Medical Additive Manufacturing

Concepts and Fundamentals

1st Edition - April 3, 2024
Imprint: Elsevier
Editors: Shadpour Mallakpour, Chaudhery Mustansar Hussain
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 3 8 3 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 3 8 4 - 9

Medical Additive Manufacturing: Concepts and Fundamentals provides an overview of the latest research in the field of additively manufactured medical materials. It starts with a… Read more

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Medical Additive Manufacturing: Concepts and Fundamentals provides an overview of the latest research in the field of additively manufactured medical materials. It starts with a broad overview of the current state of medical additive manufacturing and then dives into cutting-edge topics such as medical imaging technologies for additive manufacturing and computer-aided design principles for anatomic modeling. The chapters discuss the state of additive manufacturing in an array of medical fields such as radiology, tissue engineering, nuclear medicine, orthopedics, surgery, cardiology, neurology, optometry, obstetrics, and veterinary medicine. This book concludes with chapters discussing regulatory considerations for additive manufacturing in hospitals and what the future holds for the field.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editors
Preface
Acknowledgments
1. COVID-19 pandemic: the latest achievements in the field of emergency medical devices using 3D printing technology
Abstract
1.1 Introduction
1.2 The development of medical equipment through 3D printing during COVID-19
1.3 Conclusions
Acknowledgments
Significant websites about the topic
References
2. Medical additive manufacturing in the battle against the COVID-19 pandemic
Abstract
2.1 Introduction
2.2 Medical additive manufacturing
2.3 Additively manufactured medical healthcare devices
2.4 MAM against the COVID-19 pandemic
2.5 COVID-19’s effects on the MAM industry
2.6 Technology evolution pathways of MAM-versus-COVID-19 research
2.7 Challenges in MAM against COVID-19
2.8 Summary and future perspectives
References
3. Latest innovations in tissue engineering by 3D-printed hyaluronic acid-based hydrogels
Abstract
3.1 Introduction
3.2 Applications of 3D-printed hyaluronic acid hydrogels in regenerative biomedicine
3.3 Conclusions and future perspectives
Acknowledgments
Significant websites about the topic
References
4. Engineering aspects and medical materials of medical additive manufacturing
Abstract
4.1 Additive manufacturing
4.2 Distinct types of materials used for biomedical implant manufacturing applications
4.3 Mechanical properties of distinct biomedical materials
4.4 Merits and demerits of additive manufactured parts
4.5 Application of distinct 3D printing materials in distinct sectors
4.6 Future scope and challenges
4.7 Conclusion
Acknowledgments
Declaration of competing interest
References
5. Computer-aided modeling principles for anatomic design
Abstract
5.1 Introduction
5.2 3D printing/additive manufacturing technologies
5.3 3D printing/additive manufacturing techniques for additive production of anatomical models
5.4 Material choice
5.5 Biomaterials
5.6 Printing techniques
5.7 Initial anatomical models
5.8 Traditional Anatomical models and their flaws
5.9 Associated work
5.10 Computer-aided synthesis technology development
5.11 Computerized 3D modeling—simulations and 3D printing
5.12 Three-dimensional (3D) model deformation
5.13 The model of deformation
5.14 Parametrization of the surface
5.15 Strain energy density function variations
5.16 Conclusion
References
6. Advanced application of additive manufacturing in the footwear industry: from customized insoles to fully 3D-printed shoes
Abstract
6.1 Introduction
6.2 Different additive manufacturing techniques
6.3 3D-printed personalized footwear
6.4 Customized 3D-printed shoe soles
6.5 Therapeutic 3D-printed shoe soles
6.6 3D-printed shoe lasts
6.7 Conclusion and outlook
Acknowledgment
Declaration of competing interest
References
7. Additive manufacturing in limb prosthetics and orthotics: the past, present and future of 3D printing orthopedic assistive devices
Abstract
7.1 Introduction
7.2 3D printing technologies in prosthetics and orthotics
7.3 3D printing materials in prosthetics and orthotics
7.4 Infrastructural aspects and initial costs
7.5 Use cases and good practices
7.6 The future of 3D printing in prosthetics and orthotics—toward 4D printing
7.7 Summary
References
8. Design of bionically adequate “soft-soft” joint endoprosthesis. FDM fabricated UHMWPE and PEEK-based composites
Abstract
8.1 Introduction
8.2 Materials and experimental methods
8.3 Wear patterns for polymer-polymer tribological contacts, providing the possibility of their fabrication by 3D-printing
8.4 Simulation of the wear process in the UHMWPE/20PP(3D)–PEEK/30CF(3D) tribological contact for different both loading schemes and lubrication conditions
8.5 FEM analysis of the role of the gradient elastic properties of the cup material in the formation of the stress–strain state of an endoprosthesis
8.6 Conclusions
Funding
References
9. Digital fabrication in craniofacial surgery
Abstract
9.1 Digital fabrication: a life-changer for health professionals
9.2 The six main principles of medical digital fabrication
9.3 Digital fabrication in craniofacial surgery
9.4 Digital fabrication and surgical education
9.5 Digital fabrication and the social image of craniofacial surgery
9.6 Conclusion
References
10. Entering a new era in pharmaceutics through 3D/4D printing technologies
Abstract
10.1 A brief introduction to 3D/4D printing
10.2 Applications of 3D/4D printing technology in pharmaceutic
10.3 Conclusions
Other sources regarding pharmaceutical applications of 3D/4D printing
Acknowledgments
Conflict of interests
References
11. Novel biomaterials based on diverse polysaccharide gums with gelatin used in three-dimensional printing techniques
Abstract
11.1 Introduction
11.2 Gellan gum ink
11.3 Xanthan gum ink
11.4 Guar gum ink
11.5 Arabic gum ink
11.6 Gelatin ink
11.7 Conclusions and further remarks
Acknowledgments
Significant websites about the topic
References
12. Additive manufacturing in the next world
Abstract
12.1 Introduction
12.2 Additive manufacturing technologies
12.3 Additive manufacturing applications in key sectors
12.4 Advantages and challenges of additive manufacturing in the next world
12.5 Implications for the next world
12.6 Future trends and opportunities
12.7 Conclusion
References
13. Medical additive manufacturing—The way to the future!
Abstract
13.1 Introduction
13.2 Medical additives
13.3 Historical development
13.4 Medical additive manufacturing
13.5 Additive manufacturing process
13.6 Applications
13.7 Future possibilities and challenges
13.8 Conclusion
References
14. Medical additive manufacturing then, now, and will
Abstract
14.1 Introduction
14.2 Current state of additive manufacturing in medicine
14.3 Advancements in additive manufacturing technologies
14.4 Innovative materials in additive manufacturing for medicine
14.5 Regulatory and ethical aspects
14.6 Economic impact and commercial aspects
14.7 Future directions and potential of additive manufacturing in medicine
14.8 Conclusion
References
15. Applications and scope of nanotechnology in additive manufacturing for healthcare industry
Abstract
15.1 Introduction
15.2 Boosting mechanical properties by CNT, carbon fibers, and nanomaterials
15.3 Biomedical and healthcare application of 3D printer
15.4 Nanoparticles used in additive manufacturing process
15.5 Conclusion
References
16. Usage of autodesk fusion 360 software for 3D reconstruction of anatomical structure from the 2D X-ray image
Abstract
16.1 Introduction
16.2 Objective
16.3 Target persons
16.4 3D reconstruction of anatomical structure from the 2D x-ray image
16.5 Selection
16.6 Preview mesh
16.7 Number of triangles
16.8 Refinement
16.9 Introduction
16.10 Literature reviews
16.11 Traditional method
16.12 Motivation
16.13 Development of novel dental implant guideway
16.14 Scope of work
16.15 Phase TWO
16.16 Phase THREE
16.17 Phase FOUR
16.18 Fabrication
16.19 Slice and preview
16.20 Print the file
16.21 Material of 3D printing
16.22 Assembly
16.23 Testing and validation
16.24 Concluding remarks/summary
References
17. Advancements and future prospects of additive manufacturing in orthopedics
Abstract
17.1 Introduction
17.2 Overview of 3D printing technology
17.3 Patient-matched implants and surgical guides
17.4 Advancements in 3D printing technology
17.5 Enhancing orthopedic education through 3D printing
17.6 3D-printed models for surgical planning
17.7 Future prospectss and implications
17.8 Conclusion
Reference
18. Medical additive manufacturing—the magic wand for cardiology
Abstract
18.1 Introduction
18.2 Classification of additive manufacturing
18.3 AM in cardiology
18.4 Advantages of AM in cardiology
18.5 3D printing in cardiology
18.6 Application of AM in cardiology
18.7 Conclusions
References
19. Advances and new developments in cardiovascular research with additive manufacturing
Abstract
19.1 Introduction
19.2 Additive manufacturing for cardiology
19.3 Conclusion
References
20. 3D printing in ophthalmology: a progressive application
Abstract
20.1 Introduction
20.2 Cornea
20.3 Retina
20.4 Spectacles
20.5 Contact lenses and intraocular lenses
20.6 Educational tools
20.7 Safety equipment in the COVID-19 pandemic
20.8 Future direction
20.9 Conclusion
References
21. Medical additive manufacturing in pharmacy
Abstract
21.1 Introduction
21.2 Pharmaceutical additive manufacturing/3D printing technological elements
21.3 3D printing technology
21.4 Combination products and medical technologies
21.5 The effect of gases and nanoparticles emitted from 3D printers
21.6 Obstacles as well as future viewpoints of drug additive manufacturing
21.7 Conclusion
References
22. Medical additive manufacturing in pharmacy
Abstract
22.1 Introduction
22.2 Personalized medicines
22.3 AM and drug delivery
22.4 Advanced additive manufacturing
22.5 4D printing technology
22.6 5D printing technology
22.7 6D printing technology
22.8 Applications of additive manufacturing
22.9 Designing of transdermal dosage form
22.10 Pulmonary drug delivery
22.11 Ophthalmic drug delivery
22.12 Nanomedicines
22.13 Conclusion and future perspective
References
23. Multicomponent and multimaterials medical additive manufacturing
Abstract
23.1 Introduction
23.2 Multimaterial composites for additive manufacturing
23.3 Summary
References
24. Graphene-based nanocomposites in additive manufacturing
Abstract
24.1 Introduction
24.2 Additive manufacturing techniques for preparing graphene nanocomposites
24.3 Graphene-based composites fabricated via AM
24.4 Applications of graphene-based nanocomposites fabricated via AM
24.5 Future scope
References
25. Additive manufacturing strategies for personalized drug delivery systems and medical devices
Abstract
25.1 Introduction
25.2 Conceptualization and development of 3DP medicines and medical devices
25.3 Factors affecting the 3D printing techniques
25.4 MAM or 3D printing manufacturing: technical aspects
25.5 Extrusion-based method
25.6 Powder-based method
25.7 Resin-based method
25.8 Droplet-based method
25.9 Polymers used in 3D printing techniques
25.10 Applications of 3D printing techniques
25.11 Modified 3D tablets
25.12 Effect of physical printing parameters on evaluation of 3D tablets
25.13 Immediate release tablets and caplets
25.14 Controlled, sustained, and delayed release dosage forms
25.15 Novel floating drug delivery systems
25.16 Buccal films
25.17 Application of additive manufacturing in medical devices
25.18 Challenges and future perspectives
References
26. Technoeconomic analysis of medical additive manufacturing by cognitive data analysis and blockchain
Abstract
26.1 Introduction
26.2 Medical additive manufacturing in the cardiology
26.3 Data analysis of the cardiovascular data set
26.4 Medical additive manufacturing in the neurology
26.5 Parkinson’s diseases assessment
26.6 Medical additive manufacturing by blockchain
26.7 Economic analysis of medical additive manufacturing
26.8 Case study on the blockchain-based medical additive manufacturing
26.9 Conclusion
References
27. Additive manufacturing and its impact on pharmaceutical supply chains
Abstract
27.1 Introduction
27.2 Systematic literature review
27.3 Analysis and synthesis
27.4 Thematic analysis
27.5 Discussion
27.6 Conclusion and limitations
References
28. The future of medical additives manufacturing
Abstract
28.1 Introduction
28.2 AM methods
28.3 Applications of 3DP in biomedicine and healthcare
28.4 Conclusion
References
Index

Shadpour Mallakpour

Professor Shadpour Mallakpour, organic polymer chemist, graduated from chemistry department, University of Florida (UF), Gainesville, Florida, U.S.A. in 1984. He spent two years as post-doc at UF. He joint to the department of chemistry, Isfahan University of Technology (IUT), Iran, since 1986. He held several positions such as chairman of department of chemistry and deputy of research, department of chemistry at IUT. From 1994-1995 he worked as visiting professor, University of Mainz, Germany and from 2003-2004 as visiting professor, Virginia Tech, Blacksburg, USA. Now he has published more than 900 journal papers and book chapters and more than 440 conference papers and got more than 40 items of awards. The most important award to him was given for the selection of first laureate on fundamental research, at 21st Khwarizmi International award in 2008. He is listed as the Top 1% Scientists in Chemistry in ISI Essential Science Indicators Since 2003. He was selected as academic guest of the 59th Meeting of Nobel Prize Winners in Chemistry, 2009, at Lindau, Germany. He presented many lectures as invited or keynote speaker in different national and international conferences or universities. He was member of organizing and scientific committees for many national and international conferences. He was also the chairperson of many national and international meetings. In recent year he focused on the preparation and characterization of polymers containing chiral amino acid moieties under green conditions using ionic liquids and microwave irradiation as new technology and bringing these aspects towards nanotechnology for the preparation of novel chiral bionanocomposite polymers as well as polymer nanocomposities for hazardous materials removal technologies.

Affiliations and expertise

Professor Shadpour Mallakpour, PhD, Organic polymer chemist,Department of Chemistry, Isfahan University of Technology, Isfahan, Iran

Chaudhery Mustansar Hussain

Dr. Chaudhery Mustansar Hussain, PhD, is an Adjunct Professor and Director of Laboratories in the Department of Chemistry & Environmental Sciences at the New Jersey Institute of Technology (NJIT), Newark, New Jersey, United States. His research is focused on the applications of nanotechnology and advanced materials, environmental management, analytical chemistry, and other various industries. Dr. Hussain is the author of numerous papers in peer-reviewed journals as well as a prolific author and editor of around One hundred and fifty (150) books, including scientific monographs and handbooks in his research areas. He has published with ELSEVIER, American Chemical Society, Royal Society of Chemistry, John Wiley & Sons, CRC Press, and Springer.

Affiliations and expertise

Adjunct Professor & Director of Laboratories, New Jersey Institute of Technology (NJIT), Newark, NJ, USA

Life Sciences

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