Membrane Biomechanics
- 1st Edition, Volume 86 - October 23, 2020
- Imprint: Academic Press
- Editors: Irena Levitan, Andreea Trache
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 0 2 1 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 0 2 2 - 2
Membrane Biomechanics, Volume 86, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting intere… Read more
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Request a sales quoteMembrane Biomechanics, Volume 86, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on Lipid bilayers: phase behavior and mechanics, Molecular mechanisms of cell membrane structure modification by omega-3 fatty acids, Mechanical properties of magnetoliposomes, Mechanosensitive ion channels and membrane tension, From cell membrane to the nuclear membrane through modulation of cytoskeleton, Endothelial stiffness in dyslipidemia and aging, Vascular smooth muscle stiffness in aging and vascular disease, Mechanobiology of macrovesicle release and activation, Interplay of membrane cholesterol and substrate on vascular smooth muscle mechanics, and more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Current Topics in Membranes series
- Includes the latest information on Membrane Biomechanics
Undergraduates, graduates, academics and researchers in the field of plasma membrane repair
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Lipid bilayers: Phase behavior and nanomechanics
- Abstract
- 1: Introduction
- 2: Experimental approaches to study membrane mechanics
- 3: Phase behavior and nanomechanics. From one-component membranes to higher complexity
- 4: Connection between nanoscale measurements and thermodynamic descriptors of membranes
- 5: Conclusions and future perspectives
- Acknowledgments
- Glossary of lipid acronyms
- Chapter Two: Membrane modulatory effects of omega-3 fatty acids: Analysis of molecular level interactions
- Abstract
- 1: Introduction
- 2: Health benefits of omega-3 polyunsaturated fatty acids
- 3: Chemical structures of long-chain omega-3 polyunsaturated fatty acids
- 4: Hypothesized mechanisms of action of omega-3 PUFAs on cardiovascular health
- 5: Membrane modulatory effects of omega-3 PUFAs
- 6: Conclusion
- Acknowledgment
- Chapter Three: Cell membrane mechanics and mechanosensory transduction
- Abstract
- 1: Introduction
- 2: Cell membrane mechanics
- 3: Mechanosensitive ion channels
- 4: Summary and conclusions
- Chapter Four: Mechanics of the cell: Interaction mechanisms and mechanobiological models
- Abstract
- 1: Introduction
- 2: Interconnection between extracellular matrix and cytoskeleton through cell membrane
- 3: Cytoskeletal structure and function
- 4: Nuclear membrane
- 5: Computational modeling of intracellular biomechanics
- Chapter Five: Mechanisms of endothelial stiffening in dyslipidemia and aging: Oxidized lipids and shear stress
- Abstract
- 1: Introduction
- 2: Discriminating between the stiffness of the arterial wall and the stiffness of the endothelium
- 3: Endothelial stiffening in atheroprone regions: Impact of dyslipidemia
- 4: Endothelial stiffening in aging
- 5: Physiological factors that cause EC stiffening and mechanistic insights
- 6: Functional outcomes of EC stiffening
- 7: Conclusions
- Chapter Six: Vascular smooth muscle stiffness and its role in aging
- Abstract
- 1: Introduction
- 2: Aging as an independent risk factor in cardiovascular disease
- 3: Arterial stiffness and its contribution to aging
- 4: Vascular smooth muscle function in aged arteries
- 5: Conclusions
- Acknowledgments
- Chapter Seven: Mechanobiology of microvesicle release, uptake, and microvesicle-mediated activation
- Abstract
- 1: Introduction
- 2: Mechanobiology of microvesicle biogenesis
- 3: Mechanobiology of microvesicle transport and uptake
- 4: Mechanobiology of MV-mediated cell activation
- 5: Conclusions
- Acknowledgments
- Chapter Eight: The interplay of membrane cholesterol and substrate on vascular smooth muscle biomechanics
- Abstract
- 1: Introduction
- 2: Alterations in VSMC biomechanics in the progression of atherosclerosis
- 3: The role of lipids and cholesterol in driving cardiovascular disease
- 4: Atomic Force Microscope, a powerful tool to study live VSMC biomechanics
- 5: Impact of vascular ECM stiffness and cholesterol on VSMC biomechanics
- 6: Conclusions and future directions
- Acknowledgment
- Chapter Nine: Roles of microglial membranes in Alzheimer's disease
- Abstract
- 1: Introduction
- 2: The roles of lipid rafts in microglial-mediated oxidative stress
- 3: The roles of membrane-cytoskeleton adhesion in microglial-mediated clearance of Aβ
- 4: Roles of microglial-derived extracellular vesicles in AD
- 5: Conclusion
- Acknowledgment
- Edition: 1
- Volume: 86
- Published: October 23, 2020
- Imprint: Academic Press
- No. of pages: 326
- Language: English
- Hardback ISBN: 9780128210215
- eBook ISBN: 9780128210222
IL
Irena Levitan
Irena Levitan, PhD, is a Professor of Medicine and Bioengineering at the University of Illinois at Chicago. She received her PhD in Biophysics and Neurobiology at the Hebrew University of Jerusalem in 1994 and completed postdoctoral training at the Medical College of Pennsylvania and Institute for Medicine and Engineering at the University of Pennsylvania. Her research focuses on the biophysical properties of endothelial membranes and sub-membrane cytoskeleton. Specifically, the studies of her group, which combine computational and experimental biophysical approaches, provided the first comprehensive structural insights into cholesterol regulation of K+ channels. In 2012, she was named a Guyton Distinguished Lecturer “for her quantitative and biophysical work on cholesterol modulation of ion channels and how this can affect integrated organ function”. She and her group also discovered a paradoxical relationship between fluidity/deformability of the membrane and cell stiffness. In 2018, she was elected a Fellow of AIMBE for “outstanding contributions to our understanding of lipid-ion channel interactions, cellular biomechanics and vascular dysfunction under dyslipidemia”.
Affiliations and expertise
Professor of Medicine and Adjunct Professor of Pharmacology and Bioengineering, University of Illinois, Chicago, USAAT
Andreea Trache
Andreea Trache is at Texas A&M University, USA
Affiliations and expertise
Texas A&M University, USARead Membrane Biomechanics on ScienceDirect