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Melatonin
A Ubiquitous Pleiotropic Molecule
- 1st Edition - July 31, 2024
- Editors: Sheikh Mansoor Shafi, Faheem Shahzad Baloch, Yong Suk Chung, Alejandro Romero Martínez
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 8 1 4 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 8 1 5 - 7
Melatonin: A Ubiquitous Pleiotropic Molecule equips researchers with an understanding of the molecular biology of melatonin in plants. The book explores the occurrence of melatonin… Read more
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Request a sales quoteMelatonin: A Ubiquitous Pleiotropic Molecule equips researchers with an understanding of the molecular biology of melatonin in plants. The book explores the occurrence of melatonin in several plant species, covering key aspects, including its biosynthesis, physiological function in plant growth and development, and signaling pathways. It then discusses the benefits melatonin has for plant and agricultural development, as well as how it can be utilized as a therapeutic in the treatment of human diseases. The role it can play in the oxidative stress response and circadian rhythm modulation are covered, as well as its nutraceutical potential for human health.
The book also covers the importance of melatonin in a range of fields, including drug discovery and disease resistance, agriculture, botany, and biotechnology, and is an ideal reference for researchers across these disciplines.
- Examines melatonin’s pivotal role as a signaling molecule, elucidating its involvement in a diverse array of biological responses within plants
- Covers essential aspects like melatonin biosynthesis, regulation, antioxidant properties, and its involvement in stress management in plants
- Provides an interdisciplinary study of melatonin and its potential uses, including disease management, crop improvement, and nutraceutical development
- Addresses melatonin’s multifaceted role in regulating key physiological processes in the human body, including circadian rhythms, sleep–wake cycles, and neurological protection
- Delves into melatonin’s dual role as an immunomodulator influencing immune cells and a powerful antioxidant combating free radicals and alleviating oxidative stress
- Explores melatonin’s therapeutic and anticancer potential, emphasizing its importance in cardiovascular health, neurology, and cancer research, attributed to its antioxidant and anti-inflammatory characteristics
Scientists, researchers and students involved in the development and role of melatonin; those in plant molecular biology, biochemistry, plant science, agriculture, biotechnology and related fields, Related industries including plant growth regulators, food industries and pharmaceutical companies
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- About the editors
- Foreword
- Preface
- Section I. Phyto-melatonin in plant system
- Chapter 1. Phytomelatonin occurrence, biosynthesis and regulation
- 1. Introduction
- 2. Biosynthesis and occurrence of phytomelatonin
- 3. Regulation of phytomelatonin
- 4. Conclusion
- Chapter 2. Phytomelatonin receptors and interacting protein
- 1. Introduction
- Chapter 3. Melatonin: A positive regulator of plant growth and development
- 1. Introduction
- 2. Melatonin synthesis evidence
- 3. Melatonin transport
- 4. Melatonin in plant kingdom
- 5. MEL as a potential antioxidant
- 6. Melatonin as a plant growth stimulant
- 7. MEL controls plant–rhizomicrobial interactions
- 8. Melatonin possibilities in phytoremediation
- 9. Conclusion
- Chapter 4. Phytomelatonin: Plant immunity and plant–microbial interactions
- 1. Introduction
- 2. Phytomelatonin biosynthesis
- 3. Active sites for phytomelatonin synthesis in plant cells
- 4. Impact of radicals in phytomelatonin actions during plant defense response
- 5. Role of phytomelatonin in plant defense responses
- 6. Phytomelatonin and plant–microbe interaction
- 7. Conclusion
- Chapter 5. Exogenous application of melatonin in plants under stress conditions to enhance the quality of agricultural/horticulture crops
- 1. Introduction
- 2. Biosynthesis of melatonin in plants
- 3. The quantity of melatonin present in agricultural plants
- 4. Drought-resistant horticulture crops can benefit from melatonin
- 5. The effects of melatonin on how horticultural crops react to heat stress are profound
- 6. Horticultural crops can tolerate salt stress with the aid of melatonin
- 7. Horticultural crops can experience less cold stress due to the functions of melatonin
- 8. An essential tool for controlling biotic stress is melatonin
- 9. Melatonin's functions in the regulation of the production and maturation of horticultural plants
- 10. Root growth of agricultural plants: Melatonin's impacts
- 11. Conclusion
- Chapter 6. Antioxidant potential of phytomelatonin
- 1. Introduction
- 2. Isolation of phytomelatonin
- 3. Chemistry of melatonin
- 4. Melatonin synthesis
- 5. Melatonin uptake
- 6. Melatonin in plant material
- 7. Antioxidant candidate from medicinal plants
- 8. Melatonin as a plant development promoter
- 9. Conclusion
- Chapter 7. Phytomelatonin crosstalk with plant growth regulators
- 1. Introduction
- 2. Crosstalk between phytomelatonin and PGRS
- 3. Role of phytomelatonin in plants
- 4. Conclusion and future perspectives
- Chapter 8. Multidimensional role of melatonin
- 1. Introduction
- 2. Melatonin and controlling body weight
- 3. Melatonin with postprandial dysmetabolism, hyperglycemia, and dyslipidemia
- 4. Melatonin and oxidative stress regulation
- 5. Controlling blood pressure with melatonin
- 6. Conclusion
- Section II. Melatonin in human system
- Chapter 9. Physiological functions of melatonin
- 1. Introduction
- 2. Pharmacokinetics
- 3. Mechanisms of action
- 4. Effects of melatonin
- 5. Conclusion and future directions
- Chapter 10. Therapeutic and pharmacological potential of melatonin
- 1. Introduction
- 2. Pharmacology
- 3. Melatonin receptors
- 4. Mechanism of action
- 5. Bioavailability
- 6. Pharmacokinetics
- 7. Drug–drug interactions, contraindication and, adverse reactions
- 8. Adverse reactions
- 9. Therapeutic effects of melatonin
- 10. Conclusion
- Chapter 11. Melatonin and immune modulation
- 1. Introduction
- 2. Melatonin and innate immunity
- 3. Adaptive immune responses and melatonin
- 4. Melatonin and autoimmune diseases
- 5. Inflammatory response and melatonin
- 6. Melatonin and immunosenescence
- 7. Clinical implications and future directions
- Chapter 12. Neuroendocrine role of melatonin
- 1. Introduction
- 2. Propagation of time-signal by melatonin
- 3. Melatonin reception in the pituitary
- 4. Putative postreceptor pathways in the pituitary
- 5. Melatonin–prolactin interaction
- 6. Effects on reproductive hormones
- 7. Dysregulation of circadian rhythms in shift workers
- 8. Effects of melatonin in pregnancy
- 9. Effects on male reproductive hormones
- 10. Effects on the thyroid
- 11. Effects on the suprarenal glands
- 12. Conclusion
- Chapter 13. Melatonin and its derivatives: The potential roles as anticancer agents
- 1. Introduction
- 2. Melatonin biosynthesis and metabolism
- 3. Roles of melatonin in cancer chemoprevention and therapy
- 4. Anticancer mechanisms of melatonin: Effects on major cancer hallmarks
- 5. Potential challenges of melatonin as an anticancer agent
- 6. Conclusion
- Chapter 14. Melatonin in cancer research and treatment: From bench to bedside
- 1. Introduction
- 2. Melatonin: Chemical properties and natural sources
- 3. Melatonin: Absorption, metabolism, and bioavailability
- 4. Melatonin as an anticancer agent: Mechanisms of action
- 5. Melatonin drug formulation and dosage form
- 6. Melatonin in clinical trials
- 7. Conclusion
- Chapter 15. Melatonin in oxidative stress management
- 1. Introduction
- 2. Melatonin synthesis
- 3. Melatonin in oxidative stress
- 4. Direct scavenging of free radicals by melatonin
- 5. Indirect antioxidant effects, including enhancement of other antioxidants
- 6. Metal chelation
- 7. Mitochondrial protection
- 8. Neuroprotective effects of melatonin
- 9. Cardioprotective effects of melatonin
- 10. Melatonin and aging
- 11. Conclusion
- Section III. Melatonin: The multitasking hormone
- Chapter 16. Melatonin and sleep
- 1. Introduction
- 2. Sleep physiology
- 3. Role of melatonin in sleep
- 4. Melatonin for curing sleep disorder
- 5. Shortcomings of melatonin
- 6. Conclusion
- Chapter 17. Melatonin signaling and drug–receptor interaction
- 1. Introduction
- 2. Receptor types
- 3. Cross-talk with other signaling pathways
- 4. Clock genes and circadian rhythms
- 5. Drug–receptor interaction
- 6. Clinical applications
- 7. Conclusion and future implications
- Chapter 18. Nutraceutical potential of melatonin on human health
- 1. Introduction
- 2. Phytomelatonin in plants
- 3. Biosynthesis of phytomelatonin
- 4. Phytomelatonin as a nutraceutical
- 5. Melatonin in human being
- 6. Average range of conditions for which melatonin may be clinically useful
- 7. Phytomelatonin as an antioxidant
- 8. Anticarcinogenic activity of phytomelatonin
- 9. Phytomelatonin as a jet lag treatment and sleep quality enhancement
- 10. Melatonin and phytomelatonin sources
- Chapter 19. The impact of melatonin on maternal and fetal health during pregnancy
- 1. Introduction
- 2. Melatonin on fetal neuro and cardiovascular development
- 3. Conclusion
- Index
- No. of pages: 360
- Language: English
- Edition: 1
- Published: July 31, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443138140
- eBook ISBN: 9780443138157
SS
Sheikh Mansoor Shafi
FB
Faheem Shahzad Baloch
YC
Yong Suk Chung
AR