Section IV Metabolic Fate of Oxygenated Compounds
Rate-Limiting Factors in Xenobiotic Metabolism by Cytochome P-450, Sulphotransferase, and Glucuronyl Transferase
Epoxide Hydratase
Kinetic Studies on Mechanism and Substrate Specificity of the Microsomal Flavin-Containing Monooxygenase
Epoxide Hydratase and its Membrane Environment
Interindividual Variations of Epoxide Hydratase Activity in Human Liver and Lung Biopsies, Lymphocytes and Fibroblast Cultures
Extramicrosomal Epoxide Hydration
Metabolism of Benzo(a)pyrene by Liposomes containing Purified Microsomal Drug-Metabolizing Enzymes
Comparison of Glutathione S-Transferases from Rat Tissues with the Activity in Human Placenta
Formation, Metabolism, and Excretion of Conjugates of Paracetamol
Subcellular Localization of Glutathione S-Transferase Activity in Rat Liver
Biliary Metabolites of Benzo(a)pyrene 4,5-Oxide in the Rat
Hepatic and Extrahepatic Glutathione S-Transferase Activities in Vitamin A Deficiency
Pulmonary Metabolism and Excretion of Arene Oxides
Metabolism of Arylamines: Evidence for Common Genetic Control of Arylhydroxamic Acid Acyltransferase (AHAT) and Genetically Polymorphic N-Acetyltransferase (NAT) of Rabbit Liver
Partial Purification of Glutathione (GSH)-S-Aryl- and Epodixe Transferase(s) of Trypanosoma Cruzi
Purification and Properties of UDP-Glucuronyltransferase from Rabbit Liver Microsomes
Section V Microsomal Enzymes and Lipid Metabolism
Cholesterol 7α-Hydroxylase in Rat Liver Microsomes—Characteristics, Solubilization, Resolution, and Substrate Specificity
Laurate Hydroxylation and Drug Metabolism in Pig Liver and Kidney Microsomes and in Reconstituted Systems from Pig Liver and Kidney
Product Specificity and Regulation of Two Laurate Hydroxylases in Higher Plants
Effect of Phenobarbital on Triglyceride Metabolism in the Rat
ω- and (ω-1)-Hydroxylation of Fatty Acids in Rabbit Intestinal Mucosa Microsomes
The Role of Cytochrome b5 in the Liver Microsomal Elongation of Fatty Acids
Evidence for Different Hepatic Monooxygenases in (ω-1)- and ω-Hydroxylation of Prostaglandins
Effect of Inducing Agents and Cytochrome P-450 Inhibitors on Laurate Hydroxylase Activities in Rat Liver Microsomes
Steroid Hydroxylases in Liver Microsomes and Mitochondria
C-21 and 6α-Hydroxylation of Progesterone by Solubilized Rabbit Hepatic Microsomal Fractions: Nonobligatory Requirement for Cytochrome P-450
Microsomal Lipid Peroxidation: Catalysis, Effects, and Inhibition by Cytosolic Protein
Cytochrome P-450-Containing Monooxygenase System of Yeast Microsomes, Properties and Role in Sterol Biosynthesis
Studies on Liver and Kidney Drug and Lauric Acid Monooxygenases in Both Microsomal and Reconstituted Systems
Lipid Peroxidation induced by Glutathione Depletion
Metabolism of Juvenile Hormone (JH) Mimics by a Reconstituted Rat Liver Cytochrome P-450 Preparation
Section VI Microsomal Enzymes and Toxicity of Foreign Compounds
An overview of the Role of Microsomal Enzymes in the Formation of Toxic Metabolites
Microsomal Enzymes and the Toxicity of Thiono-Sulphur Compounds
The Ah Locus, Genetic Differences in Toxic and Tumorigenic Response to Foreign Compounds
Comparison of Caffeine Metabolism by Perfused Rat Liver and Isolated Microsomes
Rhythmic Response of the Hepatic 2- and 4-Biphenyl Hydroxylase in Rats to Drugs Upon Intermittent Treatment
Functional Changes of Hepatic Endoplasmic Reticulum by Adverse Drug Treatment
A Procedure for Isolation of Rabbit Pulmonary Epithelial Cells for Study of Foreign Compound Metabolism
The Formation of Amphetamine Metabolic Intermediate Complexes with CytoChrome P-450 in Microsomes and Intact Tissues
Comparative Aspects of Hepatic Monooxygenase Induction in Rat and Rainbow Trout by Several PCB Isomers
Genetic and Environmental Influences on Tolbutamide Metabolism
Ethchlorvynol: Potential of Metabolites for Adverse Effects in Man
Irreversible Binding of 6-Thiopurine to Rat Hepatic Microsomal Proteins In Vitro and In Vivo
Activation of a Proestrogen—Methoxychlor (DDT Analog)—by Hepatic Monooxygenase
Effects of Some Flame Retardants on the Liver Microsomal Enzyme Systems
The Development of Hepatic Mixed-Function Oxidases—Warfarin Metabolism as a Probe
Loss and Recovery of Hepatic Monooxygenase Activities After the Administration of Allylisopropylacetamide (AIA) to Mice
Metabolism of Fluroxene and Analogous Fluorinated Ether Anesthetics by Highly Purified Cytochromes P-450 and the Associated Enzyme Destruction
Evaluation of 4-Formylaminoantipyrine and other N-Demethylated Products of Aminopyrine in Hepatic Microsomes by HPLC
The Effect of Selenium and Vitamin E Deficiency on the Toxicity of Nitrofurantoin in the Chick
The Reductive Metabolism of Carbon Tetrachloride in Reconstituted Monooxygenase Systems
Oxidative Bioactivation of Haloforms into Hepatotoxins
Effects of Isoniazid Metabolites on the Rate of Hepatic Microsomal Defluorination of Volatile Fluorinated Ether Anesthetics
Effects of Indole Derivatives on Monooxygenase Activity in Rabbit Liver Microsomes
Coincident Induction of Cytochrome P-450 and Phenol Red Conjugation in Cultured Chick Embryo Hepatocytes: Effects of Cobaltous and Manganous Ions
Benzene Metabolism and Toxicity in CD-1, C57/B6, and DBA/2N Mice
Hepatotoxicity Due to Tetrachlorodibenzo(p)dioxin Depends Upon AHH Responsiveness and Nonhemoprotein Iron
The Mechanism of Cytochrome P-450-Mediated Cytotoxicity Studied with Isolated Hepatocytes Exposed to Bromobenzene
The Influence of the Nutritional State of Rates of p-Nitroanisole O-Demethylation and p-Nitrophenol Conjugation in Perfused Rat Livers
Acute Decline of Hepatic Microsomal Monooxygenase Activity and Other Properties by Morphine Sulfate
Substituent Effects on Toxicity and Covalent Binding of Bromobenzene Derivatives
Hepatic Microsomal Epoxidation of Bromobenzene to Phenols and its Toxicological Implication
Toxicity of 2-Chlorobenzylidene Malononitrile and Hepatic Microsomal Mixed Function Oxidase System
Alteration of Microsomal Monooxygenase Activities by Cobalt Pretreatment of Mice
Characteristics of the Microsomal and Mitochondrial Deamination of Benzylamine
Oxidation of N-Hydroxy-Amphetamine and -Phentermine by Active Oxygen
N-Methylcarbazole Metabolism: A Probe for Characterizing the Multiple Forms of Cytochrome P-450
Increased Activity of the Pentose Pathway after Administration of trans-Stilbene Oxide
Interactions Between Energy Metabolism and Mixed-Function Oxidation in Perfused Rat Liver
Evidence for More Than One Form of Cytochrome P-450 in Hepatic Microsomal Fractions of Human Liver Samples
The In Vitro Metabolism of 3-Acetylpyridine, 3-Acetylpyridine-N-Oxide, and 1-(-3-Pyridyl)-Ethanol
Studies on Sex Differences in the O-Dealkylation Activities of 7-Hydroxycoumarin O-Alkyl Derivatives in Liver Microsomes of Rats
Augmentation by Hematin of Rates of Benzo(a)pyrene Hydroxylation: the Possible involvement of Cytochrome P-450
Multiplicity of NADPH- and NADH-Supported N- and O-Dealkylating Systems of Hepatic Microsomes
4-Chlorobiphenyl Hydroxylase: a Monooxygenase Preferentially Induced by 3-Methlcholanthrene
NADH- and NADPH-Dependent Reduction of Indicine N-Oxide by Microsomal Cytochrome P-450
Metabolism and Irreversible Binding of Phencyclidine by Rabbit Lung and Liver Microsomes
Cleavage of Vicinal Diols by Liver Microsomes
Characterization of the Form of P-450 Induced by Methylenedioxy Compounds in Rats and Mice
Interaction of the Enzyme Inducer, HOE 17,879, with Microsomal Enzyme Systems
Relation Between In Vitro Alteration by Allyl Compounds and Forms of Cytochrome P-450
The Rapid Activation of P-450-Mediated Metabolism by Corticosteroids
Metabolism In Vitro of Capsaicin, a Pungent Principle of Red Pepper, with Rat Liver Homogenates
Section VII Microsomal Enzymes and Chemical Mutagenesis and Carcinogenesis
Metabolism of Benzo(a)pyrene and Oncogenic Transformation of C3H/10T1/2 Mouse Embryo Fibroblasts
An Overview of the Salmonella Mutagenicity Test
Bay-Region Activation of Polycyclic Aromatic Hydrocarbons to Ultimate Mutagens and Carcinogens
Biotransformation of Benzo(a)pyrene to DNA-Binding Products by Isolated Hepatocytes
Catalytic Activity and Stereospecificity of Phenobarbital-Inducible and 5,6,-Benzoflavone-Inducible Isozymes of Liver Microsomal Cytochrome P-450 in the Oxygenation of Benzo(a)pyrene and trans-7,8-Dihydroxy-7,8-Dihydrobenzo(a)pyrene
Metabolism of Nitrosamines: an Overview
Species Differences in Microsomal Activation of Mutagens and Carcinogens, with Special Reference to New Potent Mutagens from Pyrolysates of Amino Acids and Proteins
Microsomes and Drug Oxidations: Perspectives and Challenges
Catalytic Properties of Microsomal and Purified Epoxide Hydrolase Toward K-Region Arene Oxides
Drug-Metabolizing Systems in the Liver of the Northern Pike, Esox Lucius
Dietary Protein and Mixed Function Oxidase Activity
The Metabolism of 1,2-Disubstituted Hydrazines in Isolated Hepatocytes
Mutagenicity and Metabolism of Cyclopenta(cd)pyrene
Some Characteristics of the Drug-Metabolizing Enzymes in Isolated Hepatic Nuclei
Microsomal Metabolism of Diallylnitrosamine
Mutants of Cultured Hepatoma Cells Deficient in Aryl Hydrocarbon Hydroxylase
Qualitative and Quantitative Studies of DNA-Binding Metabolites of Benzo(a)pyrene by Fluorescence Spectroscopy
Use of the Ames Assay for Studying Factors Affecting the Activation of 2-Aminoanthracene to Mutagenic Metabolites
Cytochrome P-450 Form 4, a Major Determinant of 2-Aminoanthracene Mutagenesis
Rat Hepatocytes of in Primary Monolayer Culture: a Tool for Investigating the Regulation of Carcinogen Metabolism
The Metabolism of 3- and 9-Hydroxybenzo(a)pyrene by Rat Liver Microsomal Fractions
Effect of Chronic Ethanol Consumption on Microsomal Enzymes: Potential Relationship to Chemical Mutagenesis and Carcinogenesis
Characterization of the Cytochrome P-450-Containing Mixed Function Oxidase System of Rat Colon
Induction of N- and C-Hydroxylations of 2-Acetylaminofluorene in Rat Hyperplastic Liver Nodules and Hepatomas
Multiple Activation Pathways of 7,12-Dimethylbenz(a)anthracene
Influence of Modifiers of MFO Activity on the In Vitro Metabolism of Cyclic Nitrosamines
Autocatalyzed Covalent Binding of 3H(-)t-7,8-Diol Benzo(a)pyrene to Mixed-Function Oxidase Enzymes and DNA: the Role of Epoxide Hydratase
Regulation of DNA Modification by Selective Conjugation of Benzo(a)pyrene Metabolites
Metabolism of Benzo(a)pyrene in Little Skate Mixed-Function Oxidase Systems
Inducibility of the Metabolism of Benzo(a)pyrene by Polychlorinated Biphenyls (PCBs) in Liver and Lung Microsomal Preparations from Rats and Rabbits
Covalent Binding of Vinyl Chloride Metabolites In Vitro: Roles of Cytochrome P-450, NADPH-Cytochrome P-450 Reductase, Epoxide Hydratase, and Alcohol Dehydrogenase
Evidence for Inhibitory Complexed Formed with Cytochrome P-450 and a Metabolite of 1,1-Disubstituted Hydrazines
Ovarian Aryl Hydrocarbon Hydroxylase Activity and Oocyte Destruction
Binding of Reactive Metabolites of Aromatic Hydrocarbons to Specific Microsomal Proteins
Secondary Oxygenation of the Carcinogen 2-AcetylaminoFluorene (= 2-AAF) In Vitro and In Vivo
Metabolism of 7,12-Dimethylbenz(a)anthracene in Rat Adrenals
The Influence of Organic Solvents on Cytochrome P-450-Mediated Metabolism of Biphenyl and Benzo(a)pyrene
Effects of Estrone, Estradiol, and Estriol Pretreatment on Hepatic, Lung, and Intestinal Aryl Hydrocarbon Hydroxylase Activities in Female Rats
Formation of Benzo(a)pyrene Metabolites in Isolated Intestinal Sacs
Index for Volumes I and II