Lignin-based Materials for Biomedical Applications

Preparation, Characterization, and Implementation

1st Edition - July 26, 2021
Imprint: Elsevier
Editors: Patrícia Figueiredo, Hélder A. Santos
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 3 0 3 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 3 0 4 - 0

Lignin-based Materials for Biomedical Applications: Preparation, Characterization, and Implementation explores the emerging area of lignin-based materials as a platform for advan… Read more

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Lignin-based Materials for Biomedical Applications: Preparation, Characterization, and Implementation explores the emerging area of lignin-based materials as a platform for advanced biomedical applications, guiding the reader from source through to implementation.

The first part of the book introduces the basics of lignin, including extraction methods, chemical modifications, structure and composition, and properties that make lignin suitable for biomedical applications. In addition, structural characterization techniques are described in detail. The next chapters focus on the preparation of lignin-based materials for biomedical applications, presenting methodologies for lignin-based nanoparticles, hydrogels, aerogels, and nanofibers, and providing in-depth coverage of lignin-based materials with specific properties—including antioxidant properties, UV absorbing capability, antimicrobial properties, and colloidal particles with tailored properties—and applications, such as drug and gene delivery, and tissue engineering. Finally, future perspectives and possible new applications are considered.

This is an essential reference for all those with an interest in lignin-based materials and their biomedical applications, including researchers and advanced students across bio-based polymers, polymer science, polymer chemistry, biomaterials, nanotechnology, materials science and engineering, drug delivery, and biomedical engineering, as well as industrial R&D and scientists involved with bio-based polymers, specifically for biomedical applications.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
1 Introduction to lignocellulosic materials
Abstract
1.1 Introduction
1.2 Lignocellulosic materials: sources, components, and pretreatment methods
1.3 Applications of cellulose-based materials
1.4 Applications of hemicellulose-based materials
1.5 Applications of lignin-based materials
1.6 Conclusions
Acknowledgments
References
2 Lignin: an innovative, complex, and highly flexible plant material/component
Abstract
2.1 Introduction
2.2 Lignin occurs in both nonvascular and vascular plants
2.3 Monolignol biosynthesis and lignin polymerization genes appeared early during plant evolution
2.4 Lignin content and composition is highly variable
2.5 Lignin structure and composition is complex but highly flexible
2.6 Methods to analyze lignin composition
2.7 Conclusions
Acknowledgments
References
3 Lignin extraction and isolation methods
Abstract
3.1 Introduction
3.2 Industrial processes
3.3 Biorefinery processes
3.4 New advances in lignin extraction processes
3.5 Conclusions
References
4 Types of lignin, properties, and structural characterization techniques
Abstract
4.1 Introduction
4.2 Types of lignin and its classification
4.3 Lignin analysis and structure-property relationships
4.4 Lignins in biomedicine
References
5 Chemical modifications of lignin
Abstract
5.1 Introduction
5.2 General background
5.3 Chemical modifications
5.4 Conclusion
References
6 Requirements and properties of biomaterials for biomedical applications
Abstract
6.1 Introduction
6.2 Engineering nanoparticles for therapeutic applications
6.3 Surface functionalization
6.4 Stimuli-responsive nanomaterials
6.5 Conclusions
Acknowledgments
References
7 Development of lignin-based nanoparticles: fabrication methods and functionalization approaches
Abstract
7.1 Introduction
7.2 Fabrication of lignin nanoparticles
7.3 Functionalization of lignin nanoparticles for biomedical applications
7.5 Conclusions and future perspectives
Acknowledgments
References
8 Lignin-based materials with UV-blocking property
Abstract
8.1 Introduction
8.2 Natural macromolecular UV adsorbing structure of lignin
8.3 Light-color and broad-spectrum modifications on lignin
8.4 UV-blocking applications of lignin-based materials
8.5 Conclusions and perspectives
References
9 Lignin-based materials with antioxidant and antimicrobial properties
Abstract
9.1 Introduction
9.2 Antimicrobial and antioxidant behavior of lignin-derived composites
9.3 Antimicrobial and antioxidant behavior of lignin-derived nanocomposites
9.4 Fabrication of lignin-stabilized noble metal nanoparticles
9.5 Main applications of lignin-based materials
9.6 Conclusions
References
10 Lignin-based materials for drug and gene delivery
Abstract
10.1 Introduction
10.2 Physicochemical properties and biological activities
10.3 Lignin derivates approaches
10.4 Drug/gene delivery applications
10.5 Bioimaging
10.6 Current status and future outlook
References
11 Fabrication of lignin-based hydrogels and their applications
Abstract
11.1 Introduction
11.2 Lignin-based hydrogels
11.3 Biomedical applications of lignin-based hydrogels
11.4 Conclusions and future perspectives
References
12 Present and future prospective of lignin-based materials in biomedical fields
Abstract
12.1 Introduction
12.2 Lignin-based materials for biomedical applications
12.3 Limitations, challenges, and future perspectives
12.4 Conclusions
Acknowledgments
References
Index

Patrícia Figueiredo

Patrícia Figueiredo is a postdoctoral researcher at the University of Helsinki, where she obtained her PhD in Pharmaceutical Technology with honors in 2020. Her research is focused on the development of lignin-based nanosystems with potential application in biomedicine and food science. She has authored/co-authored 37 publications, including reviews and book chapters, and 6 oral/poster presentations in international scientific meetings. She also has more than 800 citations and h-index=14.

Affiliations and expertise

Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland

Hélder A. Santos

Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor in Department of Biomedical Engineering at the University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of MSCA-ITN P4 FIT network in tendon repair (~4.1 m€). He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is also in Editorial board member of several international journals, and Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious awards/grants, for example, the "Talent Prize in Science" in 2010 attributed by the Portuguese Government, ERC Starting Grant in 2013 and ERC Proof-of-Concept Grant in 2018, Young Researcher Award in 2013 attributed by Faculty of Pharmacy, the Academy of Finland Award for Social Impact in 2016, and the CRS Young Investigator Award 2021.

Affiliations and expertise

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Biomedical Engineering, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands

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