
Microbial Genomics: Clinical, Pharmaceutical, and Industrial Applications
- 1st Edition - July 27, 2024
- Imprint: Academic Press
- Editors: Huseyin Tombuloglu, Amal Mahmoud
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 6 6 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 6 7 - 1
Microbial Genomics: Clinical, Pharmaceutical and Industrial Applications focuses on the various applications of microbial genomics in clinical, pharmaceutical, and industria… Read more

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Request a sales quoteMicrobial Genomics: Clinical, Pharmaceutical and Industrial Applications focuses on the various applications of microbial genomics in clinical, pharmaceutical, and industrial fields. The book consists of four parts devoted to bacterial, viral, and fungal genomics, as well as their applications in clinical, pharmaceutical, and industrial fields. Chapters are written by experts in their respective disciplines and are tightly organized with an introduction to detailed descriptions, available software implementation, applications, advanced topics, summaries, analytic questions, exercises, and suggested readings. Throughout this book, the latest genomics and biotechnological developments and discoveries as well as open problems and future challenges on microbial genomics are highlighted. Readers will be introduced to state-of-the-art developments and trends of microbial genomics, its clinical, pharmaceutical, and industrial applications.
- Presents the recent genomic developments in the industrial applications of microorganisms
- Summarizes recent developments in microbial genomics, emphasizing the role of next-generation sequencing in functional genomics
- Focus on how transcriptomics can help better understand host responses to pathogen infection
- Describes applications of genomics in clinical microbiology
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Chapter 1. Introduction to microbial genomics
- 1. Introduction
- 2. Architecture of microbial genomes
- 3. Genome sequencing technologies and advances
- 4. Microbial genome annotation
- 5. Applications of microbial genomics
- 6. Current limitations and challenges of microbial genomics
- 7. Future perspectives in microbial genomics
- Chapter 2. Viral genomics
- 1. Introduction
- 2. Decoding the genome: A comprehensive look at viral genomics
- 3. Exploring viral evolution through genomic analysis
- 4. From genome to pandemic: Understanding viral genomics in the era of COVID-19
- 5. Using genomics to predict the next viral outbreak
- 6. The promise of viral genomics: Developing vaccines, therapies for emerging diseases and other applications of viral genomics
- 7. Tracking the spread of viruses: How genomic sequencing is revolutionizing public health
- 8. Future directions in viral genomics
- Chapter 3. Fungal genomics
- 1. Introduction
- 2. Fungal genome history
- 3. Fungal genome sequencing
- 4. Importance of fungal genome databases
- 5. Genome sequencing and human health
- 6. Genomic sequences and plant health
- 7. Genomic sequence and bioactive compounds
- 8. Genomic sequence and enzyme biotechnology
- Chapter 4. Introduction to genomic-based clinical applications
- 1. Introduction
- 2. Genomics in the clinical context
- 3. Genomic basis of pathogens
- 4. Methods and strategies used for pathogen diagnosis and predicting the emergence of pathogens
- 5. Impact of genomics on pathogen diagnosis and prediction of novel pathogen emergence
- 6. Bioinformatics based clinical applications
- 7. Conclusion
- Chapter 5. Molecular techniques for the diagnosis of viral infections
- 1. Viral diagnosis in clinics
- 2. Nucleic acid amplification methods
- 3. CRISPR-Cas-based viral diseases diagnosis
- 4. Nanotechnology for viral disease diagnosis
- 5. Weaknesses and technical challenges of different viral diagnosis methods
- 6. Future perspectives
- 7. Conclusion
- Chapter 6. Bacterial identification and diagnosis of bacterial infections through genomics, proteomics, nanotechnology, machine learning, and microelectromechanical systems
- 1. Introduction
- 2. Bacterial identification and characterization
- 3. Genome-based approaches
- 4. Proteomics methods
- 5. Nanotechnology in bacterial pathogen detection
- 6. Machine learning in bacterial identification and diagnosis
- 7. Microelectromechanical systems (MEMS) in bacterial identification and diagnosis
- 8. The role of microfluidics in bacterial identification and diagnosis
- 9. Raman spectroscopy in bacterial identification and diagnosis
- 10. Conclusions
- Chapter 7. Fungal identification and diagnosis
- 1. Fungi: An overview
- 2. Phenotypic identification of fungi in a modern view
- 3. Incorporating molecular data in fungal identification
- 4. Rapid fungal identification methods
- 5. Integrative fungal identification
- 6. Key points
- World wide web links
- Chapter 8. Introduction to genomics-based pharmaceutical applications
- 1. Introduction
- 2. Genomics revolutionizing the field of pharmaceuticals
- 3. Genomics applications in the pharmaceutical fields
- Chapter 9. Antiviral history and viral targets for antiviral therapy
- 1. History of viruses and antiviral therapy
- 2. Viruses' composition and specific viral targets
- 3. Natural products as antiviral agents
- 4. Perspectives and conclusions
- Conflict of interest
- Author contributions
- Funding
- Chapter 10. Host- and genomics-based antiviral approaches
- 1. Cell signaling and virus-dependent cell-based targets
- 2. Genomics-based antiviral pharmaceutical applications
- 3. Drug repurposing for antiviral use
- 4. Perspectives and conclusions
- Chapter 11. Antibiotic resistance and target-based technologies for drug development
- 1. Introduction
- 2. Development of antimicrobial agents for drug-resistant strains
- 3. Sources of antibacterial agents
- 4. Obstacles in the development of new antibacterial drugs and their proposed solutions
- 5. Innovative approaches for antimicrobial drug discovery
- 6. Quorum sensing and drug discovery
- 7. Nanotechnology and antibacterial drug development
- 8. Conclusion
- Chapter 12. Discovery and development of new antibacterial drugs
- 1. Introduction
- 2. Antibacterial treatment
- 3. Bacterial resistance
- 4. Antibiotic discovery in the pre-genome era
- 5. Bacterial genomes and genome sequencing
- 6. RNA as a target for drug design
- 7. Genetic approaches to facilitate antibacterial drug development
- 8. Facilitating target-based drug discovery
- 9. The power and limits of genetic target validation
- 10. Concluding remarks
- Chapter 13. Potential targets for the development of antifungal drugs
- 1. Introduction
- 2. Classification and mechanism of antifungal drugs
- 3. Antifungal targets and strategies
- 4. Therapeutic interventions against fungal drug resistance
- 5. A multifaceted approach to tackle fungal virulence
- 6. Antifungal vaccines to combat fungal infections
- 7. Novel antifungal therapeutics
- 8. Conclusions and future perspectives
- Chapter 14. Introduction to genomics-based industrial applications
- 1. History of genomics in biotechnology
- 2. The colors of biotechnology
- 3. Classification of genomics-based applications
- 4. Regulation of genomics-based applications
- 5. The future of genomics-based applications
- Chapter 15. Tailed phage machinery: toward advanced biocontrol
- 1. Introduction
- 2. Bacteriophage assembly
- 3. Conformational changes during infection
- 4. Advanced applications
- 5. Conclusions
- Chapter 16. Advances in fungal biotechnology in agriculture
- 1. Introduction
- 2. Fungi and pest control
- 3. Fungal bioremediation of organic pollutants: Mechanisms, advantages, constraints and future perspectives
- 4. Fungal genetic engineering
- 5. Plants genetic engineering for fungal disease resistance
- Index
- Edition: 1
- Published: July 27, 2024
- Imprint: Academic Press
- No. of pages: 488
- Language: English
- Paperback ISBN: 9780443188664
- eBook ISBN: 9780443188671
HT
Huseyin Tombuloglu
Huseyin Tombuloglu, PhD, is an Associate Professor at the Institute of Research and Medical Consultation (IRMC) of Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia. He received his BSc degree in Molecular Biology and Genetics, an MS degree in Biology and a PhD degree in Biotechnology. He has more than 15 years of teaching and research experience in Genetics, Molecular Biology, Plant Genomics, and Biotechnology, as well as Bioinformatics. His current research focuses on nanoparticle-plant interaction. He has published more than 60 internationally indexed articles. Among those, approximately 20 recent articles are related to nanoparticle and plant interactions at molecular and physiological levels. He has also edited two books published by a global publisher.
AM
Amal Mahmoud
Amal Mahmoud, PhD, is a Professor of Bioinformatics, Head of the Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt, previously worked as a Professor of Bioinformatics, Department of Biology, Faculty of Science, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia (2017-2022). She had a PhD fellowship in CIRAD-Montpellier, France (1995-1998) and previously worked at UC-Davis-CA as a post-doc (2001-2002) in the field of viral bioinformatics. She teaches undergraduate and graduate bioinformatics, genetics, molecular biology, gene regulation and virology as well as supervises research students. Her current research is focused on the application of artificial intelligence and bioinformatics tools for developing novel therapeutic strategies for emerging viruses.