynamics
- Drug Interactions
- Uses
- Flumazenil
- Phencyclidines (Ketamine)
- Pharmacodynamics
- Etomidate
- Pharmacodynamics
- Uses
- Dexmedetomidine
- Effects on the Central Nervous System
- Central Nervous System Protection and Other Central Nervous System Effects
- Droperidol
- Pharmacodynamics
- Summary
- 24. Opioids
- Introduction
- Pharmacology of Opioids
- Neurophysiologic Effects of Opioids
- Respiratory Effects of Opioids
- Cardiovascular Effects of Opioids
- Endocrinologic Effects of Opioids
- Renal and Urodynamic Effects of Opioids
- Effects of Opioids on Digestive Organs
- Other Opioid Effects
- Pharmacokinetics and Pharmacodynamics of Opioids
- Anesthetic Techniques Using Opioids
- Other Opioid Agonists
- Agonist-Antagonist Opioid Compounds
- Opioid Antagonists
- Drug Interactions With Opioids
- 25. Nonopioid Pain Medications
- Introduction
- Nonsteroidal antiinflammatory drugs
- Acetaminophen
- Calcium Channel Blockers
- Sodium Channel Blockers
- 26. Intravenous Drug Delivery Systems
- Introduction
- Pharmacokinetic Considerations
- Pharmacodynamic Considerations
- Designing Dosing Regimens
- Intravenous Infusion Devices and Technologies
- Future Perspectives
- 27. Pharmacology of Neuromuscular Blocking Drugs
- History and Clinical Use
- Principles of Action of Neuromuscular Blocking Drugs at the Neuromuscular Junction
- Pharmacology of Succinylcholine
- Nondepolarizing Neuromuscular Blocking Drugs
- Special Populations
- 28. Reversal (Antagonism) of Neuromuscular Blockade
- History
- Antagonism of Neuromuscular Blockade: Current Management Practices
- Drugs Used to Antagonize (Reverse) Neuromuscular Blockade
- 29. Local Anesthetics
- Basic Pharmacology
- Anatomy of the Peripheral Nerve
- Mechanism of Action of Local Anesthetics (Pharmacodynamics)
- Clinical Pharmacology
- Choice of Local Anesthetic for Various Regional Anesthetic Procedures
- Pharmacokinetics
- Toxicity
- Development of Prolonged-Duration and Sensory- or Nociceptive-Selective Local Anesthetics
- Biologic Mechanisms of Local Anesthetic Failure: Inflammation, Hyperalgesia, Tachyphylaxis, and Genetic Variants
- Conclusions
- Section III. Anesthesia Management
- 30. Risk of Anesthesia
- Introduction
- Framework of Perioperative Risk
- Issues Related to Study Design
- Risks Related to Patient Characteristics
- Special Patient Groups
- Risks Directly Related to the Anesthetic Drug
- Risks Related to Surgery
- Risks Related to the Location of Surgery and Postoperative Monitoring
- Risks Related to the Anesthesia Provider
- Improving Anesthesia Safety
- Summary
- 31. Preoperative Evaluation
- Evolution of Preanesthesia Evaluation
- Goals and Benefits of Preanesthesia Evaluation
- Clinical Examination During Preoperative Evaluation
- Frailty, Geriatric Conditions, and the Older Surgical Patient
- Preoperative Evaluation of Patients With Coexisting Disease
- Special Issues in Preoperative Evaluation
- Preoperative Laboratory and Diagnostic Studies
- Preoperative Risk Assessment
- Preoperative Medication Management
- Planning for Anesthesia
- Regulatory Issues
- Preoperative Evaluation Clinic
- Conclusion
- 32. Anesthetic Implications of Concurrent Diseases
- Role of the Primary Care Physician or Consultant
- Diseases Involving the Endocrine System and Disorders of Nutrition
- Diseases Involving the Cardiovascular System
- Disorders of the Respiratory and Immune Systems
- Diseases of the Central Nervous System, Neuromuscular Diseases, and Psychiatric Disorders
- Renal Disease and Electrolyte Disorders
- Gastrointestinal and Liver Diseases
- Hematologic Disorders and Oncologic Disease
- Patients Given Drug Therapy for Chronic and Acute Medical Conditions
- 33. Anesthetic Implications of Complementary and Alternative Therapies
- Herbal Medicines
- Preoperative Assessment and Management
- Coenzyme Q10
- Other Dietary Supplements
- Summary
- Acupuncture
- Music Therapy
- Conclusion
- 34. Patient Positioning and Associated Risks
- Introduction
- Physiologic Considerations of Positioning
- General Positioning Considerations
- Specific Positions
- Peripheral Nerve Injury
- Pressure Injuries
- Bite Injuries
- Anesthesia Outside the Operating Room
- Perioperative Visual Loss
- Conclusion
- Disclosure
- 35. Neuromuscular Disorders Including Malignant Hyperthermia and Other Genetic Disorders
- Malignant Hyperthermia
- Malignant Hyperthermia Is the Result of Abnormal Function of Muscle Calcium Release Units
- Genetics
- Fulminant Malignant Hyperthermia
- Malignant Hyperthermia–Associated Syndromes
- Diagnosis in the Operating Room and Postanesthesia Care Unit
- Anesthesia for Susceptible Patients
- Multiple Sclerosis
- Motor Neuron Disorders
- Guillain-Barré Syndrome
- Hereditary Motor-Sensory Neuropathies, including Charcot-Marie-Tooth Disease
- Duchenne Muscular Dystrophy and Becker Muscular Dystrophy
- Limb-Girdle Muscular Dystrophy
- Myotonic Dystrophy
- Myotonia Congenita
- Myotubular Myopathy
- Metabolic Myopathies
- Glycogen Storage Disease Type I
- Glycogen Storage Disease Type II (Acid Maltase Deficiency)
- Mitochondrial Myopathies
- Myasthenia Gravis
- Periodic Paralysis (Hyperkalemic, Hypokalemic, and Normokalemic)
- Summary
- 36. Cardiovascular Monitoring
- Introduction to Cardiovascular Monitoring: Focused Physical Examination
- Heart Rate and Pulse Rate Monitoring
- Electrocardiography Monitoring
- Blood Pressure Monitoring
- Central Venous Pressure Monitoring
- Pulmonary Artery Catheter Monitoring
- Cardiac Output Monitoring
- 37. Perioperative Echocardiography
- Introduction
- History of Perioperative Echocardiography
- Principles of Ultrasound
- Ultrasound Modalities
- Three-Dimensional Image Acquisition
- Indications and Practice Guidelines
- Transesophageal Echocardiography Examination
- Epicardial and Epiaortic Imaging
- Transthoracic Echocardiography Examination
- Qualitative Assessment
- Quantitative Assessment
- Hemodynamic Failure and Shock
- Intraoperative Transesophageal Echocardiography - Noncardiac Surgery
- Intraoperative Transesophageal Echocardiography - Cardiac Surgery
- Intraprocedural Transesophageal Echocardiography- Structural Heart Interventions
- Emerging Technologies
- Perioperative Transthoracic Echocardiography and Focused Cardiac Ultrasound
- Critical Care
- Training and Certification
- Future Directions
- 38. Implantable Cardiac Pulse Generators: Pacemakers and Cardioverter-Defibrillators
- Introduction
- Basic Cardiac Implantable Electronic Device Function
- Perioperative Considerations
- Conclusions
- 39. Neurologic Monitoring
- Monitoring Modalities
- Clinical Applications of Neurologic Monitoring
- Nonsurgical Factors Influencing Monitoring Results
- Summary
- 40. Monitoring the State of the Brain and Central Nervous System During General Anesthesia and Sedation
- Induction of General Anesthesia
- Maintenance of General Anesthesia: Physiologic Signs and the Nociceptive-Medullary-Autonomic Pathway
- Maintenance of General Anesthesia: Electroencephalogram-Based Indices of Level of Consciousness
- Emergence From General Anesthesia
- Emerging Strategies for Monitoring the Brain States of General Anesthesia and Sedation
- 41. Respiratory Monitoring
- Overview of Respiratory Monitoring
- The Physical Examination
- Pulse Oximetry
- Mixed Venous Oxygen Saturation
- Tissue Oxygenation
- Capnometry and Capnography
- Blood Gas Analysis
- Monitoring Lung Flows, Volumes, and Pressures:
- Plethysmographic Monitoring
- Respiratory Rate Monitoring: Apnea Monitoring
- Imaging for Respiratory Monitoring
- Point of Care Tests
- Respiratory Monitoring in Special Conditions
- Automated Data Systems
- Additional Monitored Variables
- 42. Renal Pathophysiology and Treatment for Perioperative Ischemia and Nephrotoxic Injury
- Introduction and Acute Kidney Injury Definitions
- Pathophysiologic Processes of Ischemic Acute Kidney Injury
- Renal Response to Hypoperfusion: Autoregulation and Distribution of Cardiac Output to the Kidneys
- Detection of Acute Kidney Injury
- Preoperative Evaluation of Renal Function and Risk Stratification
- Perioperative Acute Kidney Injury: Mechanisms and Treatment
- Perioperative Blood Pressure and Fluid Management
- Nephrotoxins and Acute Kidney Injury
- Renal Replacement Therapy
- Summary
- 43. Neuromuscular Monitoring
- Principles of Peripheral Nerve Stimulation
- Types of Peripheral Nerve Stimulation
- Basic Considerations
- Sites of Nerve Stimulation and Different Muscle Responses
- Patterns of Nerve Stimulation
- Equipment
- Peripheral Nerve Stimulator
- Objective Monitors
- Evaluation of Recorded Evoked Responses
- Use of Nerve Stimulators in Daily Clinical Practice
- When to Use a Peripheral Nerve Stimulator
- 44. Airway Management in the Adult
- Introduction
- Functional Airway Anatomy
- Airway Assessment
- Physiologic Concepts for Airway Management
- Anesthesia for Airway Management
- Mask Ventilation
- Supraglottic Airways
- Tracheal Intubation
- Emergency Front of Neck Access
- Extubation of the Trachea
- Dissemination of Critical Airway Information
- Summary
- 45. Spinal, Epidural, and Caudal Anesthesia
- Principles
- Practice
- Historical Perspectives
- Anatomy
- Anatomic Variations
- Mechanism of Action
- Physiologic Effects
- Indications
- Contraindications
- Spinal Anesthesia
- Epidural Anesthesia
- Combined Spinal-Epidural
- Caudal Anesthesia
- Complications
- Outcomes
- Recent Advances
- 46. Peripheral Nerve Blocks and Ultrasound Guidance for Regional Anesthesia
- Introduction
- Techniques for Localizing Neural Structures
- Ultrasound Guidance
- Transducer Selection, Manipulation, and Modes of Imaging
- Needle Tip Visibility
- Approaches to Regional Block With Ultrasound
- Brachial Plexus Blocks
- Trunk Blocks
- Lower Extremity Blocks
- Continuous Catheter Techniques
- Choice of Local Anesthetic
- Complications and Safety
- Training
- Summary and Conclusions
- 47. Perioperative Fluid and Electrolyte Therapy
- Physiology
- Fluid Pharmacology
- Clinical Fluid and Electrolyte Management
- 48. Perioperative Acid-Base Balance
- Introduction—Why Is Acid-Base Balance Important?
- What Are Acids and Bases?
- What Determines the Acidity or Alkalinity of a Solution?
- Acid-Base Abnormalities
- Regulation of Acid-Base Balance
- Analytic Tools Used in Acid-Base Chemistry
- Acid-Base Problems in Perioperative and Critical Care Medicine
- Metabolic Acidosis and Alkalosis
- Ketoacidosis
- Renal Acidosis
- Hyperchloremic Acidosis
- Perioperative Metabolic Alkalosis
- Summary
- 49. Patient Blood Management: Transfusion Therapy
- Evolution and Recent History of Blood Transfusion Therapy
- Blood Procurement
- Blood Component Therapy: Indications for Transfusion
- Synthetic Oxygen-Carrying Substances
- Autologous Blood
- Compatibility Testing
- Maximal Surgical Blood Order Schedule
- Emergency Transfusion
- Fresh Whole Blood
- Complications
- Citrate Intoxication and Hyperkalemia
- Temperature
- Acid-Base Abnormalities
- Transfusion Reactions
- Leukoreduction and Irradiation of Blood Transfusions
- Informed Consent
- 50. Patient Blood Management: Coagulation
- Introduction
- Normal Hemostasis
- Disorders of Hemostasis
- Antithrombotics, Thrombolytics, and Procoagulant Drugs
- Perioperative Management of Anticoagulation
- Emergent Reversal of Anticoagulants
- Conclusion
- VOLUME 2
- Section IV. Adult Subspecialty Management
- 51. Management of the Patient with Chronic Pain
- Introduction
- Drugs Used for Chronic Pain
- Interventional Methods used for Chronic Pain
- Perioperative Management of Patients with Chronic Pain
- 52. Palliative Medicine
- What Is Palliative Medicine?
- Where Is Palliative Care Delivered?
- Differences Between Hospice Care and Palliative Care
- Anesthetic Concerns in the Patient Receiving Palliative Care
- Communication
- Prognosis
- The Dying Process
- 53. Anesthesia for Thoracic Surgery
- Introduction
- Concomitant Medical Conditions
- Difficult Endobronchial Intubation
- Prediction of Desaturation During One-Lung Ventilation
- Assessment for Repeat Thoracic Surgery
- Intraoperative Monitoring
- Invasive Hemodynamic Monitoring
- Other Monitoring Technology
- Indirect Cardiac Output
- Lung Isolation
- Difficult Airways and One-Lung Ventilation
- Lung-Isolation Techniques in Patients With a Tracheostomy in Place
- Anesthetic Management
- Management of One-Lung Ventilation
- Hypoxic Pulmonary Vasoconstriction
- Ventilation Strategies During One-Lung Ventilation
- Prediction of Hypoxemia During One-Lung Ventilation
- Treatment of Hypoxemia During One-Lung Ventilation
- Anesthetic Management for Common Surgical Procedures
- Pulmonary Surgery
- Lobectomy
- Pneumonectomy
- Limited Pulmonary Resections: Segmentectomy and Wedge Resection
- Anesthetic Management for Specific Surgical Procedures
- Anesthesia for Tracheal Resection
- Blebs, Bullae, Cysts, and Pneumatoceles
- Lung Transplantation
- Pulmonary Hemorrhage
- Pulmonary Thromboendarterectomy
- Bronchopulmonary Lavage
- Mediastinal Masses
- Thymectomy for Myasthenia Gravis
- Postoperative Management
- Postoperative Analgesia
- 54. Anesthesia for Cardiac Surgical Procedures
- Cardiovascular Disease in the 21st Century
- Approach to Anesthesia for the Adult Cardiac Patient
- Cardiopulmonary Bypass
- Specific Cardiovascular Disease States
- Procedures in the Hybrid Operating Room
- 55. Anesthesia for Correction of Cardiac Arrhythmias
- Historical Perspectives
- Scope of Cardiac Arrhythmias
- Normal Cardiac Rhythm
- Cardiac Arrhythmias
- Permanent Pacing
- Resynchronization Therapy
- Implantable Cardioverter-Defibrillator
- Correction of Cardiac Arrhythmias With Ablation Therapy
- Future Trends
- 56. Anesthesia for Vascular Surgery
- Preoperative Evaluation
- Abdominal Aortic Reconstruction
- Endovascular Aortic Repair Surgery
- Hybrid Arch Repairs
- Carotid Endarterectomy
- Endovascular Treatment of Carotid Disease: Carotid Artery Stenting
- Lower Extremity Revascularization
- 57. Anesthesia for Neurologic Surgery and Neurointerventions
- Recurrent Issues in Neuroanesthesia
- Specific Procedures
- 58. Anesthesia for Bariatric Surgery
- Obesity as a Disease
- Nonsurgical Management of Obesity
- Surgical Management of Obesity
- Anesthetic Management of the Bariatric Surgical Patient
- Considerations for Management of the Obese Patient Presenting for Nonbariatric Surgery
- 59. Anesthesia and the Renal and Genitourinary Systems
- Innervation of the Genitourinary System
- Anesthesia for Patients With Renal Disease
- Renal and Genitourinary Procedures
- Urogenital Pain Syndromes and Treatment
- 60. Anesthesia for Abdominal Organ Transplantation
- Kidney Transplantation
- Pancreas Transplantation
- Liver Transplantation
- Conclusions
- 61. Anesthesia for Organ Procurement
- Introduction
- Management of Organ Donors After Declaration of Neurologic Death
- Donation After Circulatory (Cardiac) Death
- Extended Criteria Donor
- Management of Organ Donors Before Procurement
- Management of Donors After Circulatory Death
- Management of Organ Donor During Procurement Surgery
- Management of Living Organ Donors
- Organ Preservation and Management After Procurement
- 62. Anesthesia for Obstetrics
- Physiologic Changes During Pregnancy and Delivery
- Uteroplacental Physiology
- Labor Progress
- Labor Analgesia
- Anesthesia Considerations for Operative Delivery
- Anesthesia for Cesarean Delivery
- Postcesarean Pain Control and Recovery
- Complications of Regional Anesthesia
- Maternal Comorbidities
- Opioid Dependence
- Anesthesia for Malpresentation and External Cephalic Version
- Obstetric Emergencies
- Nonobstetric Surgery During Pregnancy
- 63. Anesthesia for Fetal Surgery and Other Fetal Therapies
- Indications, Procedures, and Outcomes
- Twin Reversed Arterial Perfusion Sequence
- Preoperative Assessment and Counseling
- Intraoperative Management and Considerations
- Postoperative Management and Considerations
- Management of Ex Utero Intrapartum Treatment Procedure
- Conclusions and Future Considerations
- 64. Anesthesia for Orthopedic Surgery
- Preoperative Evaluation
- Special Considerations for Conditions Leading to Orthopedic Surgery
- Orthopedic Procedures in Children with Special Conditions
- Perioperative Management of the Orthopedic Patient
- Anesthesia for Spine Surgery
- 65. Geriatric Anesthesia
- Organ-Specific Age-Related Physiologic and Pathologic Changes
- Preoperative Assessment
- Intraoperative Management Considerations for Older Adults
- Postoperative Concerns
- Outcomes
- 66. Anesthesia for Trauma
- Introduction
- Prioritizing Trauma Care
- Anesthesia in War and Austere Conditions
- Emergency Airway Management
- Resuscitation from Hemorrhagic Shock
- Trauma to the Central Nervous System
- Orthopedic and Soft Tissue Trauma
- Other Traumatic Injuries
- Selected Patient Populations
- Postoperative Care
- Summary
- 67. Prehospital Care for Medical Emergencies and Trauma
- Background
- Emergency Medical Technician and Paramedic-Based Emergency Medical Service Systems
- Primary Survey and Initial Assessment at the Scene
- Out-of-Hospital Cardiac Arrest
- Respiratory Distress
- Neurologic Injury and Head Injury
- Prehospital Trauma
- Point-of-Care Diagnostics
- Overdose/Toxicology/Environmental Exposure
- Horizons in Prehospital Care
- 68. Biological, Natural, and Human-Induced Disasters: The Role of the Anesthesiologist
- Introduction
- Section 1: Natural Disasters
- Section 2: Acts of Terrorism
- Section 3: Chemical, Biological, Radiological, and Nuclear Warfare
- Section 4: Epidemic and Pandemic Infectious Outbreaks
- 69. Anesthesia for Ophthalmic Surgery
- Overview of Ophthalmic Anesthesia
- Preoperative Evaluation
- Orbital Blocks
- Monitored Anesthesia Care
- General Anesthesia
- Anesthesia for Pediatric Ophthalmology
- Postoperative Considerations in Ophthalmic Surgery
- Ophthalmic Emergencies
- Anesthesia-Related Eye Injuries
- 70. Anesthesia for Otolaryngologic and Head-Neck Surgery
- Synopsis of Ear, Nose, and Throat Anatomy
- Preoperative Evaluation for Ear, Nose, and Throat Surgery
- Airway Management in Otolaryngology
- Airway Disorders in Otolaryngology
- Anesthesia for Panendoscopy
- Otolaryngologic Trauma
- Nasal Surgery
- Tonsillectomy and Adenoidectomy
- Endoscopic Sinus Surgery
- Thyroid and Parathyroid Surgery
- Airway Fires
- Ear Surgery
- Parotid and Other Salivary Gland Surgery
- Sleep Apnea Surgery
- Zenker Diverticulum
- Anesthesia for Surgical Airways: Cricothyrotomy and Tracheostomy
- Neck Dissection and Laryngectomy
- Maxillary, Mandibular, and Temporomandibular Joint Surgery
- Ear, Nose, and Throat Laser Surgery
- Phonosurgery
- Head and Neck Flap Reconstructive Surgery
- Stridor and Heliox
- Anesthesia for Face Transplantation
- 71. Anesthesia for Robotic Surgery
- What Is a Robot?
- Why Is the Robot Preferred?
- When Is the Robot Used?
- Future Applications of Robotic Surgery
- Physiologic Changes Associated With Patient Positioning
- Types of Robotic Surgery
- Cardiac (See Also Chapter 54 Anesthesia for Cardiac Surgical Procedures)
- Robotic-Assisted Thoracoscopic Surgery (See Also Chapter 53 Anesthesia for Thoracic Surgery)
- Summary
- 72. Ambulatory (Outpatient) Anesthesia
- Introduction
- Benefits of Ambulatory Surgery
- Facilities for Ambulatory Surgery
- Patient Selection Criteria
- Preoperative Assessment
- Patient Preparation
- Anesthetic Techniques
- Monitoring Depth of Anesthesia
- Recovery from Ambulatory Anesthesia
- Postoperative Pain
- Postoperative Nausea and Vomiting
- Special Areas
- Home Readiness and Beyond
- 73. Non-Operating Room Anesthesia
- Overview: Defining Non-Operating Room Anesthesia—What It Is and How We Got Here
- Transitional Priorities for Anesthesiologists Outside of the Operating Room
- Specific Procedure-Related Issues
- Interventional Pulmonary Procedures
- Novel Anesthetic Concerns
- Anesthesiology for Image-Guided Interventions: Evolution of a New Interface
- Diagnostic and Therapeutic Interventions: New Challenges
- Procedures Guided by Computed Tomography, Positron Emission Tomography, and Magnetic Resonance Imaging
- Image-Guided Procedures for Specialty Areas: Neuroradiology and Interventional Cardiology
- Procedures in the Neuroradiology Suite
- Interventional Neuroradiology: Acute Stroke Treatments
- Interventional Cardiology Procedures: General Considerations for the Electrophysiology and Catheterization Laboratories
- Anesthesiologists in the Electrophysiology Laboratory
- Anesthesiologists in the Catheterization Laboratory
- Interventional Echocardiography Anesthesiologists as Co-Proceduralists—The Road Ahead
- The Road Ahead: Toward a Comprehensive Strategy
- 74. Clinical Care in Extreme Environments: Physiology at High Altitude and in Space
- Introduction to Altitude and Explanation of Hypobaric Hypoxia and Its Effect on Physiologic Performance
- Physiologic Responses to Hypoxia/Acclimatization
- Altitude Illness
- Special Situations at Altitude
- Anesthesia at Altitude
- Space Medicine
- The Environmental Challenges Posed by Spaceflight
- Cardiovascular Physiology During Space Flight
- Pulmonary Physiology During Space Flight
- Musculoskeletal Physiology During Space Flight
- Central Nervous System and Psychological Challenges During Space Flight
- The Effect of Spaceflight on Other Physiologic Systems (Including the Immune and Gastric Systems)
- Potential Medical Scenarios During Manned Space Missions
- Thoughts and Considerations for Anesthetic Provision in Space
- 75. Clinical Care in Extreme Environments: High Pressure, Immersion, Drowning, Hypo- and Hyperthermia
- Introduction
- Physiology of Immersion
- Drowning
- Hypothermia
- Hyperthermia
- Effects of Increased Gas Pressure
- Hyperbaric Oxygen Therapy
- Summary
- Section V. Pediatric Anesthesia
- 76. Regional Anesthesia in Children
- Introduction
- Relevant Differences Between Children and Adults
- Indications, Contraindications, and Complications
- Selection of Materials and Anesthetic Solution
- Anatomic Identification in Regional Anesthesia
- Safety, Precautions and Discharge Criteria
- Neuraxial Blocks
- Upper Extremity Conduction Blocks
- Lower Extremity Conduction Blocks
- Truncal Blocks
- Face, Head, and Neck Nerve Blocks
- Other Procedures
- 77. Pediatric Anesthesia
- Physiologic Considerations
- Pharmacology
- Perioperative Management
- Important Pediatric Anesthesia Scenarios
- 78. Anesthesia for Pediatric Cardiac Surgery
- Unique Features of Pediatric Cardiac Anesthesia
- Anesthetic Management
- Cardiopulmonary Bypass
- Anticoagulation, Hemostasis, and Blood Conservation
- Postoperative Management
- Anesthesia for Heart and Lung Transplantation
- Anesthesia for Closed-Heart Operations
- Anesthesia for Interventional or Diagnostic Cardiac Procedures
- Adult Congenital Heart Disease
- Pediatric Cardiac Electrophysiology
- Advances in Resynchronization Therapy
- Anesthesia for Noncardiac Surgery
- Offsite Anesthesia in Cardiac Surgery Patients
- 79. Pediatric and Neonatal Critical Care
- Relationship Between the Intensive Care Unit and the Operating Room
- Family Partnered Care in the Pediatric Intensive Care Unit
- Disclosure of Medical Errors
- Organization of the Pediatric Intensive Care Unit
- Cardiovascular System
- Common Cardiovascular Disease States
- Cardiovascular Pharmacology
- Neonatal Resuscitation
- Phases of Resuscitation
- Interventions During the Cardiac Arrest (No Flow) and Cardiopulmonary Resuscitation (Low Flow)
- Post-resuscitation Myocardial Dysfunction
- Ventricular Fibrillation and Ventricular Tachycardia in Children
- Respiratory System
- Pulmonary Hypertension
- Section VI. Postoperative Care
- 80. The Postanesthesia Care Unit
- Admission to the Postanesthesia Care Unit
- The Standards for Postanesthesia Care
- Early Postoperative Physiologic Changes
- Transport to the Postanesthesia Care Unit
- Upper Airway Obstruction
- Management of Upper Airway Obstruction
- Differential Diagnosis of Arterial Hypoxemia in the Postanesthesia Care Unit
- Pulmonary Edema
- Monitoring and Treatment of Hypoxemia
- Oxygen Delivery Systems
- Hemodynamic Instability
- Myocardial Ischemia: Evaluation and Treatment
- Cardiac Arrhythmias
- Renal Dysfunction
- Postoperative Hypothermia and Shivering
- Postoperative Nausea and Vomiting
- Delirium
- Emergence Excitement
- Delayed Awakening
- Discharge Criteria
- Infection Control
- Postoperative Management of Patients Undergoing Transcatheter Aortic Valve Replacement and Transcatheter Mitral Valve Repair
- Immediate Postoperative Care of Craniotomies
- Potentially Devastating Visual Complications
- Future Considerations
- Summary
- 81. Acute Postoperative Pain
- Fundamental Considerations
- Systemic Analgesic Techniques
- Acetaminophen
- Gabapentinoids
- 82. Cognitive Dysfunction and Other Long-Term Complications of Surgery and Anesthesia
- Introduction
- Nomenclature, Diagnosis, and Measurement
- Summary
- Risk Factors, Informed Consent, and Perioperative Management
- Intraoperative Management
- Postoperative Management
- Mechanisms and Biomarkers
- Summary
- Section VII. Critical Care Medicine
- 83. Critical Care Anesthesiology
- Introduction
- Intensive Care Unit Structure and Management
- Acute Respiratory Distress Syndrome and Lung Protective Ventilation
- Sepsis and Shock
- Hemodynamic Resuscitation in Shock
- Care for Patients Receiving Cancer Immunotherapy in the Intensive Care Unit
- Point-of-Care Ultrasound in Critical Care
- Conclusion
- 84. Neurocritical Care
- Intracranial Physiology and Cerebrovascular Autoregulation
- General Cardiopulmonary Considerations
- Fluids, Electrolytes, and Nutrition
- Temperature Control
- Monitoring
- Common Diseases in the Neurocritical Care Unit
- Postoperative Neurosurgical Care
- Ethical Considerations
- Conclusion
- 85. Extracorporeal Membrane Oxygenation and Cardiac Devices
- Introduction
- History of Extracorporeal Cardiorespiratory Support
- ECMO for Respiratory Failure (VV ECMO)
- Extracorporeal Membrane Oxygenation for Patients Awaiting and Undergoing Lung Transplantation
- ECMO for Circulatory Failure (VA ECMO)
- The Ethics of Extracorporeal Membrane Oxygenation
- The Mechanics of Extracorporeal Membrane Oxygenation
- Vascular Access for Extracorporeal Membrane Oxygenation
- Monitoring on Extracorporeal Membrane Oxygenation
- Anticoagulation
- Therapeutic Monitoring of Unfractionated Heparin (Table 85.4)
- Weaning from Extracorporeal Membrane Oxygenation
- Complications of Extracorporeal Membrane Oxygenation
- The Anesthesiologist’s Role in Extracorporeal Membrane Oxygenation
- 86. Cardiopulmonary Resuscitation and Advanced Cardiac Life Support
- Sudden Cardiac Arrest and Cardiopulmonary Resuscitation
- Recognition and Management of Specific Arrythmias
- Postresuscitation Interventions
- Pediatric Resuscitation
- Future of Resuscitation Science and Care
- Section VIII. Ancillary Responsibilities and Problems
- 87. Acute and Anesthetic Care of the Burn-Injured Patient
- Introduction
- Pathophysiology
- Hemodynamic Alterations
- Inhalation Injury
- Acute Management
- Estimation of Size and Depth of Burn Injury
- Fluid Resuscitation
- Electrical Injury
- Chemical Burns
- Cold Injury
- Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
- Special Considerations
- Infection Control
- Metabolic Considerations
- Nutrition
- Anesthetic Management
- Intraoperative Management
- Postoperative Care
- Pain Management
- Conclusion
- 88. Occupational Safety, Infection Control, and Substance Abuse
- Physical Exposures
- Infectious Exposures
- Substance Use Disorders
- Fatigue
- 89. Clinical Research
- Introduction
- Key Principles
- Study Design
- Study Protocol
- Ethical and Regulatory Considerations
- Study Management
- Study Reporting
- Reflection, Feedback, and Forward Planning
- 90. Interpreting the Medical Literature
- Introduction
- The Publication Process
- Accessing the Medical Literature
- Assessing the Methodology of a Study
- Tools to Ensure Study Quality
- Interpreting the Analysis of a Study
- The Dark Side of the Medical Literature
- Conclusions
- Index
- Edition: 9
- Published: May 2, 2019
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780323612630
- Hardback ISBN: 9780323596046
MG
Michael A. Gropper
LE
Lars I. Eriksson
LF
Lee A. Fleisher
JW
Jeanine P. Wiener-Kronish
NC
Neal H. Cohen
KL