Migraine Biology, Diagnosis, and Co-Morbidities

1st Edition, Volume 198 - November 30, 2023
Editors: Jerry W. Swanson, Manjit Matharu
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 3 5 6 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 4 8 0 - 8

Migraine Biology, Diagnosis, and Co-Morbidities, Volume 198 covers a wide range of issues related to migraine. The epidemiology, global, and personal impacts of migraine are cover… Read more

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Migraine Biology, Diagnosis, and Co-Morbidities, Volume 198 covers a wide range of issues related to migraine. The epidemiology, global, and personal impacts of migraine are covered, including topics on the pathophysiology of migraine and migraine aura, the pathophysiology of the associated symptoms of photophobia and phonophobia, and the genetics of migraine. The classification and diagnostic criteria of common and uncommon subtypes of migraine are also explored in detail, including childhood variants. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also covered.

Finally, the important comorbidities of migraine such as anxiety, depression and other forms of chronic pain are discussed, along with the current state and future directions of migraine research and management.

Cover image
Title page
Table of Contents
Series Page
Copyright
Handbook of Clinical Neurology 3rd Series
Foreword
Preface
Contributors
Section I: Migraine: The human and societal impact
Chapter 1 History of migraine
Abstract
Introduction
Headache in Babylon
Ancient Egypt
Greco-Roman Period
Late Antiquity and Islamic Medicine
Medieval Period
16th and 17th Centuries
18th Century
19th Century
20th Century
Conclusion
References
Chapter 2 Societal and personal impact of migraine
Abstract
Background and Introduction
Personal Impact of Migraine, the Invisible Illness
Societal Impact of Migraine
References
Further reading
Chapter 3 Epidemiology of migraine
Abstract
Global Estimates of Prevalence and Incidence
Geographical, Racial, and Ethnic Variation in Prevalence
Frequency of Migraine Days
Age and Sex
Socioeconomic Status
Educational Attainment
Medical Comorbidity and Genetics
Migraine in Adolescence and Childhood
Conclusion
References
Section II: Biology of migraine
Chapter 4 The anatomy of head pain
Abstract
Introduction
Pain-Sensitive Structures
Central Trigeminal Pathways
Conclusion
References
Chapter 5 Migraine headache pathophysiology
Abstract
Introduction
The Trigeminal System and Ascending Pathways
Descending Control of Trigeminal Central Processing
Pharmacology of the Trigeminal System
Peripheral and Central Sensitization
From the Premonitory Phase to Migraine Headache—Unanswered Questions
References
Chapter 6 Pathophysiology of migraine aura
Abstract
Introduction
References
Chapter 7 Genetics of migraine: Delineation of contemporary understanding of the genetic underpinning of migraine
Abstract
Introduction
Genetic Epidemiology of Migraine
Approaches to Discover Migraine Genes
Genetic Studies in Common Types of Migraine
Shared Genetic Architecture for Migraine With Aura and Migraine Without Aura
The Missing Heritability of Common Migraine
Shared Genetic Architecture of Migraine With Other Brain Disorders
Investigating Monogenic Migraine Syndromes
Monogenic Disorders in Which Migraine Plays a Prominent Part in the Clinical Phenotype
Other Genes Implicated in Migraine Syndromes
Scientific Insights From Genetic Studies in Monogenic Migraine Syndromes
Clinical Perspective: Relevance of Genetic Findings in Clinical Practice
Future Perspectives
References
Chapter 8 What imaging has revealed about migraine and chronic migraine
Abstract
Introduction
Imaging the Migraine Cycle
Imaging the Chronic Migraine Brain
Understanding Migraine Treatments Mechanisms of Action Using Imaging Techniques
Conclusions
References
Chapter 9 What has neurophysiology revealed about migraine and chronic migraine?
Abstract
Introduction
Cortical Hyperresponsivity
Abnormal Processing of Painful Information
Abnormal Cognitive Elaboration of Sensory Information (ERP)
Abnormal Cortical Plasticity
Migraine Chronification
Genetic Vulnerability
Conclusions
References
Chapter 10 Migraine prodromes and migraine triggers
Abstract
Introduction
Clinical Characteristics
Interrelationship of Migraine Triggers and Migraine Prodrome: Pathophysiology
Conclusion
References
Section III: Migraine diagnosis
Chapter 11 Migraine without aura
Abstract
Introduction
Diagnosis
Migraine Phases
Migraine Symptomatology
Triggers
Pediatric Migraine Without Aura
Conclusion
References
Chapter 12 Migraine with aura
Abstract
Introduction
Historical Remarks
Epidemiology
Clinical Features of the Migraine Auras
Other Aura-Like Manifestations in Migraine
Aura in Other Headache Disorders
Complications of Migraine Aura
Differential Diagnosis
Treatment Aspects
References
Chapter 13 Chronic migraine and medication overuse
Abstract
Chronic Migraine
History/Nomenclature
Epidemiology of Chronic Migraine
Pathogenesis
Medication Overuse Headache
Management
References
Section IV: Episodic syndromes that may be associated with migraine
Chapter 14 Infantile colic
Abstract
Introduction
Review
Conclusions
Disclosures
References
Chapter 15 Abdominal migraine and cyclical vomiting syndrome
Abstract
Introduction
Abdominal Migraine
Cyclical Vomiting Syndrome
Conclusion
References
Chapter 16 Alternating hemiplegia of childhood
Abstract
Introduction
Epidemiology
Pathophysiology
Clinical Presentation
Diagnosis
Treatment
Conclusion
References
Chapter 17 Benign paroxysmal vertigo of childhood
Abstract
Introduction
Embryology and Physiology of the Vestibular System
Epidemiology of BPVC
Proposed Pathophysiology
Relationship to Migraine
Clinical Presentation/Diagnostic Criteria—ICHD (2013)
History
Physical Examination
Testing
Differential Diagnosis
Treatment
Follow-Up
Key Points
References
Chapter 18 Benign paroxysmal torticollis
Abstract
Introduction
Clinical Characteristics
Epidemiology
Pathophysiology
Morbidity
Management
Association With Migraine
Conclusions
References
Index

Jerry W. Swanson

Jerry W. Swanson, MD, is a consultant in the Department of Neurology and Professor of Neurology in the Mayo Clinic College of Medicine and Science. Dr. Swanson received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago. He completed a neurology residency at Mayo Clinic. He earned the Master of Health Professions degree at the University of Illinois at Chicago. He has been on the staff of Mayo Clinic in Rochester, Minn., since 1982. He is former chair of the Headache Division in the Department of Neurology and founding director of the headache medicine fellowship at Mayo Clinic in Minnesota. Dr. Swanson is board-certified in Neurology and in the subspecialty of Headache Medicine. He has written extensively about headache and other neurologic disorders. Swanson has made more than 100 presentations at national and international meetings, published more than 60 peer-reviewed articles, and numerous book chapters; he is an associate editor for the journal Headache and is a neurology editor for MayoClinic.com, a leading site for health information for the public. He has co-edited two books including The Mayo Clinic on Headache, a highly praised book for the lay public. He is a neurology editor for MayoClinic.com and is the headache topic editor and neurology editor-in-chief for UpToDate. He was a founding member for the UCNS Headache Medicine examination committee and is currently serving another term on the committee. He was the founding director of the Headache Medicine fellowship at Mayo Clinic in Rochester, Minn. Dr. Swanson has served in several leadership roles in the American Academy of Neurology and the American Headache Society and was a member of the International Headache Congress scientific program committee. He has been the recipient of the Mayo Medical School Dean’s Recognition Award.

Affiliations and expertise

Mayo Clinic College of Medicine and Science, Rochester, MN, United States

Manjit Matharu

Dr. Manjit Matharu is a Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London. He received a BSc (First Class Honours) University of Manchester and MB, ChB (Honours Degree) University of Manchester. He earned a PhD at the University of London. He completed his residency in Neurology at The National Hospital for Neurology and Neurosurgery, The Royal London Hospital and Homerton Hospital in London in 2007. Dr Matharu’s major research interests include functional and structural imaging in Primary headaches, trigeminal autonomic cephalalgias and neurostimulation for intractable headaches. He has authored over 100 scientific papers. Dr. Matharu is the clinical and academic lead of the Headache Group at The National Hospital for Neurology and Neurosurgery, which is widely recognized as one of the foremost Headache Centers worldwide. He has lectured on headache topics both domestically and internationally.

Affiliations and expertise

Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom