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Microbiome Therapeutics

Personalized Therapy Beyond Conventional Approaches

1st Edition - May 17, 2023

Editors: Nar Singh Chauhan, Suneel Kumar

Paperback ISBN:

9 7 8 - 0 - 3 2 3 - 9 9 3 3 6 - 4

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 9 3 3 7 - 1

Microbiome Therapeutics: Personalized Therapy Beyond Conventional Approaches addresses the current knowledge and landscape of microbiome therapeutics, providing an overview of… Read more

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Microbiome Therapeutics: Personalized Therapy Beyond Conventional Approaches addresses the current knowledge and landscape of microbiome therapeutics, providing an overview of existing applications in health and disease as well as potential future directions of microbiome modulations and subsequent translation to the global industry and market. This important reference provides the most current status of microbiome therapeutics as well as possible future perspectives through coverage of topics including the application of microbiome therapeutics; various additive, subtractive and modulatory approaches; microbiome composition of health and diseases, insights into live bio-therapeutics and the clinical data supporting their efficacy.

Case studies are provided throughout the book to further define, describe and evaluate microbiome therapeutics success and failure.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1. Microbiome therapeutics: a boon to modern therapeutics
1. Introduction
2. Microbiome therapeutics
3. Microbes maintain the well-being of various body organs
4. Conclusion
Chapter 2. Microbiome additive therapy for the human health
1. Introduction
2. Microbiome additive approaches
3. Method used to design genetic engineered microbiome additives
4. Microbiome additive therapy and clinical studies
5. Conclusion
6. Future perspective
Chapter 3. Microbiome subtractive therapy for health benefits
1. Introduction
2. Microbiome for human health and diseases
3. Brief description of microbiome
4. Subtractive approach of microbiome therapeutics
5. Phage therapy–derived microbiome subtraction
6. Bacteriocin-derived microbiome subtraction
7. Antimicrobial/bioactive metabolites–derived microbiome subtraction
8. Bottlenecks in the subtractive approach of microbiome therapeutics
9. Conclusion
10. Future perspectives
11. Declarations
Chapter 4. The modulatory approaches of microbiome therapeutics
1. Introduction
2. Human microbiome-based modulatory approaches
3. Microbiome consortia: organ-specific distribution in the human body
4. Conclusion
Chapter 5. Recent advances in microbiome engineering for therapeutic applications
1. Introduction
2. Microbiomes in the cancer microenvironment
3. The microbiome of diabetic patients
4. Fecal microbiota transplantation based therapeutics
5. Probiotic for microbiome restoration
6. Genetically engineered probiotics for target microbiome engineering
7. Conclusion and future prospects
Chapter 6. Microbial management of nonalcoholic fatty acid liver diseases
1. Introduction
2. Nonalcoholic fatty acid liver disease
3. Diagnosis of nonalcoholic fatty acid liver disease
4. Causative agents of nonalcoholic fatty acid liver disease
5. Clinical/chemical features of nonalcoholic fatty acid liver disease
6. Role of gut microbes in nonalcoholic fatty acid liver disease
7. Microbial therapies
8. Dietary management of nonalcoholic fatty acid liver disease
9. Conclusion
Chapter 7. Microbiome therapeutics in psychological disorders
1. Introduction
2. Gut microbiota
3. Gut dysbiosis
4. Skin microbiota
5. Core skin microbiota
6. Resident microbiota
7. Transient microbiota
8. Cutaneous dysbiosis
9. Gut microbiota in host physiology
10. Metabolism
11. Immunity
12. Brain–gut–microbiota–stress axis
13. Bidirectional pathways of the brain–gut–microbiota axis
14. Gut–brain axis: neuropsychology
15. The microbiota and the hypothalamic–pituitary–adrenal axis
16. Can the gut microbiota influence neural circuitry and behavior associated with the stress response?
17. Role of the gut microbiota in central nervous system physiology: behavioral and neurobiological data
18. Anxiety-like behavior
19. Cognition
20. Regulation and modulation of the microbiota
21. Administration of pre/probiotics
22. The microbiota affects the immune activation of the mucous membranes
23. Psychobiotics
24. General concepts in this chapter
Chapter 8. Microbiome therapeutics for the cancer management
1. The microbiome and disease
2. The microbiome in cancer treatment
3. Microbiome therapeutics for the cancer management
4. Effect of microbiome composition on the efficacy of anticancer therapy
5. Therapeutic strategies to modulate microbiome toward improved cancer therapy
6. Conclusion and future directions in microbiome therapeutics development
Chapter 9. A Tour-d’Horizon of microbiota therapeutics for metabolic disorders
1. Introduction
2. Maintenance of healthy gut microbiota
3. Gut microbiota and metabolic disorders
4. Gut microbiota–based therapeutics
5. Microbial therapeutics: how effective are they?
6. Future prospects
Chapter 10. Microbiome therapeutics in skin diseases
1. Introduction
2. Skin microbiome
3. Skin microbiota in health and diseases
4. Microbiome and cutaneous immune response
5. Skin diseases and microbiome intervention
6. Skin diseases and the role of probiotics
7. Clinical trials on microbiome therapeutics for skin diseases
8. Conclusion and prospects
Chapter 11. Overview of microbial therapeutics in immunological disorders
1. Introduction
2. Contribution of microbes in the development of the immune system
3. Tools to investigate and understand immunological disorders
4. Brief description of immunological disorders, etiology, role of microbes, and therapies
5. Microbe-based therapeutic approaches for treating immunological disorders
6. Limitations and challenges of microbiota-based therapy
7. Future perspectives
8. Conclusions
Appendix I
Appendix II
Chapter 12. Microbiota and its therapeutic implications in reproductive health and diseases
1. Introduction
2. Microbiota in reproductive health
3. Microbiome in sexual behavior and pregnancy
4. Microbiome in gynecological cancers
5. Microbiome as therapeutics in reproductive health diseases
6. Concluding remarks and future perspectives
Chapter 13. Personalized nutrition, personalized medicine, and microbiome therapeutics
1. Introduction
2. Personalized nutrition
3. Personalized diseases diagnostics and microbiota
4. Personalized treatment and microbiota
5. Microbial signatures for personalized treatment
6. Challenges with microbiome-associated personalized medicine
7. Conclusion and future prospects
Chapter 14. Microbiome therapeutics in respiratory illnesses
1. Introduction
2. Lung microbiota
3. Challenges in the identification of lung microbiome
4. Gut–lung axis
5. Respiratory disorders
6. Use of microbes for lung health
7. Probiotics colonize the upper respiratory tract
8. Clinical implications of probiotics in the upper respiratory tract
9. Conclusion
10. Future perspectives
Chapter 15. Microbiome therapeutics as an alternative to the antibiotics
1. Introduction
2. Effect of the gut microbiome on health
3. Antibiotic effects on gut microbiota
4. Antibiotic resistance
5. Advance developed therapeutics in modulating the microbiome
6. Challenges in microbiota-based therapeutics
7. Summary
Chapter 16. Microbiome-mediated T cell regulation, inflammation, and disease
1. Introduction
2. Gut microbiome
3. Diet and gut microbiome
4. Pro- and antiinflammatory metabolites
5. Regulation of innate and adaptive immune cells by gut metabolite
6. Gut microbiome and inflammation: role in health and diseases
7. Clinical interventions and precision medicine
8. Conclusions and future directions
Chapter 17. Implementation of microbiome therapeutics: bottlenecks and their redressal refusing suitable delivery techniques—some case studies
1. Introduction
2. Probiotic delivery—scope and issue
3. Case studies
4. Concluding remarks and future scope
Chapter 18. Conclusion and future perspective
1. Introduction
2. Microbiome therapeutics
3. Future perspectives
Index