Metalloproteins and Motor Proteins

1st Edition, Volume 141 - July 4, 2024
Editor: Rossen Donev
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 3 4 4 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 3 4 5 - 3

Metalloproteins and Motor Proteins, Volume 141 focuses on recent advances in studying metalloproteins and motor proteins, along with their roles in different pathologies and drug-r… Read more

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Metalloproteins and Motor Proteins, Volume 141 focuses on recent advances in studying metalloproteins and motor proteins, along with their roles in different pathologies and drug-resistance. Chapters include Transcriptomic Analysis Reveals Zinc-Mediated Virulence and Pathogenicity in Multidrug-Resistant Acinetobacter baumannii, The Mechanistic Insights into Different Aspects of Promiscuity in Metalloenzymes, Role of Metal ion in ion channel Mechanisms, A model of microtubule depolymerization by kinesin-8 motor proteins, Metalloproteins and metalloproteomics in health and disease, Decoding Genetic and Pathophysiological Mechanisms in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis: A Comparative Study of Differentially Expressed Genes and Implicated Pathways in Motor Neuron Disorders, and much more.

Additional chapters cover Exploring the effect of disease causing mutations in metal binding sites of human ARSA in Metachromatic Leukodystrophy, Role of transmembrane proteins in regulating metalloproteins and motor proteins in human cancer, Role of transmembrane proteins in metalloproteins and motor proteinsin human neurogenesis, Role of transmembrane proteins in metalloproteins and motor proteins in human aging, Vesicle transport of metalloproteinases, Motor proteins and spermatogenesis, and much more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter One: Transcriptomic analysis reveals zinc-mediated virulence and pathogenicity in multidrug-resistant Acinetobacter baumannii
Abstract
1 Introduction
2 Materials and Methods
3 Quality control check
4 Alignment and quantification analysis
5 Differential gene expression using DESeq2
6 Functional enrichment in STRING DB
7 Cytoscape: cytohubba analysis
8 Results and discussion
9 Differentially expressed genes DESeq2
10 STRING enrichment analysis
11 Functional enrichment analysis
12 Cytohubba analysis for screening hubgene
13 Conclusion
References
Chapter Two: The mechanistic insights into different aspects of promiscuity in metalloenzymes
Abstract
1 Introduction
2 Promiscuity in enzymes
3 Promiscuity in metallo-enzymes
4 Evolutionary importance of promiscuity in metalloenzymes
5 Structural basis of promiscuity in metalloenzymes
6 Mechanisms of substrate recognition and binding
7 Active site plasticity and conformational changes
8 Structural determinants of promiscuity in metalloenzymes
9 Mechanistic insights into metalloenzyme promiscuity: Case studies
10 Cytochrome P450BM3
11 Dipeptide epimerases
12 Limonene hydroxylase (mint superfamily)
13 Homoserine kinase
14 Implications of metalloenzyme promiscuity
15 Industrial applications of promiscuous metalloenzymes
16 Conclusion
References
Further reading
Chapter Three: Metalloproteins structural and functional insights into immunological patterns
Abstract
1 Introduction
2 Metalloproteins—immunological behaviour
3 Structural and functional roles of metal ions in metalloproteins
4 Metal ion transporters in intracellular regulation
5 Conclusion
Acknowledgement
References
Chapter Four: A model of microtubule depolymerization by kinesin-8 motor proteins
Abstract
Abbreviations
1 Introduction
2 Methods
3 Results
4 Discussion
5 Conclusion
References
Chapter Five: Metalloproteins and metalloproteomics in health and disease
Abstract
Abbreviations
1 Introduction
2 Structure and classification
3 Metallochaperones
4 Mismetallation
5 Structure-function relationship
6 Metalloproteins regulome
7 Clinical implications of metalloproteins
8 Therapeutic prospective
References
Chapter Six: Decoding genetic and pathophysiological mechanisms in amyotrophic lateral sclerosis and primary lateral sclerosis: A comparative study of differentially expressed genes and implicated pathways in motor neuron disorders
Abstract
1 Introduction
2 Methodology
3 Results
4 Discussion
5 Conclusion
Acknowledgments
References
Chapter Seven: Exploring the effect of disease causing mutations in metal binding sites of human ARSA in metachromatic leukodystrophy
Abstract
1 Introduction
2 Methodology
3 Results
4 Discussion
5 Conclusion
References
Further reading
Chapter Eight: Epigenetic dysregulation in cancers by isocitrate dehydrogenase 2 (IDH2)
Abstract
1 Introduction
2 Cellular function of Isocitrate dehydrogenases
3 Pathological implications of IDH2 mutations
4 Epigenetic mechanisms of IDH2
5 Synergy exclusivity, and coordinated effects of IDH2 mutations in epigenetics
6 Isocitrate dehydrogenase 2 in acute myeloid leukemia
7 Conclusion
References
Chapter Nine: Transmembrane protein TMEM230, regulator of metalloproteins and motor proteins in gliomas and gliosis
Abstract
1 Introduction
2 Aberrant high level of transmembrane protein, TMEM230 is associated with lower survivability of glioma patients
3 TMEM230 promotes glial cell growth, cytoskeleton structure, micro channeling and extracellular matrix remodeling
4 TMEM230, regulator of metalloproteins and motor proteins
5 Transcriptomic analysis of patient derived oligodendroglioma
6 Transcriptomic analysis of patient-derived glioblastoma
7 Discussion
8 Conclusion
Acknowledgement
References
Chapter Ten: Single-cell transcriptomic analysis to identify endomembrane regulation of metalloproteins and motor proteins in autoimmunity
Abstract
1 Introduction
2 Results
3 Discussion
4 Conclusion
References
Chapter Eleven: Long-term culture of patient-derived mammary organoids in non-biogenic electrospun scaffolds for identifying metalloprotein and motor protein activities in aging and senescence
Abstract
1 Introduction
2 Polycaprolactone non-biogenic scaffolds for 2D and 3D cell culture of human patient cells for identifying secreted cellular components with tissue remodeling capacity or associated with in aging
3 Patient derived breast and skin 3D organoids and tissue for aging studies to identify aging and tissue regenerating factors
4 Discussion
5 Conclusion
Acknowledgements
References
Chapter Twelve: Vesicle transport of matrix metalloproteinases
Abstract
1 Introduction
2 ECM degrading metalloproteinases: matrix metalloproteinases (MMPs)
3 Invadopodia
4 Podosomes
5 Focal adhesion (FA)
6 Conclusions and future prospective
References
Chapter Thirteen: Motor proteins, spermatogenesis and testis function
Abstract
1 Introduction
2 Dyneins
3 Kinesins
4 Myosins
5 A hypothetical model on motor proteins-mediated germ cell transport at the BTB and the seminiferous epithelium utilizing the testis-specific anchoring junction ectoplasmic specialization (ES)
6 Concluding remarks
References
Chapter Fourteen: The crosstalk between extracellular matrix proteins and Tau
Abstract
1 Introduction
2 Glial activation intrigued by the pathological proteins in AD
3 Omega-3 fatty acids driven phagocytosis of extracellular Tau in microglia
4 Actin-remodeling-mediated phagocytic events in microglia
5 Actin remodeling and microstructures formation in immune cell function
6 α-linolenic acid induces membrane-associated actin remodeling in microglia during extracellular Tau clearance
Acknowledgments
References
Chapter Fifteen: G-protein coupled receptors regulates Tauopathy in neurodegeneration
Abstract
1 Neurodegeneration and Alzheimer’s disease
2 Tau structure and dynamics
3 Physiological and pathological characteristics of Microglia: A brain macrophage
4 Microglial role in Tau propagation and clearance in Alzheimer’s disease
5 G-protein coupled receptors in Alzheimer’s disease
6 Role of microglial purinergic receptor, P2Y12R in physiology and AD pathology
Acknowledgments
References
Chapter Sixteen: Gut microbial metalloproteins and its role in xenobiotics degradation and ROS scavenging
Abstract
Abbreviations
1 Introduction
2 Xenobiotics degrading metalloenzymes
3 ROS scavenging metalloproteins
4 Protein-protein interactions of metalloenzymes
5 Microbial metalloenzymes: the chief executives in human gut
6 Conclusion
Acknowledgements
References
Chapter Seventeen: Exploring metalloproteins found in the secretion of venomous species: Biological role and therapeutical applications
Abstract
1 Introduction
2 Metallomics on venomous species
3 Pharmaceutical and clinical applications of metalloproeteins from venomous species
4 Challenges of isolation-based venom biodiscovery
5 Outlook and concluding remarks
References
Chapter Eighteen: Coordination, cooperation, competition, crowding and congestion of molecular motors: Theoretical models and computer simulations
Abstract
Nomenclature
1 Introduction
2 Experimental methods
3 Single cytoskeletal motor proteins on a single protofilament
4 Single cytoskeletal motor proteins on single/multiple lanes of a filament
5 Multiple cytoskeletal motor proteins on single filament: rigid cargo
6 Multiple cytoskeletal motor proteins on single filament: soft cargo
7 Bidirectional cargo transport for team of antagonistic motors
8 Traffic of multiple motors on single filament
9 Multiple motors at filament intersections
10 Sliding and rowing of multiple motor crossbridges in filament bundles
11 Multiple motors in mitosis
12 Future directions
References

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Rossen Donev