1. Overview: Spatial control of signal transduction by caveolae and lipid rafts (C.J. Fielding). 2. Overview: Membrane lipid peroxidation (K. Montine, J. Quinn, T. Montine). 3. Regulation of invertebrate longevity by inositol phosphate signaling (C. Wolkow). 4. Ceramide-driven stress signals in cancer and aging
(P.P. Ruvolo, C. Johnson, W.D. Jarvis). 5. Sphingolipid metabolism and signaling in atherosclerosis (S. Chatterjee, S. Martin). 6. Sphingolipid and ceramide in brain aging, neuronal plasticity and neurodegenerative disorders (M.P. Mattson, R.G. Cutler). 7. The eicosanoid pathway and brain aging (H. Manev, T. Uz). 8. Cellular cholesterol, membrane signaling and disease
(J.P. Incardona). 9. Cholesterol, &bgr;-amyloid, and Alzheimer's disease (S. Petanceska, M.A. Pappolla et al.). 10. Phospholipase A2 in the pathogenesis of cardiovascular disease (E. Hurt-Camejo, P. Sartipy et al.). 11. Retinal docosahexaenoic acid, age-related diseases and glaucoma (N.G. Bazan, E. Rodriguez).