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Microfluidics for Cellular Applications
- 1st Edition - April 13, 2023
- Editors: Gerardo Perozziello, Ulrich Kruhne, Paola Luciani
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 4 8 2 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 4 9 7 - 7
Microfluidics for Cellular Applications describes microfluidic devices for cell screening from a physical, technological and applications point-of-view, presenting a compar… Read more
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Request a sales quoteMicrofluidics for Cellular Applications describes microfluidic devices for cell screening from a physical, technological and applications point-of-view, presenting a comparison with the cell microenvironment and conventional instruments used in medicine. Microfluidic technologies, protocols, devices for cell screening and treatment have reached an advanced state but are mainly used in research. Sections break them down into practical applications and conventional medical procedures and offers insights and analysis on how higher resolutions and fast operations can be reached. This is an important resource for those from an engineering and technology background who want to understand more and gain additional insights on cell screening processes.
- Outlines the major applications of microfluidic devices in medicine and biotechnology
- Assesses the major challenges of using microfluidic devices in terms of complexity of the control set-up, ease of use, integration capability, automation level, analysis throughput, content and costs
- Describes the major fabrication techniques for assembling effective microfluidic devices for bioapplications
Materials scientists, engineers
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Introduction
- Abstract
- Chapter 2. The cell: cell microenvironment and cell handling
- Abstract
- 2.1 What is a cell?
- 2.2 Different cell types
- 2.3 Biomarkers
- 2.4 Cell culture basics
- 2.5 Typical workflow for subculturing adherent cells
- 2.6 Usage of biomarkers in cell culture
- 2.7 Cellular staining
- 2.8 Instruments to analyze/process stained cells
- References
- Chapter 3. Microfluidic devices and their applicability to cell studies
- Abstract
- 3.1 Introduction
- 3.2 Examples of microfluidic platforms applied to different cell applications
- 3.3 Conclusion
- References
- Chapter 4. Materials
- Abstract
- 4.1 Overview
- 4.2 Material classification for microfluidic platforms
- 4.3 Biocompatibility
- 4.4 Requirements in relation to the cell–surface interface
- 4.5 Material requirements in relation to (optical, electrochemical) sensor interface
- 4.6 Fluidic compatibility (liquids and gases)
- 4.7 Conclusion
- References
- Chapter 5. Surface properties and treatments
- Abstract
- 5.1 Surface properties
- 5.2 Surface modification
- 5.3 Biological surface functionalization
- 5.4 Surface topographical modifications
- 5.5 Combined plasma and silanization method to immobilize biomolecules on microfluidic surfaces
- 5.6 Conclusion
- References
- Chapter 6. Fabrication technologies
- Abstract
- 6.1 Standard lithographic process
- 6.2 Resists
- 6.3 Optical lithography
- 6.4 Electron beam lithography
- 6.5 Etching processes
- 6.6 Cost-effective fabrication technologies
- 6.7 Fabrication of microfluidic devices
- References
- Chapter 7. Handling and control setups for microfluidic devices
- Abstract
- 7.1 Generalities on control systems
- 7.2 Design and implementation of control systems
- 7.3 Feedforward and feedback control
- 7.4 Amplifiers
- 7.5 Control systems for microfluidic devices
- 7.6 PID basics
- 7.7 Feedback control system of a cell incubator: design and implementation
- 7.8 Microfluidic device interface
- 7.9 Microscopy techniques
- 7.10 Spectroscopy techniques
- 7.11 Liquid driving methods
- References
- Chapter 8. Commercial microfluidic devices and their cost analysis
- Abstract
- 8.1 Introduction
- 8.2 Key facts about the commercial microfluidic market
- 8.3 Typical product cycle from the development phase into production
- 8.4 The strategy
- 8.5 Cost drivers in microfluidic devices
- 8.6 Summary
- References
- Chapter 9. Microfluidics for nanopharmaceutical and medical applications
- Abstract
- 9.1 Introduction
- 9.2 Nanoparticulate drug delivery systems for pharmaceutical application
- 9.3 From microfluidic 3D cell culture to human-on-a-chip
- 9.4 Conclusion
- Acknowledgement
- References
- Index
- No. of pages: 432
- Language: English
- Edition: 1
- Published: April 13, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780128224823
- eBook ISBN: 9780128224977
GP
Gerardo Perozziello
Gerardo Perozziello is Associate Professor of Applied Physics at the Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Italy. His research focuses on the development and integration of label-free nanosensors in microfluidic devices.
Affiliations and expertise
Associate Professor, Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, ItalyUK
Ulrich Kruhne
Ulrich Kruhne is Associate Professor of Biological and Chemical Engineering at the Technical University of Denmark, Denmark. His research focuses on microfluidics.
Affiliations and expertise
Associate Professor at the Department of Chemical and Biochemical Engineering, Technical University of Denmark, Lyngby, DenmarkPL
Paola Luciani
Paola Luciani is a Full Professor of Pharmaceutical Technology in the Department of Chemistry at the University of Bern in Bern, Switzerland. Her research interests are in the areas of nanomedicine and nanobiotechnology.
Affiliations and expertise
Full Professor of Pharmaceutical Technology, Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, SwitzerlandRead Microfluidics for Cellular Applications on ScienceDirect