Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders

1st Edition, Volume 168 - February 1, 2023
Imprint: Academic Press
Editors: Lori Knackstedt, Marek Schwendt
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 3 9 4 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 3 9 5 - 1

Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with t… Read more

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Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as mGlu receptors in Parkinson’s disease, Metabotropic glutamate receptors in estradiol-mediated motivated behaviors in females, mGlu regulation of sleep, Implications for sleep disruptions in psychiatric disorders, Mechanisms of mGlu receptor trafficking; alterations by methamphetamine, Group I mGlu and cocaine seeking, The role of mGlu receptors in fear and anxiety, Regulation of Alcohol Consumption, Reward, Dependence, and Perception by Metabotropic Glutamate Receptor Signaling, and mGlu5 as a biomarker for psychiatric disorders.

Cover
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Metabotropic glutamate receptors in Parkinson's disease
Abstract
1: Introduction
2: mGlu5 receptors
3: mGlu4 receptors
4: mGlu2 receptors
5: Summary and perspectives
References
Chapter Two: The interaction of membrane estradiol receptors and metabotropic glutamate receptors in adaptive and maladaptive estradiol-mediated motivated behaviors in females
Abstract
1: Introduction
2: Receptor signaling
3: Estrogen in motivated behaviors: Reproduction
4: Estrogen in motivated behaviors: Dysregulation and drug addiction
5: Conclusion
References
Chapter Three: Metabotropic glutamate receptor function and regulation of sleep-wake cycles
Abstract
1: Introduction
2: Overview of metabotropic glutamate receptors (mGlu receptors)
3: Sleep
4: Discussion
References
Chapter Four: The role of metabotropic glutamate receptors in neurobehavioral effects associated with methamphetamine use
Abstract
1: Methamphetamine use disorder (MUD)—Characteristics
2: Metabotropic glutamate receptors (mGlu)—An overview
3: mGlu receptors and methamphetamine-associated neural changes
4: mGlu receptors and meth-induced behavioral effects
5: mGlu receptor interaction with other neurotransmitter receptors in the context of methamphetamine-associated neural and behavioral effects
6: Conclusions
References
Chapter Five: The role of mGlu receptors in susceptibility to stress-induced anhedonia, fear, and anxiety-like behavior
Abstract
1: Introduction
2: Animal models of stress induction
3: Behavioral tests for anxiety-like behavior, anhedonia, and fear
4: Brain-wide mGlu5 and stress-induced anhedonia, fear, and anxiety-like behavior
5: The mGlu5-containing circuitry underlying stress-induced anhedonia, fear, and anxiety-like behavior
6: Summary of mGlu5 role in anhedonia, fear, and anxiety-like behavior
7: mGlu2 and mGlu3 receptors and stress-induced anhedonia, fear, and anxiety-like behavior
8: The mGlu2/3-containing circuitry underlying stress-induced anhedonia, fear, and anxiety-like behavior
9: mGlu2/3 conclusions
10: General conclusions
References
Chapter Six: The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders
Abstract
1: Introduction
2: Quantifying mGlu5 with PET
3: Mood disorders
4: Anxiety and trauma disorders
5: Substance use: Nicotine, cannabis, and alcohol
6: Summary and commentary
References
Chapter Seven: Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity
Abstract
1: Introduction
2: Sex differences in mGlu receptor function
3: Insight gained from behavioral pharmacology, transgenic mice, and disease models
4: Conclusions
References
Chapter Eight: Roles of metabotropic glutamate receptor 8 in neuropsychiatric and neurological disorders
Abstract
1: Introduction
2: mGlu8 receptors
3: Anxiety
4: Epilepsy
5: Parkinson's disease
6: Drug addiction
7: Chronic pain
8: Alzheimer's disease
9: Conclusions
References
Chapter Nine: Metabotropic glutamate receptors and cognition: From underlying plasticity and neuroprotection to cognitive disorders and therapeutic targets
Abstract
1: Introduction
2: Metabotropic glutamate receptor physiology
3: Cognition: An executive function
4: Mediating cognition: The prefrontal cortex
5: Synaptic plasticity and mGlu receptors
6: mGlu receptors and cognition: Diseases and associations
7: Targeting mGlu receptors as a therapeutic for cognitive therapy
8: Conclusion
Funding
References

Lori Knackstedt

Prof. Lori Knackstedt has a long-standing interest in studying the pathological changes in brain and behavior which occur in response to addictive drugs. For the past nine years, her work has focused on identifying neuroadaptations in the glutamate neurotransmitter system produced by chronic self-administration of addictive drugs such as nicotine, alcohol and cocaine. She then target these neuroadaptations with translational compounds to reduce drug-seeking. To that end, her research involves assessing brain changes in reward circuitry following self- administration of addictive drugs using western blotting, immunohistochemistry, and microdialysis. Prof. Knackstedt began her independent research career as a Research Assistant Professor at the Medical University of South Carolina in 2009. In Fall 2012, she began a tenure-track position in the Psychology Department at UF, where she now run the Neurobiology of Addiction Research Lab. She supervises three graduate students, one post-doctoral fellow and 7 undergraduates.

Affiliations and expertise

Associate Professor, Department of Psychology, College of Liberal Arts and Sciences, University of Florida, FL, USA

Marek Schwendt

Dr. Schwendt is an Assistant Professor in the Department of Psychology at the University of Florida, Gainesville, FL. His research focuses on psychostimulant induced neuroplasticity underlying persistent drug-seeking and cognitive impairments. Dr. Schwendt completed his M.S. in Comenius University, Bratislava, Slovakia, and his Ph.D. in the Institute of Exp. Endocrinology & University of P.J. Safarik, Bratislava, Slovakia. He completed his Postdoctoral Fellowship in the Medical University of South Carolina, Charleston, SC Dr. Schwendt is interested in what causes drug addiction to be a chronic relapsing disorder. He is interested in identifying cellular and molecular mechanisms underlying relapse and drug-induced cognitive deficits which persist well into abstinence. His research utilizes an animal model with high-face validity for human addiction: operant drug self-administration in combination with tasks designed to test memory performance in animals. In particular, his research attempts to elucidate the role of modulatory proteins that ‘fine-tune’ synaptic transmission during development of drug-induced neural plasticity, and further, to investigate whether in vivo manipulation of these proteins can attenuate or reverse drug-seeking and drug-induced cognitive deficits. Dr. Schwendt believes that characterization of the molecular underpinnings of the long-lasting behavioral consequences of repeated drug administration will provide critical insight into the psychopathology of drug addiction and related psychiatric disorders (including schizophrenia and depression).

Affiliations and expertise

Assistant Professor, Department of Psychology, University of Florida, FL, USA

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