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Joint and Bone
From Bench to Bedside
- 1st Edition - January 30, 2023
- Editors: Deming Jiang, Ahmed El-Hashash
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 9 3 8 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 3 3 0 - 3
Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of inform… Read more
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Request a sales quoteJoint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside.
Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.
Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.
- Provides cutting-edge research needed to understand stem cell functions in joint and bone diseases
- Develops processes to bring stem cells from bench to bedside
- Includes up-to-date references on stem cell biology and function in the joint and bone
Stem cell biology scientists, regenerative medicine scientists, physicians and surgeons, Graduate and undergraduate students, researchers and practitioners in these fields, Biomedicine, stem cell biology, regenerative medicine, and joint and bone biology, repair and regeneration, as well as translational regenerative medicine courses in the biomedical, biological and stem cell-related programs
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- About the editors
- Foreword
- Preface
- Epigraph
- Introduction
- Chapter 1. Cutting edge research on stem cell applications in joint, cartilage, and bone repair and regeneration
- Abstract
- Abbreviations
- 1.1 Introduction
- 1.2 Conclusions and future directions
- References
- Chapter 2. Stem cell-based organoid culture system as an innovative model of osteoarthritis and other joint/bone diseases
- Abstract
- 2.1 Introduction
- References
- Chapter 3. Contributions of stem cell engineering to new therapies for joint and bone diseases
- Abstract
- 3.1 Introduction
- 3.2 Stem cell engineering: technologies to promote stem cell therapeutics for joint and bone diseases
- 3.3 Applications of stem cell engineering for joint/bone diseases treatment
- 3.4 Conclusion and perspectives
- Acknowledgment
- References
- Chapter 4. Roles of innovative genome editing technologies in stem cell engineering, rheumatic diseases and other joint/bone diseases
- Abstract
- 4.1 Introduction
- 4.2 Genome editing technologies
- 4.3 Delivery methods
- 4.4 Applications of genome editing technologies in rheumatic diseases and joint/bone diseases
- 4.5 Conclusion
- Acknowledgment
- Competing interests
- Author contributions
- References
- Chapter 5. Therapies related to mesenchymal stem cells for cartilage, joint, and bone diseases
- Abstract
- 5.1 Introduction
- 5.2 Mesenchymal stem cells
- 5.3 MSCs for cartilage repair and regeneration
- 5.4 MSCs for tendon/ligament repair
- 5.5 MSCs for bone regeneration
- 5.6 Prospects
- 5.7 Conclusion
- Acknowledgement
- References
- Chapter 6. Application potentials of the iPSC technology in modeling, drug discovery and regeneration of skeletal system disorders
- Abstract
- 6.1 Introduction
- 6.2 Somatic cell reprogramming and iPSC differentiation
- 6.3 iPSC application in disease modeling and drug screening
- 6.4 iPSC-based regenerative therapy for orthopedic disorders
- 6.5 Perspectives and further challenges
- References
- Chapter 7. Advances in animal models for bone and joint diseases
- Abstract
- 7.1 Introduction
- 7.2 Osteoarthritis
- 7.3 Rheumatoid arthritis
- 7.4 Conclusions
- References
- Chapter 8. Novel biomaterials for stem cell engineering and bone regeneration
- Abstract
- 8.1 The role of biomaterials in bone regeneration
- 8.2 Biomaterials for stem cell delivery in bone regeneration
- 8.3 Biomaterials for stem cell-derived substance delivery in bone regeneration
- 8.4 Biomaterials for endogenous stem cell regulation in bone regeneration
- 8.5 Transformation and limitations of biomaterials for bone regeneration
- References
- Chapter 9. Stem cell innovation in bone and joint health and diseases: general conclusions, challenges and prospectives
- Abstract
- 9.1 Roles of stem cells in modeling bone and joint disease
- 9.2 Stem cell application in the treatment of bone and joint diseases, repair and regeneration
- References
- Index
- No. of pages: 246
- Language: English
- Edition: 1
- Published: January 30, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323919388
- eBook ISBN: 9780323983303
DJ
Deming Jiang
Dr. Gemn Jiang is an Associate Professor at the Zhejiang University School of Medicine. Professor Jiang has committed himself to scientific research in the field of sports system injury and regeneration. He has identified a new tendon differentiation model and recovered new mechanisms of tendon differentiation, as well as fabricated a functional tendon scaffold. Based on this work, he gained YIA of the international tendon/ligament conference in 2010. He also gained the second prize of the Natural Science Award of ministry of education.
Affiliations and expertise
Associate Professor, Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Zhejiang, ChinaAE
Ahmed El-Hashash
Dr. El-Hashash is a fellow of the California Institute of Regenerative Medicine and New York University Medical School. Prof. El-Hashash worked as a senior biomedical research scientist at Mount Sinai School of Medicine of New York University and Children’s Hospital Los Angeles. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at Keck School of Medicine and Ostrow School of Dentistry of The University of Southern California. In 2016, Prof. El-Hashash joined The University of Edinburgh, Edinburgh Medical School-Zhejiang International Campus, as Tenure-Track Associate Professor and Senior Principal Investigator of Biomedicine, Stem Cell & Regenerative Medicine. Prof. El-Hashash has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine and has published more than 25 papers in international journals and serves as an editorial board member of repute. He is the editor or author of several books on stem cell and regenerative medicine.
Affiliations and expertise
Associate Professor of Biomedicine, Texas A&M University, College Station, Texas, USARead Joint and Bone on ScienceDirect