Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B

1st Edition, Volume 187 - January 28, 2022
Imprint: Academic Press
Editors: Alok Pandya, Vijai Singh
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 0 3 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 0 4 - 0

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters… Read more

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Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Design and fabrication of microfluidics devices for molecular biology applications
Abstract
1: Introduction
2: Design and fabrication of microfluidics chip
3: Microfluidics for extraction of nucleic acids
4: Microfluidics for detection of nucleic acids
5: Microfluidics devices for detection of metabolites and toxins
6: Conclusion and future remarks
Acknowledgments
References
Chapter Two: Micro/nanofluidic devices for drug delivery
Abstract
1: Microfluidic in vitro drug delivery at the cellular level
2: Microfluidic in vitro drug delivery at tissue level
3: Microfluidic in situ drug delivery at organ level
4: Conclusion and future perspective
References
Chapter Three: From organ-on-chip to body-on-chip: The next generation of microfluidics platforms for in vitro drug efficacy and toxicity testing
Abstract
1: Introduction
2: Organ-on-chip development: The game changer
3: Interconnected organ-on-chips: The emergence of body-on-chips
4: Advantages and limitations of OOCs and BOCs
5: Conclusion
References
Chapter Four: Micro and nanofluidics for high throughput drug screening
Abstract
1: Introduction
2: State of the art in micro and nanofluidics
3: Current and recent development in high throughput systems
4: Micro and nanofluidics for high throughput in diagnostics application
5: Micro and nanofluidics for high throughput drug screening
6: Micro and nanofluidics for tuberculosis diagnostics
7: Future perspectives
Acknowledgments
References
Chapter Five: Design, fabrication and assembly of lab-on-a-chip and its uses
Abstract
1: Point of care diagnostics
2: Fabrication of lab-on-a-chip devices
3: Assembly of a lab-on-a-chip device
4: Applications
5: Conclusion
References
Chapter Six: Advances in microfluidic 3D cell culture for preclinical drug development
Abstract
1: Introduction
2: Materials and microfabrication methods
3: Microfluidic hydrogels and coating methods as extracellular matrix mimics
4: From microfluidic 3D cell culture to functional tissues and organs
5: Microfluidic 3D cell culture for drug development
6: Concluding remarks
References
Further reading
Chapter Seven: Cultivating human tissues and organs over lab-on-a-chip models: Recent progress and applications
Abstract
1: Introduction
2: Traditional cell culture techniques
3: Emerging organ/tissue-on-chip techniques
4: Organ-on-chip and associated biomedical applications
5: Organ-on-chip and nanomedicine
6: Limitations
7: Conclusion and future aspect
References
Chapter Eight: Microfluidics based point-of-care for disease diagnostics
Abstract
1: Introduction
2: Microfluidics based point-of-care for infectious disease diagnosis
3: Microfluidics-based point-of-care for disease diagnostics
4: Conclusion and future remarks
Acknowledgments
References
Chapter Nine: Lab on a body for biomedical electrochemical sensing applications: The next generation of microfluidic devices
Abstract
1: Introduction
2: Concepts of on-body microfluidic sensing devices
3: Challenges when developing on-body microfluidic sensing devices
4: Advances of microfluidic components toward the development of on-body microfluidic devices
5: Examples of on-body microfluidic devices integrated electrochemical sensors for diagnosis
6: Conclusion and prospects
References
Chapter Ten: Microfluidic tools for veterinary and zoonotic disease diagnostics
Abstract
1: Introduction
2: Types of microfluidic tools
3: Applications of microfluidics in veterinary diagnostics
4: Conclusion and future perspective
Acknowledgments
References
Chapter Eleven: Continuous monitoring of molecular biomarkers in microfluidic devices
Abstract
1: Introduction
2: Techniques
3: Conclusions
References
Chapter Twelve: Microfluidics device for drug discovery, screening and delivery
Abstract
1: Introduction
2: Microfluidics for drug discovery and screening
3: Microfluidics for drug delivery
4: Droplet microfluidics platforms
5: Droplet microfluidics for drug discovery, screening and delivery
6: Conclusion and future remarks
Acknowledgments
References
Index

Alok Pandya

Dr. Alok Pandya is an innovator, interdisciplinary researcher, and academic leader specializing in the development of personalized biosensors for point-of-care/need diagnostics and rapid disease detection. His work focuses on developing advanced biosensing technologies for real-time health monitoring. Currently serving as an Associate Professor at the School of Applied Science and Technology, Gujarat Technological University, he brings over 11 years of research experience dedicated to biosensor-driven rapid diagnostics. Before joining GTU, Dr. Pandya spent 8 years as an Assistant Professor at the Institute of Advanced Research (IAR) and 3 years as a Research Associate at Ahmedabad University. He has also been a Visiting Professor at the University of California, San Diego, conducting research on wearable biosensors, and an Entrepreneurial Lead under the US National Science Foundation’s I-Corps™ program, gaining expertise in medical innovation and technology commercialization. A researcher and technologist, Dr. Pandya has published 60+ research articles, authored 5 books & 12+ book chapters, and holds 5 granted patents. His work has secured national and international funding to advance biomedical and forensic diagnostic technologies. He has been honored with prestigious awards, including the SERB-International Research Experience Award, the SERB Young Scientist Award, and the IAR Research Excellence Award. Dr. Pandya has developed cutting-edge biosensing platforms for rapid AMR detection, cardiovascular disease diagnostics, plant pathogen identification, and forensic body fluid analysis. With global research collaborations spanning France, the USA, and India, Dr. Pandya continues to drive innovation in biosensor technology, translating scientific discoveries into real-world applications for precision diagnostics and personalized healthcare.

Affiliations and expertise

School of Applied of Science and Technology, Gujarat Technological technology, Ahmedabad

Vijai Singh

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health