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McKee's Pathology of the Skin
- 5th Edition - January 2, 2019
- Authors: J. Eduardo Calonje, Thomas Brenn, Alexander J Lazar, Steven D. Billings
- Language: English
- Hardback ISBN:9 7 8 - 0 - 7 0 2 0 - 6 9 8 3 - 3
Comprehensive and lavishly illustrated, McKee’s Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopa… Read more
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Request a sales quoteComprehensive and lavishly illustrated, McKee’s Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopathology. You’ll find clinical guidance from internationally renowned experts along with details on etiology, pathogenesis, histopathology, and differential diagnosis – making this unique reference unparalleled in its wealth of clinical and histopathological material. The 5th Edition of this classic text is a must-have resource for practicing dermatopathologists and general pathologists who sign out skin biopsies.
- Covers pathological aspects of skin diseases in addition to providing superb descriptions and illustrations of their clinical manifestations – the only available reference with this unique combination of features.
- Integrates dermatopathology, clinical correlations, and clinical photographs throughout, and features bulleted lists of clinical features and differential diagnosis tables for easy reference.
- Contains more than 5,000 superb histopathologic and clinical illustrations that demonstrate the range of histologic manifestations.
- Brings you fully up to date with key molecular aspects of disease, the capabilities and limitations of molecular diagnostics, and targeted/personalized medicine.
- Features up-to-date information on biologics, drug eruptions, and other developments in therapeutics.
- Helps you stay current with the latest diagnostic tumor markers and other new developments in immunohistochemistry.
- Includes a completely revised chapter on cutaneous lymphoma that reflects recent WHO-EORTC classification changes, as well as new coverage of sentinel lymph node biopsy for melanoma.
- Shares the knowledge of the main editor Dr. J. Eduardo Calonje, along with co-editors Thomas Brenn, and Alexander Lazar, and new co-editor Steven D. Billings who offers expertise on both dermatopathology and soft tissue tumors.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title Page
- Table of Contents
- Copyright
- Preface to the fifth edition
- List of contributors
- Acknowledgments
- Dedication
- Volume One
- 1 The structure and function of skin
- Introduction
- Properties of skin
- Normal epidermal histology
- Regional variations in skin anatomy
- Skin development
- Keratinocyte biology
- Epidermal stem cells
- Skin barrier
- Skin immunity
- Melanocytes
- Merkel cells
- Intercellular junctions
- Pilosebaceous units
- Eccrine glands
- Apocrine glands
- Dermal–epidermal junction
- Dermal collagen
- Dermal elastic tissue
- Ground substance
- Fibroblast biology
- Cutaneous blood vessels and lymphatics
- Nervous system of the skin
- Subcutaneous fat
- References
- 2 Specialized techniques in dermatopathology
- Specimen fixation, grossing/put-through, processing, embedding and sectioning
- Routine and ‘special’ stains
- Immunohistochemical techniques
- Immunohistochemical techniques and trouble shooting
- Immunofluorescence
- Electron microscopy
- Frozen section examination of skin specimens
- Diagnostic cytopathological techniques in dermatopathology
- Diagnosis of inherited skin diseases
- Molecular techniques
- Diagnosis of lymphomas
- References
- 3 Disorders of keratinization
- Ichthyosis
- Trichothiodystrophy
- Other rare neuro-ichthyotic syndromes
- Acquired ichthyosis-like conditions
- Erythrokeratoderma
- Keratitis-ichthyosis-deafness syndrome, hystrix-like ichthyosis with deafness, porokeratotic adnexal ostial nevus
- Acquired symmetrical acrokeratoderma
- Palmoplantar keratoderma
- Acquired palmoplantar keratoderma and malignancies
- References
- 4 Inherited and autoimmune subepidermal blistering diseases
- Split skin immunofluorescence
- Immunoperoxidase antigen mapping
- Epidermolysis bullosa
- Bullous pemphigoid
- Pemphigoid gestationis
- Lichen planus pemphigoides
- Mucous membrane pemphigoid (cicatricial pemphigoid)
- Epidermolysis bullosa acquisita (dermolytic pemphigoid)
- Bullous systemic lupus erythematosus
- Dermatitis herpetiformis
- Linear IgA disease
- References
- 5 Acantholytic disorders
- Introduction
- Pemphigus
- Acantholytic dermatoses with dyskeratosis
- References
- 6 Spongiotic, psoriasiform and pustular dermatoses
- Eczematous Dermatitis
- Psoriasiform Dermatoses
- Pustular Dermatoses
- References
- 7 Lichenoid and interface dermatitis
- Lichenoid dermatoses
- Interface dermatoses
- References
- 8 Superficial and deep perivascular inflammatory dermatoses
- Chronic superficial dermatitis
- Toxic erythema
- Lymphocytic infiltrate of the skin (Jessner)
- Reticular erythematous mucinosis
- Polymorphous light eruption (including juvenile spring eruption and lambing ears)
- Tumid lupus erythematosus
- Perniosis, atypical chilblains and cold equestrian panniculitis
- Chilblain lupus erythematosus
- Pigmented purpuric dermatoses including Majocchi disease, Schamberg disease, pigmented purpuric lichenoid dermatitis of Gougerot and Blum, and itching purpura
- Lichen aureus
- Pruritic urticarial papules and plaques of pregnancy
- Pregnancy prurigo
- Urticarial vasculitis
- Tumor necrosis factor receptor-associated periodic syndrome (familiar Hibernian fever)
- Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy
- Viral exanthemata
- References
- 9 Granulomatous, necrobiotic and perforating dermatoses
- Sarcoidosis
- Granuloma annulare
- Necrobiosis lipoidica
- Rheumatoid nodule
- Elastolytic granulomata
- Rheumatic fever nodule
- Necrobiotic xanthogranuloma
- Palisaded neutrophilic and granulomatous dermatitis
- ‘Metastatic’ Crohn disease
- Acne agminata
- Periorificial (perioral) dermatitis
- Demodicosis
- Infective granulomata
- Foreign body granulomata
- Granulomatous contact dermatitis
- Granulomata in congenital immunodeficiency syndromes
- Perforating disorders
- Necrotizing infundibular crystalline folliculitis
- Chondrodermatitis nodularis chronica helicis
- References
- 10 Inflammatory diseases of the subcutaneous fat
- Lipodystrophy
- References
- 11 Diseases of the oral mucosa
- Hereditary Conditions
- Reactive Conditions
- Ulcerative Conditions
- Papillary Lesions
- Tumorlike Conditions
- Infections
- Lichenoid and Hypersensitivity Reactions
- Autoimmune Conditions
- Salivary Gland Disease
- Premalignant Conditions
- Squamous Cell Carcinoma and Variants
- Oral Lymphoma
- Pigmented Lesions
- Other Tumors
- References
- 12 Diseases of the anogenital skin
- Introduction
- Normal female anatomy
- Normal male anatomy
- Embryology
- Pubic hair
- Anogenital mammary-like glands
- Normal variants
- Inflammatory dermatoses
- Associations with systemic disease
- Infectious diseases
- Miscellaneous conditions
- Genital pigmentation
- Benign epithelial lesions
- Genital intraepithelial neoplasia and squamous cell carcinoma
- Cloacogenic carcinoma
- Tumors of anogenital mammary-like glands
- Other vulval adnexal neoplasms
- Basal cell carcinoma
- Metastatic tumors
- Lymphoma and leukemia
- Juvenile xanthogranuloma
- Langerhans cell histiocytosis
- Soft tissue tumors
- References
- 13 Degenerative and metabolic diseases
- The hyperlipidemias
- Angiokeratoma corporis diffusum
- The amyloidoses
- Colloid milium
- Hyalinosis cutis et mucosae
- Cutaneous macroglobulinosis
- Porphyria
- Pseudoporphyria
- Gout
- Ochronosis
- Hartnup disease
- Pellagra
- Scurvy
- Calcinosis cutis
- The mucinoses
- Acanthosis nigricans
- Acrodermatitis enteropathica
- Necrolytic migratory erythema
- Bullosis diabeticorum
- References
- 14 Cutaneous adverse reactions to drugs
- Adverse Drug Reactions – Introduction
- Adverse Drug Reactions – Clinical Manifestations
- References
- 15 Neutrophilic and eosinophilic dermatoses
- Pyoderma gangrenosum
- Acute febrile neutrophilic dermatosis (Sweet syndrome)
- Neutrophilic dermatoses associated with gastrointestinal and hepatobiliary disease
- Rheumatoid neutrophilic dermatitis
- Arthropod and arachnid bite reactions
- Seabather's eruption and coelenterate stings
- Erythema marginatum rheumaticum
- Still disease
- Urticaria
- Papular urticaria
- Neutrophilic urticarial dermatosis
- Cutaneous atypical neutrophilic dermatosis with lipodystrophy and elevated temperature
- Hypereosinophilic syndrome
- Eosinophilic cellulitis
- Eosinophilic pustular folliculitis
- Incontinentia pigmenti
- Toxic erythema of the neonate
- Hidradenitis suppurativa
- Prurigo pigmentosa
- References
- 16 Vascular diseases
- Introduction
- Leukocytoclastic vasculitis
- IgA vasculitis (Henoch-Schönlein purpura)
- Infantile acute hemorrhagic edema
- Urticarial vasculitis
- Granulomatosis with polyangiitis
- Eosinophilic granulomatosis with polyangiitis
- Microscopic polyangiitis
- Polyarteritis nodosa
- Kawasaki disease (mucocutaneous lymph node syndrome)
- Granuloma faciale
- Erythema elevatum diutinum
- Behçet disease
- Thromboangiitis obliterans
- Giant cell arteritis (temporal arteritis)
- Juvenile temporal arteritis
- Takayasu arteritis
- Infection-related vasculitis
- Paraneoplastic vasculitis
- Vasculitis associated with palisaded neutrophilic and granulomatous dermatitis
- Lymphocytic vasculitis
- Malignant atrophic papulosis
- Livedoid vasculopathy and atrophie blanche
- Dermatological manifestations of cholesterol crystal embolism and embolism from atrial myxoma
- Disseminated intravascular coagulation
- Cryoglobulinemia
- Antiphospholipid antibody syndrome and Sneddon syndrome
- Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
- Immune thrombocytopenic purpura
- Factor V (Leiden) mutation
- Hypergammaglobulinemic purpura
- Hyperimmunoglobulinemia D syndrome/mevalonate kinase deficiency
- Superficial thrombophlebitis
- Sclerosing lymphangitis
- Senile purpura
- Cocaine-related retiform purpura
- References
- 17 Idiopathic connective tissue disorders
- Lupus erythematosus
- Systemic sclerosis
- Localized scleroderma (morphea)
- Atrophoderma of Pasini and Pierini
- Eosinophilic fasciitis
- Polymyositis/dermatomyositis
- Mixed connective tissue disease
- Relapsing polychondritis
- References
- 18 Infectious diseases of the skin
- Viral Infections
- Bacterial Infections
- Protozoal Infections
- Algal Infections
- Fungal Infections
- Diseases Caused by Mesomycetozoea
- Arthropod Infestations
- Nematode Infestation
- Trematode Infestation
- Cestode Infestation
- References
- Volume Two
- 19 Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS)-associated cutaneous diseases
- Introduction
- Acute HIV exanthem
- HIV-associated papulosquamous dermatoses
- HIV-associated photodistributed eruptions
- HIV-associated pruritic papular eruptions
- HIV-associated vasculitic disorders
- HIV-associated autoimmune bullous diseases
- HIV-associated cutaneous mucinoses
- Lichenoid reactions in HIV
- HIV interface dermatitis
- Other HIV-associated dermatoses
- Cutaneous infections
- Lipodystrophy in HIV
- Neoplasia
- Immune reconstitution inflammatory syndrome
- Acknowledgments
- References
- 20 Disorders of pigmentation
- Disorders of Hypopigmentation
- Disorders of Hyperpigmentation
- References
- 21 Diseases of collagen and elastic tissue
- Diseases of Collagen: Generalized Disorders
- Diseases of Collagen: Localized Disorders
- Diseases of Elastic Tissue
- References
- 22 Diseases of the hair
- Classification of Alopecia
- Hair Shaft Diseases
- Miscellaneous Follicular Dermatoses
- References
- 23 Diseases of the nails
- Introduction
- Infectious Diseases of the Nail
- Inflammatory Diseases of the Nail
- Melanocytic Lesions of the Nail Apparatus
- Nonmelanocytic Tumors of the Nail Apparatus
- References
- 24 Tumors of the surface epithelium
- Epidermal nevi
- Cornu cutaneum
- Acanthoma fissuratum
- Seborrheic keratosis
- Dermatosis papulosa nigra
- Actinic lentigo
- Large cell acanthoma
- Stucco keratoses
- Intraepidermal epithelioma of Borst-Jadassohn
- Porokeratoma
- Psoriasiform keratosis
- Granular parakeratotic acanthoma
- Clear cell acanthoma
- Pseudoepitheliomatous hyperplasia
- Basal cell carcinoma
- Nevoid basal cell carcinoma syndrome
- Bazex-Dupré-Christol and Rombo syndromes
- Fibroepithelioma of Pinkus
- Actinic keratoses
- Squamous carcinoma in situ (Bowen disease)
- PUVA keratosis
- Arsenical keratoses
- Squamous cell carcinoma
- Variants of squamous cell carcinoma
- Metaplastic carcinoma of the skin (carcinosarcoma, carcinoma with heterologous differentiation)
- Squamous cell carcinoma with chronic lymphocytic leukemia
- Xeroderma pigmentosum
- Merkel cell carcinoma
- Lymphoepithelioma-like carcinoma of the skin
- References
- 25 Melanocytic nevi
- Ephelide
- Lentigo simplex
- Labial melanotic macule and labial lentigo
- Laugier-Hunziker syndrome
- Oral melanoacanthoma
- Cutaneous melanoacanthoma
- Peutz-Jeghers syndrome
- Genital lentiginosis
- Acral lentigo
- Multiple lentigines syndrome
- Carney complex
- Centrofacial lentiginosis
- PUVA and sunbed lentigines
- Ink spot lentigo
- Becker nevus
- Pseudomelanocytic nests
- Melanocytic nevus
- Clonal nevus
- Eccrine centered nevus
- Melanocytic nevi at special sites
- Acral nevus
- Nevus spilus
- Cockarde nevus
- Combined nevus (melanocytic nevus with phenotypic heterogeneity)
- Recurrent and sclerosing nevus
- Balloon cell nevus
- Halo nevus
- Meyerson nevus
- Spitz nevus, atypical Spitz nevus and spitzoid melanoma
- Pigmented epithelioid cell nevus
- Pagetoid Spitz nevus
- Desmoplastic nevus
- Pigmented spindle cell tumor of Reed
- Deep penetrating nevus
- Dysplastic nevus syndrome and dysplastic nevi
- Atypical (dysplastic) lentiginous nevus of the elderly
- Congenital nevus
- Congenital nevi in neonates and young children
- Dermal melanocytic lesions (dermal melanocytoses)
- Superficial atypical melanocytic proliferations of unknown significance
- Melanocytic tumors of uncertain malignant potential
- The molecular pathology of melanocytic nevi
- References
- 26 Melanoma
- Melanoma
- References
- 27 Tumors of the conjunctiva
- Introduction
- Epithelial tumors
- Melanocytic tumors
- Hematopoietic tumors
- Conjunctival stromal tumors
- Vascular tumors
- Fibrous tumors
- Neural tumors
- Histiocytic tumors
- Myogenic tumors
- Lipomatous tumors
- Other tumorlike lesions
- Metastatic and secondary tumors
- References
- 28 Sentinel lymph node biopsies
- Introduction
- Laboratory management and gross evaluation of sentinel nodes
- Confirmation of the sentinel status of submitted lymph nodes
- Can tissue from a sentinel node ethically be made available for research?
- Intraoperative evaluation of sentinel nodes
- The need to evaluate multiple levels of the sentinel node
- The role of immunohistochemistry in detecting tumor in sentinel nodes
- Separation of nevus cells and metastatic melanoma in sentinel nodes
- Is there a role for SNB in the evaluation of melanocytic lesions of uncertain metastatic potential?
- Molecular biology techniques in the assessment of sentinel nodes from melanoma patients
- Prediction of outcome based on the extent of nodal replacement by tumor and its distribution within the sentinel node
- Pathological evaluation of nonsentinel nodes
- The impact of complete lymph node dissection after positive sentinel lymph node biopsy in melanoma-specific survival
- Lymphatic mapping and sentinel node biopsy for nonmelanocytic neoplasms
- Reporting the sentinel node
- References
- 29 Cutaneous lymphoproliferative diseases and related disorders
- T-Cell Lymphomas
- Benign Cutaneous Infiltrates That Can Be Mistaken for Cutaneous T-Cell Lymphoma (Cutaneous T-Cell Pseudolymphoma)
- B-Cell Lymphomas
- Benign Cutaneous Infiltrates That Can Be Mistaken for Cutaneous B-Cell Lymphoma (So-Called Cutaneous B-Cell Pseudolymphoma)
- Histiocytic Disorders
- Cutaneous and Mucocutaneous Histiocytoses
- Cutaneous Leukemic Infiltrates and Precursor Cell Neoplasms
- References
- 30 Cutaneous metastases and Paget disease of the skin
- Cutaneous Metastases
- Mammary and Extramammary Paget Disease
- References
- 31 Tumors of the hair follicle
- Hair nevi
- Hair follicle nevus
- Woolly hair nevus
- Comedo nevus
- Basaloid follicular hamartoma
- Dilated pore
- Pilar sheath acanthoma
- Follicular infundibulum tumor (infundibuloma)
- Trichoadenoma
- Trichilemmoma and Cowden disease
- Desmoplastic trichilemmoma
- Trichilemmal carcinoma
- Proliferating trichilemmal (pilar) cyst
- Pilomatrixoma
- Pilomatrix carcinoma
- Melanocytic matricoma
- Trichofolliculoma
- Folliculosebaceous cystic hamartoma
- Sebaceous trichofolliculoma
- Trichoepithelioma
- Desmoplastic trichoepithelioma (sclerosing epithelial hamartoma)
- Trichoblastoma
- Malignant trichoblastoma
- Cutaneous lymphadenoma (lymphoepithelial tumor of the skin)
- Perifollicular fibroma
- Fibrofolliculoma
- Trichodiscoma, Birt-Hogg-Dubé, and Hornstein-Knickenberg syndromes
- Neurofollicular hamartoma (spindle cell predominant trichodiscoma)
- References
- 32 Tumors and related lesions of the sebaceous glands
- Ectopic sebaceous glands
- Sebaceous hyperplasia
- Nevus sebaceous
- Steatocystoma and sebocystomatosis
- Sebaceous adenoma
- Sebaceous epithelioma
- Sebaceoma
- Superficial epithelioma with sebaceous differentiation
- Sebomatricoma
- Basal cell carcinoma with sebaceous differentiation
- Sebaceous carcinoma
- Muir-Torre syndrome
- Mantleoma
- Other cutaneous tumors showing sebaceous differentiation
- References
- 33 Tumors of the sweat glands
- Apocrine nevus
- Apocrine hidrocystoma and apocrine cystadenoma
- Hybrid epidermoid and apocrine cyst
- Syringocystadenoma papilliferum
- Syringocystadenocarcinoma papilliferum
- Hidradenoma papilliferum
- Tubular apocrine adenoma
- Adenoma and adenocarcinoma of the anogenital mammary-like glands
- Nipple adenoma
- Syringomatous adenoma of the nipple
- Apocrine poroma
- Cutaneous oncocytoma
- Apocrine carcinoma
- Primary cutaneous cribriform apocrine carcinoma
- Ceruminous gland tumors
- Mixed tumor of the skin
- Malignant mixed tumor
- Myoepithelioma and malignant myoepithelioma
- Eccrine nevus
- Adnexal polyp of neonatal skin
- Eccrine syringofibroadenoma
- Eccrine angiomatous hamartoma
- Porokeratotic eccrine ostial and dermal duct nevus
- Eccrine hidrocystoma
- Hidroacanthoma simplex
- Eccrine poroma
- Dermal duct tumor
- Eccrine porocarcinoma
- Syringoma
- Papillary eccrine adenoma
- Digital papillary adenocarcinoma
- Hidradenoma
- Clear cell hidradenocarcinoma
- Dermal cylindroma
- Malignant cylindroma
- Eccrine spiradenoma
- Eccrine spiradenocarcinoma
- Syringoid eccrine carcinoma
- Microcystic adnexal carcinoma
- Primary cutaneous adenoid cystic carcinoma
- Primary cutaneous mucinous carcinoma
- Endocrine mucin-producing sweat gland carcinoma
- Mammary-type secretory carcinoma of the skin
- Eccrine ductal carcinoma
- Squamoid eccrine ductal carcinoma
- Polymorphous sweat gland carcinoma
- Primary cutaneous signet ring cell carcinoma
- References
- 34 Cutaneous cysts
- Follicular cysts
- Glandular cysts
- Cutaneous metaplastic synovial cyst
- Pilonidal sinus
- Dental sinus
- Mucinous syringometaplasia
- Umbilical polyp and granuloma
- Pseudocyst of the auricle
- References
- 35 Connective tissue tumors
- Adipocytic Tumors
- Tumors of Fibrous, Fibroblastic and Myofibroblastic Tissue
- Fibrohistiocytic tumors
- Nerve Sheath and Neuroectodermal Tumors and Tumorlike Lesions
- Smooth Muscle Tumors
- Striated Muscle Tumors
- Tumors of Vascular Origin
- Tumors of Bone and Cartilage-Forming Tissue
- Miscellaneous Reactive, Benign Lesions and Tumors of Uncertain Differentiation
- Miscellaneous Low-Grade and Malignant Tumors
- References
- 36 Animal models of skin disease
- Introduction
- One gene, one disease
- Comparative anatomy of the human and mouse skin and adnexa
- Specialized techniques for mouse skin
- Creation of models of human disease
- Examples of mouse models for human skin in health and disease
- Infectious diseases
- Vascular changes in the skin
- Genetic-based skin diseases
- Coat color genetics
- A locus
- B locus
- C locus
- D locus
- P locus
- Mouse models of melanoma
- Carcinogen-induced melanoma
- Genetically engineered mouse melanoma models
- Syngeneic mouse melanoma models
- Humanized mouse melanoma models
- Anhidrotic ectodermal dysplasia: mouse models that helped define the receptor-ligand concept
- Hairless, rhino, papular atrichia and genocopies
- Alopecia areata
- Psoriasiform mouse models
- Xenographs: transplanting tissues from humans to mice
- Currently missing mouse models of human skin pathology
- Zebrafish as a model system to study skin biology and pathology
- Zebrafish skin development
- The zebrafish genome and genetic manipulation
- Application of the zebrafish model for skin research
- Summary
- Resources
- References
- Index
- Glossary of abbreviations
- No. of pages: 1980
- Language: English
- Edition: 5
- Published: January 2, 2019
- Imprint: Elsevier
- Hardback ISBN: 9780702069833
JC
J. Eduardo Calonje
TB
Thomas Brenn
AL
Alexander J Lazar
SB