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Medical Epigenetics

  • 2nd Edition, Volume 29 - August 26, 2021
  • Latest edition
  • Editor: Trygve Tollefsbol
  • Language: English

**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a… Read more

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Description

**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine.

This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs.

Key features

  • Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice
  • Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine
  • Organized from system disorders to multi-system disorders that involve epigenetic aberrations
  • Examines the role of epigenetics in precision medicine

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology; life science researchers; developmental biologists. Clinicians and graduate students in the biosciences

Table of contents

Section A Overview

1. Advances in medical epigenetics
Section B General medical aspects of epigenetics

2. Environmental epigenetic epidemiology

3. Lifestyle and preventive medical epigenetics

4. Environmental medical epigenetics: A review of epigenetically induced medical risks generated from exposures in our air, food, and personal products

5. Behavioral medical epigenetics

6. Medical epigenetics and twins

7. Epigenetic biomarkers of disease

8. Prognostic epigenetics
Section C Epigenetics of system disorders

9. Autoimmune disease and epigenetics

10. Epigenetics of pulmonary diseases

11. Cardiovascular disorders and epigenetics

12. Epigenomics of intestinal disease

13. Epigenetics of skin disorders

14. Epigenetics in bone and joint disorders

15. Epigenetics of muscle disorders

16. Reproductive disease epigenetics

17. Epigenetics in ocular medicine
Section D Multi-system medical epigenetics

18. Pediatric diseases and epigenetics

19. Epigenetics of infectious diseases

20. Clinical utility of solid tumor epigenetics

21. Epigenetics in acute myeloid leukemia

22. Epigenetic regulation in cancer metastasis

23. Epigenetics in exercise science and sports medicine
Section E Bioinformatics of epigenetic medicine

24. Machine learning in epigenetic diseases
Section F Pharmacology of epigenetics

25. Epigenetics in toxicology and drug development

26. Pharmacoepigenomics in neurodegenerative diseases
Section G Therapeutic epigenetics

27. Therapeutics and DNA methylation inhibitors

28. Histone deacetylase inhibitors in medical therapeutics

29. Sirtuins as NAD+-dependent deacetylases and their potential in medical therapy

30. Experimental approaches toward histone acetyltransferase modulators as therapeutics

31. Histone methylation modifiers in medical therapeutics

32. Modulation of noncoding RNAs (ncRNAs) and their potential role as therapeutics

33. Nutrients and phytonutrients as promising epigenetic nutraceuticals

34. Epigenetics of pain management

35. Precision medical epigenetics

36. Epigenetics and regenerative medicine

37. Stem cell epigenetics in medical therapy

38. The clinical landscape of HDAC inhibitors
Section H Medical epigenetics: Future prospects

39. Epigenetics: Future prospective in human disorders and therapeutics

40. Prospective advances in medical epigenetics

Review quotes

"This volume is wonderfully comprehensive and addresses all the relevant aspects of medical epigenetics. It will take a true expert in the field to digest all the information available in the collected chapters of this publication. Most commonly, readers will focus on one or a few chapters of most relevance to their own practice or research. Overall, however, this is an outstanding resource book that brings together all the most up-to-date discussions of medical epigenetics in one place. This is a must-have book for any medical school library."—© Doody’s Review Service, 2021, Mark F. Sanders, PhD, reviewer, expert opinion

Product details

  • Edition: 2
  • Latest edition
  • Volume: 29
  • Published: August 26, 2021
  • Language: English

About the editor

TT

Trygve Tollefsbol

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Distinguished Professor of Biology Senior Scientist, O’Neal Comprehensive Cancer Center Senior Scientist, Integrative Center for Aging Research Senior Scientist, Comprehensive Diabetes Center Senior Scientist, Nutrition Obesity Research Center Senior Scientist, University Wide Microbiome Center Director, Cell Senescence Culture Facility University of Alabama at Birmingham, AL, USA

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