Microbial Genomics: Clinical, Pharmaceutical, and Industrial Applications

1st Edition - July 27, 2024
Imprint: Academic Press
Editors: Huseyin Tombuloglu, Amal Mahmoud
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 8 6 6 - 4
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 8 6 7 - 1

Microbial Genomics: Clinical, Pharmaceutical and Industrial Applications focuses on the various applications of microbial genomics in clinical, pharmaceutical, and industria… Read more

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Microbial Genomics: Clinical, Pharmaceutical and Industrial Applications focuses on the various applications of microbial genomics in clinical, pharmaceutical, and industrial fields. The book consists of four parts devoted to bacterial, viral, and fungal genomics, as well as their applications in clinical, pharmaceutical, and industrial fields. Chapters are written by experts in their respective disciplines and are tightly organized with an introduction to detailed descriptions, available software implementation, applications, advanced topics, summaries, analytic questions, exercises, and suggested readings. Throughout this book, the latest genomics and biotechnological developments and discoveries as well as open problems and future challenges on microbial genomics are highlighted. Readers will be introduced to state-of-the-art developments and trends of microbial genomics, its clinical, pharmaceutical, and industrial applications.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Chapter 1. Introduction to microbial genomics
1. Introduction
2. Architecture of microbial genomes
3. Genome sequencing technologies and advances
4. Microbial genome annotation
5. Applications of microbial genomics
6. Current limitations and challenges of microbial genomics
7. Future perspectives in microbial genomics
Chapter 2. Viral genomics
1. Introduction
2. Decoding the genome: A comprehensive look at viral genomics
3. Exploring viral evolution through genomic analysis
4. From genome to pandemic: Understanding viral genomics in the era of COVID-19
5. Using genomics to predict the next viral outbreak
6. The promise of viral genomics: Developing vaccines, therapies for emerging diseases and other applications of viral genomics
7. Tracking the spread of viruses: How genomic sequencing is revolutionizing public health
8. Future directions in viral genomics
Chapter 3. Fungal genomics
1. Introduction
2. Fungal genome history
3. Fungal genome sequencing
4. Importance of fungal genome databases
5. Genome sequencing and human health
6. Genomic sequences and plant health
7. Genomic sequence and bioactive compounds
8. Genomic sequence and enzyme biotechnology
Chapter 4. Introduction to genomic-based clinical applications
1. Introduction
2. Genomics in the clinical context
3. Genomic basis of pathogens
4. Methods and strategies used for pathogen diagnosis and predicting the emergence of pathogens
5. Impact of genomics on pathogen diagnosis and prediction of novel pathogen emergence
6. Bioinformatics based clinical applications
7. Conclusion
Chapter 5. Molecular techniques for the diagnosis of viral infections
1. Viral diagnosis in clinics
2. Nucleic acid amplification methods
3. CRISPR-Cas-based viral diseases diagnosis
4. Nanotechnology for viral disease diagnosis
5. Weaknesses and technical challenges of different viral diagnosis methods
6. Future perspectives
7. Conclusion
Chapter 6. Bacterial identification and diagnosis of bacterial infections through genomics, proteomics, nanotechnology, machine learning, and microelectromechanical systems
1. Introduction
2. Bacterial identification and characterization
3. Genome-based approaches
4. Proteomics methods
5. Nanotechnology in bacterial pathogen detection
6. Machine learning in bacterial identification and diagnosis
7. Microelectromechanical systems (MEMS) in bacterial identification and diagnosis
8. The role of microfluidics in bacterial identification and diagnosis
9. Raman spectroscopy in bacterial identification and diagnosis
10. Conclusions
Chapter 7. Fungal identification and diagnosis
1. Fungi: An overview
2. Phenotypic identification of fungi in a modern view
3. Incorporating molecular data in fungal identification
4. Rapid fungal identification methods
5. Integrative fungal identification
6. Key points
World wide web links
Chapter 8. Introduction to genomics-based pharmaceutical applications
1. Introduction
2. Genomics revolutionizing the field of pharmaceuticals
3. Genomics applications in the pharmaceutical fields
Chapter 9. Antiviral history and viral targets for antiviral therapy
1. History of viruses and antiviral therapy
2. Viruses' composition and specific viral targets
3. Natural products as antiviral agents
4. Perspectives and conclusions
Conflict of interest
Author contributions
Funding
Chapter 10. Host- and genomics-based antiviral approaches
1. Cell signaling and virus-dependent cell-based targets
2. Genomics-based antiviral pharmaceutical applications
3. Drug repurposing for antiviral use
4. Perspectives and conclusions
Chapter 11. Antibiotic resistance and target-based technologies for drug development
1. Introduction
2. Development of antimicrobial agents for drug-resistant strains
3. Sources of antibacterial agents
4. Obstacles in the development of new antibacterial drugs and their proposed solutions
5. Innovative approaches for antimicrobial drug discovery
6. Quorum sensing and drug discovery
7. Nanotechnology and antibacterial drug development
8. Conclusion
Chapter 12. Discovery and development of new antibacterial drugs
1. Introduction
2. Antibacterial treatment
3. Bacterial resistance
4. Antibiotic discovery in the pre-genome era
5. Bacterial genomes and genome sequencing
6. RNA as a target for drug design
7. Genetic approaches to facilitate antibacterial drug development
8. Facilitating target-based drug discovery
9. The power and limits of genetic target validation
10. Concluding remarks
Chapter 13. Potential targets for the development of antifungal drugs
1. Introduction
2. Classification and mechanism of antifungal drugs
3. Antifungal targets and strategies
4. Therapeutic interventions against fungal drug resistance
5. A multifaceted approach to tackle fungal virulence
6. Antifungal vaccines to combat fungal infections
7. Novel antifungal therapeutics
8. Conclusions and future perspectives
Chapter 14. Introduction to genomics-based industrial applications
1. History of genomics in biotechnology
2. The colors of biotechnology
3. Classification of genomics-based applications
4. Regulation of genomics-based applications
5. The future of genomics-based applications
Chapter 15. Tailed phage machinery: toward advanced biocontrol
1. Introduction
2. Bacteriophage assembly
3. Conformational changes during infection
4. Advanced applications
5. Conclusions
Chapter 16. Advances in fungal biotechnology in agriculture
1. Introduction
2. Fungi and pest control
3. Fungal bioremediation of organic pollutants: Mechanisms, advantages, constraints and future perspectives
4. Fungal genetic engineering
5. Plants genetic engineering for fungal disease resistance
Index

Huseyin Tombuloglu

Huseyin Tombuloglu, PhD, is an Associate Professor at the Institute of Research and Medical Consultation (IRMC) of Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia. He received his BSc degree in Molecular Biology and Genetics, an MS degree in Biology and a PhD degree in Biotechnology. He has more than 15 years of teaching and research experience in Genetics, Molecular Biology, Plant Genomics, and Biotechnology, as well as Bioinformatics. His current research focuses on nanoparticle-plant interaction. He has published more than 60 internationally indexed articles. Among those, approximately 20 recent articles are related to nanoparticle and plant interactions at molecular and physiological levels. He has also edited two books published by a global publisher.

Affiliations and expertise

Associate Professor, Department of Genetics, Institute for Research and Medical Consultations (IRMC), University of Dammam, Saudi Arabia

Amal Mahmoud

Amal Mahmoud, PhD, is a Professor of Bioinformatics, Head of the Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt, previously worked as a Professor of Bioinformatics, Department of Biology, Faculty of Science, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia (2017-2022). She had a PhD fellowship in CIRAD-Montpellier, France (1995-1998) and previously worked at UC-Davis-CA as a post-doc (2001-2002) in the field of viral bioinformatics. She teaches undergraduate and graduate bioinformatics, genetics, molecular biology, gene regulation and virology as well as supervises research students. Her current research is focused on the application of artificial intelligence and bioinformatics tools for developing novel therapeutic strategies for emerging viruses.

Affiliations and expertise

Professor, Head of the Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health