Kaufman’s Atlas of Mouse Development Supplement
With Coronal Sections
- 2nd Edition - November 30, 2024
- Imprint: Academic Press
- Editors: Gillian Morriss-Kay, Shankar Srinivas
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 7 3 9 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 7 3 8 - 6
Kaufman's Atlas of Mouse Development Supplement, Second Edition continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morph… Read more
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Request a sales quoteKaufman's Atlas of Mouse Development Supplement, Second Edition continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems. The book explores the developmental origins of the organ systems, following the original atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. In this new edition, each chapter has been updated to include the latest research, along with while new chapters on the functional aspects of mouse and human heart development, the immune system, and the inner ear.
These additions ensure an up-to-date resource for all biomedical scientists who use the mouse as a model species for understanding the normal and abnormal development of human systems.
- Offers in-depth anatomy and morphological views of organ systems and their developmental origins
- Includes the latest techniques for visualizing gene expression and other functional aspects of tissue and organ development
- Explores the links between mouse and human developmental processes
- Features high-quality color images to help readers visualize key developmental processes and structures
Researchers and graduate students in developmental biology and related fields across biological and biomedical research, Graduate students in the field of molecular genetics, biochemistry, regenerative medicine, and mammalian anatomy
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editors
- Chapter 1. Introduction
- Chapter 2. Coronal sections
- Introduction
- Methods
- Results
- Discussion
- Chapter 3. A revised staging of mouse development before organogenesis
- Introduction
- Methods
- Overview of the revised staging system, TS1–12
- Anatomy of stages with representative molecular markers
- Preimplantation stages: TS1–5, E0 to E3.5 (Fig. 3.1)
- From implantation to the prestreak stage: TS6–9a, E4.5–6.5 (Fig. 3.2)
- Early primitive streak to late pre-headfold. TS9b–11b, E 6.5–E7.5 (Fig. 3.3)
- Early headfold to early somitogenesis. TS11a–12, E7.5–8 (Fig. 3.4)
- Timing and litter variation
- Comparison of early mouse and human development
- Discussion
- Chapter 4. Establishment of early embryonic lineages and the basic body plan
- Introduction
- Development of the preimplantation conceptus
- Formation of the postimplantation egg cylinder
- The primitive streak and gastrulation
- The three germ layers and their derivatives
- Embryonic folding
- Concluding remarks
- Chapter 5. Early organogenesis: Placing and elaborating the organ primordia
- Introduction
- Left/right patterning (TS11d-TS12; E7.5-8.0)
- Initiation of somitogenesis and the restriction of potency in the epiblast (TS11d; E8.0 onwards)
- Axial progenitor populations
- Primary versus secondary neurulation: Accepted view and known facts
- Somitogenesis
- Comparison of mouse and human tail development and the end of axis elongation
- In vitro embryo models: Micropatterns, gastruloids, trunk-like structures and embryo-like structures
- Discussion and prospects
- Chapter 6. Placenta formation—Developmental milestones toward the establishment of a functional feto-maternal interface
- Introduction
- The emergence of the trophoblast lineage—From fertilization to blastocyst formation (Stages E0.5–E4.5)
- Early postimplantation development—Stages E5.0–E7.5
- Trophoblast invasion and spiral artery remodeling—Stages E7.5 to E9.5
- Gastrulation, extraembryonic mesoderm formation and chorio-allantoic fusion—Stages E7.5–E9.5
- The establishment of a functional placenta—Stages E9.5–E10.5
- Placental structure—Stages E10.5–E19.5
- Links with human pregnancy conditions and developmental abnormalities
- Digital and other resources
- Chapter 7. Spatiotemporal dynamics of mouse heart tube development
- Imaging mouse heart development
- Staging mouse heart development
- Spatiotemporal mapping of heart precursors, lineages, and differentiation
- Tube formation
- Tube elongation and remodeling
- Chamber growth
- Cell type diversification
- Left–right asymmetries
- Conclusions
- Resources
- Supplementary material
- Companion website
- Chapter 8. Establishment of a double blood circulation in the developing mouse heart
- Introduction
- Formation and connection of the caval veins to the right atrium
- Formation and incorporation of the pulmonary vein into the left atrium
- Atrial septation
- Ventricular septation
- Septation of the outflow tract into the trunks of the great arteries
- Valve development
- The mouse as an experimental model of human congenital heart defects
- Abbreviations
- Chapter 9. Development of the hematopoietic system
- Introduction
- Cells of the developing hematopoietic system
- Sites of emergence of hematopoietic potential
- Pre-circulation sites of de novo hematopoiesis
- Yolk sac blood islands
- Allantois and chorion
- Sites of de novo hematopoiesis after the onset of circulation
- Yolk sac vascular plexus
- Heart
- Placenta
- Dorsal aorta
- Proximal regions of the vitelline and umbilical arteries
- Head
- Co-development of the hematopoietic and vascular system
- Sites of hematopoietic colonization and differentiation
- Fetal liver
- Thymus
- Spleen
- Bone marrow
- Lymphoid organs and tissues
- Adrenal gland
- Parallels with human hematopoietic development
- Chapter 10. Thymus development
- Introduction
- The first stage of thymus organogenesis: Pharyngeal development
- The second stage of thymus organogenesis: Cross-talk patterns the thymus anlage
- Third stage of thymus organogenesis: Late fetal thymus development
- Cells resident in the embryonic thymus
- Thymocytes
- Thymic stromal cells
- Thymic epithelial cells
- Non-epithelial thymic stromal cells
- Transcriptional regulation of thymus organogenesis
- Signaling in thymus organogenesis
- Conclusion
- Chapter 11. Gastrointestinal tract
- Introduction
- Anterior–posterior patterning: A focus on transcription factors and the tissue specificities they bring about in the adult
- Esophagus
- Stomach
- Small intestine
- Caecum
- Colon and rectum
- Herniation, lengthening, and looping
- Epithelial vilification and differentiation
- Smooth muscle and interstitial cells of Cajal
- Enteric nervous system
- Vasculature and lymphatic development
- Conclusion
- Chapter 12. Development of the pancreas
- Introduction
- The current view of the developmental anatomy of the pancreas
- Primary transition (part I): Formation of the pancreatic anlagen (mouse, E8.5–10.5; human, 22–33 days post conception, dpc)
- Primary transition (part II): Morphogenesis and fusion of the pancreatic anlagen (mouse, E10.5–12.5; human, 33–40 dpc)
- Secondary transition: Lineage and differentiation (mouse, E12.5–16.5; human, 40–54 dpc)
- Morphogenesis of the spleen as it relates to pancreatic development
- Tertiary transition: Final glandular formation and positioning (mouse, E16.5 to postnatal stages; human, 54–58 dpc and after birth (>58 dpc))
- The adult pancreas and islet formation
- Discussion
- Chapter 13. The reproductive system
- Introduction
- The early stages and bipotential gonad
- Formation of the intermediate mesoderm
- Primordial germ cell specification and migration
- Main genes and pathways involved in PGC specification and migration
- The developmental fate of PGCs in the testis or ovary
- The emergence of in vitro gametogenesis
- Formation of the bipotential gonad
- Anatomical structure of the bipotential gonad
- Cell types comprising the bipotential gonad
- Main genes and pathways involved in bipotential gonad specification
- Early development of dual reproductive tracts and external genitalia
- Molecular pathways and genes involved in early specification of reproductive tracts and genitalia
- The big decision: To become a testis or an ovary?
- Male development
- The anatomical structure of the testis
- Cell types comprising the testis
- Male germ cells enter mitotic arrest till puberty
- Main genes and pathways involved in male sex determination
- Formation of the male reproductive tract and external genitalia
- Molecular factors involved in the development of the male reproductive tract and external genitalia
- Female development
- The anatomical structure of the ovary
- Cell types comprising the ovary
- Female germ cells enter first meiosis in the ovary and are arrested
- Main genes and pathways involved in female sex determination
- Formation of the female reproductive tract and external genitalia
- Molecular factors involved the female reproductive tract and external genitalia
- Sex maintenance in adulthood
- Discussion and future prospects
- Chapter 14. Development of the respiratory system
- Overview
- Foregut morphogenesis and establishment of trachea and primary lung buds
- Structure of the trachea and submucosal glands
- Branching morphogenesis of the primary lung buds
- Alveologenesis
- Vasculature, lymphatics, immune cells, and nerves
- Diversity of mesodermal cells
- Mesothelium
- Discussion
- Chapter 15. The urinary system
- Introduction
- The current view of the developmental anatomy of the system
- Recent lineage data
- Molecular mechanisms regulating development
- Branching
- Self-renewal versus differentiation in the cap
- Tubule segmentation
- Differences between mouse and human urinary system development
- In vitro models for kidney development
- Discussion
- Further resources
- Chapter 16. Integument and associated integumentary appendages
- Introduction: The structural diversity of mouse integument
- Early integumental development
- Specification of discrete domains in the ectoderm
- Origin, migration, and formation of the dermis
- Cornea, interfollicular skin, and pilosebaceous units
- Cornea
- Interfollicular skin
- Different types of hairs, their pattern and time schedule
- Molecular mechanisms involved in the formation of hair placodes and subsequent cellular proliferation
- Hair follicle morphogenesis and segregation of two types of stem cells in the developing pilosebaceous unit
- Development of the sebaceous gland and related glandular structures
- The mammary gland
- Formation of the mammary line and associated mesenchyme
- Formation of the embryonic mammary gland
- Other ducted cutaneous glands
- Eccrine sweat glands
- Salivary glands
- Lacrimal and Harderian glands
- Discussion
- Chapter 17. The axial musculoskeletal system
- Introduction
- The current view of the developmental anatomy of the system
- Developmental anatomy of the segmentation process
- Somite differentiation
- The sclerotome
- The dermomyotome and the myotome
- The syndetome
- New lineage data
- Sclerotome
- Dermomyotome and myotome
- Insights into segmental specificity of somite development
- Differential progression of somite differentiation along the anterior posterior axis
- The different origin of occipital and postoccipital somites
- The neck as a transition region between cranial and trunk development
- Lessons from the mouse to understand congenital human malformations affecting the axial skeleton
- Discussion
- Chapter 18. Spinal cord and peripheral nervous system
- Introduction
- Developmental anatomy of the spinal cord
- Neurulation and neural tube defects
- Anteroposterior patterning and segmental organization of the spinal cord
- Dorsoventral patterning of the neural tube
- The peripheral nervous system
- Principles of segmental organization of the peripheral nervous system
- Segmental neural crest cell migration and segmental nerve formation
- Segmental organization of somatic and sympathetic efferent nerves
- The enteric nervous system
- The development of neuronal pathways within the spinal cord
- General principles
- The formation of sensory–motor connections
- The formation of motor columns
- Formation of spinal nerves
- The refinement of connections
- Discussion and clinical perspective
- Chapter 19. Limb development
- Introduction
- Anatomical features of the early limb bud
- Limb initiation, specification, and outgrowth
- Limb patterning
- Proximodistal axis
- Anteroposterior axis
- Integrating proximodistal and anteroposterior signaling
- Dorsoventral axis
- Programmed cell death
- Chondrogenesis and joint formation
- Tendon and ligament development
- Limb development and human abnormalities
- Conclusion
- Online resources
- Chapter 20. The craniofacial region
- Introduction
- Early morphogenesis of the cranial region
- The embryonic face, pharynx and middle ear
- Facial swellings
- Pharyngeal arch cartilages and their derivatives
- Pharyngeal clefts
- Cranial nerves
- The skull
- The skull base
- The skull vault and face
- Discussion
- Chapter 21. Regulatory mechanisms of palate and tongue development
- Summary
- Introduction
- The current view of the developmental anatomy of the palate and tongue
- Palate development
- Patterning of the palatal shelves
- Dynamic growth of the palatal shelves
- Palatal shelf growth: Proliferation of the CNCC-derived mesenchyme
- Epigenetic regulation of palatogenesis
- Palatal fusion
- Soft palate development
- Tongue development
- Myogenic lineage in the developing tongue
- Cranial neural crest-derived mesenchyme in the developing tongue
- Myogenic stem cells, tongue disease, and therapeutic perspectives
- Discussion
- Chapter 22. The developmental anatomy of teeth
- Introduction
- Developmental stages
- Dental and vestibular laminae
- Tooth placodes
- Bud to cap
- Bell stage onward
- Sequential molar formation
- Tooth replacement and incisor stem cells
- Discussion: Insights into human tooth development and anomalies
- Digital resources
- Chapter 23. Brain development
- Introduction
- Early mouse brain neurodevelopment
- Neural induction and neurulation
- Signal gradients and early regionalization
- Primary brain divisions
- The developmental anatomy of the mouse cerebral neocortex
- Cortical neuron origin and migration
- Excitatory and inhibitory cell subtypes
- Pyramidal cells and radial migration
- Interneuron generation and tangential migration
- Cell death and plasticity during cortical development
- Other mechanisms controlling mouse neocortical development
- Extrinsic and intrinsic influences
- Thalamocortical development and connectivity
- Formation of cortical maps and barrel cytoarchitecture
- The development of the mouse cerebellum
- Primordial morphogenesis
- Cerebellar cell proliferation and differentiation
- The formation of cerebellar connections
- Developmental mouse brain atlases
- Adult mouse brain atlases
- Developmental mouse brain atlases and common coordinate frameworks
- Developmental cell-type-specific atlas registration
- Conclusions
- Chapter 24. The visual system
- Introduction
- The current view of the developmental anatomy of the visual system
- Establishing the eye field
- Signals
- Transcription factors
- Separating the eye field
- Optic vesicle patterning and morphogenesis
- Optic cup development
- The lens
- Lens placode: Transcription factors and signals
- Lens placode invagination
- Retinal histogenesis
- The optic nerve and chiasm
- RGC growth to the optic nerve
- The optic chiasm
- Topographic mapping
- The anterior segment
- Cornea
- Iris
- Signals and transcription factors in anterior segment development
- Accessory structures
- Eyelids
- Extraocular muscles, choroid, and sclera
- Blood supply
- Discussion
- Chapter 25. Development of the mouse inner ear
- Introduction
- Development of the membranous labyrinth
- The vestibular system
- The auditory system
- Neuronal fate and formation of the inner ear
- Contribution from the neural crest
- Contribution from the mesenchyme
- Relevance to human disease
- Future directions
- Chapter 26. Olfactory system embryonic development
- Introduction
- The current view of the developmental anatomy of the olfactory system
- A brief scheme of the basic organization of the mature olfactory system
- Olfactory pathway development
- Establishment of the olfactory circuitry
- Neural pathways and molecular signaling
- Neurogenesis in the olfactory system
- Cell fate and lineage relationships
- Olfactory research: Current insights and future directions
- Abbreviations
- Chapter 27. The Mouse Developmental Anatomy Ontology (EMAPA) and the Gene Expression Database for Mouse Development (GXD)
- Introduction
- The anatomic ontology for mouse development: Evolution and current status
- Ontology content
- Hierarchical structure
- “Abstract” and stage-specific representations
- Ontology extension and refinement
- Current status
- The Gene Expression Database for Mouse Development (GXD)
- GXD search forms
- Developmental anatomy browser
- Expression data and image search
- Differential expression search
- Expression profile search
- Expression search result summaries, assay details, and images
- Gene expression matrix views
- Anatomy-based data integration: Other datasets and resources
- Future directions
- Anatomy ontology development
- GXD and anatomic integration with other resources
- Chapter 28. Digital graphical resources and developmental anatomy in the mouse
- Introduction
- 3D digital atlas models as a framework for understanding developmental anatomy
- Kaufman eHistology Atlas
- Spatial transcriptomics
- 3D spatial mapping of mouse embryo gene expression data
- Phenotyping of embryonic lethal mouse embryos
- Comparing mouse and human embryo development
- Chapter 29. The informatics of developmental phenotypes
- Introduction
- What are developmental phenotypes?
- Methods for capturing morphological phenotype information
- Phenotype ontologies
- Challenges in morphometric phenotyping
- Developmental lethality as an embryonic phenotype
- Integrating developmental phenotypes within and across species
- Discussion
- Index
- Edition: 2
- Published: November 30, 2024
- No. of pages (Hardback): 498
- No. of pages (eBook): 450
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443237393
- eBook ISBN: 9780443237386
GM
Gillian Morriss-Kay
Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
Gillian Morriss-Kay is Emeritus Professor of Developmental Anatomy at the University of Oxford, where she taught embryology, histology and anatomy to medical students. Her research goal, using first rat, then mouse embryos, was to enhance understanding of normal and abnormal human development, especially of the craniofacial region and neural tube. This led to collaborative mouse-human work on the developmental genetics and morphogenesis of craniosynostosis. She was editor of the Journal of Anatomy for ten years.
Affiliations and expertise
Department of Human Anatomy and Genetics, University of Oxford, Oxford, UKSS
Shankar Srinivas
Shankar Srinivas has a research career spanning 30 years, focusing on mouse developmental genetics (kidney, peri-implantation embryology, gastrulation and early cardiogenesis). More recently his work involves also using human embryos to understand early cell type diversification and cardiogenesis. He teaches anatomy and embryology to medical students. In 2004 Dr. Srinivas started his independent group at the University of Oxford as a Wellcome Trust Career Development Fellow and as Zeitlyn Fellow and Tutor in Medicine at Jesus College. In 2016 he became Professor of Developmental Biology.
His research group studies how the coordinated cell movements that shape the early mammalian embryo prior to and during gastrulation are controlled and understanding how the heart forms and starts to beat. His group takes a multidisciplinary and collaborative approach to address these questions, using techniques spanning molecular genetics, lightsheet and confocal time-lapse imaging, single cell approaches, proteomics and embryo explant culture.
Affiliations and expertise
Professor of Developmental Biology, Department of Physiology, Anatomy and Genetics, Oxford University, Department of Pharmacology, Oxford University, UKRead Kaufman’s Atlas of Mouse Development Supplement on ScienceDirect