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McKee's Pathology of the Skin
- 5th Edition - January 2, 2019
- Authors: J. Eduardo Calonje, Thomas Brenn, Alexander J Lazar, Steven D. Billings
- Language: English
- Hardback ISBN:9 7 8 - 0 - 7 0 2 0 - 6 9 8 3 - 3
Comprehensive and lavishly illustrated, McKee’s Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopa… Read more
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Request a sales quoteComprehensive and lavishly illustrated, McKee’s Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopathology. You’ll find clinical guidance from internationally renowned experts along with details on etiology, pathogenesis, histopathology, and differential diagnosis – making this unique reference unparalleled in its wealth of clinical and histopathological material. The 5th Edition of this classic text is a must-have resource for practicing dermatopathologists and general pathologists who sign out skin biopsies.
- Covers pathological aspects of skin diseases in addition to providing superb descriptions and illustrations of their clinical manifestations – the only available reference with this unique combination of features.
- Integrates dermatopathology, clinical correlations, and clinical photographs throughout, and features bulleted lists of clinical features and differential diagnosis tables for easy reference.
- Contains more than 5,000 superb histopathologic and clinical illustrations that demonstrate the range of histologic manifestations.
- Brings you fully up to date with key molecular aspects of disease, the capabilities and limitations of molecular diagnostics, and targeted/personalized medicine.
- Features up-to-date information on biologics, drug eruptions, and other developments in therapeutics.
- Helps you stay current with the latest diagnostic tumor markers and other new developments in immunohistochemistry.
- Includes a completely revised chapter on cutaneous lymphoma that reflects recent WHO-EORTC classification changes, as well as new coverage of sentinel lymph node biopsy for melanoma.
- Shares the knowledge of the main editor Dr. J. Eduardo Calonje, along with co-editors Thomas Brenn, and Alexander Lazar, and new co-editor Steven D. Billings who offers expertise on both dermatopathology and soft tissue tumors.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title Page
- Table of Contents
- Copyright
- Preface to the fifth edition
- List of contributors
- Acknowledgments
- Dedication
- Volume One
- 1 The structure and function of skin
- Introduction
- Properties of skin
- Normal epidermal histology
- Regional variations in skin anatomy
- Skin development
- Keratinocyte biology
- Epidermal stem cells
- Skin barrier
- Skin immunity
- Melanocytes
- Merkel cells
- Intercellular junctions
- Pilosebaceous units
- Eccrine glands
- Apocrine glands
- Dermal–epidermal junction
- Dermal collagen
- Dermal elastic tissue
- Ground substance
- Fibroblast biology
- Cutaneous blood vessels and lymphatics
- Nervous system of the skin
- Subcutaneous fat
- References
- 2 Specialized techniques in dermatopathology
- Specimen fixation, grossing/put-through, processing, embedding and sectioning
- Routine and ‘special’ stains
- Immunohistochemical techniques
- Immunohistochemical techniques and trouble shooting
- Immunofluorescence
- Electron microscopy
- Frozen section examination of skin specimens
- Diagnostic cytopathological techniques in dermatopathology
- Diagnosis of inherited skin diseases
- Molecular techniques
- Diagnosis of lymphomas
- References
- 3 Disorders of keratinization
- Ichthyosis
- Trichothiodystrophy
- Other rare neuro-ichthyotic syndromes
- Acquired ichthyosis-like conditions
- Erythrokeratoderma
- Keratitis-ichthyosis-deafness syndrome, hystrix-like ichthyosis with deafness, porokeratotic adnexal ostial nevus
- Acquired symmetrical acrokeratoderma
- Palmoplantar keratoderma
- Acquired palmoplantar keratoderma and malignancies
- References
- 4 Inherited and autoimmune subepidermal blistering diseases
- Split skin immunofluorescence
- Immunoperoxidase antigen mapping
- Epidermolysis bullosa
- Bullous pemphigoid
- Pemphigoid gestationis
- Lichen planus pemphigoides
- Mucous membrane pemphigoid (cicatricial pemphigoid)
- Epidermolysis bullosa acquisita (dermolytic pemphigoid)
- Bullous systemic lupus erythematosus
- Dermatitis herpetiformis
- Linear IgA disease
- References
- 5 Acantholytic disorders
- Introduction
- Pemphigus
- Acantholytic dermatoses with dyskeratosis
- References
- 6 Spongiotic, psoriasiform and pustular dermatoses
- Eczematous Dermatitis
- Psoriasiform Dermatoses
- Pustular Dermatoses
- References
- 7 Lichenoid and interface dermatitis
- Lichenoid dermatoses
- Interface dermatoses
- References
- 8 Superficial and deep perivascular inflammatory dermatoses
- Chronic superficial dermatitis
- Toxic erythema
- Lymphocytic infiltrate of the skin (Jessner)
- Reticular erythematous mucinosis
- Polymorphous light eruption (including juvenile spring eruption and lambing ears)
- Tumid lupus erythematosus
- Perniosis, atypical chilblains and cold equestrian panniculitis
- Chilblain lupus erythematosus
- Pigmented purpuric dermatoses including Majocchi disease, Schamberg disease, pigmented purpuric lichenoid dermatitis of Gougerot and Blum, and itching purpura
- Lichen aureus
- Pruritic urticarial papules and plaques of pregnancy
- Pregnancy prurigo
- Urticarial vasculitis
- Tumor necrosis factor receptor-associated periodic syndrome (familiar Hibernian fever)
- Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy
- Viral exanthemata
- References
- 9 Granulomatous, necrobiotic and perforating dermatoses
- Sarcoidosis
- Granuloma annulare
- Necrobiosis lipoidica
- Rheumatoid nodule
- Elastolytic granulomata
- Rheumatic fever nodule
- Necrobiotic xanthogranuloma
- Palisaded neutrophilic and granulomatous dermatitis
- ‘Metastatic’ Crohn disease
- Acne agminata
- Periorificial (perioral) dermatitis
- Demodicosis
- Infective granulomata
- Foreign body granulomata
- Granulomatous contact dermatitis
- Granulomata in congenital immunodeficiency syndromes
- Perforating disorders
- Necrotizing infundibular crystalline folliculitis
- Chondrodermatitis nodularis chronica helicis
- References
- 10 Inflammatory diseases of the subcutaneous fat
- Lipodystrophy
- References
- 11 Diseases of the oral mucosa
- Hereditary Conditions
- Reactive Conditions
- Ulcerative Conditions
- Papillary Lesions
- Tumorlike Conditions
- Infections
- Lichenoid and Hypersensitivity Reactions
- Autoimmune Conditions
- Salivary Gland Disease
- Premalignant Conditions
- Squamous Cell Carcinoma and Variants
- Oral Lymphoma
- Pigmented Lesions
- Other Tumors
- References
- 12 Diseases of the anogenital skin
- Introduction
- Normal female anatomy
- Normal male anatomy
- Embryology
- Pubic hair
- Anogenital mammary-like glands
- Normal variants
- Inflammatory dermatoses
- Associations with systemic disease
- Infectious diseases
- Miscellaneous conditions
- Genital pigmentation
- Benign epithelial lesions
- Genital intraepithelial neoplasia and squamous cell carcinoma
- Cloacogenic carcinoma
- Tumors of anogenital mammary-like glands
- Other vulval adnexal neoplasms
- Basal cell carcinoma
- Metastatic tumors
- Lymphoma and leukemia
- Juvenile xanthogranuloma
- Langerhans cell histiocytosis
- Soft tissue tumors
- References
- 13 Degenerative and metabolic diseases
- The hyperlipidemias
- Angiokeratoma corporis diffusum
- The amyloidoses
- Colloid milium
- Hyalinosis cutis et mucosae
- Cutaneous macroglobulinosis
- Porphyria
- Pseudoporphyria
- Gout
- Ochronosis
- Hartnup disease
- Pellagra
- Scurvy
- Calcinosis cutis
- The mucinoses
- Acanthosis nigricans
- Acrodermatitis enteropathica
- Necrolytic migratory erythema
- Bullosis diabeticorum
- References
- 14 Cutaneous adverse reactions to drugs
- Adverse Drug Reactions – Introduction
- Adverse Drug Reactions – Clinical Manifestations
- References
- 15 Neutrophilic and eosinophilic dermatoses
- Pyoderma gangrenosum
- Acute febrile neutrophilic dermatosis (Sweet syndrome)
- Neutrophilic dermatoses associated with gastrointestinal and hepatobiliary disease
- Rheumatoid neutrophilic dermatitis
- Arthropod and arachnid bite reactions
- Seabather's eruption and coelenterate stings
- Erythema marginatum rheumaticum
- Still disease
- Urticaria
- Papular urticaria
- Neutrophilic urticarial dermatosis
- Cutaneous atypical neutrophilic dermatosis with lipodystrophy and elevated temperature
- Hypereosinophilic syndrome
- Eosinophilic cellulitis
- Eosinophilic pustular folliculitis
- Incontinentia pigmenti
- Toxic erythema of the neonate
- Hidradenitis suppurativa
- Prurigo pigmentosa
- References
- 16 Vascular diseases
- Introduction
- Leukocytoclastic vasculitis
- IgA vasculitis (Henoch-Schönlein purpura)
- Infantile acute hemorrhagic edema
- Urticarial vasculitis
- Granulomatosis with polyangiitis
- Eosinophilic granulomatosis with polyangiitis
- Microscopic polyangiitis
- Polyarteritis nodosa
- Kawasaki disease (mucocutaneous lymph node syndrome)
- Granuloma faciale
- Erythema elevatum diutinum
- Behçet disease
- Thromboangiitis obliterans
- Giant cell arteritis (temporal arteritis)
- Juvenile temporal arteritis
- Takayasu arteritis
- Infection-related vasculitis
- Paraneoplastic vasculitis
- Vasculitis associated with palisaded neutrophilic and granulomatous dermatitis
- Lymphocytic vasculitis
- Malignant atrophic papulosis
- Livedoid vasculopathy and atrophie blanche
- Dermatological manifestations of cholesterol crystal embolism and embolism from atrial myxoma
- Disseminated intravascular coagulation
- Cryoglobulinemia
- Antiphospholipid antibody syndrome and Sneddon syndrome
- Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
- Immune thrombocytopenic purpura
- Factor V (Leiden) mutation
- Hypergammaglobulinemic purpura
- Hyperimmunoglobulinemia D syndrome/mevalonate kinase deficiency
- Superficial thrombophlebitis
- Sclerosing lymphangitis
- Senile purpura
- Cocaine-related retiform purpura
- References
- 17 Idiopathic connective tissue disorders
- Lupus erythematosus
- Systemic sclerosis
- Localized scleroderma (morphea)
- Atrophoderma of Pasini and Pierini
- Eosinophilic fasciitis
- Polymyositis/dermatomyositis
- Mixed connective tissue disease
- Relapsing polychondritis
- References
- 18 Infectious diseases of the skin
- Viral Infections
- Bacterial Infections
- Protozoal Infections
- Algal Infections
- Fungal Infections
- Diseases Caused by Mesomycetozoea
- Arthropod Infestations
- Nematode Infestation
- Trematode Infestation
- Cestode Infestation
- References
- Volume Two
- 19 Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS)-associated cutaneous diseases
- Introduction
- Acute HIV exanthem
- HIV-associated papulosquamous dermatoses
- HIV-associated photodistributed eruptions
- HIV-associated pruritic papular eruptions
- HIV-associated vasculitic disorders
- HIV-associated autoimmune bullous diseases
- HIV-associated cutaneous mucinoses
- Lichenoid reactions in HIV
- HIV interface dermatitis
- Other HIV-associated dermatoses
- Cutaneous infections
- Lipodystrophy in HIV
- Neoplasia
- Immune reconstitution inflammatory syndrome
- Acknowledgments
- References
- 20 Disorders of pigmentation
- Disorders of Hypopigmentation
- Disorders of Hyperpigmentation
- References
- 21 Diseases of collagen and elastic tissue
- Diseases of Collagen: Generalized Disorders
- Diseases of Collagen: Localized Disorders
- Diseases of Elastic Tissue
- References
- 22 Diseases of the hair
- Classification of Alopecia
- Hair Shaft Diseases
- Miscellaneous Follicular Dermatoses
- References
- 23 Diseases of the nails
- Introduction
- Infectious Diseases of the Nail
- Inflammatory Diseases of the Nail
- Melanocytic Lesions of the Nail Apparatus
- Nonmelanocytic Tumors of the Nail Apparatus
- References
- 24 Tumors of the surface epithelium
- Epidermal nevi
- Cornu cutaneum
- Acanthoma fissuratum
- Seborrheic keratosis
- Dermatosis papulosa nigra
- Actinic lentigo
- Large cell acanthoma
- Stucco keratoses
- Intraepidermal epithelioma of Borst-Jadassohn
- Porokeratoma
- Psoriasiform keratosis
- Granular parakeratotic acanthoma
- Clear cell acanthoma
- Pseudoepitheliomatous hyperplasia
- Basal cell carcinoma
- Nevoid basal cell carcinoma syndrome
- Bazex-Dupré-Christol and Rombo syndromes
- Fibroepithelioma of Pinkus
- Actinic keratoses
- Squamous carcinoma in situ (Bowen disease)
- PUVA keratosis
- Arsenical keratoses
- Squamous cell carcinoma
- Variants of squamous cell carcinoma
- Metaplastic carcinoma of the skin (carcinosarcoma, carcinoma with heterologous differentiation)
- Squamous cell carcinoma with chronic lymphocytic leukemia
- Xeroderma pigmentosum
- Merkel cell carcinoma
- Lymphoepithelioma-like carcinoma of the skin
- References
- 25 Melanocytic nevi
- Ephelide
- Lentigo simplex
- Labial melanotic macule and labial lentigo
- Laugier-Hunziker syndrome
- Oral melanoacanthoma
- Cutaneous melanoacanthoma
- Peutz-Jeghers syndrome
- Genital lentiginosis
- Acral lentigo
- Multiple lentigines syndrome
- Carney complex
- Centrofacial lentiginosis
- PUVA and sunbed lentigines
- Ink spot lentigo
- Becker nevus
- Pseudomelanocytic nests
- Melanocytic nevus
- Clonal nevus
- Eccrine centered nevus
- Melanocytic nevi at special sites
- Acral nevus
- Nevus spilus
- Cockarde nevus
- Combined nevus (melanocytic nevus with phenotypic heterogeneity)
- Recurrent and sclerosing nevus
- Balloon cell nevus
- Halo nevus
- Meyerson nevus
- Spitz nevus, atypical Spitz nevus and spitzoid melanoma
- Pigmented epithelioid cell nevus
- Pagetoid Spitz nevus
- Desmoplastic nevus
- Pigmented spindle cell tumor of Reed
- Deep penetrating nevus
- Dysplastic nevus syndrome and dysplastic nevi
- Atypical (dysplastic) lentiginous nevus of the elderly
- Congenital nevus
- Congenital nevi in neonates and young children
- Dermal melanocytic lesions (dermal melanocytoses)
- Superficial atypical melanocytic proliferations of unknown significance
- Melanocytic tumors of uncertain malignant potential
- The molecular pathology of melanocytic nevi
- References
- 26 Melanoma
- Melanoma
- References
- 27 Tumors of the conjunctiva
- Introduction
- Epithelial tumors
- Melanocytic tumors
- Hematopoietic tumors
- Conjunctival stromal tumors
- Vascular tumors
- Fibrous tumors
- Neural tumors
- Histiocytic tumors
- Myogenic tumors
- Lipomatous tumors
- Other tumorlike lesions
- Metastatic and secondary tumors
- References
- 28 Sentinel lymph node biopsies
- Introduction
- Laboratory management and gross evaluation of sentinel nodes
- Confirmation of the sentinel status of submitted lymph nodes
- Can tissue from a sentinel node ethically be made available for research?
- Intraoperative evaluation of sentinel nodes
- The need to evaluate multiple levels of the sentinel node
- The role of immunohistochemistry in detecting tumor in sentinel nodes
- Separation of nevus cells and metastatic melanoma in sentinel nodes
- Is there a role for SNB in the evaluation of melanocytic lesions of uncertain metastatic potential?
- Molecular biology techniques in the assessment of sentinel nodes from melanoma patients
- Prediction of outcome based on the extent of nodal replacement by tumor and its distribution within the sentinel node
- Pathological evaluation of nonsentinel nodes
- The impact of complete lymph node dissection after positive sentinel lymph node biopsy in melanoma-specific survival
- Lymphatic mapping and sentinel node biopsy for nonmelanocytic neoplasms
- Reporting the sentinel node
- References
- 29 Cutaneous lymphoproliferative diseases and related disorders
- T-Cell Lymphomas
- Benign Cutaneous Infiltrates That Can Be Mistaken for Cutaneous T-Cell Lymphoma (Cutaneous T-Cell Pseudolymphoma)
- B-Cell Lymphomas
- Benign Cutaneous Infiltrates That Can Be Mistaken for Cutaneous B-Cell Lymphoma (So-Called Cutaneous B-Cell Pseudolymphoma)
- Histiocytic Disorders
- Cutaneous and Mucocutaneous Histiocytoses
- Cutaneous Leukemic Infiltrates and Precursor Cell Neoplasms
- References
- 30 Cutaneous metastases and Paget disease of the skin
- Cutaneous Metastases
- Mammary and Extramammary Paget Disease
- References
- 31 Tumors of the hair follicle
- Hair nevi
- Hair follicle nevus
- Woolly hair nevus
- Comedo nevus
- Basaloid follicular hamartoma
- Dilated pore
- Pilar sheath acanthoma
- Follicular infundibulum tumor (infundibuloma)
- Trichoadenoma
- Trichilemmoma and Cowden disease
- Desmoplastic trichilemmoma
- Trichilemmal carcinoma
- Proliferating trichilemmal (pilar) cyst
- Pilomatrixoma
- Pilomatrix carcinoma
- Melanocytic matricoma
- Trichofolliculoma
- Folliculosebaceous cystic hamartoma
- Sebaceous trichofolliculoma
- Trichoepithelioma
- Desmoplastic trichoepithelioma (sclerosing epithelial hamartoma)
- Trichoblastoma
- Malignant trichoblastoma
- Cutaneous lymphadenoma (lymphoepithelial tumor of the skin)
- Perifollicular fibroma
- Fibrofolliculoma
- Trichodiscoma, Birt-Hogg-Dubé, and Hornstein-Knickenberg syndromes
- Neurofollicular hamartoma (spindle cell predominant trichodiscoma)
- References
- 32 Tumors and related lesions of the sebaceous glands
- Ectopic sebaceous glands
- Sebaceous hyperplasia
- Nevus sebaceous
- Steatocystoma and sebocystomatosis
- Sebaceous adenoma
- Sebaceous epithelioma
- Sebaceoma
- Superficial epithelioma with sebaceous differentiation
- Sebomatricoma
- Basal cell carcinoma with sebaceous differentiation
- Sebaceous carcinoma
- Muir-Torre syndrome
- Mantleoma
- Other cutaneous tumors showing sebaceous differentiation
- References
- 33 Tumors of the sweat glands
- Apocrine nevus
- Apocrine hidrocystoma and apocrine cystadenoma
- Hybrid epidermoid and apocrine cyst
- Syringocystadenoma papilliferum
- Syringocystadenocarcinoma papilliferum
- Hidradenoma papilliferum
- Tubular apocrine adenoma
- Adenoma and adenocarcinoma of the anogenital mammary-like glands
- Nipple adenoma
- Syringomatous adenoma of the nipple
- Apocrine poroma
- Cutaneous oncocytoma
- Apocrine carcinoma
- Primary cutaneous cribriform apocrine carcinoma
- Ceruminous gland tumors
- Mixed tumor of the skin
- Malignant mixed tumor
- Myoepithelioma and malignant myoepithelioma
- Eccrine nevus
- Adnexal polyp of neonatal skin
- Eccrine syringofibroadenoma
- Eccrine angiomatous hamartoma
- Porokeratotic eccrine ostial and dermal duct nevus
- Eccrine hidrocystoma
- Hidroacanthoma simplex
- Eccrine poroma
- Dermal duct tumor
- Eccrine porocarcinoma
- Syringoma
- Papillary eccrine adenoma
- Digital papillary adenocarcinoma
- Hidradenoma
- Clear cell hidradenocarcinoma
- Dermal cylindroma
- Malignant cylindroma
- Eccrine spiradenoma
- Eccrine spiradenocarcinoma
- Syringoid eccrine carcinoma
- Microcystic adnexal carcinoma
- Primary cutaneous adenoid cystic carcinoma
- Primary cutaneous mucinous carcinoma
- Endocrine mucin-producing sweat gland carcinoma
- Mammary-type secretory carcinoma of the skin
- Eccrine ductal carcinoma
- Squamoid eccrine ductal carcinoma
- Polymorphous sweat gland carcinoma
- Primary cutaneous signet ring cell carcinoma
- References
- 34 Cutaneous cysts
- Follicular cysts
- Glandular cysts
- Cutaneous metaplastic synovial cyst
- Pilonidal sinus
- Dental sinus
- Mucinous syringometaplasia
- Umbilical polyp and granuloma
- Pseudocyst of the auricle
- References
- 35 Connective tissue tumors
- Adipocytic Tumors
- Tumors of Fibrous, Fibroblastic and Myofibroblastic Tissue
- Fibrohistiocytic tumors
- Nerve Sheath and Neuroectodermal Tumors and Tumorlike Lesions
- Smooth Muscle Tumors
- Striated Muscle Tumors
- Tumors of Vascular Origin
- Tumors of Bone and Cartilage-Forming Tissue
- Miscellaneous Reactive, Benign Lesions and Tumors of Uncertain Differentiation
- Miscellaneous Low-Grade and Malignant Tumors
- References
- 36 Animal models of skin disease
- Introduction
- One gene, one disease
- Comparative anatomy of the human and mouse skin and adnexa
- Specialized techniques for mouse skin
- Creation of models of human disease
- Examples of mouse models for human skin in health and disease
- Infectious diseases
- Vascular changes in the skin
- Genetic-based skin diseases
- Coat color genetics
- A locus
- B locus
- C locus
- D locus
- P locus
- Mouse models of melanoma
- Carcinogen-induced melanoma
- Genetically engineered mouse melanoma models
- Syngeneic mouse melanoma models
- Humanized mouse melanoma models
- Anhidrotic ectodermal dysplasia: mouse models that helped define the receptor-ligand concept
- Hairless, rhino, papular atrichia and genocopies
- Alopecia areata
- Psoriasiform mouse models
- Xenographs: transplanting tissues from humans to mice
- Currently missing mouse models of human skin pathology
- Zebrafish as a model system to study skin biology and pathology
- Zebrafish skin development
- The zebrafish genome and genetic manipulation
- Application of the zebrafish model for skin research
- Summary
- Resources
- References
- Index
- Glossary of abbreviations
- No. of pages: 1980
- Language: English
- Edition: 5
- Published: January 2, 2019
- Imprint: Elsevier
- Hardback ISBN: 9780702069833
JC
J. Eduardo Calonje
Affiliations and expertise
Director of Diagnostic Dermatopathology, Department of Dermato-Histopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, UKTB
Thomas Brenn
Affiliations and expertise
Professor of Pathology & Laboratory Medicine and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, CanadaAL
Alexander J Lazar
Affiliations and expertise
Associate Professor, Departments of Pathology and Dermatology, Sections of Dermatopathology and Sarcoma Pathology, The University of Texas M.D. Anderson Cancer Center,SB
Steven D. Billings
Affiliations and expertise
Co-Section Head, Department of Anatomic Pathology, Cleveland Clinic Main Campus