Microfluidic Devices for Biomedical Applications

2nd Edition - August 5, 2021
Imprint: Woodhead Publishing
Editors: Xiujun (James) Li, Yu Zhou
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 9 9 7 1 - 8
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 7 5 5 - 8

Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical a… Read more

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Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.

This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.

Cover image
Title page
Table of Contents
Copyright
Contributors
Editor Biographies
Preface to the first edition
Preface to the second edition
1. Materials and methods for microfabrication of microfluidic devices
1.1. Introduction
1.2. Microfabrication methods
1.3. Materials
1.4. Conclusion and future trends
1.5. Acronyms
2. Surface coatings for microfluidic biomedical devices
2.1. Introduction
2.2. Covalent immobilization strategies: polymer devices
2.3. Covalent immobilization strategies: glass devices
2.4. Adsorption strategies
2.5. Other strategies utilizing surface treatments
2.6. Examples of applications
2.7. Conclusions and future trends
2.8. Sources of further information and advice
3. Actuation mechanisms for microfluidic biomedical devices
3.1. Introduction
3.2. Electrokinetics
3.3. Acoustics
3.4. Limitations and future trends
4. Droplet microfluidics for biomedical devices
4.1. Introduction—droplets in the wider context of microfluidics
4.2. Fundamental principles of droplet microfluidics
4.3. Droplet microfluidic approaches
4.4. Biomedical applications
4.5. Conclusion—perspective on the future of biomedical applications using droplet microfluidics
5. Controlled drug delivery using microdevices
5.1. Introduction
5.2. Microreservoir-based drug delivery systems
5.3. Micro/nanofluidics-based drug delivery systems
5.4. Future trends and challenges
6. Microneedles for drug delivery and monitoring
6.1. Introduction
6.2. Microneedle design parameters and structure
6.3. Drug delivery strategies using microneedle arrays
6.4. Other microneedle array applications
6.5. Microneedle-mediated patient monitoring and diagnosis
6.6. Clinical translation and commercialisation of microneedle products
6.7. Conclusion
7. Microfluidic systems for drug discovery, pharmaceutical analysis, and diagnostic applications
7.1. Introduction
7.2. Microfluidics for drug discovery
7.3. Microfluidics for pharmaceutical analysis and diagnostic applications
7.4. Examples of commercial microfluidic devices
7.5. Future trends
8. Microfluidic devices for cell manipulation
8.1. Introduction
8.2. Microenvironment on cell integrity
8.3. Microscale fluid dynamics
8.4. Manipulation technologies
8.5. Manipulation of cancer cells in microfluidic systems
8.6. Conclusion and future trends
8.7. Sources of further information and advice
9. Microfluidic devices for immobilization and micromanipulation of single cells and small organisms
9.1. Introduction
9.2. Glass microfluidic device for rapid single cell immobilization and microinjection
9.3. Microfluidic device for automated, high-speed microinjection of C. elegans
9.4. Microfabricated device for immobilization and mechanical stimulation of Drosophila larvae
9.5. Conclusions and outlook
10. Microfluidic devices for developing tissue scaffolds
10.1. Introduction
10.2. Key issues and technical challenges for successful tissue engineering
10.3. Microfluidic device platforms
10.4. Conclusion and future trends
11. Microfluidic devices for stem cell analysis
11.1. Introduction
11.2. Technologies used in stem cell analysis
11.3. Examples of microfluidic platform for stem cell analysis: stem cell culture platform—mimicking in vivo culture conditions in vitro
11.4. Examples of microfluidic platform for stem cell analysis: single stem cell analysis
11.5. Microdevices for label-free and noninvasive monitoring of stem cell differentiation
11.6. Microfluidics stem cell separation technology
11.7. Conclusion and future trends
11.8. Sources of further information and advice
12. Development of the immunoassay of antibodies and cytokines on nanobioarray chips
12.1. Introduction to immunoassays
12.2. Technologies
12.3. Immobilization chemistry
12.4. Detection methods
12.5. Applications
12.6. Conclusion and future trends
13. Integrated microfluidic systems for genetic analysis
13.1. Introduction
13.2. Integrated microfluidic systems
13.3. Development of integrated microdevices
13.4. Applications of fully integrated systems in genetic analysis
13.5. Future of integrated microfluidic systems
14. Paper-based microfluidic devices for low-cost assays
14.1. Introduction
14.2. Fabrication techniques for paper-based microfluidic devices
14.3. Detection and read-out technologies
14.4. Application of paper-based microfluidic devices
14.5. Current limitations and future perspectives in paper-based microfluidics
15. Microfluidic devices for viral detection
15.1. Introduction
15.2. Microfluidic technologies used for viral detection
15.3. Examples of applications
15.4. Conclusion and future trends
16. Microfluidic applications on pancreatic islets and β-cells study for human islet transplant
16.1. Introduction
16.2. Microfluidic technologies: the emergence of microfluidics applied to islet transplantation
16.3. Design and validation of microfluidic devices for islet study and transplantation
16.4. Protocol: materials
16.5. Protocol: procedures
16.6. Conclusion and future trends
17. 3D printed microfluidic devices and applications
17.1. Introduction
17.2. Direct 3D printing of microfluidic devices and applications
17.3. 3D-printing of molds for fabricating PDMS microfluidic devices and applications
17.4. Conclusions and future trends
Index

Xiujun (James) Li

XiuJun (James) Li, Ph.D., is an Associate Professor with early tenure in the Department of Chemistry and Biochemistry, Biomedical Engineering, and Border Biomedical Research Center at the University of Texas at El Paso (UTEP), USA. After he obtained his Ph.D. degree in microfluidic lab-on-a-chip bioanalysis from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University, while holding a Postdoctoral Fellowship from Natural Sciences and Engineering Research Council (NSERC) of Canada. He has gained extensive experience in bioanalysis using microfluidic systems, such as single-cell analysis, genetic analysis, low-cost diagnosis, pathogen detection, 3D cell culture, and so on. Dr. Li’s current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, biomaterial, biomedical engineering, and environmental applications, including but not limited to low-cost diagnosis, nano-biosensing, tissue engineering, and single-cell analysis. He has coauthored about 100 publications in high-impact journals (such as Adv. Drug Deliv. Rev, Appl. Catal. B-Environ, Anal. Chem., Lab Chip, Biosens. Bioelectron.) and 22 patents, including two books from Elsevier on microfluidic devices for biomedical applications. He is an Advisory Board member of Lab on a Chip and Analyst, the Founder of microBioChip Diagnostics LLC, and an editor of 6 journals including Scientific Reports from the Nature publishing group, Micromachines, etc. He is the recipient of the “Bioanalysis New Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award in 2009, and so on. For more information, please visit http://li.utep.edu.

Affiliations and expertise

Department of Chemistry and Biochemistry, Biomedical Engineering, Environmental Science and Engineering, Border Biomedical Research Center, University of Texas at El Paso

Yu Zhou

Yu Zhou, PhD, is a Research Scientist in the Department of Research and Development at ABS Global Inc., USA. Dr Zhou received his Ph.D. degree in mechanical engineering from University of Illinois at Chicago in 2010. After graduation, he joined ABS Global, the world-leading genetics provider company as a key researcher and has been working on the development of a high-throughput microfluidic cytometry for biological cell detection and manipulation. He obtained extensive experience in design and fabrication of silicon-based microsystems and disposal plastic microfluidic chips, precision fluid delivery, and microfluidics-based single cell separation and analysis. He is a member of ASME and serves on the advisory editorial board for several technical journals including Microsystem Technologies, and Journal of Mechanical Engineering Research (Canada) since 2011.

Affiliations and expertise

Department of R&D at ABS Global Inc., USA

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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