Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Introduction: The Lung Epithelium

• 1.1 Lung Anatomy
• 1.2 Lung Epithelial Composition
• 1.3 Epithelial Dysfunction in Lung Disease
• 1.4 Epithelia as a Therapeutic Target
• 1.5 Summary
• Acknowledgments
• References

Chapter 1. Junctional Interplay in Lung Epithelial Barrier Function

• Abstract
• 1.1 Introduction
• 1.2 Epithelial Cell Polarity Complex
• 1.3 Adherens Junctions
• 1.4 Tight Junctions
• 1.5 Gap Junctions and Pannexin Channels
• 1.6 Processes Regulated by Intercellular Communication
• 1.7 Summary and Perspectives
• Acknowledgments
• References

Chapter 2. Ion Transport and Lung Fluid Balance

• Abstract
• 2.1 Introduction
• 2.2 Lung Fluid Balance in the Airways
• 2.3 Altered Lung Fluid Balance and Disease of the Airways
• 2.4 Lung Fluid Balance in the Alveoli
• 2.5 Altered Lung Fluid Balance and Disease of the Alveolar Capillary Membrane
• 2.6 Summary
• References

Chapter 3. Glucose Transport and Homeostasis in Lung Epithelia

• Abstract
• 3.1 Introduction
• 3.2 Glucose Transport and Epithelial Glucose Homeostasis
• 3.3 Glucose Transporters in the Lung
• 3.4 Abnormal Epithelial Glucose Homeostasis and Lung Infection
• References

Chapter 4. Pulmonary Surfactant Trafficking and Homeostasis

• Abstract
• 4.1 Introduction
• 4.2 The Alveolus
• 4.3 Pulmonary Surfactant
• 4.4 Surfactant Proteins
• 4.5 Lamellar Bodies
• 4.6 Exocytosis of Lamellar Bodies and Surfactant
• 4.7 Endocytosis of Surfactant
• 4.8 Endocytic Vesicle Trafficking
• 4.9 Surfactant Catabolism
• References

Chapter 5. Integrin Regulation of the Lung Epithelium

• Abstract
• 5.1 Lung Extracellular Matrix in Development, Homeostasis, and Repair
• 5.2 Integrins are the Principal Receptors for ECM
• 5.3 Integrins in Lung Development, Alveolar Homeostasis, and Disease
• 5.4 β1 Integrin—The Central Integrin Subunit
• 5.5 Laminin-Binding Integrins
• 5.6 Collagen-Binding Integrins
• 5.7 RGD-Binding Integrins
• 5.8 Summary
• References

Chapter 6. Epithelial Regeneration and Lung Stem Cells

• Abstract
• 6.1 Lung Epithelial Stem/Progenitor Cells
• 6.2 Mechanisms/Pathways of Repair by Airway Progenitors
• Acknowledgments
• References

Chapter 7. The Function of Epithelial Cells in Pulmonary Fibrosis

• Abstract
• 7.1 Introduction
• 7.2 Epithelial–Mesenchymal Transition
• 7.3 Epithelial Gene Mutations and Familial Fibrosis
• 7.4 Paracrine Functions of Epithelial Cells During Fibrosis
• 7.5 Reepithelization versus Progressive Fibrosis
• 7.6 Conclusions
• References

Chapter 8. The Role of Epithelial Cell Quality Control in Health and Disease of the Distal Lung

• Abstract
• 8.1 Introduction
• 8.2 AT2 Cells and the Biosynthetic Challenge of Surfactant
• 8.3 A New “Old” Hypothesis: Alveolar Epithelial Dysfunction and Parenchymal Lung Disease
• 8.4 Cellular Quality Control
• 8.5 Epithelial Dysfunction is Induced By Surfactant Protein C Mutations
• 8.6 Linking Epithelial Dysfunction in vitro to Fibrotic Remodeling in vivo
• 8.7 Quality Control Issues in Other Parenchymal Lung Diseases
• 8.8 Unanswered Questions, New Approaches, and Opportunities
• Grant Support
• Disclosures
• Acknowledgments
• References

Chapter 9. The Respiratory Epithelium in COPD

• Abstract
• 9.1 Introduction
• 9.2 Airway Remodeling
• 9.3 Emphysema
• 9.4 Epithelial Dysfunction in COPD
• 9.5 The Role of the Epithelium in the Development of Emphysema
• 9.6 The Epithelium as Therapeutic Target
• 9.7 Conclusion
• References

Chapter 10. Acute Respiratory Distress Syndrome

• Abstract
• 10.1 Introduction
• 10.2 Epithelial Injury
• 10.3 Role of Epithelium in Host Defense & Inflammation
• 10.4 Repair
• 10.5 Conclusion
• References

Chapter 11. Epithelial Barrier Dysfunction in Asthma

• Abstract
• 11.1 Evidence for Barrier Dysfunction in Asthma
• 11.2 Causes of Epithelial Barrier Dysfunction in Asthma
• 11.3 Implications of Epithelial Barrier Dysfunction for Asthma Immunology and Therapy
• References

Chapter 12. Cystic Fibrosis: An Overview of the Past, Present, and the Future

• Abstract
• 12.1 Introduction to Cystic Fibrosis
• 12.2 Models of Cystic Fibrosis Disease
• 12.3 Epithelial Contributions to Innate Immunity in Cystic Fibrosis
• 12.4 Cystic Fibrosis-Related Diabetes and the Airway Epithelium
• 12.5 Therapeutic Interventions for Cystic Fibrosis Disease
• 12.6 Future Directions of Therapies for Cystic Fibrosis
• References