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iPSCs from Diverse Species
- 1st Edition - September 29, 2020
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 2 2 8 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 1 8 5 - 5
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs from Di… Read more
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Request a sales quoteThe series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.
iPSCs from Diverse Species, Volume 2 addresses how induced pluripotent stem cells (iPSCs) can be derived from different species.
The volume teaches the reader about modern state-of-the-art methodologies to derive iPSCs from distinct species. This volume will cover how to derive iPSCs from species like nonhuman primates, horses, dogs, pigs, rats, rabbits, and others. It also discusses the importance of iPSCs in species conservation. Detailed description on methods used to obtain iPSCs from humans and other species expands the knowledge and understanding of stem cell biology and provides a potent tool to model diseases.
The volume is written for researchers and scientists in stem cell biology, and regenerative medicine and is contributed by world-renowned authors in the field.
- Provides overview of the fast-moving field of iPSC technology
- Covers iPCSs from the following species: humans, monkeys, horses, dogs, pigs, rats, rabbits, and more
- Consists of contributions from stem cell leaders around the world
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. Human iPSCs and their uses in developmental toxicology
- Developmental toxicology: A brief history
- iPSCs in developmental toxicology
- iPSCs use and study developmental toxicology
- Endodermal lineage differentiation for hepatic developmental toxicology
- Ectodermal lineage differentiation for neuronal developmental toxicology
- Mesodermal lineage differentiation for cardiomyocyte developmental toxicology
- Alternative applications of iPSCs
- Challenges surrounding iPSCs
- Conclusions
- Chapter 2. Induced pluripotent stem cells from nonhuman primates
- Introduction
- Advances in the range of NHP species that have been subjected to reprogramming
- Advances in genetic modification of NHP iPSCs
- Advances in cell transplantation in NHP models
- Summary
- Chapter 3. Equine induced pluripotent stem cells
- Introduction
- Derivation of equine iPSCs
- Characterization of equine iPSCs
- Directed differentiation of equine iPSCs
- Cell therapy with equine iPSCs
- Equine iPSCs for disease modeling
- Future directions
- Chapter 4. Canine induced pluripotent stem cells: an in vitro approach to validate the dog as a large animal model for Alzheimer’s disease
- Introduction
- Canine cognitive dysfunction—a natural model for Alzheimer’s disease
- Generation of induced pluripotent stem cells from geriatric dogs
- Generation of disease-affected target cell types from canine iPSCs
- Role of signaling pathways in neural development
- Neural induction
- Neuronal differentiation
- Conclusions
- Chapter 5. Porcine iPSCs
- Introduction
- The porcine model
- Historical perspective of piPSCs generation
- Characterization
- Culture strategies
- Future trends
- Glossary
- Chapter 6. Bovine iPSC and applications in precise genome engineering
- Introduction
- Pluripotent stem cells
- Isolation of ESC from Bos taurus species
- Conclusion
- Chapter 7. Induced pluripotent stem cells from buffalo
- Introduction
- Factors and delivery approaches for cellular reprogramming
- Derivation of iPS cells from buffalo
- Culture conditions of buffalo iPS cells
- Characterization of buffalo iPS cells
- Differentiation of buffalo iPS cells
- Future prospectives
- Chapter 8. Establishment of induced pluripotent stem cells from prairie vole-derived fibroblast
- Introduction
- Optimization of the reprogramming conditions for prairie vole iPS cells with prairie vole immortalized cells
- Establishment of prairie vole iPS cells from primary fibroblasts
- Evaluation of iPS cells from prairie vole primary cells
- Conclusions
- A commentary on the likely future trends or directions
- Chapter 9. Rabbit induced pluripotent stem cells: the challenges
- Rabbit as a disease model
- Pluripotent stem cells
- Regulating pathways of pluripotency: lessons learned from the rabbit ESC model
- Technological aspects of reprogramming cells into rabbit iPSCs
- Prospects and conclusions
- Chapter 10. Naked mole rat iPSCs and their noncanonical features: a novel tool for aging research
- Introduction
- Generation of NMR induced pluripotent stem cells
- Characterization of NMR iPSCs
- Noncanonic features of NMR iPSCs
- Commentary on possible future research directions
- Chapter 11. Induced pluripotent stem cells in species conservation: advantages, applications, and the road ahead
- Introduction
- iPSCs: what makes them so attractive for species conservation?
- Applications of iPSCs for species conservation
- The long road ahead: the need for further research into iPSCs
- Future perspectives
- Index
- No. of pages: 272
- Language: English
- Edition: 1
- Published: September 29, 2020
- Imprint: Academic Press
- Paperback ISBN: 9780128222287
- eBook ISBN: 9780323851855
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead iPSCs from Diverse Species on ScienceDirect