Lipid-Drug Conjugates
Innovation and Applications
- 1st Edition - May 16, 2025
- Imprint: Academic Press
- Editor: Malay K. Das
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 3 3 8 2 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 3 3 8 3 - 5
Lipid-Drug Conjugates: Innovation and Applications highlights the most recent advances and clinical applications of nano lipid-drug conjugates for enhanced drug delivery and target… Read more
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Request a sales quoteLipid-Drug Conjugates: Innovation and Applications highlights the most recent advances and clinical applications of nano lipid-drug conjugates for enhanced drug delivery and targeting in the treatment of cancer, glioblastoma, Alzheimer’s, AIDS, and bacterial diseases. In addition, various conjugation methods to prepare lipid-drug conjugates and their pharmacokinetics in vivo are explored, together with the production and characterization of various delivery carriers for lipid-drug conjugates. The contents of this book provide pharmaceutical science researchers with the tools to explore targeted drug delivery leveraging the unique characteristics of lipid conjugates. Scientists in the corporate setting can benefit of the cases and techniques presented in developing new formulations and products.
- Introduces the principles, methods and therapeutic benefits of lipid-drug conjugates
- Summarizes recent scientific progress and novel applications of nano lipid-drug conjugates
- Provides supportive clinical evidence for several applications
Researchers, professors, and students in the field of pharmaceutical sciences, biotechnology, and applied chemistry
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Part 1: Innovations in lipid-drug conjugates
- Chapter 1. Lipid-drug conjugates: application of lipid in drug delivery
- Abstract
- 1.1 Introduction
- 1.2 The concept of lipid-drug conjugates
- 1.3 Various lipid moieties used in lipid-drug conjugate designing
- 1.4 Method of preparation
- 1.5 Incorporation of lipid-drug conjugates in delivery systems
- 1.6 Delivery system for lipid-drug conjugates
- 1.7 Advantages of lipid-drug conjugates
- 1.8 Applications of lipid-drug conjugates
- 1.9 Conclusion and future perspective
- References
- Chapter 2. Lipid-drug conjugates: conjugation methods and therapeutic benefits
- Abstract
- 2.1 Introduction
- 2.2 Lipid-drug conjugation methods
- 2.3 Therapeutic benefits of lipid-drug conjugates
- 2.4 Current status quo on clinical trials of lipid-drug conjugates
- 2.5 Conclusion and future perspectives
- References
- Further reading
- Chapter 3. Route of administration and cellular interaction of lipid drug conjugates
- Abstract
- 3.1 Introduction
- 3.2 Delivery system of lipid drug conjugations
- 3.3 Routes of administration
- 3.4 Cellular interaction of lipid drug conjugates
- 3.5 Conclusion
- References
- Chapter 4. Lipid–drug conjugates for enhanced drug delivery and targeting
- Abstract
- 4.1 Introduction
- 4.2 Lipid–drug conjugate
- 4.3 Selection of drugs, lipids, solvents, and possible linkers in the formulation of lipid–drug conjugates
- 4.4 Application of lipid–drug conjugates: a flourishing approach for enhanced drug targeting
- 4.5 Mechanism of drug release from lipid–drug conjugates
- 4.6 Conclusion and future perspectives
- Acknowledgment
- Conflict of interest
- References
- Further reading
- Chapter 5. Antibody-conjugated lipid nanoparticles as a targeted drug delivery system for hydrophobic drugs
- Abstract
- 5.1 Introduction
- 5.2 Hydrophobic drugs and their delivery challenges
- 5.3 Lipid nanoparticles, and antibodies as targeting agents
- 5.4 Antibodies as targeting agents
- 5.5 Conjugation techniques for ACNP production
- 5.6 Challenges in the development of ACNPs for medical use
- 5.7 Diagnostic applications of ACNPs
- 5.8 Future perspectives
- 5.9 Conclusion
- Author contributions
- Declaration of competing interest
- Acknowledgments
- References
- Chapter 6. Pharmacokinetics of lipid drug conjugates
- Abstract
- 6.1 Introduction
- 6.2 Structural features, conjugation methods, and delivery carriers
- 6.3 Pharmacokinetics of lipid drug conjugates
- 6.4 Clinical implications of lipid drug conjugates and its challenges
- 6.5 Conclusion and future directions
- References
- Chapter 7. Production and characterization of various delivery carriers for lipid–drug conjugates
- Abstract
- 7.1 Introduction
- 7.2 Delivery carries of lipid–drug conjugates
- 7.3 Production method of lipid–drug conjugate loaded delivery carriers
- 7.4 Characterization of lipid–drug conjugates loaded delivery carrier
- 7.5 Mechanism of drug release from lipid–drug conjugates based carriers
- 7.6 Clinical aspects of lipid–drug conjugates based drug development
- 7.7 Patent review on lipid–drug conjugates
- 7.8 Regulatory aspects of lipid–drug conjugate nanocarriers
- 7.9 Conclusion
- References
- Part 2: Applications of lipid-drug conjugates
- Chapter 8. Lipid-drug conjugates for cancer chemotherapy
- Abstract
- 8.1 Overview of lipid-drug conjugates in cancer chemotherapy
- 8.2 Chemistry of lipid-drug conjugates
- 8.3 Benefits of lipid-drug conjugate over traditional chemotherapy agents
- 8.4 Delivery systems for lipid-drug conjugates
- 8.5 Stimuli-responsive lipid-drug conjugates
- 8.6 Current status of lipid-drug conjugates in clinical trials
- 8.7 Conclusion
- References
- Chapter 9. Lipid-drug conjugates for enhanced antiretroviral efficacy
- Abstract
- 9.1 Introduction
- 9.2 Principles and mechanisms of lipid-drug conjugates
- 9.3 Preclinical studies and in vitro evaluation
- 9.4 Clinical studies and translational research
- 9.5 Future directions and challenges
- 9.6 Conclusion
- References
- Chapter 10. Nano lipid-drug conjugates for the treatment of Alzheimer’s disease
- Abstract
- 10.1 Introduction
- 10.2 Nanotechnology in the treatment of Alzheimer’s disease
- 10.3 Nano lipid-drug conjugates
- 10.4 Applications of nano lipid-drug conjugates in Alzheimer’s disease
- 10.5 Preclinical and clinical evidences of nano lipid-drug conjugates in the treatment of Alzheimer’s disease
- 10.6 Safety and toxicity considerations
- 10.7 Conclusion and future perspectives
- References
- Chapter 11. Lipid-drug conjugates for the treatment of glioblastomas
- Abstract
- 11.1 Introduction
- 11.2 Conventional chemotherapy for glioblastoma multiforme
- 11.3 The significance of combination therapy as a promising approach against glioblastoma multiforme
- 11.4 Progression in glioblastoma multiforme by use of nanocarriers
- 11.5 Challenges associated with combination drugs
- 11.6 Clinical trials
- 11.7 Conclusion
- References
- Further reading
- Chapter 12. Antibody drug conjugates integrated with lipid nanocarrier for cancer theranostics
- Abstract
- 12.1 Introduction
- 12.2 Structure-activity of antibody-drug conjugate
- 12.3 Various types of lipid nanocarriers
- 12.4 Integration of antibody-drug conjugates with lipid nanocarriers
- 12.5 Antibody-drug conjugate with lipid nanocarriers in cancer therapy
- 12.6 Conclusion and future perspectives
- References
- Chapter 13. Antibacterial drug conjugates for bacterial diseases
- Abstract
- 13.1 Introduction
- 13.2 Mechanisms of antibacterial drug conjugates
- 13.3 Recent advances in antibacterial drug conjugates
- 13.4 Challenges and limitations in antibacterial drug conjugates
- 13.5 Conclusion
- References
- Further reading
- Chapter 14. Lipid-drug conjugates: future perspectives, industry trends and global forecast
- Abstract
- 14.1 Introduction
- 14.2 Industrial feasibility of manufacturing
- 14.3 Current industry trends on lipid-drug conjugates
- 14.4 Regulatory aspects of lipid-drug conjugates
- 14.5 Global forecast
- 14.6 Conclusion and future perspectives of lipid-drug conjugates
- References
- Index
- Edition: 1
- Published: May 16, 2025
- No. of pages (Paperback): 430
- No. of pages (eBook): 450
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443333828
- eBook ISBN: 9780443333835
MD
Malay K. Das
Malay K. Das (MPharm, PhD) is a Professor of Pharmaceutics at the Department of Pharmaceutical Sciences, Dibrugarh University, in India. His research interests include novel drug delivery systems, pharmaceutical nanotechnology, nanomedicine, and transdermal and targeted drug delivery systems. He has handled several major research projects sponsored by the DST, DBT, ICMR, UGC, and AICTE. Professor Das has been honored with the prestigious DBT-Biotechnology Overseas Associateship at the University of South Florida, Tampa, United States and the DST-UKIERI Research Award in collaboration with the Institute of Pharmaceutical Sciences, King’s College, London, United Kingdom. He has several publications including peer-reviewed research and review articles in various international journals, as well as chapters in various books published by international publishers.
Affiliations and expertise
Professor of Pharmaceutics, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, IndiaRead Lipid-Drug Conjugates on ScienceDirect