Medicinal Chemistry
The Role of Organic Chemistry in Drug Research
- 2nd Edition - December 7, 1992
- Authors: Stanley M. Roberts, C. R. Ganellin
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 2 7 4 1 2 0 - 3
This Second Edition covers exciting progress recently made with individual drugs and includes a special chapter on the impact of molecular biology on drug design. Other additions… Read more
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Request a sales quoteThis Second Edition covers exciting progress recently made with individual drugs and includes a special chapter on the impact of molecular biology on drug design. Other additions to the Second Edition include structure-activity relationships, the role of molecular biology in drug discovery, and drug access and prodrugs. Written for students considering a research career in drug development, this volume is conveniently divided into two parts. The first half introduces readers to the mechanisms of action of drugs and the approaches adopted in designing new drugs. The second half contains chapters written by the discoverers or developers of individual successful drugs who trace the history of the drugs to the present day.
AUDIENCE: Senior undergraduate students in organic chemistry and medicinal chemistry.
Contributors
Preface
1. Introduction to Receptors and the Action of Drugs
2. Structure and Atalytic Properties of Enzymes
3. Receptor Pharmacology
4. Drug Access and Prodrugs
5. QSAR and the Role of Computers in Drug Design
6. The Current Status and Future Impact of Molecular Biology in Drug Discovery
7. General Approaches to Discovering New Drugs: An Historical Perspective.
8. Discovery and Development of Cromakalim and Related Potassium Channel Activators
9. Angiotension-Converting Enzyme (ACE) inhibitors and the Design of Cilazapril
10. Beta Blockers
11. Salbutamol: A Selective B2-Stimulant Bronchodilator
12. Discovery of CCimetidine, Ranitidine and Other H2-Receptor Histamine Antagonists
13. Fluconazole, An Orally Active Antifungal Agent
14. Clavulanic Acid and Related Compounds: Inhibitors of B-Lactamase Enzymes
Index
Preface
1. Introduction to Receptors and the Action of Drugs
2. Structure and Atalytic Properties of Enzymes
3. Receptor Pharmacology
4. Drug Access and Prodrugs
5. QSAR and the Role of Computers in Drug Design
6. The Current Status and Future Impact of Molecular Biology in Drug Discovery
7. General Approaches to Discovering New Drugs: An Historical Perspective.
8. Discovery and Development of Cromakalim and Related Potassium Channel Activators
9. Angiotension-Converting Enzyme (ACE) inhibitors and the Design of Cilazapril
10. Beta Blockers
11. Salbutamol: A Selective B2-Stimulant Bronchodilator
12. Discovery of CCimetidine, Ranitidine and Other H2-Receptor Histamine Antagonists
13. Fluconazole, An Orally Active Antifungal Agent
14. Clavulanic Acid and Related Compounds: Inhibitors of B-Lactamase Enzymes
Index
- No. of pages: 368
- Language: English
- Edition: 2
- Published: December 7, 1992
- Imprint: Academic Press
- Hardback ISBN: 9780122741203
CG
C. R. Ganellin
Affiliations and expertise
University College London, UK