Metalloproteins and Motor Proteins
- 1st Edition, Volume 141 - July 4, 2024
- Imprint: Academic Press
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 4 4 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 4 5 - 3
Metalloproteins and Motor Proteins, Volume 141 focuses on recent advances in studying metalloproteins and motor proteins, along with their roles in different pathologies and drug-r… Read more
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Request a sales quoteMetalloproteins and Motor Proteins, Volume 141 focuses on recent advances in studying metalloproteins and motor proteins, along with their roles in different pathologies and drug-resistance. Chapters include Transcriptomic Analysis Reveals Zinc-Mediated Virulence and Pathogenicity in Multidrug-Resistant Acinetobacter baumannii, The Mechanistic Insights into Different Aspects of Promiscuity in Metalloenzymes, Role of Metal ion in ion channel Mechanisms, A model of microtubule depolymerization by kinesin-8 motor proteins, Metalloproteins and metalloproteomics in health and disease, Decoding Genetic and Pathophysiological Mechanisms in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis: A Comparative Study of Differentially Expressed Genes and Implicated Pathways in Motor Neuron Disorders, and much more.
Additional chapters cover Exploring the effect of disease causing mutations in metal binding sites of human ARSA in Metachromatic Leukodystrophy, Role of transmembrane proteins in regulating metalloproteins and motor proteins in human cancer, Role of transmembrane proteins in metalloproteins and motor proteinsin human neurogenesis, Role of transmembrane proteins in metalloproteins and motor proteins in human aging, Vesicle transport of metalloproteinases, Motor proteins and spermatogenesis, and much more.
Additional chapters cover Exploring the effect of disease causing mutations in metal binding sites of human ARSA in Metachromatic Leukodystrophy, Role of transmembrane proteins in regulating metalloproteins and motor proteins in human cancer, Role of transmembrane proteins in metalloproteins and motor proteinsin human neurogenesis, Role of transmembrane proteins in metalloproteins and motor proteins in human aging, Vesicle transport of metalloproteinases, Motor proteins and spermatogenesis, and much more.
- Integrates experimental and computational methods for studying structure and function of metalloproteins and motor proteins and their implication in drug design
- Presents timely chapters written by well-renowned authorities in their field
- Contains a high number of high quality illustrations, figures, and tables and targets a very wide audience of specialists, researchers, and students
Protein chemists, molecular cell biologists, immunologists, structural biologists, computational biochemists, medical doctors, pharmacologists and other researchers working in the field of metalloproteins and motor proteins, drug design and drug resistance. Articles published here would also be of a considerable benefit to medical, biology and pharmacology students specializing in this field
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Transcriptomic analysis reveals zinc-mediated virulence and pathogenicity in multidrug-resistant Acinetobacter baumannii
- Abstract
- 1 Introduction
- 2 Materials and Methods
- 3 Quality control check
- 4 Alignment and quantification analysis
- 5 Differential gene expression using DESeq2
- 6 Functional enrichment in STRING DB
- 7 Cytoscape: cytohubba analysis
- 8 Results and discussion
- 9 Differentially expressed genes DESeq2
- 10 STRING enrichment analysis
- 11 Functional enrichment analysis
- 12 Cytohubba analysis for screening hubgene
- 13 Conclusion
- References
- Chapter Two: The mechanistic insights into different aspects of promiscuity in metalloenzymes
- Abstract
- 1 Introduction
- 2 Promiscuity in enzymes
- 3 Promiscuity in metallo-enzymes
- 4 Evolutionary importance of promiscuity in metalloenzymes
- 5 Structural basis of promiscuity in metalloenzymes
- 6 Mechanisms of substrate recognition and binding
- 7 Active site plasticity and conformational changes
- 8 Structural determinants of promiscuity in metalloenzymes
- 9 Mechanistic insights into metalloenzyme promiscuity: Case studies
- 10 Cytochrome P450BM3
- 11 Dipeptide epimerases
- 12 Limonene hydroxylase (mint superfamily)
- 13 Homoserine kinase
- 14 Implications of metalloenzyme promiscuity
- 15 Industrial applications of promiscuous metalloenzymes
- 16 Conclusion
- References
- Further reading
- Chapter Three: Metalloproteins structural and functional insights into immunological patterns
- Abstract
- 1 Introduction
- 2 Metalloproteins—immunological behaviour
- 3 Structural and functional roles of metal ions in metalloproteins
- 4 Metal ion transporters in intracellular regulation
- 5 Conclusion
- Acknowledgement
- References
- Chapter Four: A model of microtubule depolymerization by kinesin-8 motor proteins
- Abstract
- Abbreviations
- 1 Introduction
- 2 Methods
- 3 Results
- 4 Discussion
- 5 Conclusion
- References
- Chapter Five: Metalloproteins and metalloproteomics in health and disease
- Abstract
- Abbreviations
- 1 Introduction
- 2 Structure and classification
- 3 Metallochaperones
- 4 Mismetallation
- 5 Structure-function relationship
- 6 Metalloproteins regulome
- 7 Clinical implications of metalloproteins
- 8 Therapeutic prospective
- References
- Chapter Six: Decoding genetic and pathophysiological mechanisms in amyotrophic lateral sclerosis and primary lateral sclerosis: A comparative study of differentially expressed genes and implicated pathways in motor neuron disorders
- Abstract
- 1 Introduction
- 2 Methodology
- 3 Results
- 4 Discussion
- 5 Conclusion
- Acknowledgments
- References
- Chapter Seven: Exploring the effect of disease causing mutations in metal binding sites of human ARSA in metachromatic leukodystrophy
- Abstract
- 1 Introduction
- 2 Methodology
- 3 Results
- 4 Discussion
- 5 Conclusion
- References
- Further reading
- Chapter Eight: Epigenetic dysregulation in cancers by isocitrate dehydrogenase 2 (IDH2)
- Abstract
- 1 Introduction
- 2 Cellular function of Isocitrate dehydrogenases
- 3 Pathological implications of IDH2 mutations
- 4 Epigenetic mechanisms of IDH2
- 5 Synergy exclusivity, and coordinated effects of IDH2 mutations in epigenetics
- 6 Isocitrate dehydrogenase 2 in acute myeloid leukemia
- 7 Conclusion
- References
- Chapter Nine: Transmembrane protein TMEM230, regulator of metalloproteins and motor proteins in gliomas and gliosis
- Abstract
- 1 Introduction
- 2 Aberrant high level of transmembrane protein, TMEM230 is associated with lower survivability of glioma patients
- 3 TMEM230 promotes glial cell growth, cytoskeleton structure, micro channeling and extracellular matrix remodeling
- 4 TMEM230, regulator of metalloproteins and motor proteins
- 5 Transcriptomic analysis of patient derived oligodendroglioma
- 6 Transcriptomic analysis of patient-derived glioblastoma
- 7 Discussion
- 8 Conclusion
- Acknowledgement
- References
- Chapter Ten: Single-cell transcriptomic analysis to identify endomembrane regulation of metalloproteins and motor proteins in autoimmunity
- Abstract
- 1 Introduction
- 2 Results
- 3 Discussion
- 4 Conclusion
- References
- Chapter Eleven: Long-term culture of patient-derived mammary organoids in non-biogenic electrospun scaffolds for identifying metalloprotein and motor protein activities in aging and senescence
- Abstract
- 1 Introduction
- 2 Polycaprolactone non-biogenic scaffolds for 2D and 3D cell culture of human patient cells for identifying secreted cellular components with tissue remodeling capacity or associated with in aging
- 3 Patient derived breast and skin 3D organoids and tissue for aging studies to identify aging and tissue regenerating factors
- 4 Discussion
- 5 Conclusion
- Acknowledgements
- References
- Chapter Twelve: Vesicle transport of matrix metalloproteinases
- Abstract
- 1 Introduction
- 2 ECM degrading metalloproteinases: matrix metalloproteinases (MMPs)
- 3 Invadopodia
- 4 Podosomes
- 5 Focal adhesion (FA)
- 6 Conclusions and future prospective
- References
- Chapter Thirteen: Motor proteins, spermatogenesis and testis function
- Abstract
- 1 Introduction
- 2 Dyneins
- 3 Kinesins
- 4 Myosins
- 5 A hypothetical model on motor proteins-mediated germ cell transport at the BTB and the seminiferous epithelium utilizing the testis-specific anchoring junction ectoplasmic specialization (ES)
- 6 Concluding remarks
- References
- Chapter Fourteen: The crosstalk between extracellular matrix proteins and Tau
- Abstract
- 1 Introduction
- 2 Glial activation intrigued by the pathological proteins in AD
- 3 Omega-3 fatty acids driven phagocytosis of extracellular Tau in microglia
- 4 Actin-remodeling-mediated phagocytic events in microglia
- 5 Actin remodeling and microstructures formation in immune cell function
- 6 α-linolenic acid induces membrane-associated actin remodeling in microglia during extracellular Tau clearance
- Acknowledgments
- References
- Chapter Fifteen: G-protein coupled receptors regulates Tauopathy in neurodegeneration
- Abstract
- 1 Neurodegeneration and Alzheimer’s disease
- 2 Tau structure and dynamics
- 3 Physiological and pathological characteristics of Microglia: A brain macrophage
- 4 Microglial role in Tau propagation and clearance in Alzheimer’s disease
- 5 G-protein coupled receptors in Alzheimer’s disease
- 6 Role of microglial purinergic receptor, P2Y12R in physiology and AD pathology
- Acknowledgments
- References
- Chapter Sixteen: Gut microbial metalloproteins and its role in xenobiotics degradation and ROS scavenging
- Abstract
- Abbreviations
- 1 Introduction
- 2 Xenobiotics degrading metalloenzymes
- 3 ROS scavenging metalloproteins
- 4 Protein-protein interactions of metalloenzymes
- 5 Microbial metalloenzymes: the chief executives in human gut
- 6 Conclusion
- Acknowledgements
- References
- Chapter Seventeen: Exploring metalloproteins found in the secretion of venomous species: Biological role and therapeutical applications
- Abstract
- 1 Introduction
- 2 Metallomics on venomous species
- 3 Pharmaceutical and clinical applications of metalloproeteins from venomous species
- 4 Challenges of isolation-based venom biodiscovery
- 5 Outlook and concluding remarks
- References
- Chapter Eighteen: Coordination, cooperation, competition, crowding and congestion of molecular motors: Theoretical models and computer simulations
- Abstract
- Nomenclature
- 1 Introduction
- 2 Experimental methods
- 3 Single cytoskeletal motor proteins on a single protofilament
- 4 Single cytoskeletal motor proteins on single/multiple lanes of a filament
- 5 Multiple cytoskeletal motor proteins on single filament: rigid cargo
- 6 Multiple cytoskeletal motor proteins on single filament: soft cargo
- 7 Bidirectional cargo transport for team of antagonistic motors
- 8 Traffic of multiple motors on single filament
- 9 Multiple motors at filament intersections
- 10 Sliding and rowing of multiple motor crossbridges in filament bundles
- 11 Multiple motors in mitosis
- 12 Future directions
- References
- Edition: 1
- Volume: 141
- Published: July 4, 2024
- No. of pages (Hardback): 676
- No. of pages (eBook): 488
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443193446
- eBook ISBN: 9780443193453
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Metalloproteins and Motor Proteins on ScienceDirect