Major Methods of Peptide Bond Formation
The Peptides Analysis, Synthesis, Biology, Vol. 1
- 1st Edition - April 28, 1979
- Editors: Erhard Gross, Johannes Meienhofer
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 4 5 3 - 6
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 7 9 6 - 3
The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major… Read more
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Request a sales quoteThe Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.
List of Contributors
Preface
Nomenclature and Abbreviations
Chapter 1 The Peptide Bond
I Introduction
II Nature of the Peptide Bond
III Cleavage of the Peptide Bond
IV Formation of the Peptide Bond
V Conclusion and Outlook
References
Chapter 2 The Formation of Peptide Bonds: A General Survey
I Introduction
II Coupling between Amino Acid Residues
III Ab Initio Assembly of the Backbone
IV Conclusions
References
Chapter 3 Active Esters in Peptide Synthesis
I The Development of Active Esters
II Classes of Active Esters
III Preparation of Active Esters
IV Catalysis of Active Ester Reactions
V Side Reactions
VI Active Esters and the Strategy of Peptide Synthesis
VII Active Esters in Various Techniques of Peptide Synthesis
VIII Conclusions
References
Chapter 4 The Azide Method in Peptide Synthesis
I Introduction
II Experimental Procedure
III The Formation of Hydrazides
IV The Generation of Azides
V Azide Segment Condensation
VI Special Applications
VII Opportunities and Constraints
References
Chapter 5 The Carbodiimide Method
I Introduction
II Mechanism of Carboxyl Activation
III Reaction Conditions for Dicyclohexyl-Carbodiimide-Mediated Peptide Bond Formation
IV Reactions of Carbodiimides with Amines
References
Chapter 6 The Mixed Carbonic Anhydride Method of Peptide Synthesis
I Introduction
II The Experimental Procedure
III Reaction Conditions
IV Coupling Reagents: EEDQ and IIDQ
V Applications
VI Related Methods
VII Opportunities and Constraints
References
Chapter 7 Racemization in Peptide Synthesis
I Introduction
II Racemization of Amino Acids, Peptides, and Their Unactivated Derivatives
III Racemization of Activated Acyl Derivatives of Amino Acids and Peptides
IV Control of Racemization during Peptide Synthesis
V Strategies for Minimizing Racemization During Amide-Forming Steps
VI Assays for Chiral Purity
References
Author Index
Subject Index
- No. of pages: 454
- Language: English
- Edition: 1
- Published: April 28, 1979
- Imprint: Academic Press
- Paperback ISBN: 9781483204536
- eBook ISBN: 9781483217963
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