MicroRNA in Human Infectious Diseases
- 1st Edition - January 23, 2024
- Editors: Vijay Kumar Prajapati, Rupal Ojha
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 6 6 1 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 6 6 2 - 4
MicroRNA in Human Infectious Diseases offers an overview of the therapeutic and diagnostic role microRNAs can play in treating infectious diseases. Beginning with an introduct… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteMicroRNA in Human Infectious Diseases offers an overview of the therapeutic and diagnostic role microRNAs can play in treating infectious diseases. Beginning with an introduction on microRNAs and their mechanisms, the book then delves into the therapeutic role of microRNAs in various categories of diseases, including bacterial, viral, and parasitic. A wide range of diseases are explored, including STDs, typhoid, tuberculosis, Dengue fever, Ebola, Covid-19, Malaria, Leishmaniasis, and Lymphatic filariasis. The final section of the book covers microRNA-based system approaches, considering aspects such as web-based tools available for detecting and predicting microRNA targets and the latest technologies for modifying and manipulating microRNAs.
This volume explores microRNA across a multitude of conditions and is an ideal reference for those involved in the investigation and development of treatments in this area.
- Includes foundational knowledge on microRNAs and the fundamental aspects of its biogenesis
- Explores the potential role microRNAs can play in therapeutics and diagnostics to treat various infectious diseases, including sexually-transmitted diseases, bacterial diseases, viral infections, and parasitic diseases
- Features a chapter dedicated to the role of microRNA for therapeutics in respiratory viral infections, such as Covid-19
- Considers technologies used for manipulating and modifying microRNAs in preparation for applications to treat infectious diseases
Researchers in molecular biology, biochemistry, molecular medicine, immunology, pharmacology and related fields, Graduate and PhD students studying RNA therapeutics and those in related fields
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Section 1: Introduction of MiRNAs
- Chapter 1. Paradigms in miRNA biogenesis pathways
- Abstract
- 1.1 Introduction
- 1.2 miRNA biogenesis
- 1.3 RNA-derived miRNAs
- 1.4 tRNA-derived miRNAs
- 1.5 tRNase Z-dependent pathway
- 1.6 Short-hairpin RNAs (endo-shRNAs)-derived miRNAs
- 1.7 Functions of miRNA biogenesis
- 1.8 Pathological effects of dysregulation in miRNA biogenesis
- 1.9 Future direction
- 1.10 Conclusion
- References
- Chapter 2. Diverse roles of miRNAs in breast cancer and gynecologic cancers
- Abstract
- 2.1 Introduction
- 2.2 Classification of miRNA and databases
- 2.3 miRNA biogenesis
- 2.4 Breast cancer and its diagnostic stages
- 2.5 Cervical cancer and its subtypes
- 2.6 Ovarian cancer
- 2.7 Uterine cancer (endometrial cancer)
- 2.8 Common miRNA in breast cancer and gynecologic cancers
- 2.9 Therapeutic and diagnostic significance of miRNA in breast cancer and gynecologic cancers
- References
- Section 2: MiRNAs in human bacterial infections
- Chapter 3. Role of miRNA in bacterial respiratory infection diagnosis and therapeutics
- Abstract
- 3.1 Introduction
- 3.2 What is miRNA?
- 3.3 Inhibition of protein synthesis by miRNA
- 3.4 Types of miRNA in bacterial respiratory infections
- 3.5 Role of miRNA in immune system regulation
- 3.6 Role of various miRNAs in different diseases
- 3.7 Current miRNA-based therapeutics
- 3.8 Conclusion and future perspective
- References
- Section 3: MiRNAs in human viral infections
- Chapter 4. MicroRNAs in arboviral disease diagnosis and therapeutics
- Abstract
- 4.1 Introduction to arboviral diseases
- 4.2 Diagnosis of arboviral diseases
- 4.3 Prognosis tools for arboviral diseases
- 4.4 Therapeutics for arboviral diseases
- 4.5 MicroRNAs
- 4.6 MicroRNA in host responses to arboviral infections
- 4.7 MicroRNA in disease diagnosis and prognosis of arboviral infections
- 4.8 MicroRNA in therapeutic interventions for arboviral diseases
- References
- Chapter 5. MicroRNAs and dengue viral disease
- Abstract
- 5.1 Introduction
- 5.2 Dengue virus and dengue viral diseases
- 5.3 Role of miRNAs in biological processes
- 5.4 Role of miRNAs in dengue viral disease
- 5.5 Conclusion and future direction
- References
- Chapter 6. Role of miRNA in Ebola diagnosis and therapeutics
- Abstract
- Abbreviations
- 6.1 Introduction
- 6.2 Ebola virus: structure, life cycle, epidemiology
- 6.3 Disease symptoms and severity
- 6.4 Role of miRNAs in Ebola virus infection
- 6.5 Ebola virus diagnosis
- 6.6 Therapeutics of Ebola viruses
- 6.7 Conclusion
- References
- Chapter 7. Influence of microRNAs on clinical alliance of COVID-19 and diabetes
- Abstract
- 7.1 Introduction
- 7.2 Emergence of COVID-19 disease
- 7.3 Diabetes and clinical vulnerability to COVID-19
- 7.4 MiRNAs as genetic regulators and potential biomarkers
- 7.5 Influence of miRNAs on SARS-CoV2 gene expression
- 7.6 Regulatory interactions of miRNAs in diabetes
- 7.7 Concluding remarks and future perspectives
- References
- Chapter 8. Role of microRNAs in oncogenic viral infection diagnosis and therapeutics
- Abstract
- 8.1 Introduction
- 8.2 Viral miRNA origin and biogenesis
- 8.3 Regulation of tumor suppressor genes and oncogenes
- 8.4 Viruses in oncogenic transformation
- 8.5 Oncogenic viruses
- 8.6 Diagnostic and therapeutic approaches
- 8.7 Conclusions and future perspectives
- Acknowledgment
- References
- Chapter 9. Role of miRNA in monkeypox viral diagnosis and therapeutic developments
- Abstract
- 9.1 Introduction to monkeypox virus infection
- 9.2 Challenges and opportunities of miRNA as a therapeutic regimen
- 9.3 Use of RNAi against viral infections
- 9.4 Role of miRNA in intracellular defense
- 9.5 Vaccinia viral miRNA with therapeutic potential to combat poxvirus infections: an emerging theory
- 9.6 List of human miRNAs matching with monkeypox-miRNA
- 9.7 Human and camel miRNAs homologous to poxvirus
- 9.8 List of miRNAs with experimental evidence in monkeypox infection
- 9.9 Tools to identify and analyze miRNAs and possibility of using them as biomarkers to diagnose MPV infection
- 9.10 Importance of reference genes to investigate expressions of miRNAs
- 9.11 Future perspectives: identification and future of miRNA-based therapies to target MPV infection
- 9.12 Conclusion
- Acknowledgments
- Author contributions
- Competing interests
- References
- Section 4: MiRNAs in human parasitic infections
- Chapter 10. MiRNA in malaria diagnosis and therapeutics
- Abstract
- 10.1 Introduction
- 10.2 Recent trends in miRNA-based malaria research
- 10.3 Different miRNAs and their role in Plasmodium falciparum infection
- 10.4 Role of miRNA in diagnostic studies and as a biomarker
- 10.5 miRNA-based therapeutics
- 10.6 Conclusion and future prospects
- References
- Chapter 11. MicroRNAs-mediated regulation of immune responses in parasitic infection
- Abstract
- 11.1 Introduction
- 11.2 Functions of miRNA
- 11.3 Leishmaniasis: a neglected disease
- 11.4 Regulatory function of miRNA in Leishmania-infected antigen-presenting cells
- 11.5 Role of miRNA in T-cell responses in leishmaniasis
- 11.6 Manipulation of miRNA-mediated responses to improve antiparasitic activity
- 11.7 Future perspectives and concluding remarks
- References
- Chapter 12. Therapeutic potential of miRNAs in parasitic infectious diseases
- Abstract
- 12.1 Introduction
- 12.2 Strategies employed for miRNA therapeutics
- 12.3 AntimiR oligonucleotides/antisense oligonucleotides
- 12.4 Identification and validation of dysregulated miRNAs in parasitic infectious diseases
- 12.5 Delivery vehicles for miRNA modulators
- 12.6 Challenges in miRNA-based therapeutics in parasitic diseases
- 12.7 Future perspectives
- References
- Chapter 13. Extracellular vesicle-associated microRNA in human parasitic diseases
- Abstract
- 13.1 Introduction
- 13.2 MiRNA and host immune response
- 13.3 Most common parasitic diseases
- 13.4 Summary
- Reference
- Index
- No. of pages: 344
- Language: English
- Edition: 1
- Published: January 23, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780323996617
- eBook ISBN: 9780323996624
VP
Vijay Kumar Prajapati
Dr. Vijay Kumar Prajapati is working as an Associate Professor at Department of Biochemistry, University of Delhi South Campus, New Delhi, India. He has extensive experience on Immunotherapy, antibody engineering and vaccine development for infectious diseases. He has published approx. 100 research articles in the international journal with >10 book chapters with reputed publishers. He is a recipient of prestigious INSA Medal for Young Scientist from Indian National Science Academy (INSA) and Associate from Indian Academy of Sciences, Benguluru. He has published research work in the prestigious journal such as Journal of Infectious Diseases, Clinical Infectious Diseases, Scientific Reports, Medicinal Research Review, Journal of Cellular Physiology etc. His current h-index is 41 with 5243 citations. .
Affiliations and expertise
Assistant Professor, Department of Biochemistry, School of Life Sciences, Central University of Rajasthan, Kishangarh, Ajmer, Rajasthan, IndiaRO
Rupal Ojha
Rupal Ojha’s research has highlighted the emerging role of circulating microRNA's in the diagnosing human infectious diseases. Rupal has presented her research work at the international platform on the invitation of host institutions. She has published her research work in international journals such as the International Journal of Biological Macromolecules, ACS Omega, European Journal of Pharmaceutical Sciences, and Journal of Cellular Physiology, and 3 book chapters with reputed publishers.
Affiliations and expertise
Department of Biochemistry, School of Life Sciences, Central University of Rajasthan, Ajmer, Rajasthan, India.Read MicroRNA in Human Infectious Diseases on ScienceDirect