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Microbial Crosstalk with Immune System
New Insights in Therapeutics
1st Edition - July 26, 2022
Editor: Asmita Das
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 6 1 2 8 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 5 7 9 - 5
Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a… Read more
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Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a continuous and dynamic way. In 8 chapters, Microbial Crosstalk with Immune System: New Insights in Therapeutics provides an overall introduction with special focus on how the immune system which is specifically geared to get rid of non-self-antigens, allows numerous microbes to colonize the human body. In the presence of microbes there are several observations that suggest that there are multiple roles that are played by these microbes in tumor progression and shaping of our immune system which is explained at length in subsequent chapters.
Microbial Crosstalk with Immune System: New Insights in Therapeutics discusses the emerging mechanisms of immune-therapeutics as well as its limitations while emphasizing the potential role of microbes in shaping immune-therapeutic and evolving novel strategies to deal with any limitations.
- Focuses on the modulation of immune system by the microbiome, thus affecting cancer prognosis
- Discusses various current research strategies in the field that are still in experimental stages. enabling readers to gain a perspective on the ongoing research in the field
- Gives insight into the emerging mechanisms of immune-therapeutics and its limitations
- Emphasizes the potential role of microbes in shaping immune-therapeutics
Researchers and students in Microbiology; Medical Microbiology; Immunology, Biotechnology and cancer research. Medical practitioners; Cancer biologists; Researchers in Therapeutics; Industry R&D personnel
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Introduction
- Abstract
- 1.1 Host immune response against infections
- 1.2 Increased tolerization in gut
- 1.3 Dynamics of gut microbiota and its dependency on external factors
- 1.4 Cancer and its hallmarks
- 1.5 Involvement of immune system in cancer
- 1.6 Microbiota and cancer
- References
- Chapter 2. Significance of the normal microflora of the body
- Abstract
- 2.1 Introduction
- 2.2 Normal microflora
- 2.3 Human microbiome
- 2.4 Conclusion
- References
- Chapter 3. Immunological paradox for maintaining normal flora: it is all by design, not by chance
- Abstract
- 3.1 Microflora in the development of immune system
- 3.2 Immune system tolerance of microflora
- 3.3 Protective role of short-chain fatty acids in inflammation and cancer prevalence
- 3.4 Microflora and adaptive immune system
- 3.5 Environmental factors altering microflora and influencing immune system
- 3.6 Microflora dysbiosis in disease and impact on immune system
- 3.7 Conclusion
- Acknowledgments
- References
- Chapter 4. Cancer prognosis and immune system
- Abstract
- 4.1 Introduction
- 4.2 Defining pathology
- 4.3 Molecular pathology
- 4.4 Need for molecular diagnosis
- 4.5 Techniques involved in molecular diagnosis
- 4.6 Pathological and molecular aspects of different cancers
- 4.7 Artificial intelligence in studying cancer pathology
- 4.8 Immune system: innate and adaptive immunity
- 4.9 Conclusion
- References
- Chapter 5. Human microbiota: role in cancer progression and therapy
- Abstract
- 5.1 Introduction
- 5.2 Relationship between human microbiota and cancer
- 5.3 Conventional therapies used for treatment of cancer
- 5.4 Role of microbiota in cancer progression
- 5.5 Role of microbiota in cancer regression and therapy
- 5.6 Challenges, gaps, and future perspectives
- 5.7 Conclusion
- Acknowledgments
- References
- Chapter 6. Microflora impacts immune system and its antitumor function
- Abstract
- 6.1 Introduction
- 6.2 Cancer immunotherapy
- 6.3 Diverse microflora in humans
- 6.4 Microbiota, disease development, and effect on immune system
- 6.5 Microbes and autoimmune diseases
- 6.6 Evidence for the antitumor function of microflora
- 6.7 Conclusion
- References
- Chapter 7. Cancer therapeutics and gut microflora
- Abstract
- 7.1 Cancer: biology and treatment
- 7.2 Gut microbiota: an organ in itself!
- 7.3 Gut microbiota, immune system, and cancer development
- 7.4 Role of gut microbiota in cancer therapy
- 7.5 Conclusion
- Conflict of interest
- Author contributions
- Funding
- References
- Chapter 8. Missing rungs in cancer therapeutics and strategies to climb them
- Abstract
- 8.1 Surgery–radiation–chemo-therapy
- 8.2 Genomically targeted therapy
- 8.3 Cancer immunotherapy
- 8.4 Upcoming therapies
- 8.5 Advancements in therapeutic procedure
- 8.6 Microbes in cancer therapeutics
- 8.7 Biobanking of cancer samples
- 8.8 Centralized data curation
- 8.9 Affordability of cancer treatment
- References
- Index
- No. of pages: 272
- Language: English
- Published: July 26, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323961288
- eBook ISBN: 9780323995795
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Asmita Das
Dr. Asmita Das completed her PhD from School of Life Sciences, Jawaharlal Nehru University and thereafter joined National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA for a postdoctoral position for about 5 years.
She has since been employed in Delhi Technological University since 2010 as Assistant Professor. Her research interests include Immunotherapeutics and Immunoinformatics. She is also involved in various interdisciplinary research. She has published several high impact peer reviewed papers including Immunity (IF: 21), Autophagy (IF: 11), Journal of Immunology (IF: 5.6) (top 10% articles in the journal in 2010) and many others. She serves on the editorial board of several peer reviewed journals. She has been actively involved in Industry- Academia partnership, including research guidance of industry personnel. She has served in several selection boards, external examiners and invited speakers in several institutes of repute.
Affiliations and expertise
Assistant Professor, Department of Biotechnology, Delhi Technological University, Govt. of Delhi, NCT, Shahbad, India