Meiosis in Development and Disease

1st Edition, Volume 151 - January 11, 2023
Imprint: Academic Press
Editor: Francesca Cole
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 1 5 6 - 5
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 1 6 2 - 6

Meiosis in Development and Disease, Volume 151 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting inter… Read more

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Meiosis in Development and Disease, Volume 151 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The initiation stages of meiosis, The molecular basis and dynamics of meiotic cohesions, and their significance in human infertility, Chromatin, recombination, and the centromeres, Sites and structures that mediate segregation when crossing over calls out sick/Life (or at Least Meiosis) Without Crossing Over, Crossover maturation inefficiency, Non coding RNA mediated gene regulation in meiosis, Short chromosomes in meiotic recombination, Chromatin level changes during meiosis initiation vs. oncogenesis, and much more.

Other sections of note include Chromosomal speciation revisited: Meiotic recombination and synapsis of evolutionary diverged homologs, Recombination suppression at specific chromosome regions, Unwinding during stressful times - mechanisms of helicases in meiotic recombination, Meiotic functions of PCH-2/TRIP13 and HORMADs, Crossover interference, Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics, The breadth of meiotic drive genes and mechanisms across the tree of life, and many more interesting topics.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Mechanism of initiation of meiosis in mouse germ cells
Abstract
1: Introduction
2: STRA8 plays a key role in the initiation of meiosis
3: MEIOSIN interacts with STRA8 during meiotic initiation
4: MEIOSIN and STRA8 direct the switch from mitosis to meiosis
5: MEIOSIN together with STRA8 determines meiotic entry
6: MEIOSIN and STRA8 activate meiotic prophase program
7: MEIOSIN and STRA8 boost the transcription of the meiotic genes
8: Sexual difference of meiotic initiation
9: Evolutionary conservation and divergence in the meiotic entry system
10: Conclusion
Acknowledgments
Conflict of interest statement
References
Chapter Two: Orchestrating recombination initiation in mice and men
Abstract
1: Introduction—Orchestrating the critical stages of recombination initiation
2: Germline replication timing affects broad-scale recombination patterning
3: Chromatin loop array formation and loop extrusion
4: Creating an accessible local chromatin environment
5: Chromatin opening meiosis-specific Pioneer Complex
6: Associate putative hotspot sites in the DNA loops with the chromosomal axis
7: Facilitating efficient homology engagement and DSB repair
8: PRDM9 redundant meiotic recombination initiation
9: Summary
References
Chapter Three: Cancer and meiotic gene expression: Two sides of the same coin?
Abstract
1: Introduction
2: Global DNA demethylation
3: Histone modifications
4: DNA accessibility
5: Higher-order of chromatin structure
6: Conclusions
Acknowledgments
Author contributions
References
Chapter Four: Phase separation in controlling meiotic chromosome dynamics
Abstract
1: Chromosome dynamics during meiosis
2: Phase separation to form biomolecular condensates in cells
3: Phase separation in controlling chromatin organization and activities
4: Phase separation in meiotic recombination initiation
5: Phase separation in homologous chromosome pairing
6: Phase separation in synapsis
7: Potential phase separation in mammalian sex body formation
8: Perspectives
Acknowledgments
References
Chapter Five: Meiotic chromosome organization and its role in recombination and cancer
Abstract
1: Chromatin and chromosome organization during meiosis
2: Evolution of the core axis proteins and the synaptonemal complex
3: Morphogenesis and remodeling of the chromosome axis
4: Roles of chromosomal axis proteins in DSB and crossover formation during meiosis
5: Does the chromosome axis play a role in CO interference?
6: Temperature-based regulation of axis proteins and the impact on recombination
7: Aberrant expression of the HORMADs and SC proteins regulates intrinsic DNA repair activities in somatic cancer cells
Acknowledgments
References
Chapter Six: Chromosome-specific behaviors during early meiosis
Abstract
1: Introduction
2: What is meiosis?
3: How do chromosomes differ from each other?
4: Association between meiotic errors and chromosome structure in humans
5: Regulation of crossing over on different chromosomes
6: Chromatin composition can influence multiple aspects of meiosis
7: Aspects of chromosome biology that alter meiotic nuclear organization
8: Other examples of chromosome-specific defects
9: Summary
Acknowledgments
References
Chapter Seven: Emerging mechanisms and roles of meiotic crossover repression at centromeres
Abstract
1: Introduction
2: The “centromere” effect
3: Mechanisms of meiotic crossover repression at centromeres
4: Saccharomyces cerevisiae
5: Schizosaccharomyces pombe
6: Caenorhabditis elegans
7: Drosophila melanogaster
8: Plants
9: Mammals
10: Pericentric crossovers and chromosomal mis-segregation
11: Role of pericentric crossovers in human diseases
12: Future perspectives
Acknowledgment
References
Chapter Eight: Unwinding during stressful times: Mechanisms of helicases in meiotic recombination
Abstract
1: Introduction
2: Helicases and meiotic recombination
3: Summary
Acknowledgments
References
Chapter Nine: Meiotic crossover interference: Methods of analysis and mechanisms of action
Abstract
1: Introduction
2: Methods for measuring crossover interference
3: Complications in interpreting interference data
4: Proteins required for crossover interference
5: Models of crossover interference
6: Conclusions and future research
Acknowledgments
References
Further reading
Chapter Ten: Small RNAs and their protein partners in animal meiosis
Abstract
1: Introduction
2: RNA binding proteins in non-coding RNA pathways
3: Roles for small RNAs and associated RBPs in the germline
4: Meiotic silencing of unpaired chromatin
5: Meiotic silencing of sex chromatin
6: Pericentromeric heterochromatin remodeling during meiosis
7: Regulation of meiotic recombination and double strand break repair
8: Concluding remarks
Acknowledgments
References
Chapter Eleven: Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics
Abstract
1: Mitotic and meiotic checkpoints
2: Unique requirements of meiotic prophase
3: The meiotic prophase checkpoint
4: The logic of the spindle assembly checkpoint
5: The meiotic prophase checkpoint: Logic and open questions in light of the SAC
6: Meiotic checkpoint factors in cancer?
Acknowledgments
References
Chapter Twelve: PCH-2 and meiotic HORMADs: A module for evolutionary innovation in meiosis?
Abstract
1: Introduction
2: The PCH-2/HORMAD module
3: The role of meiotic HORMADs
4: PCH-2/Pch2/PCH2/TRIP13 in meiosis
5: Localization of PCH-2
6: Role in pairing and synapsis
7: Role in recombination
8: Role in regulating meiotic progression
9: Requirement for a cofactor
10: A unified model of PCH-2’s role in meiotic prophase
11: Conclusion
References
Chapter Thirteen: In vitro spermatogenesis: Why meiotic checkpoints matter
Abstract
1: Introduction
2: Key meiotic events during meiosis
3: Meiotic checkpoint mechanisms
4: Prospects of in vitro spermatogenesis for research or clinical use
Acknowledgments
References

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