McCance & Huether’s Pathophysiology

The Biologic Basis for Disease in Adults and Children

9th Edition - May 13, 2022
Imprint: Mosby
Author: Julia Rogers
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 8 9 8 7 - 5
LooseLeaf ISBN:
9 7 8 - 0 - 3 2 3 - 7 8 9 8 8 - 2

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, McCance and Huether’s Pathophys… Read more

Purchase options

Info / Buy

World Book Day Celebration!

Save up to 30% on books and eBooks!

Shop now

Institutional subscription on ScienceDirect

Request a sales quote

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, McCance and Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. It’s the most comprehensive and authoritative pathophysiology text available!

Title of Book
Cover image
Title page
Table of Contents
Emerging Science Boxes
Evolve Student Resources
Copyright
Dedication
Contributors
Preface
Organization and Content: What's New in the Ninth Edition
Part One: Central Concepts of Pathophysiology: Cells and Tissues
Part Two: Pathophysiologic Alterations: Organs and Systems
Features to Promote Learning
Art Program
Ancillaries
Acknowledgments
Part One: Central Concepts of Pathophysiology: Cells and Tissues
Unit I: The Cell
1. Cellular Biology
Chapter Outline
Prokaryotes and Eukaryotes
Cellular Functions
Structure and Function of Cellular Components
Cell-to-Cell Adhesions
Cellular Communication and Signal Transduction
Cellular Metabolism
Membrane Transport: Cellular Intake and Output
Cellular Reproduction: The Cell Cycle
Tissues
Summary Review
References
2. Altered Cellular and Tissue Biology: Environmental Agents
Chapter Outline
Cellular Adaptation
Cellular Injury
Manifestations of Cellular Injury
Cellular Death
Aging and Altered Cellular and Tissue Biology
Somatic Death
Summary Review
References
3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases
Chapter Outline
Distribution of Body Fluids
Aging and Distribution of Body Fluids
Alterations in Water Movement
Alterations in Sodium, Water, and Chloride Balance
Alterations in Potassium, Calcium, Phosphate, and Magnesium Balance
ACID-Base Balance
Summary Review
References
Unit II: Genes and Gene-Environment Interaction
4. Genes and Genetic Diseases
Chapter Outline
DNA, RNA, and Proteins: Heredity at the Molecular Level
Chromosomes
Elements of Formal Genetics
Transmission of Genetic Diseases
Linkage Analysis and Gene Mapping
Summary Review
References
5. Genes, Environment-Lifestyle, and Common Diseases
Chapter Outline
Factors Influencing Incidence of Disease in Populations
Principles of Multifactorial Inheritance
Nature and Nurture: Disentangling the Effects of Genes and Environment
Genetics of Common Diseases
Summary Review
References
6. Epigenetics and Disease
Chapter Outline
Overview of Epigenetic Mechanisms
Epigenetic Mechanisms
Three Types of Epigenetic Processes
Exploring the Multigenerational Persistence of Epigenetic States
Epigenetic Change Over the Lifespan
Tools for Exploring Epigenetic States
Epigenetics and Cancer
Epigenetics and Covid-19
Epigenetic Modification of mRNA
Future Directions
References
Unit III: Mechanisms of Self-Defense
7. Innate Immunity Inflammation and Wound Healing
Chapter Outline
Innate Immunity
First Line Of Defense: Physical and Biochemical Barriers and the Human Microbiome
Second Line of Defense: Inflammation
Wound Healing
Summary Review
References
8. Adaptive Immunity
Chapter Outline
Overview of Adaptive Immunity
Antigens
Lymphocyte Development
Induction of the Immune Response
Humoral Immunity
Cell-Mediated Immunity
Immunologic Memory
Summary Review
References
9. Alterations in Immunity
Chapter Outline
Hypersensitivity Reactions
Deficiencies in Immunity
Summary Review
References
10. Infection
Chapter Outline
Microorganisms and Humans: A Dynamic Relationship
Infectious Disease
Antibiotic/Antimicrobial Resistance
Vaccines and Protection Against Infection
Summary Review
References
11. Stress and Disease
Chapter Outline
Background and General Concepts of Stress
The Stress Systems
The Impact of Chronic Stress Across the life Span
Coping and Intervention Strategies
Summary Review
References
Unit IV: Cellular Proliferation: Cancer
12. Cancer Biology
Outline
Cancer Terminology and Characteristics
The Biology of Cancer Cells
Activating Invasion and Metastasis
Clinical Manifestations of Cancer
Diagnosis and Staging of Cancer
Treatment of Cancer
Targeted Disruption of Cancer
Summary Review
References
13. Cancer Epidemiology
CHAPTER Outline
Incidence, Mortality Trends, and Race
Genetics, Epigenetics, Tumor Microenvironment, and Cellular Signaling in Cancer
In Utero and Early Life Conditions
Environmental-Lifestyle Factors
Summary Review
References
14. Cancer in Children and Adolescents
Chapter Outline
Incidence and Types of Childhood Cancer
Etiology
Prognosis
Summary Review
References
Part Two: Structure, Function, and Pathophysiologic Alterations: Organs and Systems
Unit V: The Neurologic System
15. Structure and Function of the Neurologic System
Chapter Outline
Overview and Organization of the Nervous System
Cells of the Nervous System
Nerve Impulse
Central Nervous System
Blood Supply
Peripheral Nervous System
Autonomic Nervous System
Tests of Nervous System Structure and Function
Summary Review
References
16. Pain, Temperature Regulation, Sleep, and Sensory Function
Chapter Outline
Pain
Temperature Regulation
Sleep
The Special Senses
Somatosensory Function
Summary Review
References
17. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
Chapter Outline
Alterations in Cognitive Systems
Alterations in Cerebral Hemodynamics
Alterations in Neuromotor Function
Chronic Diseases and Disorders Involving Motor Function
Summary Review
References
18. Alterations of the Brain, Spinal Cord, and Peripheral Nerves
Chapter Outline
Central Nervous System Disorders
Infection and Inflammation of the Central Nervous System
Peripheral Nervous System Disorders
Tumors of the Central Nervous System
Summary Review
References
19. Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder
Chapter Outline
Schizophrenia
Mood Disorders: Depression And Bipolar Disorder
Anxiety Disorders
Posttraumatic Stress Disorder
Obsessive-Compulsive Disorder
Summary Review
References
20. Alterations of Neurologic Function in Children
Chapter Outline
Development of the Nervous System in Children
Structural Malformations
Alterations In Function: Encephalopathies
Cerebrovascular Disease in Children
Epilepsy and Seizure Disorders in Children
Childhood Tumors
Summary Review
References
Unit VI: The Endocrine System
21. Mechanisms of Hormonal Regulation
Chapter Outline
Mechanisms of Hormonal Regulation
Structure and Function of the Endocrine Glands
Aging and the Endocrine System
Summary Review
References
22. Alterations of Hormonal Regulation
Chapter Outline
Mechanisms of Hormonal Alterations
Alterations of the Hypothalamic–Pituitary System
Alterations of Thyroid Function
Alterations of Parathyroid Function
Dysfunction of the Endocrine Pancreas: Diabetes Mellitus
Alterations of Adrenal Function
Summary Review
References
23. Obesity, Starvation, and Anorexia of Aging
Chapter Outline
Adipose Tissue
Obesity
Starvation
Anorexia of Aging
Summary Review
References
Unit VII: The Reproductive Systems
24. Structure and Function of the Reproductive Systems
Chapter Outline
Development of the Reproductive Systems
The Female Reproductive System
Structure and Function of the Breast
The Male Reproductive System
Tests of Reproductive Function
Aging and Reproductive Function
Summary Review
References
25. Alterations of the Female Reproductive System
Chapter Outline
Abnormalities of the Female Reproductive Tract
Alterations of Sexual Maturation
Disorders of the Female Reproductive System
Disorders of the Female Breast
Summary Review
References
26. Alterations of the Male Reproductive System
Chapter Outline
Alterations of Sexual Maturation
Disorders of the Male Reproductive System
Disorders of the Male Breast
Summary Review
References
Online References
27. Sexually Transmitted Infections
Chapter Outline
Sexually Transmitted Urogenital Infections
Sexually Transmitted Infections of other body Systems
Summary Review
References
Unit VIII: The Hematologic System
28. Structure and Function of the Hematologic System
Chapter Outline
Components of the Hematologic System
Development of Blood Cells
Mechanisms of Hemostasis
Clinical Evaluation of the Hematologic System
Pediatrics and the Hematologic System
Aging and the Hematologic System
Summary Review
References
29. Alterations of Hematologic Function
Chapter Outline
Anemia
Myeloproliferative Red Cell Disorders
Alterations of Leukocyte Function
Alterations of Lymphoid Function
Alterations of Splenic Function
Hemorrhagic Disorders and Alterations of Platelets and Coagulation
Summary Review
References
30. Alterations of Hematologic Function in Children
Chapter Outline
Fetal and Neonatal Hematopoiesis
Postnatal Changes in the Blood
Disorders of Erythrocytes
Disorders of Coagulation and Platelets
Neoplastic Disorders
Summary Review
References
Unit IX: The Cardiovascular and Lymphatic Systems
31. Structure and Function of the Cardiovascular and Lymphatic Systems
Chapter Outline
Circulatory System
Heart
Structures that Direct Circulation Through the Heart
Heart Wall
Great Vessels
Chambers of the Heart
Valves of the Heart
Fibrous Skeleton of the Heart
Intracardiac Pressures
Blood Flow during the Cardiac Cycle
Structures that Support Cardiac Metabolism: Coronary Circulation
Structures that Control Heart Action
Factors Affecting Cardiac Output
Systemic Circulation
Lymphatic System
Tests of Cardiovascular Function
Cardiac and Coronary Artery Evaluation
Systemic Vascular Evaluation
Aging and the Cardiovascular System
Summary Review
References
32. Alterations of Cardiovascular Function
Chapter Outline
Diseases of the Veins
Diseases of the Arteries
Disorders of the Heart Wall
Manifestations of Heart Disease
Summary Review
References
33. Alterations of Cardiovascular Function in Children
Chapter Outline
Congenital Heart Disease
Acquired Cardiovascular Disorders
Summary Review
References
Unit X: The Pulmonary System
34. Structure and Function of the Pulmonary System
Chapter Outline
Structures of the Pulmonary System
Function of the Pulmonary System
Tests of Pulmonary Function
Summary Review
References
35. Alterations of Pulmonary Function
Chapter Outline
Clinical Manifestations of Pulmonary Alterations
Disorders of the Chest wall and Pleura
Pulmonary Disorders
Summary Review
References
36. Alterations of Pulmonary Function in Children
Chapter Outline
Disorders of the Upper Airways
Disorders of the Lower Airways
Sudden Infant Death Syndrome
Summary Review
References
Unit XI: The Renal and Urologic Systems
37. Structure and Function of the Renal and Urologic Systems
Chapter Outline
Structures Of The Renal System
Renal Blood Flow and Glomerular Filtration
Kidney Function
Tests of Renal Function
Pediatric Considerations
Geriatric Considerations
Summary Review
References
38. Alterations of Renal and Urinary Tract Function
Chapter Outline
Urinary Tract Obstruction
Urinary Tract Infection
Glomerular Disorders
Acute Kidney Injury
Chronic Kidney Disease
Summary Review
References
39. Alterations of Renal and Urinary Tract Function in Children
Chapter Outline
Structure and Function of the Urinary System in Children
Alterations in Renal and Bladder Function in Children
Glomerular Disorders
Nephroblastoma
Bladder Disorders
Urinary Incontinence
Summary Review
References
Unit XII: The Digestive System
40. Structure and Function of the Digestive System
Chapter Outline
The Gastrointestinal Tract
Accessory Organs of Digestion
Tests of Digestive Function
GERIATRIC CONSIDERATIONS
Summary Review
References
41. Alterations of Digestive Function
Chapter Outline
Disorders of the Gastrointestinal Tract
Disorders of the accessory Organs of Digestion
Cancer of the Digestive System
Summary Review
References
42. Alterations of Digestive Function in Children
Chapter Outline
Disorders of the Gastrointestinal Tract
Disorders Of The Liver
Summary Review
References
Unit XIII: The Musculoskeletal System
43. Structure and Function of the Musculoskeletal System
Chapter Outline
Structure and Function of Bones
Structure and Function of Joints
Structure and Function of Skeletal Muscles
Tests of Musculoskeletal Function
Geriatric Considerations
Summary Review
References
44. Alterations of Musculoskeletal Function
Chapter Outline
Musculoskeletal Injuries
Disorders of Bones
Disorders of Joints
Disorders of Skeletal Muscle
Muscle Tumors
Summary Review
References
45. Alterations of Musculoskeletal Function in Children
Chapter Outline
Musculoskeletal Development In Children
Musculoskeletal Alterations In Children
Rheumatologic Disorders
Avascular Disease Of The Bone
Musculoskeletal Tumors In Children
Nonaccidental Trauma
Summary Review
References
Unit XIV: The Integumentary System
46. Structure, Function, and Disorders of the Integument
Chapter Outline
Structure and Function of the Skin
Disorders of the Skin
Disorders of the Hair
Disorders of the Nail
Summary Review
References
47. Alterations of the Integument in Children
Chapter Outline
Acne Vulgaris
Dermatitis
Infections of the Skin
Insect Bites and Parasites
Vascular Anomalies
Other Skin Disorders
Summary Review
References
Unit XV: Multiple Interacting Systems
48. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
Chapter Outline
Shock
Multiple Organ Dysfunction Syndrome
Thermal Injury and Burns
Summary Review
References
49. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children
Chapter Outline
Shock and Multiple Organ Dysfunction Syndrome
Burns
Summary Review
References
Glossary
Index
Common Laboratory Values

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

McCance & Huether’s Pathophysiology

The Biologic Basis for Disease in Adults and Children

Purchase options

World Book Day Celebration!

Institutional subscription on ScienceDirect

Julia Rogers

Related books