Magnetic Nanoparticles in Nanomedicine
- 1st Edition - June 4, 2024
- Imprint: Woodhead Publishing
- Editors: Kai Wu, Jian-Ping Wang
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 6 6 8 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 1 6 6 9 - 5
Magnetic Nanoparticles in Nanomedicine provides readers with the fundamental theories and principles of magnetic materials, the synthesis and surface functionalization strategie… Read more
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Request a sales quoteMagnetic Nanoparticles in Nanomedicine provides readers with the fundamental theories and principles of magnetic materials, the synthesis and surface functionalization strategies of MNPs, and the standard techniques for characterizing physicochemical properties of MNPs. Other sections review MNP-based therapies such as magnetic hyperthermia therapy, drug/gene delivery, and magnetic neurostimulation and cover MNP-based in vitro and in vivo disease diagnosis, respectively, including techniques such as magnetoresistive (MR), nuclear magnetic resonance (NMR), magnetic particle spectroscopy (MPS) biosensing platforms, magnetic resonance imaging (MRI), and magnetic particle imaging (MPI).
Final chapters address biocompatibility and safety issues in applying MNPs to in vivo biomedical applications, including coverage of the toxicity of MNPs to human tissues, the immune responses of the human body to these particles, as well as blood circulation time of MNPs.
- Provides a valuable tool for academics and clinicians, pushing the frontiers of magnetic-based early-stage disease diagnosis and screening
- Clearly explains the synthesis, functionalization, and biocompatibility of magnetic nanoparticles
- Describes micromagnetic simulation, a valuable tool for predicting the properties of magnetic nanomaterials
Researchers working in the areas of magnetic materials and biomedical applications. Senior undergraduates and graduate students in Electrical Engineering, Materials Science, Biomedical Engineering, Chemical Engineering, Engineers working in the industry of magnetic nanomaterials, Clinicians working in magnetic therapy and magnetic diagnosis
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Preface
- Section I: Introduction to magnetic materials and magnetic nanoparticles (MNPs)
- Chapter 1. Basics of magnetic materials and magnetism
- Abstract
- 1.1 Introduction to magnetic materials
- 1.2 Different types of magnetism and hysteresis loops
- 1.3 Units and measurement
- 1.4 Magnetic anisotropy
- 1.5 Magnetostriction and stress anisotropy
- 1.6 Exchange in magnetic systems
- 1.7 Magnetic domains
- 1.8 Magnetization process and magnetization dynamics
- 1.9 Conclusions and perspectives
- Acknowledgments
- Conflict of interest
- References
- Section II: Micromagnetic simulation
- Chapter 2. Micromagnetic simulation tools: OOMMF, Mumax3, and COMSOL Multiphysics
- Abstract
- 2.1 Introduction
- 2.2 Theoretical background of micromagnetic simulation
- 2.3 Numerical tools for micromagnetic simulation
- 2.4 Micromagnetic simulation with object-oriented micromagnetic framework
- 2.5 Micromagnetic simulation of magnetic nanoparticles with Mumax3
- 2.6 Micromagnetic simulation with COMSOL Multiphysics
- 2.7 Conclusion
- Acknowledgments
- References
- Section III: MNPs: synthesis, functionalization, and characterization
- Chapter 3. Physical methods for the synthesis of MNPs
- Abstract
- 3.1 Introduction
- 3.2 Ball milling method
- 3.3 Lithography method
- 3.4 Gas-phase condensation method
- 3.5 Conclusion and perspectives
- Acknowledgments
- References
- Chapter 4. Chemical and biological methods for the synthesis of magnetic nanoparticles
- Abstract
- 4.1 Introduction
- 4.2 Chemical methods
- 4.3 Biological methods
- 4.4 Comparison of synthesis methods
- 4.5 Conclusions
- Acknowledgments
- References
- Chapter 5. Surface chemical functionalization of magnetic nanoparticles
- Abstract
- 5.1 Introduction
- 5.2 Techniques to increase colloidal stabilities
- 5.3 Surface functionalization for facile conjugations
- 5.4 Biomimetic membrane coated magnetic nanoparticles
- 5.5 Conclusion and perspectives
- Acknowledgment
- References
- Chapter 6. Characterization methods for magnetic nanoparticles
- Abstract
- 6.1 Introduction
- 6.2 Transmission electron microscopy
- 6.3 Vibrating sample magnetometry
- 6.4 Superconducting quantum interference device magnetometry
- 6.5 X-ray diffraction
- 6.6 Dynamic light scattering
- 6.7 Mössbauer spectroscopy
- 6.8 Magnetic force microscopy and atomic force microscopy
- 6.9 Fourier transform infrared spectroscopy
- 6.10 Conclusion
- Acknowledgments
- References
- Section IV: MNPs for therapy
- Chapter 7. Self-regulating magnetic nanoparticles for hyperthermia therapy
- Abstract
- 7.1 Introduction
- 7.2 Ball-milling methods for synthesis of Gd-based magnetic nanoparticles
- 7.3 Particle size–dependent magnetization of Gd-based nanoparticles
- 7.4 Self-regulating hyperthermia
- 7.5 Conclusion
- Acknowledgments
- Declaration
- References
- Chapter 8. Magnetic nanoparticles for drug/gene delivery
- Abstract
- 8.1 Introduction
- 8.2 Physicochemical properties of magnetic nanoparticles for drug delivery
- 8.3 Design principles
- 8.4 Delivery vehicles
- 8.5 Controlled release
- 8.6 Conclusion and perspectives
- Acknowledgments
- References
- Chapter 9. Magnetic nanoparticles for neurostimulation
- Abstract
- 9.1 Introduction
- 9.2 Basics of neuromodulation
- 9.3 Magnetothermal neuromodulation
- 9.4 Magnetomechanical neuromodulation
- 9.5 Magnetoelectrical neuromodulation
- 9.6 Chemomagnetic neuromodulation
- 9.7 Magnetogenetic veuromodulation
- 9.8 Challenges for magnetic nanoparticles in neurostimulation
- 9.9 Conclusions and outlook
- Acknowledgments
- References
- Section V: MNPs for in vitro disease diagnosis
- Chapter 10. Magnetoresistive (MR) biosensor
- Abstract
- 10.1 Introduction
- 10.2 Giant magnetoresistance and GMR biosensors
- 10.3 Tunneling magnetoresistance and TMR biosensors
- 10.4 Detection mechanisms in magnetoresistive biosensors
- 10.5 Applications of magnetoresistive biosensor in biological detection
- 10.6 Emerging trends and future directions of MR biosensors
- 10.7 Conclusions
- Acknowledgment
- Conflict of interest
- References
- Chapter 11. Magnetic particle spectroscopy (MPS) biosensor
- Abstract
- 11.1 Introduction
- 11.2 Principles of magnetic particle spectroscopy
- 11.3 Magnetic particle spectroscopy platform classifications
- 11.4 Magnetic particle spectroscopy for bioassay applications
- 11.5 Conclusion and perspectives
- Acknowledgment
- References
- Chapter 12. Magnetic separation-assisted diagnosis
- Abstract
- 12.1 Introduction
- 12.2 Theory
- 12.3 Labeled magnetic detection
- 12.4 Label-free magnetic detection
- 12.5 Conclusions
- Acknowledgments
- References
- Section VI: MNPs for in vivo disease diagnostic imaging
- Chapter 13. Magnetic nanoparticles in magnetic resonance imaging: principles and applications
- Abstract
- 13.1 Introduction
- 13.2 Magnetic nanoparticles in magnetic resonance imaging
- 13.3 Magnetic nanoparticles in cancer therapy
- 13.4 Conclusion
- Acknowledgment
- References
- Chapter 14. Magnetic nanoparticles in magnetic particle imaging: principles and applications
- Abstract
- 14.1 Introduction
- 14.2 Imaging principles of magnetic particle imaging
- 14.3 Superparamagnetic iron oxide nanoparticles in magnetic particle imaging
- 14.4 Superferromagnetic nanoparticles in magnetic particle imaging
- 14.5 Biocompatibility and safety in magnetic particle imaging
- 14.6 Biomedical applications of magnetic particle imaging in imaging and therapy
- 14.7 Conclusion
- Abbreviations
- Acknowledgments
- Conflict of interests
- References
- Section VII: Biocompatibility and immunotoxicity of MNPs
- Chapter 15. Immunotoxicity and safety considerations
- Abstract
- 15.1 The biocompatibility and toxicity of magnetic nanoparticles to human health
- 15.2 Administration routes of magnetic nanoparticles
- 15.3 Blood circulation half-life
- 15.4 Immunotoxicity of magnetic nanoparticles
- 15.5 Toxicological and immunological effects of hyperthermia
- 15.6 Conclusion
- Acknowledgments
- References
- Index
- Edition: 1
- Published: June 4, 2024
- Imprint: Woodhead Publishing
- No. of pages: 542
- Language: English
- Paperback ISBN: 9780443216688
- eBook ISBN: 9780443216695
KW
Kai Wu
Kai Wu is an assistant professor in the Department of Electrical & Computer Engineering at Texas Tech University in Lubbock, TX, United States. His research interests include the synthesis of magnetic nanomaterials, fabrication of magnetic nanodevices, micromagnetic simulation, development of point-of-care medical devices based on magnetic biosensors, and magnetic neuron stimulation and recording.
Affiliations and expertise
Assistant Professor, Texas Tech University, Department of Electrical and Computer Engineering, USAJW
Jian-Ping Wang
Jian-Ping Wang is a professor in the Department of Electrical and Computer Engineering at the University of Minnesota, Minneapolis, MN, United States. His research interests include nanomagnetism and quantum spintronics with a focus on searching, fundamentally understanding, and fabricating novel magnetic materials and quantum spintronic devices.
Affiliations and expertise
University of Minnesota, USARead Magnetic Nanoparticles in Nanomedicine on ScienceDirect