Living Donor Organ Transplantation
- 2nd Edition - November 24, 2023
- Imprint: Academic Press
- Editors: Rainer W.G. Gruessner, Enrico Benedetti
- Language: English
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 8 5 8 5 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 3 6 6 - 0
Living Organ Donor Transplantation, Second Edition puts the entire discipline in perspective while guiding readers step-by-step through the most common organ transplant surger… Read more
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Living Organ Donor Transplantation, Second Edition puts the entire discipline in perspective while guiding readers step-by-step through the most common organ transplant surgeries. Organized into four cohesive parts and featuring numerous surgical illustrations, this sourcebook delivers an incisive look at every key consideration for general surgeons who perform transplantations, from patient selection to recipient workup and outcomes, and emphasizes the most humanitarian approaches. Sections provide content on living donor uterus transplantation, new operative techniques, including the use of robotic and minimally invasive transplant procedures, new immunosuppressive regimens, new protocols of tolerance induction including stem cell therapy and transplantation, and much more.
Chapter authors are international leaders in their fields and represent institutions from four continents (Americas: USA, Argentina, Brazil, Canada; Europe: France, Germany, Italy, Spain, Sweden, UK; Asia: China, Japan, Korea, Taiwan; Australia).
Chapter authors are international leaders in their fields and represent institutions from four continents (Americas: USA, Argentina, Brazil, Canada; Europe: France, Germany, Italy, Spain, Sweden, UK; Asia: China, Japan, Korea, Taiwan; Australia).
- An A-Z, operation-oriented guide to the field of living donor organ transplantation
- Examines a wide spectrum of solid organ transplantation procedures (liver, pancreas, kidney, intestine), with accompanying chapters on history of the procedure, the donor, the recipient and cost analysis
- Covers techniques that explain adequate pretransplant workup and posttransplant care
- Covers cultural differences, ethical and legal issues, social issues, current financial incentives, and the illegal organ trade
Transplant surgeons (established and in-training), pancreas and HPB surgeons, urologists, gastroenterologists, hepatologists, nephrologists, diabetologists, endocrinologists, pancreatologists, obstetricians
PART I. GENERAL ASPECTS OF LIVING DONOR ORGAN TRANSPLANTATION
1. Introduction and Rationale
2. Cultural Differences In Living Organ Donation
2.1. A Global Perspective
2.2. The United States Experience
2.2.1 Racial Disparities in Living Donor Transplant
2.2.2 Cultural Differences in Living Organ Donation: The United States Experience: Hispanics
2.3. Cultural Differences in Living Organ Donation: The European East-West Difference Regarding Organ Transplantation
3. Ethical and Legal Issues
3.1. The American Perspective
3.2. The Asian Perspective
3.2.1. East Asia
3.2.2. India
3.2.3. Near and Middle East
3.3. The European Perspective
3.4. Ethical and Legal Issues: UNOS and Living Donation: Present and Future Donor Policies
4. Donor Counseling and Consent
4.1. Ethically teaching and testing living organ donors
4.2. Donor Counseling and Consent: Informed Consent
4.3. Donor Counseling and Consent: Donor Advocate
5. Nondirected Donors
6. General Aspects of Living Donor Organ Transplantation: Social Issues
PART II. PAID LEGAL AND ILLEGAL ORGAN DONATION
7. Current Financial Incentives
7.1. Current Financial Incentives: Incentives in Western Countries
7.2. Current Financial Incentives: Incentives in Non-Western Countries - The Iranian Model
7.3. Current Financial Incentives: Impact of Government-Sponsored Financial Reimbursement of Expenses
8. Paid Legal Organ Donation
8.1. A Regulated System of Incentives for Living Kidney Donation - PRO
8.2. Paid Legal Organ Donation: Pro - The Philosopher's Perspective
8.3. Paid Legal Organ Donation: Con- The Clinician's Perspective
8.4. Paid Legal Organ Donation: Con- The Ethicist's Perspective
9. Challenges of Paid Organ Donation for Public Health Care Policy
10. Who’s Got the Knife? The Role of Surgeons in Transplant Trafficking
PART III. THE ROLE OF SOCIAL MEDIA
11. Living Donor Organ Transplantation: The Role of Public Solicitation
12. The Impact of the Internet and Social Media on Paid Legal and Illegal Organ Donation
PART IV. ORGAN-SPECIFIC ASPECTS OF LIVING DONOR ABDOMINAL ORGAN TRANSPLANTATION
SECTION I. KIDNEY TRANSPLANTATION
13. Kidney Transplantation: Personal Reflections
14. History of Living Donor Kidney Transplantation
15. Kidney Transplantation: Geographical Differences
16. Preemptive Living Transplantation: The Ideal Therapeutic Modality for End-Stage Renal Disease
17. KIDNEY TRANSPLANTATION: THE DONOR
17.1. Kidney Transplantation - The Donor: Selection and Workup
17.2. Kidney Transplantation - The Donor: The Marginal Donor
17.3. Kidney Transplantation - The Donor: The Hepatitis C Positive Donor
17.4. Kidney Transplantation - The Donor: Infection Transmission from Donors Including COVID-19
17.5. Kidney Transplantation - The Donor: Immunologic Evaluation and Histocompatibility
17.6. Kidney Transplantation - The Donor: Anesthesiologic Management
17.7. Surgical Procedures
17.7.1. Kidney Transplantation - The Donor, Surgical Procedures: Open Standard Nephrectomy
17.7.2. Kidney Transplantation: Minimally Invasive Open Donor Nephrectomy ‘Mini-nephrectomy’
17.7.3. Kidney Transplantation - The Donor, Surgical Procedures: Transperitoneal Laparoscopic Nephrectomy
17.7.4. Retroperitoneal Laparoscopic Nephrectomy
17.7.5. Kidney Transplantation - The Donor, Surgical Procedures: Robotic Nephrectomy
17.7.6. Living Donor Nephrectomy Techniques: Comparative Review and Critical Appraisal
17.7.7. Vaginal Donor Nephrectomy
17.8. Kidney Transplantation - The Donor: Peri-operative Care of the Living Kidney Donor
17.9. Kidney Transplantation - The Donor: Donor Morbidity and Mortality
17.10. Kidney Transplantation - Living Kidney Donor: Long-Term Medical Outcomes
17.11 Kidney Transplantation - Living Kidney Donor: Long-Term Psychosocial Outcomes
17.12. Kidney Transplantation - The Donor: Psychological Aspects
17.13. Kidney Transplantation - The Donor: International Living Donor registry
17.14 Kidney Transplantation - The Donor: Clinical Trial on Tolerance Induction in Living Donor Kidney Transplantation
18. KIDNEY TRANSPLANTATION: THE RECIPIENT
18.1. Kidney Transplantation - The Recipient: Selection and Workup
18.2. Kidney Transplantation - The Recipient: Anesthesiologic Management
18.3. Kidney Transplantation - The Recipient: Surgical Procedures
18.3.1. Kidney Transplantation - The Recipient, Surgical Procedures: Open Procedures
18.3.2. Kidney Transplantation - The Recipient, Surgical Procedures: Robotic Procedures
18.3.3. Laparoscopic and Robotic Kidney Transplant with Vaginal Insertion of the Graft
18.4. Kidney Transplantation - The Recipient: Ischemia and Reperfusion Injury
18.5. Kidney Transplantation - The Recipient: Perioperative Care
18.6. Kidney Transplantation - The Recipient: Posttransplant Complications
18.7. Kidney Transplantation - The Recipient: Immunosuppressive Therapy
18.8. Kidney Transplantation - The Recipient: Immunobiology
18.9. Kidney Transplantation - The Recipient: Molecular Fingerprinting and Omics
18.10. Kidney Transplantation - The Recipient: Biomarkers of Tolerant Patients
18.11. Kidney Transplantation - The Recipient: Recurrence of Disease
18.12. Kidney Transplantation - The Recipient: APOL 1 and Donor/Recipient Risk of Graft Failure
18.13. Kidney Transplantation - The Recipient: Retransplantation
18.14. Kidney Transplantation - The Recipient: Pediatric Transplantation
18.14.1. Medical Aspects of the Pediatric Kidney Recipient
18.14.2. Kidney Transplantation - The Recipient: Surgical Technique and Complications
18.15. Kidney Transplantation - The Recipient: Long-Term Outcome
18.16. Kidney Transplantation - The Recipient, Living Donor Kidney Transplantation And Malignancy
18.17. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool
18.17.1. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool: Options Available to Recipients with Incompatible Donors
18.17.2. ABO-Incompatible Kidney Transplantation
18.17.3. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool: Living Donor Exchange
18.17.4. Kidney Transplantation - The Recipient: Desensitization Protocols for High-PRA recipients
18.17.5. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool: Auxiliary Liver Transplants for Highly Sensitized Kidney Recipients
19. Kidney Transplantation: Cost Analysis
SECTION II. PANCREAS TRANSPLANTATION
20. History of and Rationale for Pancreas Transplantation
20.1. History of living Donor Pancreas Transplantation
20.2. Rationale for Living Donor Pancreas Transplants
21. Pancreas Transplantation: The Donor
21.1. Pancreas Transplantation - The Donor: Selection and Workup
21.2. Pancreas Transplantation - The Donor: Surgical Procedures and Perioperative Care
21.2.1. Pancreas Transplantation - The Donor, Surgical Procedures and Perioperative Care: Standard Open Distal Pancreatectomy
21.2.2. Pancreas Transplantation - The Donor, Surgical Procedures and Perioperative Care: Laparoscopic Donor Distal Pancreatectomy
21.2.3. Pancreas Transplantation - The Donor, Surgical Procedures and Perioperative Care: Robotic Donor Distal Pancreatectomy
21.3. Pancreas Transplantation - The Donor: Morbidity, Mortality, and Long-Term Outcome
22. Pancreas Transplantation: The Recipient
22.1. Pancreas Transplantation: The Recipient: Selection and Workup
22.2. Pancreas Transplantation - The Recipient: Surgical Procedures
22.3. Pancreas Transplantation - The Recipient: Perioperative Care, Immunosuppressive Therapy, and Posttransplant Complications
22.4. Pancreas Transplantation - The Recipient: The Identical Twin Transplant Experience - Recurrence of Disease
23. The Asian Experience
24. International Pancreas Registry Report (IPTR) and Long-Term Outcome
25. Islet Autotransplantation after Pancreatectomy
25.1. Islet Autotransplantation After Pancreatectomy: History and Surgical Techniques of Total Pancreatectomy with Islet Autotransplantation (TPIAT)
25.2. Islet Autotransplantation After Pancreatectomy: Islet Isolation
25.3. Islet Autotransplantation After Pancreatectomy: Short and Long-Term Outcome
26. Islet Transplantation Using Living Donors
SECTION III. LIVER TRANSPLANTATION
27. Personal Reflections and History of Living Donor Liver Transplantation
28. The Impact of the A2all Study
29. Regional Variations in the U.S. Living Donor Experience
30. Institutional Needs for Living Donor Liver Transplantation
31. Role of Split Liver Transplantation from Deceased Donors: Lessons Learned
32. Liver Regeneration
33. Living Donor Liver Transplantation: The Donor
33.1. Living Donor Liver Transplantation - The Donor: Selection and Workup
33.2. Living Donor Liver Transplantation - The Donor: All in One MRI Donor Evaluation
33.3. Living Donor Liver Transplantation - The Donor: Anesthesiologic Management
33.4. Living Donor Liver Transplantation - The Donor: Surgical Procedures
33.4.1. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Adult Recipient, Right Lobe
33.4.2. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Adult Recipient, Extended Right Lobe
33.4.3. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Adult Recipient, Left Lobe
33.4.4. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Pediatric Recipient
33.4.5. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Laparascopic Donor Hepatectomy for the Pediatric Recipient
33.4.6. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Laparoscopic Donor Procedures for the Adult Recipient
33.4.7. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Robotic Donor Procedures for the Pediatric Recipient
33.4.8. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Robotic Donor Procedures for the Adult Recipient
33.5. Living Donor Liver Transplantation - The Donor: Perioperative Care
33.6. Living Donor Liver Transplantation - The Donor: Donor Morbidity and Mortality
33.7. Living Donor Liver Transplantation - The Donor: Long-Term Donor Outcomes
33.8. Living Donor Liver Transplantation - The Donor: Psychological Aspects
34. Liver Transplantation: The Recipient
34.1. Living Donor Liver Transplantation - Recipient Selection
34.2. Liver Transplantation: The Recipient: Anesthesiologic Management
34.3. Liver Transplantation: The Recipient: Surgical Procedures
34.3.1. Liver Transplantation - The Recipient, Surgical Procedures: Right Lobe Liver Transplant
34.3.2. Extended Right Lobe Transplant
34.3.3. Left Lobe Transplant with and without the Caudate Lobe
34.3.4. Difficult Hepatic Artery Reconstruction in Living Donor Liver Transplantation
34.3.5. Liver Transplantation - The Recipient, Surgical Procedures: Difficult Biliary Reconstruction
34.3.6. Liver Transplantation - The Recipient, Surgical Procedures: Optimized Venous Outflow
34.3.7. Liver Transplantation - The Recipient, Surgical Procedures: The Pediatric Recipient
34.3.8. Double Liver Transplants
34.3.9. Monosegment Grafts
34.3.10. Liver Transplantation - The Recipient, Surgical Procedures: Auxiliary Liver Transplants
34.3.11 Pure laparoscopic living donor hepatectomy in Pediatric LDLT
34.4. Liver Transplantation - The Recipient: Ischemia and Reperfusion Injury
34.5. Liver Transplantation - The Recipient: Small-for-size-grafts
34.6. Liver Transplantation - The Recipient: Perioperative Care of the Adult Liver Recipient
34.7. Liver Transplantation - The Recipient: Perioperative Care of the Pediatric Liver Recipient
34.8. Liver Transplantation - The Recipient: Liver Transplantation and Complications
34.9. Liver Transplantation - The Recipient: Interventional Therapies
34.10. Liver Transplantation - The Recipient: Immunosuppressive Therapy in Liver Transplantation
34.11. Liver Transplantation - The Recipient: Immunobiology
34.12. Liver Transplantation - The Recipient: Specific Indications
34.12.1. Liver Transplantation - The Recipient, Specific Indications: Hepatitic C
34.12.2. Liver Transplantation - The Recipient, Specific Indications: Cancer
34.12.3. Liver Transplantation - The Recipient, Specific Indications: Alcohol Abuse
34.12.4. Liver Transplantation - The Recipient, Specific Indications: Acute Liver Failure
34.13. Domino Liver Transplantation
34.13.1. Liver Transplantation - The Recipient, Domino Liver Transplantation: Technical Aspects
34.13.2. Liver Transplantation - The Recipient, Domino Liver Transplantation: Report from the Domino Liver Transplant Registry
34.14. Liver Retransplantation
34.14.1. Liver Retransplantation: The Recipient: Adult Recipient
34.14.2. Liver Retransplantation: The Recipient: Pediatric Recipient
34.15. Long-Term Outcome
34.15.1. Liver Transplantation - The Recipient, Long-Term Outcome: Adult Recipient
34.15.2. Liver Transplantation - The Recipient, Long-Term Outcome: Pediatric Recipient
34.16. Strategies To Maximize The Donor Pool: Abo Incompatibility
35. Liver Transplantation: Cost Analysis
SECTION IV. INTESTINAL TRANSPLANTATION
36. History of Living Donor Intestinal Transplantation
37. Indications for Living Donor Intestinal (and Liver) Transplantation
38. Intestinal Transplantation – The Donor
38.1. Intestinal Transplantation - The Donor: Selection and Workup
38.2. Intestinal Transplantation - The Donor: Surgical Procedures and Perioperative Care
39. Intestinal Transplantation – The Recipient
39.1. Intestinal Transplantation - The Recipient: Selection and Workup
39.2. Intestinal Transplantation - The Recipient: Surgical Procedures and Perioperative Care
39.3. Intestinal Transplantation - The Recipient: Sequential and Simultaneous Intestinal and Liver Transplants - Indications, Techniques and Outcome
39.4. Intestinal Transplantation - The Recipient: Immunosuppressive Therapy, Immunobiology Therapy and Postoperative Complications
39.5. Intestinal Transplantation - The Recipient: Long-Term Outcomes
39.6. Intestinal Transplantation - The Recipient: Registry Report
SECTION V. UTERUS TRANSPLANTATION
40. History of Living Donor Uterus Transplantation
41. Uterus Transplantation - The Donor
41.1. Uterus Transplantation - The Donor: Selection and Workup
41.2. Uterus Transplantation - The Donor: Surgical Procedures, Perioperative Care and Postoperative Complications
41.3. Uterus Transplantation - The Donor: Robotic And Laparoscopic Procedures
42. Uterus Transplantation - The Recipient
42.1. Uterus Transplantation - The Recipient: Indication, Selection and Workup
42.2. Uterus Transplantation - The Recipient: Psychosocial Assessment
42.3. Uterus Transplantation - The Recipient: Surgical Procedures and Perioperative Care
42.4. Uterus Transplantation - The Recipient: Immunosuppressive Therapy and Postoperative Complications
42.5. Uterus Transplantation - The Recipient: From Living Donor Uterus Transplantation to Live Birth Obstetrical Management
42.6. Uterus Transplantation - The Recipient: Global Results Of Living Donor Uterus Transplantation
42.7. Uterus Transplantation - The Recipient: Should Uterus Transplantation be Publicly Funded?
PART V. FUTURE DEVELOPMENTS AND ALTERNATIVES TO LIVING DONOR TRANSPLANTATION
43. Dual-Organ Donation and Transplantation
44. Use of Living Donors for HIV-Positive Transplant Candidates
45. New Immunosuppressive Protocols
46. Strategies to Induce Tolerance
47. Xenotransplantation
48. Gene Therapy
49. Organogenesis and related approaches for organ replacement
50. Consensus Conferences on Living Donor Organ Transplantation
50.1. Consensus Conferences on Living Donor Organ Transplantation: Commentary: The Istanbul Declaration On Organ Trafficking And Transplant Tourism
50.2. Consensus Conferences on Living Donor Organ Transplantation: Commentary: The Amsterdam And Vancouver Conferences On Living Organ Donation
51. Impact of the Coronavirus Pandemic on Living Donor Organ Transplantation
1. Introduction and Rationale
2. Cultural Differences In Living Organ Donation
2.1. A Global Perspective
2.2. The United States Experience
2.2.1 Racial Disparities in Living Donor Transplant
2.2.2 Cultural Differences in Living Organ Donation: The United States Experience: Hispanics
2.3. Cultural Differences in Living Organ Donation: The European East-West Difference Regarding Organ Transplantation
3. Ethical and Legal Issues
3.1. The American Perspective
3.2. The Asian Perspective
3.2.1. East Asia
3.2.2. India
3.2.3. Near and Middle East
3.3. The European Perspective
3.4. Ethical and Legal Issues: UNOS and Living Donation: Present and Future Donor Policies
4. Donor Counseling and Consent
4.1. Ethically teaching and testing living organ donors
4.2. Donor Counseling and Consent: Informed Consent
4.3. Donor Counseling and Consent: Donor Advocate
5. Nondirected Donors
6. General Aspects of Living Donor Organ Transplantation: Social Issues
PART II. PAID LEGAL AND ILLEGAL ORGAN DONATION
7. Current Financial Incentives
7.1. Current Financial Incentives: Incentives in Western Countries
7.2. Current Financial Incentives: Incentives in Non-Western Countries - The Iranian Model
7.3. Current Financial Incentives: Impact of Government-Sponsored Financial Reimbursement of Expenses
8. Paid Legal Organ Donation
8.1. A Regulated System of Incentives for Living Kidney Donation - PRO
8.2. Paid Legal Organ Donation: Pro - The Philosopher's Perspective
8.3. Paid Legal Organ Donation: Con- The Clinician's Perspective
8.4. Paid Legal Organ Donation: Con- The Ethicist's Perspective
9. Challenges of Paid Organ Donation for Public Health Care Policy
10. Who’s Got the Knife? The Role of Surgeons in Transplant Trafficking
PART III. THE ROLE OF SOCIAL MEDIA
11. Living Donor Organ Transplantation: The Role of Public Solicitation
12. The Impact of the Internet and Social Media on Paid Legal and Illegal Organ Donation
PART IV. ORGAN-SPECIFIC ASPECTS OF LIVING DONOR ABDOMINAL ORGAN TRANSPLANTATION
SECTION I. KIDNEY TRANSPLANTATION
13. Kidney Transplantation: Personal Reflections
14. History of Living Donor Kidney Transplantation
15. Kidney Transplantation: Geographical Differences
16. Preemptive Living Transplantation: The Ideal Therapeutic Modality for End-Stage Renal Disease
17. KIDNEY TRANSPLANTATION: THE DONOR
17.1. Kidney Transplantation - The Donor: Selection and Workup
17.2. Kidney Transplantation - The Donor: The Marginal Donor
17.3. Kidney Transplantation - The Donor: The Hepatitis C Positive Donor
17.4. Kidney Transplantation - The Donor: Infection Transmission from Donors Including COVID-19
17.5. Kidney Transplantation - The Donor: Immunologic Evaluation and Histocompatibility
17.6. Kidney Transplantation - The Donor: Anesthesiologic Management
17.7. Surgical Procedures
17.7.1. Kidney Transplantation - The Donor, Surgical Procedures: Open Standard Nephrectomy
17.7.2. Kidney Transplantation: Minimally Invasive Open Donor Nephrectomy ‘Mini-nephrectomy’
17.7.3. Kidney Transplantation - The Donor, Surgical Procedures: Transperitoneal Laparoscopic Nephrectomy
17.7.4. Retroperitoneal Laparoscopic Nephrectomy
17.7.5. Kidney Transplantation - The Donor, Surgical Procedures: Robotic Nephrectomy
17.7.6. Living Donor Nephrectomy Techniques: Comparative Review and Critical Appraisal
17.7.7. Vaginal Donor Nephrectomy
17.8. Kidney Transplantation - The Donor: Peri-operative Care of the Living Kidney Donor
17.9. Kidney Transplantation - The Donor: Donor Morbidity and Mortality
17.10. Kidney Transplantation - Living Kidney Donor: Long-Term Medical Outcomes
17.11 Kidney Transplantation - Living Kidney Donor: Long-Term Psychosocial Outcomes
17.12. Kidney Transplantation - The Donor: Psychological Aspects
17.13. Kidney Transplantation - The Donor: International Living Donor registry
17.14 Kidney Transplantation - The Donor: Clinical Trial on Tolerance Induction in Living Donor Kidney Transplantation
18. KIDNEY TRANSPLANTATION: THE RECIPIENT
18.1. Kidney Transplantation - The Recipient: Selection and Workup
18.2. Kidney Transplantation - The Recipient: Anesthesiologic Management
18.3. Kidney Transplantation - The Recipient: Surgical Procedures
18.3.1. Kidney Transplantation - The Recipient, Surgical Procedures: Open Procedures
18.3.2. Kidney Transplantation - The Recipient, Surgical Procedures: Robotic Procedures
18.3.3. Laparoscopic and Robotic Kidney Transplant with Vaginal Insertion of the Graft
18.4. Kidney Transplantation - The Recipient: Ischemia and Reperfusion Injury
18.5. Kidney Transplantation - The Recipient: Perioperative Care
18.6. Kidney Transplantation - The Recipient: Posttransplant Complications
18.7. Kidney Transplantation - The Recipient: Immunosuppressive Therapy
18.8. Kidney Transplantation - The Recipient: Immunobiology
18.9. Kidney Transplantation - The Recipient: Molecular Fingerprinting and Omics
18.10. Kidney Transplantation - The Recipient: Biomarkers of Tolerant Patients
18.11. Kidney Transplantation - The Recipient: Recurrence of Disease
18.12. Kidney Transplantation - The Recipient: APOL 1 and Donor/Recipient Risk of Graft Failure
18.13. Kidney Transplantation - The Recipient: Retransplantation
18.14. Kidney Transplantation - The Recipient: Pediatric Transplantation
18.14.1. Medical Aspects of the Pediatric Kidney Recipient
18.14.2. Kidney Transplantation - The Recipient: Surgical Technique and Complications
18.15. Kidney Transplantation - The Recipient: Long-Term Outcome
18.16. Kidney Transplantation - The Recipient, Living Donor Kidney Transplantation And Malignancy
18.17. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool
18.17.1. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool: Options Available to Recipients with Incompatible Donors
18.17.2. ABO-Incompatible Kidney Transplantation
18.17.3. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool: Living Donor Exchange
18.17.4. Kidney Transplantation - The Recipient: Desensitization Protocols for High-PRA recipients
18.17.5. Kidney Transplantation - The Recipient, Strategies to Maximize the Donor Pool: Auxiliary Liver Transplants for Highly Sensitized Kidney Recipients
19. Kidney Transplantation: Cost Analysis
SECTION II. PANCREAS TRANSPLANTATION
20. History of and Rationale for Pancreas Transplantation
20.1. History of living Donor Pancreas Transplantation
20.2. Rationale for Living Donor Pancreas Transplants
21. Pancreas Transplantation: The Donor
21.1. Pancreas Transplantation - The Donor: Selection and Workup
21.2. Pancreas Transplantation - The Donor: Surgical Procedures and Perioperative Care
21.2.1. Pancreas Transplantation - The Donor, Surgical Procedures and Perioperative Care: Standard Open Distal Pancreatectomy
21.2.2. Pancreas Transplantation - The Donor, Surgical Procedures and Perioperative Care: Laparoscopic Donor Distal Pancreatectomy
21.2.3. Pancreas Transplantation - The Donor, Surgical Procedures and Perioperative Care: Robotic Donor Distal Pancreatectomy
21.3. Pancreas Transplantation - The Donor: Morbidity, Mortality, and Long-Term Outcome
22. Pancreas Transplantation: The Recipient
22.1. Pancreas Transplantation: The Recipient: Selection and Workup
22.2. Pancreas Transplantation - The Recipient: Surgical Procedures
22.3. Pancreas Transplantation - The Recipient: Perioperative Care, Immunosuppressive Therapy, and Posttransplant Complications
22.4. Pancreas Transplantation - The Recipient: The Identical Twin Transplant Experience - Recurrence of Disease
23. The Asian Experience
24. International Pancreas Registry Report (IPTR) and Long-Term Outcome
25. Islet Autotransplantation after Pancreatectomy
25.1. Islet Autotransplantation After Pancreatectomy: History and Surgical Techniques of Total Pancreatectomy with Islet Autotransplantation (TPIAT)
25.2. Islet Autotransplantation After Pancreatectomy: Islet Isolation
25.3. Islet Autotransplantation After Pancreatectomy: Short and Long-Term Outcome
26. Islet Transplantation Using Living Donors
SECTION III. LIVER TRANSPLANTATION
27. Personal Reflections and History of Living Donor Liver Transplantation
28. The Impact of the A2all Study
29. Regional Variations in the U.S. Living Donor Experience
30. Institutional Needs for Living Donor Liver Transplantation
31. Role of Split Liver Transplantation from Deceased Donors: Lessons Learned
32. Liver Regeneration
33. Living Donor Liver Transplantation: The Donor
33.1. Living Donor Liver Transplantation - The Donor: Selection and Workup
33.2. Living Donor Liver Transplantation - The Donor: All in One MRI Donor Evaluation
33.3. Living Donor Liver Transplantation - The Donor: Anesthesiologic Management
33.4. Living Donor Liver Transplantation - The Donor: Surgical Procedures
33.4.1. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Adult Recipient, Right Lobe
33.4.2. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Adult Recipient, Extended Right Lobe
33.4.3. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Adult Recipient, Left Lobe
33.4.4. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Adult Donor to Pediatric Recipient
33.4.5. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Laparascopic Donor Hepatectomy for the Pediatric Recipient
33.4.6. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Laparoscopic Donor Procedures for the Adult Recipient
33.4.7. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Robotic Donor Procedures for the Pediatric Recipient
33.4.8. Living Donor Liver Transplantation - The Donor, Surgical Procedures: Robotic Donor Procedures for the Adult Recipient
33.5. Living Donor Liver Transplantation - The Donor: Perioperative Care
33.6. Living Donor Liver Transplantation - The Donor: Donor Morbidity and Mortality
33.7. Living Donor Liver Transplantation - The Donor: Long-Term Donor Outcomes
33.8. Living Donor Liver Transplantation - The Donor: Psychological Aspects
34. Liver Transplantation: The Recipient
34.1. Living Donor Liver Transplantation - Recipient Selection
34.2. Liver Transplantation: The Recipient: Anesthesiologic Management
34.3. Liver Transplantation: The Recipient: Surgical Procedures
34.3.1. Liver Transplantation - The Recipient, Surgical Procedures: Right Lobe Liver Transplant
34.3.2. Extended Right Lobe Transplant
34.3.3. Left Lobe Transplant with and without the Caudate Lobe
34.3.4. Difficult Hepatic Artery Reconstruction in Living Donor Liver Transplantation
34.3.5. Liver Transplantation - The Recipient, Surgical Procedures: Difficult Biliary Reconstruction
34.3.6. Liver Transplantation - The Recipient, Surgical Procedures: Optimized Venous Outflow
34.3.7. Liver Transplantation - The Recipient, Surgical Procedures: The Pediatric Recipient
34.3.8. Double Liver Transplants
34.3.9. Monosegment Grafts
34.3.10. Liver Transplantation - The Recipient, Surgical Procedures: Auxiliary Liver Transplants
34.3.11 Pure laparoscopic living donor hepatectomy in Pediatric LDLT
34.4. Liver Transplantation - The Recipient: Ischemia and Reperfusion Injury
34.5. Liver Transplantation - The Recipient: Small-for-size-grafts
34.6. Liver Transplantation - The Recipient: Perioperative Care of the Adult Liver Recipient
34.7. Liver Transplantation - The Recipient: Perioperative Care of the Pediatric Liver Recipient
34.8. Liver Transplantation - The Recipient: Liver Transplantation and Complications
34.9. Liver Transplantation - The Recipient: Interventional Therapies
34.10. Liver Transplantation - The Recipient: Immunosuppressive Therapy in Liver Transplantation
34.11. Liver Transplantation - The Recipient: Immunobiology
34.12. Liver Transplantation - The Recipient: Specific Indications
34.12.1. Liver Transplantation - The Recipient, Specific Indications: Hepatitic C
34.12.2. Liver Transplantation - The Recipient, Specific Indications: Cancer
34.12.3. Liver Transplantation - The Recipient, Specific Indications: Alcohol Abuse
34.12.4. Liver Transplantation - The Recipient, Specific Indications: Acute Liver Failure
34.13. Domino Liver Transplantation
34.13.1. Liver Transplantation - The Recipient, Domino Liver Transplantation: Technical Aspects
34.13.2. Liver Transplantation - The Recipient, Domino Liver Transplantation: Report from the Domino Liver Transplant Registry
34.14. Liver Retransplantation
34.14.1. Liver Retransplantation: The Recipient: Adult Recipient
34.14.2. Liver Retransplantation: The Recipient: Pediatric Recipient
34.15. Long-Term Outcome
34.15.1. Liver Transplantation - The Recipient, Long-Term Outcome: Adult Recipient
34.15.2. Liver Transplantation - The Recipient, Long-Term Outcome: Pediatric Recipient
34.16. Strategies To Maximize The Donor Pool: Abo Incompatibility
35. Liver Transplantation: Cost Analysis
SECTION IV. INTESTINAL TRANSPLANTATION
36. History of Living Donor Intestinal Transplantation
37. Indications for Living Donor Intestinal (and Liver) Transplantation
38. Intestinal Transplantation – The Donor
38.1. Intestinal Transplantation - The Donor: Selection and Workup
38.2. Intestinal Transplantation - The Donor: Surgical Procedures and Perioperative Care
39. Intestinal Transplantation – The Recipient
39.1. Intestinal Transplantation - The Recipient: Selection and Workup
39.2. Intestinal Transplantation - The Recipient: Surgical Procedures and Perioperative Care
39.3. Intestinal Transplantation - The Recipient: Sequential and Simultaneous Intestinal and Liver Transplants - Indications, Techniques and Outcome
39.4. Intestinal Transplantation - The Recipient: Immunosuppressive Therapy, Immunobiology Therapy and Postoperative Complications
39.5. Intestinal Transplantation - The Recipient: Long-Term Outcomes
39.6. Intestinal Transplantation - The Recipient: Registry Report
SECTION V. UTERUS TRANSPLANTATION
40. History of Living Donor Uterus Transplantation
41. Uterus Transplantation - The Donor
41.1. Uterus Transplantation - The Donor: Selection and Workup
41.2. Uterus Transplantation - The Donor: Surgical Procedures, Perioperative Care and Postoperative Complications
41.3. Uterus Transplantation - The Donor: Robotic And Laparoscopic Procedures
42. Uterus Transplantation - The Recipient
42.1. Uterus Transplantation - The Recipient: Indication, Selection and Workup
42.2. Uterus Transplantation - The Recipient: Psychosocial Assessment
42.3. Uterus Transplantation - The Recipient: Surgical Procedures and Perioperative Care
42.4. Uterus Transplantation - The Recipient: Immunosuppressive Therapy and Postoperative Complications
42.5. Uterus Transplantation - The Recipient: From Living Donor Uterus Transplantation to Live Birth Obstetrical Management
42.6. Uterus Transplantation - The Recipient: Global Results Of Living Donor Uterus Transplantation
42.7. Uterus Transplantation - The Recipient: Should Uterus Transplantation be Publicly Funded?
PART V. FUTURE DEVELOPMENTS AND ALTERNATIVES TO LIVING DONOR TRANSPLANTATION
43. Dual-Organ Donation and Transplantation
44. Use of Living Donors for HIV-Positive Transplant Candidates
45. New Immunosuppressive Protocols
46. Strategies to Induce Tolerance
47. Xenotransplantation
48. Gene Therapy
49. Organogenesis and related approaches for organ replacement
50. Consensus Conferences on Living Donor Organ Transplantation
50.1. Consensus Conferences on Living Donor Organ Transplantation: Commentary: The Istanbul Declaration On Organ Trafficking And Transplant Tourism
50.2. Consensus Conferences on Living Donor Organ Transplantation: Commentary: The Amsterdam And Vancouver Conferences On Living Organ Donation
51. Impact of the Coronavirus Pandemic on Living Donor Organ Transplantation
- Edition: 2
- Published: November 24, 2023
- Imprint: Academic Press
- Language: English
RG
Rainer W.G. Gruessner
Dr. Rainer W. G. Gruessner, MD, FACS, FICS, is Professor of Surgery at SUNY Downstate Health Sciences University. He formerly served as Chairmen of the Departments of Surgery at the University of Zurich, University of Arizona, and State University of New York. Dr. Gruessner is a nationally renowned surgeon and clinical innovator who has developed new surgical techniques for intestinal, pancreas, and liver transplants. He is prolific academic, a committed educator, and successful mentor to surgical and transplant faculty, residents and fellows. Dr. Gruessner’s academic accomplishments include more than 700 published manuscripts, review articles, book chapters, and published abstracts. Dr. Gruessner has been an invited speaker at over 170 institutions and meetings worldwide. He’s (co-) edited five textbooks: the standard textbooks on Transplantation of the Pancreas, Living Donor Transplantation, and Robotic Surgery and serving as senior editor of a textbook on Transplantation, Bioengineering and Regeneration of the Endocrine Pancreas and a textbook on Technological Advances in Surgery, Trauma and Critical Care. He has served as PI and co-investigator on over 20 research projects and clinical trials, supported by industry, foundations, and the NIH. Dr. Gruessner is a member of over 20 national and international professional societies, has organized many international congresses, is an editorial board member for about 10 journals and has served on many professional and societal committees. In 2019, he received the Richard C. Lillehei award from the International Pancreas and Islet Association (IPITA) for his lifetime achievements in the field of pancreas transplantation.
Affiliations and expertise
Professor and Former Chairman, Department of Surgery, University of Zurich, University of Arizona, and State University of New York, SUNY-Downstate Medical Center, Brooklyn, NY, USAEB
Enrico Benedetti
Enrico Benedetti, MD, FACS, Warren H. Cole Chair in Surgery, Professor and Head of the Department of Surgery and Medical Director, Abdominal Organ Transplant Program at the University of Illinois at Chicago.
Enrico Benedetti was born in Perugia, Italy, on Oct. 3, 1960. Dr. Benedetti graduated cum laude from the medical school in the University of Florence in 1985 and completed a surgical residency at the same university by 1989.
In 1989, he moved to Chicago to start a United States surgery residency at the University of Illinois at Chicago, which he completed in 1993. Dr. Benedetti earned a fellowship in transplant surgery at the University of Minnesota. Since 1994, Dr. Benedetti has been a transplant surgeon at the University of Illinois. He started as an Assistant Professor of Surgery and rose through the ranks first to Associate Professor in 1999 and then to Professor in 2005. Dr. Benedetti is currently the Head of Department of Surgery and the Director of the Abdominal Organ Transplant Program at the University of Illinois at Chicago. Dr. Benedetti is also the recipient of the Joseph Cardinal Bernardin Humanitarian of the Year Award. Dr. Benedetti has published more than 300 articles and more than 30 book chapters and is the editor of the seminal book, “Living Donor Organ Transplantation.”
Included among his many surgical accomplishments are:
• The first successful combined coronary artery bypass and liver transplant worldwide
• The first robotic donor nephrectomy for living donor kidney transplant worldwide in 2000
• The first combined living donor liver/bowel transplant from adult to an infant worldwide in 2003
• The first robotic combined kidney/pancreas procurement for living donor kidney/pancreas transplant worldwide in 2005
• The largest series worldwide of living donor intestinal transplantation (32 of a total of 47 cases done in the world)
• First robotic kidney transplant in obese recipient in 2009
Affiliations and expertise
Warren H. Cole Chair in Surgery, Professor & Head, Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA