Metal Transporters

Series Editors

Contributors

Preface

The Blossoming Field of Metal Transport Enters the Era of Mechanistic Research

Previous Volumes in Series

Chapter One Transferrin-Mediated Cellular Iron Delivery

1 Iron

2 Iron Homeostasis

3 Transferrin

4 The TFR

5 Recombinant Expression

6 Kinetics of Iron Release

7 Structure of the hTF/TFR Complex

Chapter Two Structure, Function and Binding Selectivity and Stereoselectivity of Siderophore–Iron Outer Membrane Transporters

1 Introduction

2 Siderophores

3 Structure of Siderophore–Iron TBDTs

4 Binding Sites of Siderophore–Iron TBDTs

5 Siderophore–Iron Transport by TBDTs

6 TBDT are Involved in Signaling Cascades

7 Conclusion

Chapter Three Iron Transport Machinery of Human Cells

1 Introduction

2 Iron Import across the Plasma Membrane

3 Iron Exporters and their Implications in Human Diseases

4 Intracellular Iron Transport and Iron Chaperones

5 Mitochondrial Iron Import and Export

6 Future Directions

Chapter Four Structure and Function of Copper Uptake Transporters

1 Introduction

2 CTR—A Conserved Family of CTRs

3 The Structure of Human CTR1

4 Implications for the Mechanism of Copper Transport

5 Copper Transport in the Physiological Milieu

6 Structure–Function Relations in CTR proteins

Chapter Five Toward a Molecular Understanding of Metal Transport by P1B-Type ATPases

1 Introduction

2 Mechanism

3 Structure

4 Future Directions and Challenges

Chapter Six Regulation of Copper Transporters in Human Cells

1 Copper Auto Regulates its Cytoplasmic Levels by Modulating the Amounts of a High-Affinity Transporter CTR1 at the Plasma Membrane

2 Regulation of Copper Export via Protein Trafficking and Kinase-Mediated Phosphorylation

3 Redox Control of Copper Uptake and Efflux from Human Cells

Chapter Seven Metal Export by CusCFBA, the Periplasmic Cu(I)/Ag(I) Transport System of Escherichia coli

1 Introduction

2 Cus System Components

3 Cus Complex Assembly and Mechanism

Chapter Eight Molecular Architecture and Function of ZnT Transporters

1 Introduction

2 Structure and Transport Mechanism

3 Expression and Subcellular Localization

4 Physiological Significance

5 Conclusion

Chapter Nine The Cation Selectivity of the ZIP Transporters

1 Introduction

2 Mammalian Zinc Transporter Subfamilies

3 Cation Selectivity of the ZIP Proteins

4 Future Perspectives

Chapter Ten Nramp

1 Introduction

2 A Family of Membrane Permeases Highly Conserved from Bacteria to Man

3 The Nramp Family is Distantly Related to the LeuT Superfamily

4 Structure–Function Relationships Among Slc11 Carriers

5 Regulation of Bacterial mnth Expression and Virulence

6 Nramp Role in Eukaryotic Host Defense

7 Natural Evolution of Nramp in Nutritional Immunity

8 Pathological Implications of Nramp Function

9 Conclusions

Chapter Eleven Genetic and Biochemical Approaches for Studying the Yellow Stripe-Like Transporter Family in Plants

1 Introduction

2 Founders of the Family: The YS Transporters

3 Genetic Studies of YSL Genes

4 Biochemical Studies of YSL Genes

5 Conclusions and Future Perspectives

Chapter Twelve Pathways of Arsenic Uptake and Efflux

1 Introduction

2 Uptake Systems for Arsenic

3 Efflux Systems for Arsenic

4 The ArsD As(III) Metallochaperone and Its Interaction with the ArsA ATPase

Chapter Thirteen Extracellular Heme Uptake and the Challenges of Bacterial Cell Membranes

1 Introduction

2 Heme Capture and Transport Across the Cell Wall and Membranes

3 Transmembrane Heme Sensors and ATP-Dependent Efflux Pumps

4 Heme Uptake and Utilization in Antimicrobial Drug Development

5 Future Perspectives

Chapter Fourteen The Mechanisms of Mg2+ and Co2+ Transport by the CorA Family of Divalent Cation Transporters

1 Overview

2 Introduction

3 Properties of Mg2+ and Co2+

4 The CorA Family of Mg2+/Co2+ Transporters

5 The Mechanisms of Mg2+ and Co2+ Transport Through CorA

6 Concluding Remarks

Index

Color Plates